| As filed with the United States Securities and Exchange Commission on April 2, 2026. |
| Registration No. 333-284263 |
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
POST-EFFECTIVE
AMENDMENT NO. 2
TO
FORM S-1
ON FORM S-3
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Adagio Medical Holdings, Inc.
(Exact name of registrant as specified in its charter)
Delaware
(State or other
jurisdiction of
incorporation organization) |
001-42199
(Commission
File Number) |
99-1151466
(I.R.S. Employer
Identification No.) |
| |
|
|
| |
26051 Merit
Circle, Suite 102
Laguna Hills,
California 92653
(949) 348-1188 |
|
(Address, Including Zip Code, and Telephone
Number, Including Area Code, of Registrant’s Principal Executive Offices)
Todd Usen
Chief Executive Officer
26051 Merit Circle, Suite 102
Laguna Hills, California 92653
(949) 348-1188
(Name, Address, Including Zip Code, and Telephone
Number, Including Area Code, of Agent for Service)
Copies to:
Eric Blanchard
Paul Alexander
Cooley LLP
500 Boylston Street
14th Floor
Boston, MA 02116
(617) 937-2300
Approximate date of commencement of proposed
sale to the public:
From time to time after the effective date of
this registration statement.
If the only securities being registered on this Form are being
offered pursuant to dividend or interest reinvestment plans, please check the following box: ¨
If any of the securities being registered on this Form are to
be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered
only in connection with dividend or interest reinvestment plans, check the following box: x
If this Form is filed to register additional securities for an
offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration
statement number of the earlier effective registration statement for the same offering. ¨
If this Form is a post-effective amendment filed pursuant to Rule 462(c) under
the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration
statement for the same offering. ¨
If this Form is a registration statement pursuant to General Instruction
I.D. or a post-effective amendment thereto that shall become effective upon filing with the Commission pursuant to Rule 462(c) under
the Securities Act, check the following box. ¨
If this Form is a post-effective amendment to a registration statement
filed pursuant to General Instruction I.D. filed to register additional securities or additional classes of securities pursuant to Rule 413(b) under
the Securities Act, check the following box. ¨
Indicate by check mark whether the registrant is a large accelerated
filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions
of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging
growth company” in Rule 12b-2 of the Exchange Act.
| Large
accelerated filer |
¨ |
Accelerated
filer |
¨ |
| Non-accelerated
filer |
x |
Smaller
reporting company |
x |
| |
|
Emerging
growth company |
x |
If an emerging growth company,
indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial
accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ¨
The registrant hereby amends this registration statement on such
date or dates as may be necessary to delay its effective date until the registrant shall file a further amendment which specifically states
that this registration statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of
1933 or until this registration statement shall become effective on such date as the Securities and Exchange Commission, acting pursuant
to said Section 8(a), may determine.
EXPLANATORY NOTE
This Post-Effective Amendment No. 2 to the Registration Statement on Form S-1 on Form S-3 (File No. 333-284263) (“Post-Effective
Amendment No. 2”) of Adagio Medical Holdings, Inc. is being filed solely to amend the Post-Effective Amendment No. 1 to the Registration
Statement filed with the U.S. Securities and Exchange Commission on April 1, 2026, to correct Exhibit 23.4, the Consent of Independent
Registered Public Accounting Firm. The original filing mistakenly included an unsigned version of the consent of WithumSmith+Brown, PC.
No other changes have been made to the Registration Statement. This Post-Effective Amendment No. 2 does not modify any provision of the
prospectus that forms part of the Registration Statement and, accordingly, the prospectus has not been included herein. This Post-Effective
Amendment No. 2 is not intended to amend or delete any part of the Registration Statement except as specifically noted herein.
