STOCK TITAN

HCW Biologics (NASDAQ: HCWB) 2025 loss, going concern and Nasdaq risk

Filing Impact
(Moderate)
Filing Sentiment
(Neutral)
Form Type
8-K

Rhea-AI Filing Summary

HCW Biologics Inc. reported fourth quarter and full-year 2025 results showing very limited revenue and ongoing losses alongside financing and listing pressures. Revenue was $27,010 for the quarter and $54,232 for 2025, down sharply from $2.6 million in 2024, mainly due to changes in a licensing arrangement.

The company cut operating expenses to $13.2 million in 2025 from $30.4 million in 2024, helped by a $5.5 million gain tied to resolving prior legal fees. Net loss improved to $7.96 million in 2025 from $30.0 million in 2024, but cash fell to $1.95 million as of December 31, 2025.

Management states that substantial doubt exists about the company’s ability to continue as a going concern for at least 12 months without new funding. HCW also received a new Nasdaq notice on March 26, 2026 for failing to maintain the $1 minimum bid price after a prior reverse stock split and plans to appeal. On the business side, the company initiated a Phase 1 trial of its lead autoimmune candidate HCW9302 in alopecia areata and received a $3.5 million upfront fee for licensing preclinical molecule HCW11-006, plus a minority equity stake and potential milestones and royalties.

Positive

  • Large improvement in annual net loss: Net loss shrank to $7.96 million in 2025 from $30.02 million in 2024, helped by a $5.46 million gain on extinguishment of a legal fee liability and related insurance reimbursement.
  • Non-dilutive upfront licensing cash: The company received a $3.5 million upfront license fee for HCW11-006 (about $2.9 million net after taxes) plus a minority equity stake and potential milestones and double-digit royalties.
  • Clinical and platform progress: Initiation of a Phase 1 trial for HCW9302 in alopecia areata and publication of HCW9206 data in Science Advances support advancement of the autoimmune and reagent platforms.

Negative

  • Going concern warning: As of December 31, 2025, management states substantial doubt about the company’s ability to continue as a going concern for at least 12 months without additional funding or financial support.
  • Collapse in operating revenue: Revenues fell from $2.57 million in 2024 to $54,232 in 2025 as licensed molecule sales to Wugen declined following a one-year suspension of the license agreement.
  • Thin cash and high short-term obligations: Cash and cash equivalents were $1.95 million at year-end 2025 versus current liabilities of $21.06 million, highlighting tight liquidity and balance sheet pressure.
  • Ongoing Nasdaq listing risk: After previously effecting a 1-for-40 reverse stock split, the company received a March 26, 2026 notice for failing to maintain the $1 minimum bid price and must appeal to avoid potential delisting.

Insights

Severely reduced revenue, going concern language, and Nasdaq bid-price risk offset licensing and legal one-time gains.

HCW Biologics shifted from $2.6 million in 2024 revenue to only $54,232 in 2025 after suspending a key license, leaving the business largely pre-revenue. The 2025 net loss narrowed to $7.96 million from $30.0 million, driven mainly by a $5.5 million gain on extinguishing legal fee obligations.

Cash was just $1.95 million as of December 31, 2025 against total current liabilities of $21.06 million, and management explicitly states “substantial doubt” about continuing as a going concern without additional funding. This puts significant weight on executing its multi-step financing and business development plan, including monetizing reagents and licensing molecules.

On listing status, Nasdaq confirmed regained compliance in February 2026, but a new notice on March 26, 2026 cited failure to maintain the $1 minimum bid price after a prior 1-for-40 reverse split. An appeal is planned, yet future equity access hinges on maintaining this listing while advancing HCW9302 and other pipeline candidates.

