CRISPR Therapeutics reporting persons Orbis Investment Management Ltd and Allan Gray Australia Pty Ltd filed an Amendment No. 2 to a Schedule 13G/A disclosing beneficial ownership. The filing shows 6,106,011 shares beneficially owned in total, representing 6.3% of common stock. Orbis holds 6,090,194 shares with sole voting and dispositive power; Allan Gray holds 15,817 shares with sole voting and dispositive power. The filing states these Reporting Persons are classified as non-U.S. institutions equivalent to an investment adviser and includes a certification regarding foreign regulatory comparability.
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Insights
Two non-U.S. investment institutions report a combined 6.3% stake in CRISPR Therapeutics.
Orbis Investment Management Ltd is shown with 6,090,194 shares of sole voting and dispositive power and Allan Gray Australia Pty Ltd with 15,817 shares. The combined beneficial ownership reported is 6,106,011 shares or 6.3%.
The filing is an ownership disclosure under a Schedule 13G/A amendment and includes a statement that the reporting persons are non-U.S. institutions equivalent to an investment adviser; timing and cash‑flow treatment are not described in the excerpt.
The amendment affirms regulatory comparability and provides standard beneficial‑ownership detail.
The filing includes a certification that the foreign regulatory scheme for the Reporting Persons is substantially comparable to the U.S. equivalent and offers to furnish additional information on request. It also disclaims group beneficial ownership between the Reporting Persons.
Documentary responsibilities and potential staff inquiries are the primary compliance implications; no transaction or change-in-control language appears in the excerpt.
Key Figures
Beneficially owned:6,106,011 sharesPercent of class:6.3%Orbis sole voting power:6,090,194 shares+1 more
4 metrics
Beneficially owned6,106,011 sharesTotal beneficial ownership reported in Item 4(a)
Percent of class6.3%Percent of common stock represented by 6,106,011 shares
Orbis sole voting power6,090,194 sharesOrbis sole power to vote and dispose listed in Item 4(c)(i)/(iii)
Allan Gray sole voting power15,817 sharesAllan Gray sole power to vote and dispose listed in Item 4(c)(i)/(iii)
Key Terms
Schedule 13G/A, beneficially owned, sole dispositive power
3 terms
Schedule 13G/Aregulatory
"Amendment No. 2 to a Schedule 13G/A disclosing beneficial ownership"
A Schedule 13G/A is an amended public filing with the U.S. securities regulator that updates a previous Schedule 13G, disclosing when an individual or group holds a substantial (typically over 5%) stake in a company and is claiming a passive, non‑controlling intent. Investors monitor these updates because rising or falling holdings can signal changing confidence, potential future moves, or shifts in voting power — like watching a public ledger where large shareholders quietly adjust their positions.
beneficially ownedfinancial
"Amount beneficially owned: 6,106,011 (b) Percent of class: 6.3 %"
Beneficially owned describes securities or assets where a person has the economic rights and control—such as the right to receive dividends and to direct voting—even if legal title is held in another name. Think of it like having the keys and using a car that’s registered to someone else: you get the benefits and make decisions. Investors care because beneficial ownership reveals who truly controls value and voting power, affecting corporate decisions and takeover dynamics.
sole dispositive powerregulatory
"Sole power to dispose or to direct the disposition of: ORBIS - 6,090,194"
Sole dispositive power is the exclusive legal authority to decide what happens to a security — for example, whether to sell, transfer, or retain shares — without needing anyone else’s permission. Investors care because it signals who truly controls the economic outcome of an investment: like holding the only key to a safe, the holder can realize gains or losses and may trigger regulatory reporting, insider rules, or influence over corporate ownership.
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SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
UNDER THE SECURITIES EXCHANGE ACT OF 1934
(Amendment No. 2)
CRISPR Therapeutics AG
(Name of Issuer)
Common Stock
(Title of Class of Securities)
H17182108
(CUSIP Number)
03/31/2026
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
Rule 13d-1(b)
Rule 13d-1(c)
Rule 13d-1(d)
schemaVersion:
SCHEDULE 13G
CUSIP Number(s):
H17182108
1
Names of Reporting Persons
ORBIS INVESTMENT MANAGEMENT LTD
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
BERMUDA
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
6,090,194.00
6
Shared Voting Power
0.00
7
Sole Dispositive Power
6,090,194.00
8
Shared Dispositive Power
0.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
6,090,194.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
6.3 %
12
Type of Reporting Person (See Instructions)
FI
SCHEDULE 13G
CUSIP Number(s):
H17182108
1
Names of Reporting Persons
Allan Gray Australia Pty Ltd
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
AUSTRALIA
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
15,817.00
6
Shared Voting Power
0.00
7
Sole Dispositive Power
15,817.00
8
Shared Dispositive Power
0.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
15,817.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
0 %
12
Type of Reporting Person (See Instructions)
FI
SCHEDULE 13G
Item 1.
(a)
Name of issuer:
CRISPR Therapeutics AG
(b)
Address of issuer's principal executive offices:
BAARERSTRASSE 14, ZUG, SWITZERLAND
6300
Item 2.
