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Item 5.02 |
Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers. |
Amendment to the Karyopharm Therapeutics Inc. 2022 Equity Incentive Plan, as amended
At the 2026 Annual Meeting of Stockholders of Karyopharm Therapeutics Inc. (the “Company”) held on May 21, 2026 (the “Annual Meeting”), the Company’s stockholders approved an amendment (the “2022 Plan Amendment”) to the Karyopharm Therapeutics Inc. 2022 Equity Incentive Plan, as amended (the “2022 Plan” and, as further amended by the 2022 Plan Amendment, the “Amended 2022 Plan”). The 2022 Plan Amendment, which had previously been adopted by the Company’s Board of Directors (the “Board”) subject to stockholder approval, increases the number of shares of common stock of the Company available for issuance under the Amended 2022 Plan by 3,000,000 shares.
The description of the Amended 2022 Plan contained on pages 26 to 44 of the Company's definitive proxy statement for the Annual Meeting, filed with the Securities and Exchange Commission (the “SEC”) on April 13, 2026 (the “Proxy Statement”), is incorporated herein by reference. A complete copy of the 2022 Plan Amendment is attached hereto as Exhibit 99.1 and is incorporated herein by reference.
Performance-based Equity Awards
On May 22, 2026, the Compensation Committee (the “Committee”) of the Board approved a broad-based retention program designed to support the continued motivation, retention and incentivization of the Company’s employees, including the Company’s named executive officers and Chief Financial Officer (the “Retention Program”). Under the Retention Program, eligible employees will receive two retention equity awards in the form of performance-based restricted stock units (“PSUs”) granted under the Amended 2022 Plan, effective as of May 31, 2026.
One PSU award will vest in full upon the achievement of a specified clinical milestone (the “First PSU Award”). The second PSU award will vest based on the achievement of two specified milestones, with 50% of such award vesting upon achievement of each milestone (the “Second PSU Award”). Vesting of the PSU awards is also subject to the applicable participant’s continued service through the applicable vesting dates, with the Second PSU Award also subject to the requirement that stockholders approve a subsequent increase in the available shares under the Amended 2022 Plan on or prior to May 31, 2027.
The following PSU awards were approved for the following named executive officers and the Chief Financial Officer: (i) Dr. Reshma Rangwala, Executive Vice President, Chief Medical Officer and Head of Research - 150,000 PSUs for each of the First PSU Award and the Second PSU Award; (ii) Lori Macomber, Executive Vice President, Chief Financial Officer and Treasurer - 130,000 PSUs for each of the First PSU Award and the Second PSU Award; and (iii) Stuart Poulton, Executive Vice President, Chief Development Officer - 130,000 PSUs for each of the First PSU Award and the Second PSU Award.
In addition, on May 22, 2026, the Board, upon the recommendation of the Committee, approved two PSU awards to Richard Paulson, President and Chief Executive Officer, also effective as of May 31, 2026, consisting of 343,000 PSUs for each of the First PSU Award and the Second PSU Award.
In addition, on May 22, 2026, the Board approved a further amendment to the Amended 2022 Plan that will increase the available shares under the Amended 2022 Plan by 950,000, with such amendment subject to approval of the Company’s stockholders on or prior to May 31, 2027.
The aggregate number of shares subject to the PSU awards granted to all eligible employees under the Retention Program, including the PSU awards granted to the named executive officers and the Chief Financial Officer described above, will be 3,838,380.
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Item 5.07. |
Submission of Matters to a Vote of Security Holders. |
The following is a summary of the matters voted on at the Annual Meeting held on May 21, 2026.