Item 2.02 Results of Operations and Financial Condition Financial
Disclosure of earnings results, typically an earnings press release or preliminary financials.
Item 9.01 Financial Statements and Exhibits Exhibits
Financial statements, pro forma financial information, and exhibit attachments filed with this report.
Q4 2025 revenue $27,010 Revenues for the three months ended December 31, 2025
2025 full-year revenue $54,232 Revenues for the year ended December 31, 2025 vs $2.57M in 2024
2025 net loss $7,959,709 Net loss for the year ended December 31, 2025
2024 net loss $30,023,814 Net loss for the year ended December 31, 2024
Cash and cash equivalents $1,952,464 Cash balance as of December 31, 2025
Upfront license fee HCW11-006 $3.5 million Gross proceeds upfront license payment received by March 16, 2026
Gain on extinguishment of liability $5,461,046 Recorded in 2025 related to settlement of legal fees
Current liabilities $21,062,713 Total current liabilities as of December 31, 2025
going concern financial
"the Company believes that substantial doubt exists regarding its ability to continue as a going concern for at least 12 months"
A going concern is a business that is expected to continue its operations and meet its obligations for the foreseeable future, rather than shutting down or selling off assets. This assumption matters to investors because it indicates stability and ongoing profitability, making the business a more reliable investment. Think of it as believing a restaurant will stay open and serve customers, rather than closing down suddenly.
Phase 1 multi-center dose-escalation study medical
"The Phase 1 multi-center dose-escalation study of HCW9302 is designed to treat up to 30 patients."
reverse stock split financial
"Due to the fact that the Company effected a 1-for-40 reverse stock split on April 11, 2025"
A reverse stock split is when a company reduces the number of its shares outstanding, making each share more valuable. For example, if you own 100 shares worth $1 each, a 1-for-10 reverse split would turn your 100 shares into 10 shares worth $10 each. Companies often do this to boost their stock price and appear more stable to investors.
minimum bid price financial
"the Company’s security did not maintain a minimum bid price of $1 per share, in accordance with Nasdaq Listing Rule 5810(c)(3)(A)"
The minimum bid price is the lowest share price that a market, regulator, or specific offering will accept for a trade, listing, or auction—think of it as a reserve or floor that a stock must meet to qualify for certain actions. It matters to investors because falling below that floor can limit trading options, trigger compliance measures or delisting risks, and affect liquidity and the perceived value of a holding, much like a reserve price in an auction sets the baseline for a sale.
double-digit royalties financial
"eligible to receive additional payments under the license, including development milestone payments and double-digit royalties on future product sales"
fusion immunotherapeutics medical
"a clinical-stage biopharmaceutical company developing transformative fusion immunotherapeutics to support or treat diseases"
Q4 2025 revenues $27,010
FY 2025 revenues $54,232
FY 2025 net loss $7,959,709
FY 2024 net loss $30,023,814
0001828673false00018286732026-03-312026-03-31

 

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

 

FORM 8-K

 

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): March 31, 2026

 

 

HCW Biologics Inc.

(Exact name of Registrant as Specified in Its Charter)

 

 

Delaware

001-40591

82-5024477

(State or Other Jurisdiction
of Incorporation)

(Commission File Number)

(IRS Employer
Identification No.)

 

 

 

 

 

2929 N. Commerce Parkway

 

Miramar, Florida

 

33025

(Address of Principal Executive Offices)

 

(Zip Code)

 

Registrant’s Telephone Number, Including Area Code: 954 842-2024

 

Not Applicable

(Former Name or Former Address, if Changed Since Last Report)

 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:


Title of each class

 

Trading
Symbol(s)

 


Name of each exchange on which registered

Common Stock, par value $0.0001 per share

 

HCWB

 

The Nasdaq Stock Market LLC

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

Emerging growth company

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.

 


Item 2.02 Results of Operations and Financial Condition.

On March 31, 2026, HCW Biologics Inc. issued a press release announcing its financial results for the quarter ended December 31, 2025. The full text of the press release issued in connection with the announcement is furnished as Exhibit 99.1 to this Current Report on Form 8-K.

The information set forth in this Item 2.02 (including Exhibit 99.1) is being furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, regardless of any general incorporation language in such filing, except as expressly set forth by specific reference in such a filing.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits

 

Exhibit No.

 

Description

99.1

 

Press release dated March 31, 2026.

104

 

Cover Page Interactive Data File (embedded within the Inline XBRL document).

 


SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

 

 

 

HCW BIOLOGICS INC.

 

 

 

 

Date:

March 31, 2026

By:

/s/ Hing C. Wong

 

 

 

Hing C. Wong
Founder and Chief Executive Officer

 


EXHIBIT 99.1

img90053791_0.gif

 

 

HCW Biologics Reports Fourth Quarter 2025 and Fiscal Year 2025

Business Highlights and Financial Results

 

Miramar, FL – March 31, 2026 – HCW Biologics Inc. (the “Company” or “HCW Biologics”) (NASDAQ: HCWB), a clinical-stage biopharmaceutical company developing transformative fusion immunotherapeutics to support or treat diseases promoted by chronic inflammation, today reported financial results and recent business highlights for its three months ended December 31, 2025.

