Janus Henderson Group plc reports beneficial ownership of 7,108,488 shares of Olema Pharmaceuticals, Inc. common stock, representing 8.2% of the class. The filing states the Asset Managers exercise shared voting and shared dispositive power over those shares. The Asset Managers act on behalf of multiple Managed Portfolios and the filing notes that the Asset Managers do not have the right to receive dividends or sale proceeds from certain securities held in those Managed Portfolios and disclaim ownership associated with those rights.
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Insights
Large institutional stake disclosed: 7,108,488 shares (8.2%).
Janus Henderson Group plc is reported as beneficial owner of 7,108,488 shares with shared voting and dispositive power. The holding is reported under Schedule 13G/A, which is typically used for passive institutional positions.
The filing attributes holdings to multiple Asset Managers acting for Managed Portfolios; subsequent disclosures would show trading activity if the position changes.
Disclosure reflects parent/manager reporting and disclaimers on economic rights.
The schedule lists Janus Henderson as ultimate parent and explains that Asset Managers exercise investment/voting discretion for clients. It also disclaims receipt rights for dividends/proceeds tied to some Managed Portfolios.
Classification and exhibits referenced (Exhibit 99, Exhibit 24) indicate standard parent/subsidiary exhibits; filings by underlying advisers may follow as required.
Key Figures
Beneficial ownership:7,108,488 sharesPercent of class:8.2%CUSIP:68062P106+2 more
5 metrics
Beneficial ownership7,108,488 sharesBeneficially owned per Schedule 13G/A
Percent of class8.2%Percent of common stock as reported
CUSIP68062P106Olema Pharmaceuticals common stock CUSIP
Shared voting power7,108,488 sharesShared power to vote or direct the vote
Shared dispositive power7,108,488 sharesShared power to dispose or direct disposition
"may be deemed to be the beneficial owner of 7,108,488 common stock"
A beneficial owner is the person who ultimately owns or controls a financial asset or property, even if their name isn't directly on official documents. Think of it like someone who secretly holds the keys to a safe deposit box—others may appear to have access, but the true owner is the one who benefits from what's inside. Identifying beneficial owners helps ensure transparency and prevent illegal activities like money laundering or fraud.
Managed Portfoliosfinancial
"collectively referred to herein as Managed Portfolios"
shared dispositive powerregulatory
"Shared power to dispose or to direct the disposition of: 7108488"
Schedule 13G/Aregulatory
"form_type: SCHEDULE 13G/A"
A Schedule 13G/A is an amended public filing with the U.S. securities regulator that updates a previous Schedule 13G, disclosing when an individual or group holds a substantial (typically over 5%) stake in a company and is claiming a passive, non‑controlling intent. Investors monitor these updates because rising or falling holdings can signal changing confidence, potential future moves, or shifts in voting power — like watching a public ledger where large shareholders quietly adjust their positions.
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SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
UNDER THE SECURITIES EXCHANGE ACT OF 1934
(Amendment No. 2)
OLEMA PHARMACEUTICALS, INC.
(Name of Issuer)
Common Stock
(Title of Class of Securities)
68062P106
(CUSIP Number)
03/31/2026
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
Rule 13d-1(b)
Rule 13d-1(c)
Rule 13d-1(d)
schemaVersion:
SCHEDULE 13G
CUSIP Number(s):
68062P106
1
Names of Reporting Persons
JANUS HENDERSON GROUP PLC
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
JERSEY
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
0.00
6
Shared Voting Power
7,108,488.00
7
Sole Dispositive Power
0.00
8
Shared Dispositive Power
7,108,488.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
7,108,488.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
8.2 %
12
Type of Reporting Person (See Instructions)
HC
SCHEDULE 13G
Item 1.
(a)
Name of issuer:
OLEMA PHARMACEUTICALS, INC.
(b)
Address of issuer's principal executive offices:
780 BRANNAN STREET
SAN FRANCISCO, CA 94103
Item 2.
(a)
Name of person filing:
Janus Henderson Group plc
(b)
Address or principal business office or, if none, residence:
201 Bishopsgate
EC2M 3AE, United Kingdom
(c)
Citizenship:
Y9
(d)
Title of class of securities:
Common Stock
(e)
CUSIP No.:
68062P106
Item 3.
