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Lakefront Biotherapeutics announced a share repurchase program under which it may buy back ordinary shares for up to €50 million. The program runs until December 31, 2026 and is conducted through Morgan Stanley & Co International PLC, following terms approved at the April 28, 2026 Extraordinary Shareholders’ Meeting.
The company notes this is an initial step under a broader transaction with Gilead that allows repurchases of up to $150 million of shares, subject to distributable reserves. Repurchased shares will be held as treasury shares, and Lakefront can suspend or stop the program, with updates provided as required by law.
Lakefront Biotherapeutics appointed Eric Hedrick, MD, as Chief Medical Officer, expanding its leadership team during a strategic transformation that follows the acquisition of Ouro Medicines’ operational assets announced on June 4, 2026.
Hedrick, who joined Lakefront in July 2025, has 25 years of experience developing successful therapies at several biotechnology companies. He will report to CEO Henry Gosebruch, join the Management Committee, and lead development of gamgertamig and future clinical programs within Lakefront’s oncology and immunology-focused R&D pipeline.
Lakefront Biotherapeutics and Gilead Sciences have completed the acquisition of Ouro Medicines, adding the T cell engager gamgertamig (OM336) to their autoimmune pipelines. Gilead acquired all Ouro equity for $1,675 million plus up to $500 million in milestones, with Lakefront and Gilead splitting these payments equally.
Gamgertamig is a BCMAxCD3 T cell engager in Phase 2 with U.S. FDA Fast Track and Orphan Drug Designations and is expected to enter registrational studies as early as 2027. Lakefront takes on Phase 1/2 development while Gilead leads later-stage and commercialization, paying Lakefront tiered royalties of 20%–23% on net sales.
Lakefront also in-licensed three preclinical autoimmune programs with a Gilead opt-in for $75 million per program and a 50/50 profit split post proof-of-concept. The deal modifies the existing OLCA, allowing Lakefront to deploy at least $500 million of its cash independently, including up to $150 million for share buybacks, and the company expects a year-end 2026 cash balance of about €2B.
Lakefront Biotherapeutics reported that Bank of America Corporation crossed a key ownership threshold under Belgian transparency rules. On May 13, 2026, Bank of America and its affiliates moved above 5% of Lakefront’s voting rights through a mix of shares and derivatives.
As of May 20, 2026, Bank of America held 623,434 direct voting rights and 5,502,802 equivalent financial instruments, together representing 9.30% of Lakefront’s currently outstanding 65,897,071 shares. The position is spread across several entities, including BofA Securities and Merrill Lynch International, via rights of use, recall, options, and swaps.