 

On November 17, 2025, the Company initiated its first-in-human clinical trial to evaluate HCW9302, the lead product candidate for the Company’s program to develop treatments for autoimmune disorders and proinflammatory diseases, in patients with areata alopecia. HCW9302 is a subcutaneously injectable, first-in-kind interleukin-2 (“IL-2”) fusion immunotherapeutic. IL-2, the active component of HCW9302, is the cytokine in humans and other vertebrates responsible for maintaining the proper numbers and functions of Treg cells in the body. Treg cells control excessive inflammation caused by other immune cells, which is the etiology of autoimmune diseases.

 

The Company believes that HCW9302 can suppress the hair-follicle killing activities of the auto-reactive immune cells by activating and expanding regulatory T cells (“Treg”) cells. There are no curative FDA approved treatments of this indication. Alopecia areata causes sudden hair loss and can have a significant negative impact on patients’ quality of life and psychological health. The National Alopecia Areata Foundation estimates approximately 160 million people worldwide and 7 million people in the United States have alopecia areata. The condition affects about 2% of the global population at some point in their lifetime.

 

The Phase 1 multi-center dose-escalation study of HCW9302 is designed to treat up to 30 patients. The primary objectives of the study are to evaluate the safety of HCW9302, injected under the skin (subcutaneously), and to determine the recommended dose level to advance to later phase clinical studies. A preliminary human data read out is expected in the first half of 2026.

 


Dr. Hing C. Wong, the Company’s Founder and Chief Executive Officer said, “We are excited to be the sponsor of this clinical study to evaluate this promising new treatment for alopecia areata. We will be conducting additional ancillary studies to provide further insights into disease responses and the effects of HCW9302 on proliferation and function of immune cells, particularly Treg cells.”

Dr. Wong continued, “Based the results of our preclinical studies including non-human primates, we believe the human data read out will show that HCW9302 has superior IL-2Rα affinity and will sustain serum exposure, which could potentially make it favorable for the expansion and in increasing the functionality of Treg for autoimmune disease treatments. HCW9302 was well tolerated in non-human primate studies. If this remains the case in human studies, this would be a significant improvement over conventional IL-2 therapies that have low tolerability profiles. We believe the data will confirm that HCW9302 can achieve strong biological activity at lower therapeutic dose levels, and as a result, will have a favorable tolerability and at the same time can potentially enhance receptor selectivity and reduce off-target effects.”

Business Highlights

Upfront License Fee Received for Exclusive Worldwide License for HCW11-006

As of March 16, 2026, we received the full payment of the upfront licensing fee for the exclusive worldwide license for HCW11-006, a preclinical molecule licensed to Beijing Trimmune Biotech Co., Ltd. (“Trimmune”). The Company received $3.5 million in gross proceeds, and $2.9 million net after taxes. In addition to the cash portion of the upfront license fee, the Company received a transferable minority equity interest in Trimmune.

HCW Biologics is eligible to receive additional payments under the license, including development milestone payments and double-digit royalties on future product sales, as well as a portion of the proceeds from certain future transaction(s) involving the licensed molecule, if and when such transaction(s) occur. Upon completion of Phase 1 by the licensee, the Company may exercise its Opt-In Rights to reclaim the rights to the Americas market. For an additional fee, Trimmune may exercise an option to license the China rights to HCW9302, the Company’s clinical-stage molecule, currently being evaluated in a Phase 1 trial in an autoimmune disorder.

Commercial-Ready Molecules Used as Reagents

During the year ended December 31, 2025, the Company launched two of its proprietary fusion protein molecules as commercial-ready molecules used as reagents to be used to support the production of cell-based immunotherapeutics to treat infectious diseases and cancer. While the Company’s focus remains on the development of fusion immunotherapeutics for the treatment of diseases promoted by chronic inflammation, the Company intends to market these reagents directly or through a corporate partnership to generate revenue which could offset development costs for its other immunotherapeutic treatments.

