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Vaccinex Provides Update on ActivMAb® Platform: Multiple Project Deals and Presentation at SITC

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Vaccinex (NASDAQ: VCNX) announced multiple proprietary project agreements with major pharmaceutical companies including Amgen, Merck, Chugai, and others for using its ActivMAb® technology platform. The technology enables expression of complex proteins for antibody discovery, particularly useful for developing immunotherapies. The company will also provide materials to strategic partners like Charles River Labs and OmniAb to support their antibody discovery programs.

Additionally, Vaccinex will present data on successful antibody discovery campaigns at the Society for Immunotherapy of Cancer's 29th Annual Meeting in Houston. The first clinical candidate using this technology (CHS-114) is currently in development by Coherus Biosciences for cancer immunotherapy.

Vaccinex (NASDAQ: VCNX) ha annunciato diversi accordi di progetto esclusivi con importanti aziende farmaceutiche, tra cui Amgen, Merck, Chugai e altre, per l'utilizzo della sua piattaforma tecnologica ActivMAb®. Questa tecnologia consente l'espressione di proteine complesse per la scoperta di anticorpi, risultando particolarmente utile nello sviluppo di immunoterapie. L'azienda fornirà anche materiali a partner strategici come Charles River Labs e OmniAb per supportare i loro programmi di scoperta di anticorpi.

Inoltre, Vaccinex presenterà dati su campagne di scoperta di anticorpi di successo al 29° Congresso Annuale della Society for Immunotherapy of Cancer a Houston. Il primo candidato clinico che utilizza questa tecnologia (CHS-114) è attualmente in fase di sviluppo da parte di Coherus Biosciences per l'immunoterapia oncologica.

Vaccinex (NASDAQ: VCNX) anunció múltiples acuerdos de proyectos exclusivos con importantes empresas farmacéuticas, incluidas Amgen, Merck, Chugai y otras, para utilizar su plataforma tecnológica ActivMAb®. Esta tecnología permite la expresión de proteínas complejas para el descubrimiento de anticuerpos, siendo particularmente útil para el desarrollo de inmunoterapias. La empresa también proporcionará materiales a socios estratégicos como Charles River Labs y OmniAb para apoyar sus programas de descubrimiento de anticuerpos.

Además, Vaccinex presentará datos sobre campañas exitosas de descubrimiento de anticuerpos en la 29ª Reunión Anual de la Sociedad de Inmunoterapia del Cáncer en Houston. El primer candidato clínico que utiliza esta tecnología (CHS-114) está actualmente en desarrollo por Coherus Biosciences para la inmunoterapia contra el cáncer.

백신엑스 (NASDAQ: VCNX)암젠, 머크, 추가이 등 여러 주요 제약 회사와 자신의 ActivMAb® 기술 플랫폼을 사용하기 위한 여러 독점 프로젝트 계약을 발표했습니다. 이 기술은 항체 발견을 위한 복합 단백질의 발현을 가능하게 하며, 특히 면역 치료제 개발에 유용합니다. 이 회사는 또한 Charles River Labs 및 OmniAb와 같은 전략적 파트너에게 항체 발견 프로그램을 지원하는 자료를 제공할 것입니다.

또한 백신엑스는 휴스턴에서 열리는 암 면역 치료를 위한 사회의 제29회 연례 회의에서 성공적인 항체 발견 캠페인에 대한 데이터를 발표할 것입니다. 이 기술을 활용한 첫 번째 임상 후보 (CHS-114)는 현재 코헤루스 바이오사이언스에 의해 암 면역 치료를 위해 개발 중입니다.

Vaccinex (NASDAQ: VCNX) a annoncé plusieurs accords de projet exclusifs avec de grandes entreprises pharmaceutiques, notamment Amgen, Merck, Chugai et d'autres, pour l'utilisation de sa plateforme technologique ActivMAb®. Cette technologie permet l'expression de protéines complexes pour la découverte d'anticorps, particulièrement utile pour le développement d'immunothérapies. L'entreprise fournira également des matériaux à des partenaires stratégiques tels que Charles River Labs et OmniAb pour soutenir leurs programmes de découverte d'anticorps.

De plus, Vaccinex présentera des données sur des campagnes de découverte d'anticorps réussies lors de la 29ème réunion annuelle de la Society for Immunotherapy of Cancer à Houston. Le premier candidat clinique utilisant cette technologie (CHS-114) est actuellement en cours de développement par Coherus Biosciences pour l'immunothérapie contre le cancer.

Vaccinex (NASDAQ: VCNX) hat mehrere exklusive Projektvereinbarungen mit großen Pharmaunternehmen, darunter Amgen, Merck, Chugai und andere, zur Nutzung seiner ActivMAb®-Technologieplattform angekündigt. Diese Technologie ermöglicht die Expression komplexer Proteine zur Entdeckung von Antikörpern und ist besonders nützlich für die Entwicklung von Immuntherapien. Das Unternehmen wird auch Materialien an strategische Partner wie Charles River Labs und OmniAb bereitstellen, um deren Antikörperentdeckungsprogramme zu unterstützen.

