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Karyopharm (NASDAQ: KPTI) boosts share plans and grants CEO PSU awards

Filing Impact
(Moderate)
Filing Sentiment
(Neutral)
Form Type
8-K

Rhea-AI Filing Summary

Karyopharm Therapeutics Inc. reported that stockholders approved an amendment to its 2022 Equity Incentive Plan, adding 3,000,000 shares of common stock for equity awards. Stockholders also increased shares available under the Amended & Restated 2013 Employee Stock Purchase Plan by 1,400,000 shares.

The Board’s Compensation Committee adopted a broad-based retention program using performance-based restricted stock units, covering an aggregate of 3,838,380 PSUs for eligible employees. Awards include 343,000 PSUs for each of two tranches to President and CEO Richard Paulson, with vesting tied to specified clinical and other milestones and continued service.

Stockholders elected two Class I directors, approved executive compensation on an advisory basis, and ratified Ernst & Young LLP as independent auditor for the fiscal year ending December 31, 2026.

Positive

  • None.

Negative

  • None.
Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers Governance
Key personnel changes including departures, elections, or appointments of directors and executive officers.
Item 5.07 Submission of Matters to a Vote of Security Holders Governance
Results of a shareholder vote on proposals at an annual or special meeting.
Item 9.01 Financial Statements and Exhibits Exhibits
Financial statements, pro forma financial information, and exhibit attachments filed with this report.
Equity plan increase 3,000,000 shares Additional shares for 2022 Equity Incentive Plan
ESPP share increase 1,400,000 shares Added to Amended & Restated 2013 Employee Stock Purchase Plan
Retention PSUs total 3,838,380 PSUs Aggregate PSUs under broad-based retention program
CEO PSU awards 343,000 + 343,000 PSUs Two performance-based awards to President and CEO
CMO PSU awards 150,000 + 150,000 PSUs Two PSU tranches to EVP, Chief Medical Officer
CFO PSU awards 130,000 + 130,000 PSUs Two PSU tranches to EVP, CFO and Treasurer
Equity plan vote for 10,474,681 votes Votes for 2022 Equity Incentive Plan amendment
Auditor ratification votes for 16,695,588 votes Votes for ratifying Ernst & Young LLP for 2026
performance-based restricted stock units financial
"eligible employees will receive two retention equity awards in the form of performance-based restricted stock units"
Performance-based restricted stock units are a type of employee equity award that converts into company shares only if predefined financial or operational targets are met over a set period. Think of it like a bonus check that becomes stock only when specific goals are hit; it ties pay to results, aligning managers’ incentives with shareholders. Investors care because these awards affect future share count, executive incentives, and signal how management’s success will be measured and rewarded.
Equity Incentive Plan financial
"amendment to the Karyopharm Therapeutics Inc. 2022 Equity Incentive Plan, as amended"
An equity incentive plan is a program that gives employees, executives or directors the right to receive company stock or options to buy stock as part of their pay. Think of it as offering slices of future company profit to motivate people to boost long‑term performance; for investors it matters because it can align employee goals with shareholder value but also increases the number of shares outstanding, which can dilute existing ownership.
Employee Stock Purchase Plan financial
"Amended & Restated 2013 Employee Stock Purchase Plan, as amended, to increase the number of shares"
An employee stock purchase plan is a company program that lets workers buy shares through small payroll deductions, often at a discount to the market price and after a set offering period. Think of it like a workplace savings plan that turns into ownership: it encourages employees to share in the company’s success and can create predictable buying or selling of stock that investors watch because it affects supply, demand and employee incentives.
broker non-votes financial
"The results of the stockholders’ vote with respect to such approval were as follows ... Broker Non-Votes"
Broker non-votes occur when a brokerage firm is unable to vote on a shareholder’s behalf during a company election or decision because the shareholder has not given specific voting instructions, and the broker is not allowed or chooses not to vote on certain matters. They are important because they can affect the outcome of votes, especially when the results are close, by effectively reducing the total number of votes cast.
retention program financial
"approved a broad-based retention program designed to support the continued motivation, retention and incentivization"
say-on-pay financial
"stockholders approved, on an advisory basis, the compensation of the Company’s named executive officers"
A say-on-pay is a shareholder vote that gives investors a chance to approve or disapprove a company’s executive compensation packages, typically held at annual meetings. It matters because the vote signals investor satisfaction with how leaders are paid—like customers rating how well managers are rewarded—and can push boards to change pay plans, reducing governance risk and affecting investor confidence and stock value even though the vote is usually advisory rather than legally binding.
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Learn about SEC filing dates
0001503802false00015038022026-05-212026-05-21

 

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d)

of the Securities Exchange Act of 1934

Date of report (Date of earliest event reported): May 21, 2026

Karyopharm Therapeutics Inc.