If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)
Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)
Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)
Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)
Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)
An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)
An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)
A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)
A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)
A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)
A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J),
please specify the type of institution:
(k)
Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.
Ownership
(a)
Amount beneficially owned:
Janus Henderson Group plc (JHG) is the ultimate parent of a number of SEC-registered investment advisers and foreign equivalents thereof, including but not limited to Janus Henderson Investors US LLC, Janus Henderson Investors UK Limited, Janus Henderson Investors Australia Institutional Funds Management Limited, Janus Henderson Investors Middle East Limited, Janus Henderson Investors (Jersey) Limited, Janus Henderson Investors (Japan) Limited, Janus Henderson Investors (Singapore) Limited, Kapstream Capital Pty Limited, Privacore Capital Advisors LLC, Tabula Investment Management Limited, and Victory Park Capital Advisors LLC (each, an Asset Manager and together, the Asset Managers). The Asset Managers generally exercise investment and/or voting discretion on behalf of their clients which include investment companies, other investment advisers, institutional separate accounts and retail separate accounts (collectively referred to herein as Managed Portfolios).
As a result of their exercise of investment and/or voting discretion on behalf of the Managed Portfolios, the Asset Managers may be deemed to be the beneficial owner of 7,108,488 common stock of Olema Pharmaceuticals, Inc. However, the Asset Managers do not have the right to receive any dividends from, or the proceeds from the sale of, the securities held in the Managed Portfolios and disclaim any ownership associated with such rights.
(b)
Percent of class:
8.2 %
(c)
Number of shares as to which the person has:
(i) Sole power to vote or to direct the vote:
0
(ii) Shared power to vote or to direct the vote:
7108488
(iii) Sole power to dispose or to direct the disposition of:
0
(iv) Shared power to dispose or to direct the disposition of:
7108488
Item 5.
Ownership of 5 Percent or Less of a Class.
Not Applicable
Item 6.
Ownership of more than 5 Percent on Behalf of Another Person.
If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required.
The Managed Portfolios have the right to receive all dividends from, and the proceeds from the sale of, the securities held in their respective accounts.
Of the Managed Portfolios, none own more than five percent of the common stock of Olema Pharmaceuticals, Inc.
Item 7.
Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary.
Please refer to Exhibit 99.
Item 8.
Identification and Classification of Members of the Group.
If a group has filed this schedule pursuant to §240.13d-1(b)(1)(ii)(J), so indicate under Item 3(j) and attach an exhibit stating the identity and Item 3 classification of each member of the group. If a group has filed this schedule pursuant to §240.13d-1(c) or §240.13d-1(d), attach an exhibit stating the identity of each member of the group.
N/A
Item 9.
Notice of Dissolution of Group.
Notice of dissolution of a group may be furnished as an exhibit stating the date of the dissolution and that all further filings with respect to transactions in the security reported on will be filed, if required, by members of the group, in their individual capacity. See Item 5.
N/A
Item 10.
Certifications:
By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
Janus Henderson reports beneficial ownership of 7,108,488 shares of Olema Pharmaceuticals common stock, representing 8.2% of the class, as stated in the Schedule 13G/A filing.
Does Janus Henderson have voting control over the OLMA shares?
The filing states the Asset Managers have shared voting power and shared dispositive power over 7,108,488 shares, indicating joint voting/disposition authority rather than sole control.
Are dividends or sale proceeds payable to Janus Henderson for these shares?
The Schedule 13G/A notes the Asset Managers do not have the right to receive dividends or sale proceeds from certain securities held in the Managed Portfolios and disclaim ownership tied to those rights.
Why did Janus Henderson file a Schedule 13G/A for OLMA?
The filing identifies Janus Henderson Group plc as the ultimate parent reporting beneficial ownership through multiple Asset Managers, reflecting passive institutional holdings under the reporting rules.
Who signed the Schedule 13G/A for Janus Henderson?
The Schedule 13G/A was signed by Kristin Mariani, Head of North America Compliance, on behalf of Janus Henderson Group plc, per the signature block in the filing.