On March 13, 2026, Science Advances, a peer-reviewed, high-impact journal, released a publication with the Company’s data that showed the Company’s proprietary, commercial-ready compound, HCW9206, could fundamentally change how CAR-T cell therapies are manufactured and potential improve their clinical efficacy against diseases such as cancer and HIV. These findings support the Company’s belief that HCW9206 is a leap forward in both clinical potential and manufacturing efficiency.


Fourth Quarter 2025 Financial Results

Revenues: Revenues for the three months ended December 31, 2024 and 2025 were $394,804 and $27,010, respectively. Revenues for the years ended December 31, 2024 and 2025 were $2.6 million and $54,232, respectively. Historically, revenues have been derived exclusively from the sale of licensed molecules to the Company’s licensee, Wugen. In the year ended December 31, 2025, the Company agreed to a one-year suspension of the Wugen License Agreement in exchange for the exclusive right to market HCW9206 and HCW9201 as reagents and potentially identify a new corporate partner during this period.

Research and development (R&D) expenses: R&D expenses for the three months ended December 31, 2024 and 2025 were $1.0 million and $1.3 million, respectively, an increase of $283,491, or 27%. R&D expenses for the years ended December 31, 2024 and 2025 were $6.4 million and $5.4 million, respectively, a decrease of $1.0 million, or 15%. R&D expenses in the year ended December 31, 2024 were higher than in the comparable period in 2025, due to higher expenses incurred for manufacturing and materials.

General and administrative (G&A) expenses: G&A expenses for the three months ended December 31, 2024 and 2025 were $2.0 million and $1.5 million, respectively, a decrease of $526,175, or 26%. G&A expenses for the years ended December 31, 2024 and 2025 were $6.8 million and $7.7 million, respectively, an increase of $884,832 or 13%. The increase in G&A expenses in 2025 was primarily due to salaries and benefits and professional fees related to audit services, tax and other advisory services, as well as required activities to remain in compliance with SEC regulations and Nasdaq listing rules.

Legal expenses (recoveries), net: Legal expenses and recoveries, net represent the legal fees that the Company incurred for an Arbitration which held its hearing in May 2024, was settled on July 13, 2024, and was dismissed on December 24, 2024. Legal expenses (recoveries), net for the three months ended December 31, 2024 and 2025 were $148,949 and $120,136, respectively. Legal expenses (recoveries), net for the years ended December 31, 2024 and 2025 were $15.9 million and a contra expense of ($1.5) million, respectively. In January 2025, the Company received a $2.0 million insurance reimbursement that was paid directly to the law firm involved in representing Dr. Hing C. Wong, the Company’s Founder and Chief Executive Officer, in the Arbitration. The Company and Dr. Wong reached a settlement agreement in 2025 for the full balance of $7.5 million which was owed for legal fees incurred in connection with the defense for Dr. Wong, resulting in a gain of $5.5 million for the year ended December 31, 2025.

Net (loss) gain: Net (loss) gain for the three months ended December 31, 2024 and 2025 was ($3.4) million and $2.2 million, respectively. Net loss for the years ended December 31, 2024 and 2025 was ($30.0) million and ($6.5) million, respectively.


Financial Guidance



As of December 31, 2025, the Company believes that substantial doubt exists regarding its ability to continue as a going concern for at least 12 months from the issuance date of the audited financial statements, without additional funding or financial support. We considered future elements of our financing plan, especially business development programs, that were probable and likely to be implemented within the next year to determine if financing activities currently underway are sufficient to mitigate the substantial doubt in our going concern analysis. We have had early success in completing key elements of our multi-step financing plan, however, we cannot be assured that we will continue to have success with remaining elements of our plan.

 

An important part of the Company’s future financing plans is the ability to access the public markets for the sale of securities. On February 26, 2026, the Nasdaq Hearings Panel found that the Company regained compliance with all continued listing rules of The Nasdaq Capital Market. Pursuant to Listing Rule 5815(d)(4)(B), the Company will be subject to a Mandatory Panel Monitor. If, within that one-year monitoring period, the Staff again finds the Company to be out of compliance with the Equity Rule that was the subject of the exception, notwithstanding Rule 5810(c)(2), the Staff will issue a Delist Determination Letter and the Company will have an opportunity to request a new hearing with the initial Panel or a newly convened Hearings Panel if the initial Panel is unavailable. On March 26, 2026, the Company received a written notice from the Staff which notified the Company that, for the 30 consecutive business days, the Company’s security did not maintain a minimum bid price of $1 per share, in accordance with Nasdaq Listing Rule 5810(c)(3)(A) (“Bid Price Rule”). Due to the fact that the Company effected a 1-for-40 reverse stock split on April 11, 2025, the Company was not afforded a 180-calendar day period to demonstrate compliance. The Company plans to request an appeal of this determination in a timely manner.