(a)
Name of person filing:
ORBIS INVESTMENT MANAGEMENT LTD
Allan Gray Australia Pty Ltd
(b)
Address or principal business office or, if none, residence:
ORBIS INVESTMENT MANAGEMENT LTD: Orbis House, 25 Front Street, Hamilton, Bermuda HM11
Allan Gray Australia Pty Ltd: Level 2, Challis House, 4 Martin Place, Sydney NSW2000, Australia
(c)
Citizenship:
ORBIS INVESTMENT MANAGEMENT LTD - BERMUDA
Allan Gray Australia Pty Ltd - AUSTRALIA
(d)
Title of class of securities:
Common Stock
(e)
CUSIP No.:
H17182108
Item 3.
If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)
Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)
Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)
Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)
Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)
An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)
An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)
A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)
A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)
A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)
A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J),
please specify the type of institution:
(k)
Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Equivalent to IA.
Item 4.
Ownership
(a)
Amount beneficially owned:
6,106,011
(b)
Percent of class:
6.3 %
(c)
Number of shares as to which the person has:
(i) Sole power to vote or to direct the vote:
ORBIS INVESTMENT MANAGEMENT LTD - 6,090,194
Allan Gray Australia Pty Ltd - 15,817
(ii) Shared power to vote or to direct the vote:
ORBIS INVESTMENT MANAGEMENT LTD - 0
Allan Gray Australia Pty Ltd - 0
(iii) Sole power to dispose or to direct the disposition of:
ORBIS INVESTMENT MANAGEMENT LTD - 6,090,194
Allan Gray Australia Pty Ltd - 15,817
(iv) Shared power to dispose or to direct the disposition of:
ORBIS INVESTMENT MANAGEMENT LTD - 0
Allan Gray Australia Pty Ltd - 0
Item 5.
Ownership of 5 Percent or Less of a Class.
Not Applicable
Item 6.
Ownership of more than 5 Percent on Behalf of Another Person.
If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required.
Other persons have the right to receive dividends from, the power to direct the receipt of dividends from, or the right to receive the proceeds from the sale of, the securities of the issuer identified in Item 4(a) that are beneficially owned by Orbis Investment Management Ltd.
Another person has the right to receive dividends from, the power to direct the receipt of dividends from, or the right to receive the proceeds from the sale of, the securities of the issuer identified in Item 4(a) that are beneficially owned by Allan Gray Australia Pty Ltd.
Item 7.
Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
Not Applicable
Item 8.
Identification and Classification of Members of the Group.
If a group has filed this schedule pursuant to §240.13d-1(b)(1)(ii)(J), so indicate under Item 3(j) and attach an exhibit stating the identity and Item 3 classification of each member of the group. If a group has filed this schedule pursuant to §240.13d-1(c) or §240.13d-1(d), attach an exhibit stating the identity of each member of the group.
Information with respect to each of Orbis Investment Management Ltd and Allan Gray Australia Pty Ltd (collectively, the "Reporting Persons") is given solely by each such Reporting Person and no Reporting Person has responsibility for the accuracy or completeness of information supplied by any other Reporting Person. Orbis Investment Management Ltd and Allan Gray Australia Pty Ltd are classified as a Non-U.S. Institution (FI) that is equivalent to an Investment Adviser (IA). Notwithstanding that the Reporting Persons are making this filing together, none of the Reporting Persons represents that it is a member of a group for the purposes of Section 13(d)(3) of the Securities Exchange Act of 1934, as amended. Each Reporting Person disclaims beneficial ownership of any shares beneficially owned by any other Reporting Person as specified in Item 4(a).
Item 9.
Notice of Dissolution of Group.
Not Applicable
Item 10.
Certifications:
By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.
By signing below I certify that, to the best of my knowledge and belief, the foreign regulatory scheme applicable to Orbis Investment Management Ltd and Allan Gray Australia Pty Ltd is substantially comparable to the regulatory scheme applicable to the functionally equivalent U.S. institution(s). I also undertake to furnish to the Commission staff, upon request, information that would otherwise be disclosed in a Schedule 13D.
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
What stake does Orbis Investment Management report in CRSP?
Orbis Investment Management Ltd reports 6,090,194 shares with sole voting and dispositive power. This holding is part of the combined 6,106,011 shares disclosed, representing 6.3% of the class.
How many shares does Allan Gray Australia report owning in CRSP?
Allan Gray Australia Pty Ltd reports ownership of 15,817 shares with sole voting and dispositive power, included in the combined total of 6,106,011 shares representing 6.3% of common stock.
Does this filing create a group between the two reporting persons?
No. The filing states that, although the two entities filed together, neither represents it is a member of a group under Section 13(d)(3) and each disclaims beneficial ownership of the other's shares.
What regulatory classification do the reporting persons claim?
Both Orbis and Allan Gray are classified as Non-U.S. Institutions (FI) equivalent to an Investment Adviser (IA). The filing includes a certification of substantial comparability to the U.S. regulatory scheme.
Does the amendment disclose any voting or disposition powers?
Yes. The filing lists specific powers: Orbis has sole voting and sole dispositive power over 6,090,194 shares; Allan Gray has sole voting and dispositive power over 15,817 shares as reported in Item 4.
