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Verve Therapeutics, Inc. - VERV STOCK NEWS

Welcome to our dedicated page for Verve Therapeutics news (Ticker: VERV), a resource for investors and traders seeking the latest updates and insights on Verve Therapeutics stock.

Company Overview

Verve Therapeutics, Inc. (VERV) is a clinical-stage biotechnology company focused on revolutionizing cardiovascular disease treatment through innovative genetic medicines. The company is dedicated to developing single-course gene editing therapies aimed at permanently lowering low‐density lipoprotein cholesterol (LDL‐C) and triglyceride levels, which are critical drivers of atherosclerotic cardiovascular disease. By harnessing breakthroughs in human genetics and advanced gene editing technologies, Verve Therapeutics is reshaping the paradigm from chronic management to one‐time interventions that offer lasting benefits.

Innovative Therapeutic Approach

At the core of Verve Therapeutics is its pioneering use of adenine base editing, delivered via specially engineered lipid nanoparticles. This approach enables precise targeting of liver cells to inactivate specific genes responsible for elevated cholesterol levels. The technology is designed to offer durable outcomes through a single course of treatment, reducing or even eliminating the chronic dependence on existing therapies. Keywords such as gene editing, cardiovascular disease, and genetic medicines are integral components in communicating its innovative value proposition.

Clinical Pipeline and Programs

Verve Therapeutics is advancing a robust pipeline of investigational therapies that address significant unmet needs in cardiovascular care:

  • PCSK9 Program: The company is developing gene editing candidates that permanently inactivate the PCSK9 gene in the liver, which plays a critical role in cholesterol metabolism. Clinical trials are targeting patients with heterozygous familial hypercholesterolemia (HeFH) and those with established atherosclerotic cardiovascular disease (ASCVD) who experience persistently high LDL‐C levels.
  • ANGPTL3 Program: Aimed at patients with refractory hypercholesterolemia, this program targets the ANGPTL3 gene. It represents a strategic venture into addressing conditions that remain inadequately managed by traditional treatments.
  • LPA Program: In collaboration with key industry partners, Verve Therapeutics is exploring gene editing strategies targeting the LPA gene, a well‐validated and independent risk factor for a range of cardiovascular conditions.

Research and Development Excellence

Verve’s approach is distinguished by its strong commitment to scientific rigor and robust research and development. The company’s comprehensive R&D framework encompasses preclinical evaluation, ongoing clinical trials, and extensive regulatory engagement. Its transparent reporting of trial endpoints, safety data, and collaborative initiatives with industry-leading partners further bolsters its reputation for expertise and authoritativeness in the competitive biotech landscape.

Market Position and Industry Landscape

In an industry frequently dominated by chronic care models, Verve Therapeutics occupies a unique niche by offering one-time treatments that have the potential for lifelong benefits. This disruptive model not only promises to improve patient adherence and quality of life but also positions the company at the forefront of a rapidly evolving therapeutic market. Despite inherent challenges, the company’s detailed clinical trial designs and rigorous safety assessments demonstrate its capability to navigate complex regulatory environments and competitive pressures.

Commitment to Patient Safety and Clinical Excellence

Patient safety is of paramount importance at Verve Therapeutics. The design and execution of its clinical trials incorporate stringent safety protocols and continuous monitoring of adverse events. By aligning its development strategies with regulatory best practices and maintaining high transparency in clinical reporting, the company instills confidence in both the medical community and investors regarding the long-term viability of its therapies.

Conclusion

Verve Therapeutics, Inc. is shaping a new future in cardiovascular treatment with its cutting-edge gene editing medicines. Its focused approach on permanently lowering cholesterol through targeted genetic interventions underlines a transformative vision that could redefine standards of care across the industry. With a strategic pipeline, a strong foundation in R&D, and an unwavering commitment to clinical excellence, Verve Therapeutics stands as a pivotal company for understanding the next frontier in genetic medicine and cardiovascular therapy.

Rhea-AI Summary

Verve Therapeutics reported pipeline updates and financial results for the first quarter of 2024. The company dosed the first patient in the Heart-2 Phase 1b clinical trial of VERVE-102, with plans to initiate the VERVE-201 clinical trial in the second half of the year. Verve also received a milestone payment from Eli Lilly for a gene editing program targeting Lp(a). The company's cash position is strong, with $606.4 million in cash and marketable securities, providing runway into late 2026.

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Verve Therapeutics announced the dosing of the first patient in the Heart-2 Phase 1b clinical trial evaluating VERVE-102, an investigational in vivo base editing medicine designed to reduce blood low-density lipoprotein cholesterol. The trial is enrolling patients with heterozygous familial hypercholesterolemia or premature coronary artery disease. VERVE-102 aims to permanently inactivate the PCSK9 gene in the liver, providing sustained reductions in LDL-C levels after a single treatment.