(Exact Name of Registrant as Specified in Charter)

 

 

 

 

 

Delaware

 

001-36167

 

26-3931704

(State or Other Jurisdiction

of Incorporation)

 

(Commission

File Number)

 

(IRS Employer

Identification No.)

 

 

 

85 Wells Avenue, 2nd Floor

Newton, Massachusetts

 

02459

(Address of Principal Executive Offices)

 

(Zip Code)

Registrant’s telephone number, including area code: (617) 658-0600

(Former Name or Former Address, if Changed Since Last Report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

 

 

 

 

 

Title of each class

 

Trading

Symbol(s)

 

Name of each exchange

on which registered

Common Stock, $0.0001 par value

 

KPTI

 

Nasdaq Global Select Market

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

 

 

 

 

 

 

 

 

 

 

 

Emerging growth company

 

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.

 


 

 

Item 5.02

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

 

Amendment to the Karyopharm Therapeutics Inc. 2022 Equity Incentive Plan, as amended

At the 2026 Annual Meeting of Stockholders of Karyopharm Therapeutics Inc. (the “Company”) held on May 21, 2026 (the “Annual Meeting”), the Company’s stockholders approved an amendment (the “2022 Plan Amendment”) to the Karyopharm Therapeutics Inc. 2022 Equity Incentive Plan, as amended (the “2022 Plan” and, as further amended by the 2022 Plan Amendment, the “Amended 2022 Plan”). The 2022 Plan Amendment, which had previously been adopted by the Company’s Board of Directors (the “Board”) subject to stockholder approval, increases the number of shares of common stock of the Company available for issuance under the Amended 2022 Plan by 3,000,000 shares.

The description of the Amended 2022 Plan contained on pages 26 to 44 of the Company's definitive proxy statement for the Annual Meeting, filed with the Securities and Exchange Commission (the “SEC”) on April 13, 2026 (the “Proxy Statement”), is incorporated herein by reference. A complete copy of the 2022 Plan Amendment is attached hereto as Exhibit 99.1 and is incorporated herein by reference.

 

Performance-based Equity Awards

 

On May 22, 2026, the Compensation Committee (the “Committee”) of the Board approved a broad-based retention program designed to support the continued motivation, retention and incentivization of the Company’s employees, including the Company’s named executive officers and Chief Financial Officer (the “Retention Program”). Under the Retention Program, eligible employees will receive two retention equity awards in the form of performance-based restricted stock units (“PSUs”) granted under the Amended 2022 Plan, effective as of May 31, 2026.

 

One PSU award will vest in full upon the achievement of a specified clinical milestone (the “First PSU Award”). The second PSU award will vest based on the achievement of two specified milestones, with 50% of such award vesting upon achievement of each milestone (the “Second PSU Award”). Vesting of the PSU awards is also subject to the applicable participant’s continued service through the applicable vesting dates, with the Second PSU Award also subject to the requirement that stockholders approve a subsequent increase in the available shares under the Amended 2022 Plan on or prior to May 31, 2027.

 

The following PSU awards were approved for the following named executive officers and the Chief Financial Officer: (i) Dr. Reshma Rangwala, Executive Vice President, Chief Medical Officer and Head of Research - 150,000 PSUs for each of the First PSU Award and the Second PSU Award; (ii) Lori Macomber, Executive Vice President, Chief Financial Officer and Treasurer - 130,000 PSUs for each of the First PSU Award and the Second PSU Award; and (iii) Stuart Poulton, Executive Vice President, Chief Development Officer - 130,000 PSUs for each of the First PSU Award and the Second PSU Award.

 

In addition, on May 22, 2026, the Board, upon the recommendation of the Committee, approved two PSU awards to Richard Paulson, President and Chief Executive Officer, also effective as of May 31, 2026, consisting of 343,000 PSUs for each of the First PSU Award and the Second PSU Award.

 

In addition, on May 22, 2026, the Board approved a further amendment to the Amended 2022 Plan that will increase the available shares under the Amended 2022 Plan by 950,000, with such amendment subject to approval of the Company’s stockholders on or prior to May 31, 2027.

 

The aggregate number of shares subject to the PSU awards granted to all eligible employees under the Retention Program, including the PSU awards granted to the named executive officers and the Chief Financial Officer described above, will be 3,838,380.

 

Item 5.07.

Submission of Matters to a Vote of Security Holders.

 

The following is a summary of the matters voted on at the Annual Meeting held on May 21, 2026.

 

 

 


 

1.

The Company’s stockholders elected Barry E. Greene and Christy J. Oliger as Class I directors, each to serve on the Board for a three-year term until the 2029 annual meeting of stockholders and until his or her resignation or removal or until his or her successor is duly elected and qualified. The results of the stockholders’ vote with respect to the election of such Class I directors were as follows:

 

 

 

Votes For

Votes Withheld

Broker Non-Votes

 

Barry E. Greene

8,961,538

2,469,147

5,410,881

 

Christy J. Oliger

10,601,387

829,298

5,410,881

 

2.