About HCW Biologics



HCW Biologics Inc. (the “Company”) (NASDAQ: HCWB) is a clinical-stage biopharmaceutical company developing transformative fusion immunotherapeutics to support or treat diseases promoted by chronic inflammation, including autoimmune diseases, cancer, and senescence-associated dysplasia. The Company’s immunotherapeutics represent a new class of drugs that it believes have the potential to fundamentally change the treatment of proinflammatory and senescence-associated diseases and conditions that are promoted by chronic inflammation — and in doing so, improve patients’ quality of life and possibly extend longevity. Chronic inflammation is believed to be a significant contributing factor to the cause of conditions that diminish healthspan, including many types of cancer, autoimmune diseases and other proinflammatory diseases such as neurodegenerative diseases, as well as senescence-associated dysplasia, such as bronchopulmonary dysplasia, that impact quality-of-life but are not life-threatening. The Company has begun commercialization of certain commercial-ready proprietary compounds for use as reagents in the production of cell-based immunotherapeutics for the treatment of infectious diseases and cancer. HCW9206 is a reagent that supports a new method of generating highly functional human CAR-T cells for treating infectious diseases and cancer. HCW9201 is a reagent that supports enhanced anti-tumor activity and contributes to treatment resilience in the adverse tumor microenvironment. The Company’s lead product candidate for its autoimmune program is HCW9302, which is subcutaneously injectable, first-in-kind interleukin-2 (“IL-2”) fusion molecule constructed using the Company’s TOBI™ platform technology. HCW9302 is currently being evaluated in a Phase 1 clinical study in patients with alopecia areata, which initiated in November 2025 (NCT07049328). The Company has identified two preclinical


lead product candidates which are currently in IND-enabling stage for internal development constructed with its proprietary TRBC drug discovery and development platform. HCW11-018b (“Big BiTE”) is a tetra-valent T-cell engager designed to address shortfalls of bi-specific T-cell engagers (“BiTE”) related to manufacturability, safety profile, and ability to treat a wide spectrum of solid tumors. HCW11-040 is a pembrolizumab-based, tetra-valent immune checkpoint inhibitor. To improve efficacy, HCW11-040 is equipped with other moieties in addition to pembrolizumab which neutralizes the immunosuppressive cytokine, TGF-β, and activates effector immune cell responses. A key aspect of the Company’s clinical development and financing strategy is to focus on its business development programs. To date, the Company has entered into two licensing agreements in which it has licensed exclusive, worldwide rights for some of its proprietary molecules. See the Company Pipeline at https://hcwbiologics.com/pipeline/

 

Forward Looking Statements



Statements in this press release contain “forward-looking statements” that are subject to substantial risks and uncertainties. These statements are made under the “safe harbor” provisions of the U.S. Private Securities Litigation Reform Act of 1995. Forward-looking statements contained in this press release may be identified by the use of words such as “anticipate,” “expect,” “believe,” “will,” “may,” “should,” “estimate,” “project,” “outlook,” “forecast” or other similar words and include: the Company’s ability to develop new immunotherapeutic treatments for non-oncology or oncology indications; timing of initiation of studies for age-related and autoimmune diseases; the Company’s ability to continue as a going concern and that after considering the elements of the Company’s financing plan that were probable to occur within a year of the date of issuance, the Company concluded that substantial doubt was not alleviated in its going concern analysis; the Company’s cash runway; the effectiveness of HCW9302 in clinical trials and data readouts against autoimmune conditions; the Company’s ability to license its preclinical molecule(s); the ability of the Company to enter into a corporate partnership to market commercial-ready reagents; the actual success and potency of the Company’s TRBC fusion molecules;; the actual success and potency of pembrolizumab-based TRBC fusion molecules;; the ability of the Company’s partner to develop, manufacture and undergo clinical trials with HCW11-006; the Company’s future capital-raising plans and ability to continue with clinical development efforts until they are achieved, if at all; and Company’s ability to pay legal fees incurred in connection with the arbitration with ImmunityBio and its affiliates. Forward-looking statements are based on the Company’s current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Further, certain forward-looking statements are based on assumptions as to future events that may not prove to be accurate. Factors that could cause actual results to differ include, but are not limited to, the risks and uncertainties that are described in the section titled “Risk Factors” in the annual report on Form 10-K filed with the United States Securities and Exchange Commission (the “SEC”) on March 31, 2026 and in other filings filed from time to time with the SEC. Forward-looking statements contained in this press release are made as of this date, and the Company undertakes no duty to update such information except as required under applicable law.


