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Serina Therapeutics, Inc. filed an Amendment No. 1 to its Annual Report for the year ended December 31, 2025 to correct the independent auditor’s consent. The original Form 10-K included an incorrect version of Exhibit 23.1, and this amendment replaces it with the correct consent from Frazier & Deeter, LLC.
The company also filed new certifications from its chief executive officer and chief financial officer, as required for amended reports. As of March 18, 2026, Serina Therapeutics had 12,314,159 shares of common stock outstanding. All other disclosures from the original Form 10-K remain unchanged and continue to speak as of the original filing date.
Serina Therapeutics, Inc. reported full-year 2025 results and highlighted progress for its neurology pipeline and financing. Grant revenue was $130,000 while operating expenses rose to $24.2 million, leading to a net loss attributable to common stockholders of $19.4 million, or $1.91 per share. Cash and cash equivalents were $3.1 million as of December 31, 2025.
In January 2026 the FDA cleared the IND for lead Parkinson’s candidate SER-252, and in February 2026 the first patient was dosed in a Phase 1b registrational trial. Serina also agreed to a private placement of common stock and pre-funded warrants of at least $15 million and up to $30 million, with 50% warrant coverage that could add up to $33.3 million upon exercise; by March 23, 2026, gross proceeds of $16.0 million had been received. In addition, the company’s at-the-market program has raised $12.9 million in gross proceeds to date.
Serina Therapeutics files its annual report detailing a clinical-stage pipeline built on its proprietary POZ polymer drug delivery platform. The company focuses on neurological diseases, especially Parkinson’s, aiming for continuous drug delivery with long-acting subcutaneous injections.
Lead candidate SER-252 (POZ-apomorphine) received FDA IND clearance in January 2026, and the first patient was dosed in a Phase 1b trial in February 2026 for advanced Parkinson’s disease. Earlier candidate SER-214 (POZ-rotigotine) completed a Phase Ia study in 19 subjects as proof of principle and is now intended for partnering.
Serina also develops POZ-lipids as alternatives to PEG-lipids for RNA lipid nanoparticle vaccines and therapeutics. In 2023, it signed a non‑exclusive license with Pfizer covering POZ technology for LNP formulations, including a $3 million upfront payment and tiered royalties between 2.75% and 3.5% on net sales. The report highlights an extensive global patent estate protecting POZ chemistries, Parkinson’s programs and POZ‑lipid applications.
Serina Therapeutics Chief Scientific Officer exercises and sells options-linked shares. On March 23, 2026, Randall Moreadith exercised stock options for 6,500 shares of common stock at an exercise price of $0.06 per share and then sold the same 6,500 shares in open-market transactions at a weighted average price of $2.8566 per share, with individual sale prices ranging from $2.68 to $3.03. This exercise-and-sell pattern represents a routine liquidity transaction rather than an open-market purchase.
Serina Therapeutics, Inc. entered into a private placement led by director Greg Bailey to raise up to $30 million through common stock and pre-funded warrants priced at $2.25 per share. The first tranche of $15 million closed around March 20, 2026, with a second tranche of up to $15 million anticipated by April 30, 2026.
Investors also receive redeemable warrants covering 50% of purchased shares at an exercise price of $5.00 per share and a four-year term, which, if fully exercised, could add up to $33.3 million in proceeds. Proceeds are intended to fund the SER‑252 Phase 1b registrational study for advanced Parkinson’s disease and related milestones. In connection with the financing, Greg Bailey will serve as Co‑Chairman of the Board, and investors gain the right to designate an additional non‑executive director once specified funding thresholds are met, while certain note funding obligations under an existing senior unsecured convertible promissory note have been removed.
Serina Therapeutics, Inc. Chief Scientific Officer Randall Moreadith exercised stock options for 39,000 shares of common stock at $0.06 per share and immediately sold all 39,000 shares at $2.50 per share in an open-market transaction.
The filing shows this was an exercise-and-sell event, with the reported common stock holdings reduced to 0 shares directly after the sale. The stock options involved were fully vested before exercise.
Serina Therapeutics, Inc. reported an insider equity award to its Chief Scientific Officer, Randall Moreadith. On February 3, 2026, he received a grant of 69,000 stock options with an exercise price of $2.76 per share, each option linked to one share of common stock.
The options were granted at no cost to him and are held as direct ownership. According to the vesting terms, 12/48ths of the options vest 12 months after the vesting commencement date, and the remaining portion vests in equal monthly installments of 1/48th until fully vested. After this grant, he beneficially owns 69,000 derivative securities in the form of these options.
Serina Therapeutics, Inc. reported that senior vice president of CMC & Formulation Tenjarla Srini received a grant of stock options on common stock. The award covers 69,000 stock options with an exercise price of $2.76 per share, dated February 3, 2026, held as direct ownership.
These options vest over time: 12/48ths of the shares vest twelve months after the vesting commencement date, and the remaining 1/48th vests on the same calendar day of each following month until fully vested. Following this grant, Srini beneficially owns 69,000 derivative securities in the form of these options.
Serina Therapeutics, Inc. reported that director Simba Gill received a grant of stock options. On 02/03/2026, he was awarded an option to acquire 92,000 shares of common stock at an exercise price of $2.76 per share, expiring on 02/03/2036.
According to the vesting terms, 12/48ths of the option shares vest twelve months after the vesting commencement date, with the remaining shares vesting in equal 1/48th monthly installments until fully vested, unless the option is earlier terminated under the option agreement.
Serina Therapeutics granted Chief Executive Officer and director Steven A. Ledger a stock option covering 230,100 shares of common stock at an exercise price of $2.76 per share. The option expires on 02/03/2036 and was awarded at a cost of $0 to the recipient.
According to the vesting terms, 12/48ths of the shares vest twelve months after the vesting commencement date, with 1/48th of the shares vesting monthly thereafter until fully vested. Following this grant, Ledger directly holds derivative securities representing 230,100 underlying shares.