PART II
INFORMATION NOT REQUIRED IN PROSPECTUS
Item 16. Exhibits
Exhibit
Number |
|
Description |
|
Schedule/
Form |
|
File No. |
|
Exhibit |
|
Filing Date |
| 2.1† |
|
Business Combination Agreement, dated as of February 13, 2024, by and among Aja HoldCo, Inc., ARYA Sciences Acquisition Corp IV, Aja Merger Sub 1, Aja Merger Sub 2, Inc. and Adagio Medical, Inc. |
|
8-K |
|
001- 42199 |
|
2.1 |
|
August 6, 2024 |
| 2.2 |
|
Consent and Amendment No. 1 to the Business Combination Agreement, dated as of June 25, 2024, by and among ARYA Sciences Acquisition Corp IV and Adagio Medical, Inc. |
|
8-K |
|
001- 42199 |
|
2.2 |
|
August 6, 2024 |
| 3.1 |
|
Amended and Restated Certificate of Incorporation of the Company. |
|
8-K |
|
001- 42199 |
|
3.1 |
|
August 6, 2024 |
| 3.2 |
|
Amended and Restated By-Laws of the Company. |
|
8-K |
|
001- 42199 |
|
3.2 |
|
August 6, 2024 |
| 4.1 |
|
Form of Base Warrant Agreement. |
|
8-K |
|
001- 42199 |
|
4.1 |
|
August 6, 2024 |
| 4.2 |
|
Form of Pre-Funded Warrant Agreement. |
|
8-K |
|
001- 42199 |
|
4.2 |
|
August 6, 2024 |
| 4.3 |
|
Form of Convert Warrant Agreement. |
|
8-K |
|
001- 42199 |
|
4.3 |
|
August 6, 2024 |
| 4.4 |
|
Specimen Common Stock Certificate. |
|
8-K |
|
001- 42199 |
|
4.4 |
|
August 6, 2024 |
| 5.1 |
|
Opinion of Reed Smith LLP. |
|
S-1 |
|
333-284266 |
|
5.1 |
|
January 14, 2025 |
| 10.1 |
|
Form of Convertible Security Subscription Agreement. |
|
8-K |
|
001- 42199 |
|
10.1 |
|
August 6, 2024 |
| 10.2 |
|
Form of Adagio Holdings Stockholder Transaction Support Agreement. |
|
8-K |
|
001-42199 |
|
10.4 |
|
August 6, 2024 |
| 10.3 |
|
Convert Guaranty, dated as of July 31, 2024, by and among Adagio Medical and the other parties thereto. |
|
8-K |
|
001- 42199 |
|
10.9 |
|
August 6, 2024 |
| 10.4 |
|
Convert Security Document, dated as of July 31, 2024, by and among Adagio Holdings, Adagio Medical and the other parties thereto. |
|
8-K |
|
001- 42199 |
|
10.10 |
|
August 6, 2024 |
| 10.5 |
|
Registration Rights Agreement dated as of July 31, 2024, by and among Adagio Medical, Perceptive Life Sciences Master Fund, Ltd. and the other parties thereto. |
|
8-K |
|
001- 42199 |
|
10.11 |
|
August 6, 2024 |
| 10.6 |
|
Form of Adagio Holdings Convertible Note. |
|
8-K |
|
001- 42199 |
|
10.12 |
|
August 6, 2024 |
| 10.7 |
|
Form of Non-Redemption Subscription Agreement. |
|
8-K |
|
001- 42199 |
|
10.13 |
|
August 6, 2024 |
| 10.8 |
|
Form of Open Market Purchase Subscription Agreement. |
|
8-K |
|
001- 42199 |
|
10.14 |
|
August 6, 2024 |
| 10.9 |
|
Form of Subscription Agreement with Pre-Funded Warrant and PIPE Warrant. |
|
8-K |
|
001- 42199 |
|
10.15 |
|
August 6, 2024 |
| 10.10 |
|
PIPE Subscription Agreement, by and among the Perceptive PIPE Investor, Adagio and ARYA. |
|
8-K |
|
001- 42199 |
|
10.16 |
|
August 6, 2024 |
Exhibit
Number |
|
Description
|
|
Schedule/
Form |
|
File
No. |
|
Exhibit |
|
Filing
Date |
| 10.11
|
|
Amendment
to PIPE Subscription Agreement, by and among the Perceptive PIPE Investor, Adagio and ARYA. |
|
8-K
|
|
001-
42199 |
|
10.17
|
|
August 6,
2024 |
| 10.12
|
|
Amended
and Restated Subscription Agreement, by and among the Perceptive PIPE Investor, Adagio and ARYA. |
|
8-K
|
|
001-
42199 |
|
10.18
|
|
August 6,
2024 |
| 10.13
|
|
Form of
Amended and Restated Subscription Agreement with Pre-Funded Warrant and Warrant. |
|
8-K
|
|
001-
42199 |
|
10.19
|
|
August 6,
2024 |
| 10.14
|
|
Form of
Amended and Restated Open Market Purchase Subscription Agreement. |
|
8-K
|
|
001-
42199 |
|
10.20
|
|
August 6,