Company Contact:

Rebecca Byam

CFO

HCW Biologics Inc.

rebeccabyam@hcwbiologics.com

 


 

 

HCW Biologics Inc.

Statements of Operations

 

 

For the Three Months Ended
December 31,

 

 

 

Years Ended
December 31,

 

 

 

 

2024

 

 

2025

 

 

 

2024

 

 

2025

 

 

Revenues:

 

Unaudited

 

 

 

Audited

 

 

Revenues

 

$

394,804

 

 

$

27,010

 

 

 

$

2,566,792

 

 

$

54,232

 

 

Cost of revenues

 

 

(315,843

)

 

 

(21,609

)

 

 

 

(1,607,389

)

 

 

(43,386

)

 

Net revenues

 

 

78,961

 

 

 

5,401

 

 

 

 

959,403

 

 

 

10,846

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Operating expenses:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Research and development

 

 

1,049,611

 

 

 

1,333,102

 

 

 

 

6,388,994

 

 

 

5,442,884

 

 

General and administrative

 

 

2,040,160

 

 

 

1,513,985

 

 

 

 

6,816,449

 

 

 

7,701,281

 

 

Legal expenses

 

 

148,949

 

 

 

120,136

 

 

 

 

15,910,480

 

 

 

(1,470,809

)

 

Impairment of long-lived asset

 

 

 

 

 

1,500,000

 

 

 

 

 

 

 

1,500,000

 

 

Nonoperating loss

 

 

 

 

 

 

 

 

 

1,300,000

 

 

 

 

 

Total operating expenses

 

 

3,238,720

 

 

 

4,467,223

 

 

 

 

30,415,923

 

 

 

13,173,356

 

 

Loss from operations

 

 

(3,159,759

)

 

 

(4,461,822

)

 

 

 

(29,456,520

)

 

 

(13,162,510

)

 

Interest expense

 

 

(248,107

)

 

 

(212,128

)

 

 

 

(654,284

)

 

 

(845,051

)

 

Change in fair value of investment

 

 

 

 

 

 

 

 

 

 

 

 

(273,422

)

 

Change in fair value of contingent liability

 

 

 

 

 

 

 

 

 

 

 

 

1,055,826

 

 

Loss on sale of put shares

 

 

 

 

 

(81,828

)

 

 

 

 

 

 

(263,974

)

 

Gain on extinguishment of liability

 

 

 

 

 

5,461,046

 

 

 

 

 

 

 

5,461,046

 

 

Other income, net

 

 

34,593

 

 

 

13,964

 

 

 

 

86,990

 

 

 

68,376

 

 

Net loss

 

$

(3,373,273

)

 

$

719,232

 

 

 

$

(30,023,814

)

 

$

(7,959,709

)

 

Equity dividend to investor

 

 

 

 

 

(4,185,194

)

 

 

 

 

 

 

(14,338,993

)

 

Net loss attributable to Common Stockholders

 

$

(3,373,273

)

 

$

(3,465,962

)

 

 

$

(30,023,814

)

 

$

(22,298,702

)

 

Net loss per share, basic and diluted

 

$

(3.19

)

 

$

(1.02

)

 

 

$

(30.96

)

 

$

(10.63

)

 

Weighted average shares outstanding, basic and diluted

 

 

1,057,542

 

 

 

3,384,062

 

 

 

 

969,825

 

 

 

2,097,701

 

 

 

 


 

HCW Biologics Inc.

