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X4 Pharmaceuticals, Inc. (Nasdaq: XFOR) is a late-stage clinical biopharmaceutical company committed to the development of novel therapeutics aimed at improving immune cell trafficking and reversing immune suppression. The company's core focus is on treating rare diseases and conditions resulting from immune system dysfunction, including cancer and genetic primary immunodeficiency diseases.
X4’s lead clinical candidate, mavorixafor, is a selective, small-molecule antagonist of the chemokine receptor CXCR4. Designed as an oral, once-daily therapy, mavorixafor targets immune cell mobilization and has shown promising results in clinical trials. It is currently under priority review by the FDA for the treatment of WHIM (Warts, Hypogammaglobulinemia, Infections, and Myelokathexis) syndrome, a rare primary immunodeficiency. The company’s recent NDA submission is supported by positive results from the global, pivotal 4WHIM Phase 3 clinical trial, which demonstrated mavorixafor's ability to reduce infection rates and improve immune cell counts without serious adverse events.
In addition to mavorixafor for WHIM syndrome, X4 is advancing its pipeline with ongoing investigations for mavorixafor in chronic neutropenic disorders and other immunodeficiencies. The company has also initiated preclinical development of other CXCR4 antagonists, including X4P-002 and X4P-003, to address different properties and mechanisms within the immune system.
Headquartered in Boston, Massachusetts, with a research center in Vienna, Austria, X4 leverages its deep understanding of CXCR4 biology to innovate and bring transformative therapies to patients with limited treatment options. The company's mission is driven by a commitment to improve the lives of those affected by rare and severe immune diseases through rigorous scientific research and strategic investment in its proprietary pipeline.
For more updates and detailed information, visit X4 Pharmaceuticals.
X4 Pharmaceuticals (Nasdaq: XFOR) announced its participation in the Stifel 2021 Virtual Healthcare Conference on November 17, 2021, at 11:20 AM ET. The event will feature a fireside chat, which will be available via live webcast on X4's investor website. X4 is focused on developing novel CXCR4-targeted therapies for immune system diseases, with mavorixafor as its lead candidate. The company is advancing mavorixafor through various clinical trials for conditions including primary immunodeficiencies and certain cancers. The archived event will be accessible for 90 days post-conference.
X4 Pharmaceuticals, Inc. (Nasdaq: XFOR) reported significant advancements in its WHIM syndrome treatment, mavorixafor, including the completion of enrollment in a pivotal Phase 3 trial. The company anticipates top-line data in Q4 2022. Recent findings indicate a potential U.S. WHIM patient population of 3,700, with mavorixafor demonstrating increased neutrophil levels and good tolerability. Financial results show a net loss of $20.2 million for Q3 2021, up from $17.4 million year-over-year. An Investor Day is scheduled for December 16, highlighting further clinical data.
X4 Pharmaceuticals (Nasdaq: XFOR) announced on November 1, 2021, that its Compensation Committee granted inducement awards to new employees under the 2019 Inducement Equity Incentive Plan. The awards include options to purchase 11,050 shares of common stock at an exercise price of $4.84 per share, matching the stock's closing price on October 29, 2021. Options vest over four years, with a quarter vesting after one year. X4 focuses on CXCR4-targeted therapies for immune system diseases, with its lead candidate mavorixafor currently undergoing multiple clinical trials.
X4 Pharmaceuticals (Nasdaq: XFOR) announced its upcoming earnings call on November 4, 2021, at 9:05 a.m. ET. The call will cover the third quarter financial results and recent business highlights. Additionally, the company is expected to discuss abstracts accepted for the 63rd American Society of Hematology (ASH) Annual Meeting, with publication set for the same day at 9:00 a.m. ET. X4 is focused on developing mavorixafor, a novel CXCR4-targeted therapy, currently undergoing clinical trials for various rare diseases.
X4 Pharmaceuticals has appointed Françoise de Craecker to its Board of Directors and hired Karolyn Park as Vice President, U.S. Commercial. These strategic moves aim to enhance the company's leadership as it prepares for the anticipated U.S. launch of its lead candidate, mavorixafor. De Craecker brings over 30 years of experience in launching rare disease products globally, while Park has nearly 20 years in life science marketing. The hiring is viewed as a critical step in maximizing mavorixafor's potential to treat immunodeficiencies and cancers.
X4 Pharmaceuticals (Nasdaq: XFOR) has completed enrollment in its pivotal Phase 3 trial for mavorixafor, targeting WHIM syndrome, with 31 patients enrolled, surpassing the original goal of 18-28. Top-line data is expected in Q4 2022, followed by a potential U.S. NDA filing in Q1 2023. WHIM syndrome is a rare primary immunodeficiency caused by mutations in the CXCR4 gene. Mavorixafor has received various designations from the FDA, highlighting its therapeutic potential in immunodeficiencies.
X4 Pharmaceuticals (Nasdaq: XFOR) announced on September 30, 2021, the issuance of inducement awards to new employees under its 2019 Inducement Equity Incentive Plan. The awards comprise options to purchase 95,200 shares and restricted stock units covering 6,000 shares of common stock. The exercise price for options is set at $5.29 per share, matching the closing price on the grant date. Options will vest over four years, while restricted stock units will vest annually over the same period, contingent upon continued employment.
X4 Pharmaceuticals (Nasdaq: XFOR) is set to present a corporate overview at the Oppenheimer Fall Healthcare Life Sciences & MedTech Summit on September 22, 2021, at 11:35 a.m. ET. Additionally, the company will participate in a fireside chat at the Cantor Global Healthcare Conference on September 30, 2021, at 10:00 a.m. ET. Live webcasts of both events will be accessible through the investors section of X4 Pharmaceuticals' website and will be archived for 90 days. X4 is focused on developing therapies for diseases linked to the CXCR4 pathway.
X4 Pharmaceuticals (Nasdaq: XFOR) promotes Mary DiBiase, Ph.D., to Chief Operating Officer, enhancing her responsibilities to include program management and IT oversight. DiBiase, with over 25 years in drug development, has been pivotal in advancing the company's lead candidate, mavorixafor, into late-stage clinical trials. CEO Paula Ragan emphasized her contributions to company growth and the potential commercialization of mavorixafor for treating diseases like WHIM syndrome. The company remains focused on developing innovative therapies targeting rare diseases.
X4 Pharmaceuticals (Nasdaq: XFOR) announced on August 31, 2021, that its Board's Compensation Committee issued an inducement award to new employees under its 2019 Inducement Equity Incentive Plan. The award consists of options to purchase a total of 20,350 shares of common stock at an exercise price of $5.13 per share, equal to the closing stock price on that date. The options have a ten-year term and will vest over four years, with 25% vesting after one year and the remainder vesting monthly thereafter, contingent on continued employment.
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