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Verve Therapeutics granted equity awards to ten new employees under the company's 2024 Inducement Stock Incentive Plan. The employees received stock options and restricted stock units, totaling 64,200 shares and 56,100 RSUs. The options have an exercise price of $6.01 per share and will vest over four years, while the RSUs will vest annually over four years.

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Verve Therapeutics announces updates from the Heart-1 Phase 1b clinical trial of VERVE-101, demonstrating significant LDL-C reduction of up to 73% at 0.45 mg/kg dose. However, enrollment in the trial is paused due to observed laboratory abnormalities in the sixth participant. Verve is prioritizing the development of VERVE-102, with clearance for the Heart-2 clinical trial expected in 2Q 2024.
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Verve Therapeutics granted equity awards to six new employees under the 2024 Inducement Stock Incentive Plan. The awards include stock options for 91,200 shares and 45,800 restricted stock units, with an exercise price of $13.28 per share. The options have a 10-year term and will vest over four years, while the RSUs will vest annually over four years.
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Verve Therapeutics grants equity awards to new employees under the 2024 Inducement Stock Incentive Plan, with 16,300 RSUs vested over four years.
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Verve Therapeutics reports pipeline updates and financial results for Q4 2023, with $624 million in cash, proof-of-concept data for VERVE-101, and upcoming clinical trials for PCSK9 and ANGPTL3 in 2024.
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Verve Therapeutics CEO to participate in fireside chat at Guggenheim Healthcare Talks 6th Annual Biotechnology Conference. The company is pioneering a new approach to cardiovascular disease with single-course gene editing medicines.
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Verve Therapeutics (VERV) to Present at J.P. Morgan Healthcare Conference on January 8, 2024
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Verve Therapeutics, Inc. (Nasdaq: VERV) has successfully closed an underwritten public offering of 14,375,000 shares of its common stock at a public offering price of $10.00 per share, resulting in total gross proceeds of approximately $143.8 million. Additionally, the company announced the closing of a private placement of 2,296,317 shares of its common stock to Eli Lilly and Company, at a price per share equal to the public offering price, totaling approximately $23.0 million.
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FAQ

What is the current stock price of Verve Therapeutics (VERV)?

The current stock price of Verve Therapeutics (VERV) is $4.135 as of April 1, 2025.

What is the market cap of Verve Therapeutics (VERV)?

The market cap of Verve Therapeutics (VERV) is approximately 368.9M.

What is the primary focus of Verve Therapeutics?

Verve Therapeutics is dedicated to developing single-course gene editing therapies aimed at permanently lowering cholesterol levels to combat cardiovascular disease.

Which genes are targeted by Verve Therapeutics' treatments?

The company targets key genes such as PCSK9, ANGPTL3, and LPA, all of which play crucial roles in regulating cholesterol and influencing cardiovascular risk.

How does Verve's approach differ from traditional cardiovascular treatments?

Unlike traditional chronic therapies, Verve's one-time gene editing treatments are designed to provide lasting benefit by permanently altering genetic expression, thereby reducing the need for ongoing medication.

What clinical trials are currently underway at Verve Therapeutics?

Verve is conducting Phase 1b clinical trials for its PCSK9 and ANGPTL3 programs, focusing on evaluating safety, tolerability, and efficacy in patients with high LDL cholesterol levels.

What innovative technologies does Verve utilize in its therapies?

Verve employs an adenine base editing system along with proprietary lipid nanoparticle delivery to precisely target liver cells for gene inactivation, ensuring a controlled and lasting therapeutic effect.

Who can benefit from Verve Therapeutics' treatments?

Patients with conditions such as heterozygous familial hypercholesterolemia (HeFH) and those with atherosclerotic cardiovascular disease (ASCVD) who suffer from persistently high LDL levels may benefit from these innovative treatments.

How does the company ensure safety in its gene editing therapies?

Verve implements rigorous clinical protocols, continuous monitoring, and stringent regulatory compliance throughout its trials to ensure that safety standards are met and maintained.

What distinguishes Verve Therapeutics in the biotechnology sector?

Its focus on one-time, permanent gene editing treatments for cardiovascular disease, backed by cutting-edge technology and robust R&D, sets Verve apart from traditional chronic management therapies.
Verve Therapeutics, Inc.

Nasdaq:VERV

VERV Rankings

VERV Stock Data

368.95M
84.27M
5.04%
90.12%
16.74%
Biotechnology
Pharmaceutical Preparations
Link
United States
BOSTON