Audited Balance Sheets

 

 

December 31,

 

 

December 31,

 

 

 

2024

 

 

2025

 

 

 

 

 

 

 

 

ASSETS

 

 

 

 

 

 

Current assets:

 

 

 

 

 

 

Cash and cash equivalents

 

$

4,674,572

 

 

$

1,952,464

 

Accounts receivable, net

 

 

582,201

 

 

 

32,175

 

Prepaid expenses

 

 

328,181

 

 

 

222,156

 

Other current assets

 

 

113,528

 

 

 

77,564

 

Total current assets

 

 

5,698,482

 

 

 

2,284,359

 

Investments

 

 

1,599,751

 

 

 

1,326,329

 

Property, plant and equipment, net

 

 

22,909,869

 

 

 

20,880,849

 

Other assets

 

 

28,476

 

 

 

28,476

 

Total assets

 

$

30,236,578

 

 

$

24,520,013

 

LIABILITIES AND STOCKHOLDERS’ EQUITY (DEFICIT)

 

 

 

 

 

 

Liabilities

 

 

 

 

 

 

Current liabilities:

 

 

 

 

 

 

Accounts payable

 

$

22,332,261

 

 

$

13,143,394

 

Accrued liabilities and other current liabilities

 

 

981,940

 

 

 

1,110,104

 

Short-term debt, net

 

 

6,314,684

 

 

 

6,809,215

 

Total current liabilities

 

 

29,628,885

 

 

 

21,062,713

 

Debt, net

 

 

7,377,865

 

 

 

 

Contingent liability - related party

 

 

 

 

 

692,531

 

Total liabilities

 

 

37,006,750

 

 

 

21,755,244

 

Commitments and contingencies (Note 17)

 

 

 

 

 

 

Stockholders’ equity (deficit):

 

 

 

 

 

 

Common stock:

 

 

 

 

 

 

Common, $0.0001 par value; 250,000,000 shares authorized
   and 1,113,532 shares issued at December 31, 2024; 250,000,000 shares
   authorized and 3,279,812 shares issued at December 31, 2025

 

 

111

 

 

 

328

 

Additional paid-in capital

 

 

93,785,854

 

 

 

111,280,287

 

Accumulated deficit

 

 

(100,556,137

)

 

 

(108,515,846

)

Total stockholders’ equity (deficit)

 

 

(6,770,172

)

 

 

2,764,769

 

Total liabilities and stockholders’ equity (deficit)

 

$

30,236,578

 

 

$

24,520,013

 

 

 


FAQ

How did HCW Biologics (HCWB) perform financially in 2025?

HCW Biologics reported a 2025 net loss of $7.96 million, an improvement from a $30.02 million loss in 2024. However, revenue dropped sharply to $54,232 from $2.57 million, reflecting reduced licensing activity and leaving the company largely pre-revenue overall.

What is the going concern status of HCW Biologics (HCWB)?

As of December 31, 2025, HCW Biologics believes substantial doubt exists about its ability to continue as a going concern for at least 12 months without new funding. Limited cash of $1.95 million and significant current liabilities drive this assessment.

What new clinical progress did HCW Biologics (HCWB) report?

HCW Biologics initiated a Phase 1 multi-center dose-escalation trial of HCW9302 in patients with alopecia areata on November 17, 2025. The study will treat up to 30 patients, focusing on safety and dose selection, with a preliminary human data readout expected in the first half of 2026.

What licensing deal did HCW Biologics (HCWB) complete for HCW11-006?

By March 16, 2026, HCW Biologics received a $3.5 million upfront license fee (about $2.9 million net) for exclusive worldwide rights to HCW11-006 granted to Beijing Trimmune Biotech. The company also gained a minority equity interest and eligibility for milestones and double-digit royalties.

What is HCW Biologics’ (HCWB) Nasdaq listing situation?

On February 26, 2026, Nasdaq found HCW Biologics back in compliance with listing rules but placed it under a one-year Panel Monitor. On March 26, 2026, the company received a new notice for failing the $1 minimum bid price requirement and plans to appeal.

What were HCW Biologics’ key balance sheet figures at year-end 2025?

At December 31, 2025, HCW Biologics reported $1.95 million in cash and cash equivalents, total assets of $24.52 million, current liabilities of $21.06 million, and total stockholders’ equity of $2.76 million, reflecting a shift from a prior equity deficit.

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