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Voyager Therapeutics Inc - VYGR STOCK NEWS

Welcome to our dedicated page for Voyager Therapeutics news (Ticker: VYGR), a resource for investors and traders seeking the latest updates and insights on Voyager Therapeutics stock.

Overview

Voyager Therapeutics Inc (VYGR) is a biotechnology company focused on developing innovative gene therapies for severe and debilitating diseases of the central nervous system (CNS). Using advanced AAV gene therapy techniques and its proprietary TRACER™ capsid discovery platform, Voyager is dedicated to overcoming traditional barriers in gene delivery and creating transformative solutions for neurological disorders.

Core Technology and Platform

The company leverages its TRACER™ (Tropism Redirection of AAV by Cell-type-specific Expression of RNA) platform to engineer and optimize novel AAV capsids that are designed to cross the blood-brain barrier with high efficiency. This RNA-based screening enables rapid identification of capsid variants with enhanced CNS tropism and controlled tissue targeting, ensuring robust genetic payload delivery to areas of the brain traditionally hard to reach. The platform underpins both its gene therapy and antibody development programs, reflecting a robust integration of genetic science and neuroscience.

Pipeline and Disease Focus

Voyager Therapeutics maintains an extensive pipeline of programs aimed at addressing several critical CNS diseases. The company is developing gene therapy candidates to target conditions such as Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), and Friedreich’s ataxia. Additionally, Voyager is advancing therapies aimed at modifying the pathological processes in Alzheimer’s disease through tau silencing and anti-tau antibodies. Each candidate is carefully designed to modulate protein expression in the CNS, aiming to slow disease progression and improve patient outcomes.

Research and Development Approach

Emphasizing rigorous process development and production scalability, Voyager invests heavily in vector optimization and sophisticated dosing techniques. The company conducts cross-species preclinical studies to ensure that its TRACER-generated capsids achieve widespread and efficient gene expression while minimizing off-target effects. Its commitment to scientific excellence is reflected in its strategic external collaborations, which not only validate its technology but also extend its reach within the neurogenetic medicines field.

Industry Significance and Competitive Position

Voyager Therapeutics distinguishes itself within the biotechnology landscape through its specialized focus on CNS diseases and its innovative AAV-based gene therapy solutions. By integrating cutting-edge gene editing methodologies with deep neuroscientific insights, the company fills a significant unmet need in neurological drug development. Its collaboration with established industry partners further underscores the scientific reliability, stringent development standards, and translational potential of its candidates. The company’s balanced portfolio and technology-driven approach position it as a critical contributor to the evolution of gene therapies for challenging neurological conditions.

Commitment to Innovation and Patient Impact

At the heart of Voyager Therapeutics’ mission is the goal of modifying the course of devastating neurological diseases. By focusing on durable gene expression attainable through a single administration, the company aims to provide long-lasting therapeutic benefits that can transform the quality of life for patients. Its efforts in process development and clinical standardization continue to set benchmarks within the field, reflecting a commitment to excellence that is both scientifically robust and patient-centered.

This comprehensive approach—encompassing advanced vector engineering, strategic collaborations, and meticulous clinical development—underscores Voyager Therapeutics’ prominence in the realm of neurogenetic medicines and offers a detailed perspective for investors and industry observers alike.

Rhea-AI Summary

Voyager Therapeutics, Inc. (Nasdaq: VYGR) announced it will disclose its third-quarter 2022 financial and operational results before the market opens on November 8, 2022. Following the results, a live conference call and webcast will occur at 8:30 a.m. ET to discuss the findings. Interested participants can register for the call to receive dial-in details and access a live webcast on Voyager's investor website. Voyager is focused on next-generation AAV gene therapy, aiming to treat debilitating diseases using its proprietary capsids from the TRACER™ discovery platform.

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Voyager Therapeutics (Nasdaq: VYGR) recently announced an employment agreement with a new hire, which includes inducement awards approved by its Compensation Committee. The agreement comprises a non-qualified stock option for 60,000 shares and restricted stock units for 30,000 shares. The stock option has a ten-year term with an exercise price of $6.01 per share and vests over four years. The restricted stock units will vest annually over three years, starting on the first anniversary of the effective date, which is set for January 1, 2023.

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Voyager Therapeutics (Nasdaq: VYGR) presented significant findings at the European Society of Gene & Cell Therapy (ESGCT) Congress 2022. The data revealed a novel cell surface receptor that enhances the delivery of Voyager's TRACER AAV capsids across the blood-brain barrier (BBB), showing potential for human translation. Additionally, preclinical results indicate ultra-low dosing might achieve therapeutic effects with reduced toxicity. These advancements could transform CNS drug delivery, underscoring Voyager's commitment to addressing critical neurological disorders.

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Voyager Therapeutics announced that Pfizer has exercised an option to license a novel capsid from its TRACER platform, triggering a $10 million payment. This validation could lead to further potential payments totaling up to $290 million, including development and regulatory milestones. The licensed capsid targets a rare neurologic disease and supports Voyager's strategy to enhance its internal pipeline, which includes candidates for Parkinson's and ALS. This collaboration indicates strong progress and potential in the gene therapy sector.

