Xilio Therapeutics Announces Upcoming Presentations at the Society for Immunotherapy of Cancer (SITC) 40th Annual Meeting

Rhea-AI Summary

Xilio Therapeutics (Nasdaq: XLO) announced multiple poster presentations at the SITC 40th Annual Meeting, Nov 6-9, 2025, Gaylord National Convention Center, National Harbor, MD.

Xilio will present clinical data for vilastobart (anti-CTLA-4) and XTX301 (efarindodekin alfa) (tumor-activated IL-12), plus preclinical data on masked T cell engager programs. Key posters: ctDNA as a surrogate biomarker for vilastobart + atezolizumab in MSS mCRC (Abstract 541) and XTX301 Phase 1 IL-12 pharmacodynamic data (Abstract 567) — both presented Friday, Nov 7, 2025, poster hall 9:00 a.m.–7:00 p.m. EST (Gaylord Exhibit Halls A & B1). Masked T cell engager poster (Abstract 972) presented Saturday, Nov 8, 2025, poster hall 9:00 a.m.–8:40 p.m. EST.

WALTHAM, Mass., Oct. 03, 2025 (GLOBE NEWSWIRE) -- Xilio Therapeutics, Inc. (Nasdaq: XLO), a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology therapies for people living with cancer, today announced multiple upcoming poster presentations at the Society for Immunotherapy of Cancer (SITC) 40^th Annual Meeting, taking place from November 6-9, 2025 at the Gaylord National Convention Center in National Harbor, Maryland.

Xilio plans to present clinical data for vilastobart, a tumor-activated, Fc-enhanced, high affinity binding anti-CTLA-4, and efarindodekin alfa (XTX301), a tumor-activated IL-12, and plans to present preclinical data highlighting the company’s masked T cell engager programs.

Poster presentation details, as follows:

• Title: ctDNA as a Potential Surrogate Biomarker for Response to Combination Vilastobart and Atezolizumab in Heavily Pretreated Microsatellite Stable (MSS) Metastatic Colorectal Cancer (mCRC)
  Abstract Number: 541
  Presentation Date: Friday, Nov. 7, 2025
  Poster Hall Hours: 9:00 a.m.-7:00 p.m. EST
  Location: Gaylord Exhibit Halls A & B1

• Title: XTX301, a Tumor-Activated Interleukin-12 (IL-12), Demonstrated IL-12 Pharmacology in Patients with Advanced Solid Tumors: Pharmacodynamic Data from First-in-Human Phase 1 Study
  Abstract Number: 567
  Presentation Date: Friday, Nov. 7, 2025
  Poster Hall Hours: 9:00 a.m.-7:00 p.m. EST
  Location: Gaylord Exhibit Halls A & B1

• Title: Masked T Cell Engagers Designed to Drive Potent Synthetic Anti-Tumor Immunity with Favorable Tolerability
  Abstract Number: 972
  Presentation Date: Saturday, Nov. 8, 2025
  Poster Hall Hours: 9:00 a.m.-8:40 p.m. EST
  Location: Gaylord Exhibit Halls A & B1

About Xilio Therapeutics

Xilio Therapeutics is a clinical-stage biotechnology company discovering and developing tumor-activated, or masked, immuno-oncology (I-O) therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current I-O treatments. The company is leveraging its proprietary platform to advance a pipeline of novel, tumor-activated I-O molecules that are designed to optimize the therapeutic index by localizing anti-tumor activity within the tumor microenvironment. Learn more by visiting www.xiliotx.com and follow us on LinkedIn (Xilio Therapeutics, Inc.).

Cautionary Note Regarding Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, statements regarding plans to present data related to Xilio’s clinical programs for vilastobart and efarindodekin alfa and preclinical programs for masked T cell engagers; and Xilio’s strategy, goals and anticipated financial performance, milestones, business plans and focus. The words “aim,” “may,” “will,” “could,” “would,” “should,” “expect,” “plan,” “anticipate,” “intend,” “believe,” “estimate,” “predict,” “project,” “potential,” “continue,” “seek,” “target” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on management’s current expectations and beliefs and are subject to a number of important risks, uncertainties and other factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, risks related to general market conditions and geopolitical uncertainties; risks and uncertainties related to ongoing and planned research and development activities, including initiating, conducting or completing preclinical studies and clinical trials and the timing and results of such preclinical studies or clinical trials; the delay of any current or planned preclinical studies or clinical trials or the development of Xilio’s current or future product candidates; Xilio’s ability to obtain and maintain sufficient preclinical and clinical supply of current or future product candidates; Xilio’s ability to advance multiple early stage masked T cell engager programs; initial, preliminary or interim preclinical or clinical data or results may not be replicated in or predictive of future preclinical or clinical data or results; Xilio’s ability to successfully demonstrate the safety and efficacy of its product candidates and gain approval of its product candidates on a timely basis, if at all; results from preclinical studies or clinical trials for Xilio’s product candidates may not support further development of such product candidates; actions of regulatory agencies may affect the initiation, timing and progress of current or future clinical trials; Xilio’s ability to obtain, maintain and enforce patent and other intellectual property protection for current or future product candidates; Xilio’s need to obtain additional cash resources to advance its pipeline of tumor-activated I-O molecules; the impact of international trade policies on Xilio’s business, including U.S. and China trade policies; and Xilio’s ability to maintain its collaboration or partnership agreements with AbbVie, Gilead and Roche. These and other risks and uncertainties are described in greater detail in the sections entitled “Risk Factor Summary” and “Risk Factors” in Xilio’s filings with the U.S. Securities and Exchange Commission (“SEC”), including Xilio’s most recent Quarterly Report on Form 10-Q and any other filings that Xilio has made or may make with the SEC in the future. Any forward-looking statements contained in this press release represent Xilio’s views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date. Except as required by law, Xilio explicitly disclaims any obligation to update any forward-looking statements.

This press release contains hyperlinks to information that is not deemed to be incorporated by reference in this press release.

TECENTRIQ is a registered trademark of Genentech USA, Inc., a member of the Roche Group.

Investor Contact  
investors@xiliotx.com

Media Contact  
Josie Butler, 1AB
josie@1abmedia.com

FAQ

When and where will Xilio Therapeutics (XLO) present at SITC 2025?

Xilio will present posters at SITC Nov 6–9, 2025, at the Gaylord National Convention Center, National Harbor, MD.

What clinical data will XLO present on vilastobart at SITC Nov 7, 2025?

Abstract 541 on ctDNA as a potential surrogate biomarker for vilastobart + atezolizumab in MSS mCRC, poster hall Nov 7, 9:00 a.m.–7:00 p.m. EST.

What does XLO plan to present about XTX301 at SITC Nov 7, 2025?

Abstract 567 reports IL-12 pharmacodynamic data from the first‑in‑human Phase 1 study of XTX301, presented Nov 7, poster hall 9:00 a.m.–7:00 p.m. EST.

When will Xilio present masked T cell engager preclinical data at SITC 2025?

The masked T cell engager poster (Abstract 972) is scheduled for Saturday, Nov 8, 2025, in the poster hall from 9:00 a.m.–8:40 p.m. EST.

How can investors find XLO poster locations and times at SITC 2025?

Poster details: Exhibit Halls A & B1 at Gaylord; check Abstracts 541, 567 (Nov 7) and 972 (Nov 8) for exact times listed in the press release.