The Company’s stockholders approved an amendment to the Karyopharm Therapeutics Inc. 2022 Equity Incentive Plan, as amended, to increase the number of shares of the Company’s common stock available for issuance thereunder by 3,000,000 shares. The results of the stockholders’ vote with respect to such approval were as follows:

 

 

Votes For

Votes Against

Votes Abstaining

Broker Non-Votes

 

10,474,681

953,411

2,593

5,410,881

 

3.

The Company’s stockholders approved an amendment to the Karyopharm Therapeutics Inc. Amended & Restated 2013 Employee Stock Purchase Plan, as amended, to increase the number of shares of the Company’s common stock available for issuance thereunder by 1,400,000 shares. The results of the stockholders’ vote with respect to such approval were as follows:

 

 

Votes For

Votes Against

Votes Abstaining

Broker Non-Votes

 

11,221,920

203,702

5,063

5,410,881

 

4.

The Company’s stockholders approved, on an advisory basis, the compensation of the Company’s named executive officers as disclosed in the Proxy Statement. The results of the stockholders’ vote with respect to such approval were as follows:

 

 

Votes For

Votes Against

Votes Abstaining

Broker Non-Votes

 

10,025,198

1,388,274

17,213

5,410,881

 

5.

The Company’s stockholders ratified the appointment of Ernst & Young LLP as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2026. The results of the stockholders’ vote with respect to such ratification were as follows:

 

 

Votes For

Votes Against

Votes Abstaining

 

 

16,695,588

86,550

59,428

 

 

Item 9.01

Financial Statements and Exhibits.

(d) Exhibits

 

Exhibit

No.

Description

99.1

Amendment No. 4 to the Karyopharm Therapeutics Inc. 2022 Equity Incentive Plan (incorporated herein by reference to Appendix A to the Company’s Definitive Proxy Statement on Schedule 14A (File No. 001-36167) filed with the SEC on April 13, 2026)

 

 

 

104

Cover Page Interactive Data File (formatted as Inline XBRL)

 

 

 


 

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

 

 

 

 

 

 

 

 

 

 

 

 

KARYOPHARM THERAPEUTICS INC.

 

 

 

 

Date: May 28, 2026

 

 

 

By:

 

/s/ Michael Mano

 

 

 

 

 

 

Michael Mano

 

 

 

 

 

 

Executive Vice President, Chief Legal Officer and Secretary

 

 

 


FAQ

What equity plan changes did Karyopharm Therapeutics (KPTI) stockholders approve?

Stockholders approved an amendment to Karyopharm’s 2022 Equity Incentive Plan adding 3,000,000 additional common shares for awards. They also backed an amendment to the 2013 Employee Stock Purchase Plan, increasing its share pool by 1,400,000 shares for employee purchases.

What is Karyopharm Therapeutics (KPTI) new performance-based retention program?

Karyopharm adopted a broad-based retention program granting performance-based restricted stock units under the Amended 2022 Plan. The program covers an aggregate of 3,838,380 PSUs for eligible employees, with vesting tied to specified clinical and other milestones and each participant’s continued service with the company.

How many PSUs did Karyopharm (KPTI) grant to its CEO under the new program?

President and CEO Richard Paulson received two performance-based awards effective May 31, 2026, each covering 343,000 PSUs. One award vests upon a specified clinical milestone, while the second vests in two 50% tranches upon achieving separate milestones and satisfying continued service requirements.

Which Karyopharm (KPTI) executive officers received PSUs and in what amounts?

Executive Vice President and Chief Medical Officer Dr. Reshma Rangwala received 150,000 PSUs in each of two awards. EVP and CFO Lori Macomber and EVP, Chief Development Officer Stuart Poulton each received 130,000 PSUs for the first award and 130,000 for the second award.

What were the voting results on Karyopharm (KPTI) equity plan amendment?

The amendment to increase shares under the 2022 Equity Incentive Plan received 10,474,681 votes for, 953,411 against, and 2,593 abstentions, with 5,410,881 broker non-votes. This approval expanded the share pool available for future equity incentive awards.

Did Karyopharm Therapeutics (KPTI) stockholders approve executive compensation?

Yes, stockholders approved named executive officer compensation on an advisory basis, with 10,025,198 votes for, 1,388,274 against, and 17,213 abstentions, plus 5,410,881 broker non-votes. This advisory vote supports the company’s disclosed pay practices.

Who was elected to Karyopharm (KPTI) board and who is the auditor for 2026?

Stockholders elected Barry E. Greene and Christy J. Oliger as Class I directors for terms ending at the 2029 annual meeting. They also ratified Ernst & Young LLP as Karyopharm’s independent registered public accounting firm for the fiscal year ending December 31, 2026.

Filing Exhibits & Attachments

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