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Voyager Therapeutics (Nasdaq: VYGR) will present three posters at the 29th Annual Congress of the European Society of Gene & Cell Therapy from October 11-14, 2022, in Edinburgh, Scotland. The presentations focus on advancements in AAV gene therapy, including an engineered BBB-penetrant capsid family and evaluations of dose-response and production methodologies for AAV-based therapies. These developments may enhance treatment for neurological disorders, showcasing the company's commitment to innovation in gene therapy.

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Voyager Therapeutics (Nasdaq: VYGR) announced its participation in two upcoming investor conferences. The first is Chardan’s 6th Annual Genetic Medicines Conference on October 4, 2022, featuring a company presentation at 3:45 p.m. ET. The second event is the Truist Securities Genetic Medicine Summit on October 20, 2022, where Voyager will participate in a CNS panel discussion (not webcast). Interested investors can access the presentation and archived webcasts on Voyager's website for 30 days following the events.

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Voyager Therapeutics (Nasdaq: VYGR) announced new employment agreements with Peter Pfreundschuh and another employee, granting them non-qualified stock options and restricted stock units. The stock options consist of 200,000 shares for Pfreundschuh and 76,000 shares for the other employee, both with an exercise price of $6.18 per share. These options will vest over four years, while the restricted stock units will vest annually over three years, starting from the first anniversary of the grant effective date of September 19, 2022.

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Voyager Therapeutics announces the appointment of new senior leaders to enhance its focus on CNS diseases. Peter Pfreundschuh joins as CFO, Todd Carter as CSO, and Trista Morrison as SVP of Corporate Affairs, effective September 19, 2022. Pfreundschuh brings over 25 years of finance experience, while Carter has significant expertise in neurology. Morrison will strengthen communications and stakeholder engagement. The company aims to maximize its AAV capsid platform and advance its pipeline addressing critical neurological conditions.

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Voyager Therapeutics (Nasdaq: VYGR) has prioritized its therapeutic pipeline focusing on gene therapies for Alzheimer's, GBA1 Parkinson's, and SOD1 ALS, which have efficient paths to human proof of biology. The company reported a net loss of $19.1 million for Q2 2022, an improvement from $30.1 million in Q2 2021, aided by reduced R&D and G&A expenses. Voyager's cash position is strong, with $148.1 million as of June 30, 2022, providing a runway into 2024. Notably, Catherine J. Mackey, Ph.D., has been appointed to the Board of Directors.

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Voyager Therapeutics (Nasdaq: VYGR) recently presented data at the Alzheimer’s Association International Conference highlighting novel antibodies that inhibit the spread of pathological tau in rodent models. The research demonstrates that these antibodies, which target specific forms of tau, could advance therapeutic options for tauopathies like Alzheimer's. Notably, vectorized antibody expression showed durability exceeding six months post-administration, with substantial efficacy in reducing tau pathology in mouse models. This research builds on prior findings about the potential of their blood-brain barrier-penetrating AAV capsids.

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FAQ

What is the current stock price of Voyager Therapeutics (VYGR)?

The current stock price of Voyager Therapeutics (VYGR) is $3.37 as of April 1, 2025.

What is the market cap of Voyager Therapeutics (VYGR)?

The market cap of Voyager Therapeutics (VYGR) is approximately 185.2M.

What is the primary focus of Voyager Therapeutics?

Voyager Therapeutics is dedicated to developing gene therapies for severe neurological diseases using innovative AAV platforms and advanced vector engineering.

What is the TRACER™ platform?

The TRACER™ platform is an RNA-based screening technology that enables rapid discovery and optimization of AAV capsids for improved blood-brain barrier penetration and targeted CNS delivery.

Which central nervous system diseases does Voyager address?

Voyager’s pipeline includes therapies for Parkinson’s disease, amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, and Alzheimer’s disease, among other CNS conditions.

How does Voyager’s technology enhance gene delivery to the brain?

Their engineered AAV capsids are designed to cross the blood-brain barrier efficiently, target specific cell types, and achieve robust gene expression while limiting off-target transduction.

What distinguishes Voyager Therapeutics from other biotech companies?

Voyager is distinguished by its specialized focus on CNS diseases, its proprietary TRACER™ capsid discovery platform, and its commitment to integrating advanced gene therapy approaches with deep neuroscientific expertise.

Does Voyager collaborate with other organizations?

Yes, Voyager has strategic collaborations with established biotech firms, enhancing the scientific rigor and translational impact of its gene therapy candidates.

How do Voyager's therapies aim to impact patient treatment?

Their gene therapy candidates are designed to modify the underlying disease mechanisms by regulating protein expression, potentially slowing disease progression and improving patient quality of life.

What research methods support Voyager's development approach?

Voyager employs cross-species preclinical studies, advanced vector optimization, and robust process development to validate the safety and efficacy of its therapies.
Voyager Therapeutics Inc

Nasdaq:VYGR

VYGR Rankings

VYGR Stock Data

185.22M
45.58M
17%
63.9%
4.95%
Biotechnology
Biological Products, (no Disgnostic Substances)
Link
United States
LEXINGTON