2024 |
| 10.15
|
|
Form of
Amended and Restated Non-Redemption Subscription Agreement. |
|
8-K
|
|
001-
42199 |
|
10.21
|
|
August 6,
2024 |
| 10.16
|
|
2024
Bridge Financing Note Subscription Agreement, dated as of February 13, 2024, by and between ListCo, the Perceptive PIPE Investor
and certain other investors thereto |
|
8-K
|
|
001-
42199 |
|
10.22
|
|
August 6,
2024 |
| 10.17 |
|
Form of
Convert Waiver |
|
8-K |
|
001-42199 |
|
10.1 |
|
January 6,
2025 |
| 23.1 |
|
Consent
of Reed Smith LLP (included as part of Exhibit 5.1). |
|
S-1 |
|
333-284266 |
|
5.1 |
|
January 14,
2025 |
| 23.2* |
|
Consent
of WithumSmith+Brown, PC, independent registered public accounting firm for Adagio Medical Holdings, Inc. |
|
|
|
|
|
|
|
|
| 24.1
|
|
Power
of Attorney. |
|
S-1
|
|
333-284266 |
|
24.1
|
|
January 14,
2025 |
* Filed herewith.
† Certain of the exhibits and schedules to this
Exhibit have been omitted in accordance with Regulation S-K Item 601. The Company agrees to furnish a copy of all omitted
exhibits and schedules to the SEC upon its request.
# Indicates a management contract or compensatory plan, contract
or arrangement.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the registrant
certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3 and has duly caused
this Post-Effective Amendment No. 2 to Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized
in Laguna Hills, California, on this 2nd day of April, 2026.
| ADAGIO MEDICAL HOLDINGS, INC. |
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| |
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| By: |
/s/ Todd Usen |
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Name: Todd Usen |
|
| |
Title: Chief Financial Officer |
|
Pursuant to the requirements of the Securities
Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated.
| Signature |
|
Title |
|
Date |
| |
|
|
|
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| /s/ Todd Usen |
|
Chief
Executive Officer and Director |
|
April 2, 2026 |
| Todd
Usen |
|
(Principal
Executive Officer) |
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| |
|
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|
|
| /s/
Deborah Kaster |
|
Chief
Financial Officer |
|
April 2, 2026 |
| Deborah
Kaster |
|
(Principal
Financial Officer and Principal Accounting Officer) |
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| * |
|
Director |
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April 2, 2026 |
| James L. Cox |
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| * |
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Director |
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April 2, 2026 |
| Orly Mishan |
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| * |
|
Director |
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April 2, 2026 |
| Keyvan Mirsaeedi-Farahani |
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| * |
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Director |
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April 2, 2026 |
| Timothy Moran |
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| * |
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Director |
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April 2, 2026 |
| Sandra Gardiner |
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| /s/ Todd Usen |
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| Todd Usen |
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| Attorney-in-fact |
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