Darüber hinaus wird Vaccinex Daten zu erfolgreichen Antikörperentdeckungskampagnen auf der 29. Jahrestagung der Society for Immunotherapy of Cancer in Houston präsentieren. Der erste klinische Kandidat, der diese Technologie nutzt (CHS-114), wird derzeit von Coherus Biosciences zur Krebsimmuntherapie entwickelt.

Positive
  • Multiple partnership agreements secured with major pharmaceutical companies
  • Technology platform successfully used in development of clinical candidate CHS-114
  • Expansion of business model through provision of materials to strategic partners
Negative
  • Financial terms of agreements not disclosed, impact on revenue unclear

Insights

The multiple partnerships announced with major pharmaceutical companies like Amgen, Merck and Chugai represent significant business development for Vaccinex's ActivMAb® platform. This technology's ability to express complex membrane proteins for antibody discovery addresses a important market need. The platform's validation through deals with established companies and the advancement of CHS-114 to clinical trials demonstrates commercial viability.

While financial terms remain undisclosed, these agreements typically involve upfront payments, research funding and potential milestone payments. For a micro-cap company ($9.2M market cap), these partnerships provide essential revenue streams and validate the technology, potentially leading to expanded collaborations. The diverse range of partners, including both large pharma and biotechnology companies, suggests broad applicability of the platform.

The ActivMAb® platform addresses a significant technical challenge in drug development - generating antibodies against complex membrane proteins like GPCRs and ion channels. These targets are notoriously difficult to work with but represent approximately 30% of all FDA-approved drugs. The platform's success with CCR8-targeting antibody (CHS-114) now in clinical development provides important validation.

The technology's versatility in supporting various antibody-based therapeutics (bi-specifics, ADCs, CAR-T cells) positions it well in the rapidly growing targeted therapy market. The partnerships with antibody discovery specialists like Adimab and OmniAb suggest the platform complements existing technologies, expanding its market potential.

Partnerships will employ Vaccinex’s ActivMAb® platform for viral display of complex antigens to enable antibody discovery

ROCHESTER, N.Y., Nov. 07, 2024 (GLOBE NEWSWIRE) -- Vaccinex, Inc. (Nasdaq: VCNX), a clinical-stage biotechnology company pioneering a differentiated approach to treating cancer and neurodegenerative disease through the inhibition of SEMA4D, today announced the signing of several proprietary project agreements with Amgen, Merck, Chugai, Absci, Gigagen (Grifols), Merus, Soleil, ThirdArc and Incyte, employing Vaccinex’s ActivMAb® technology to generate antibodies to complex antigen targets. In addition, Vaccinex has signed agreements to provide Charles River Labs, OmniAb, Adimab and other undisclosed strategic partners with materials to facilitate their antibody discovery programs using transgenic animal species for immunization or very large synthetic antibody libraries. The financial terms of the agreements are undisclosed.

Vaccinex’s proprietary ActivMAb® Technology enables expression of functional, properly folded complex proteins such as GPCRs and Ion Channels on the relatively simple membrane of poxvirus providing a source of antigen for various antibody discovery strategies. These strategies may involve development of antibody and antibody-based immunotherapies including bi-specifics, antibody drug conjugates (ADC), CAR-T cells, T cell engagers, etc. “Our technology is a powerful component of antibody discovery strategies targeting complex membrane proteins and enables both our own R&D efforts and those of our partners,” said Ernest Smith, Chief Scientific Officer of Vaccinex. “These agreements and partnerships with established companies underscore ActivMAb’s unique ability to address previously hard to drug targets in a format ideally suited for antibody discovery.”

Vaccinex will present data and examples of successful antibody discovery campaigns against potential oncology targets using the ActivMab Technology at the Society for Immunotherapy of Cancer’s 29th Annual Meeting held November 8-10, 2024, in Houston, TX.

MeetingSITC 39th Annual Meeting
Date:
Saturday, Nov. 9, 2024
Location:Exhibit Halls A B George R. Brown Convention Center
Poster Title:Discovery of high affinity functional antibodies specific for CXCR5, P2X7 and other multi-pass membrane receptors
Poster Number1100
PresenterElizabeth Evans, PhD, Chief Operating Officer, Vaccinex, Inc.


About ActivMAb®
ActivMAb is a proprietary antibody discovery platform developed by Vaccinex with unique capabilities for important multi-pass membrane targets such as G-protein-coupled receptors (GPCRs) and ion channels. The ActivMAb technology has multiple applications including discovery of antibodies specific for complex membrane antigens, discovery of antibodies with optimized developability, and protein optimization for expression and activity. Its novel capabilities enable selection of unique antibody drugs against difficult high-value targets, including multi-pass membrane proteins against which small molecule drugs have demonstrated low efficacy or high toxicity. The first clinical candidate selected through use of this technology (CHS-114, a fully human monoclonal antibody targeting CCR8), is in clinical development for cancer immunotherapy by Coherus Biosciences, Inc.

About Vaccinex Inc. 

Vaccinex, Inc. is pioneering a differentiated approach to treating slowly progressive neurodegenerative diseases and cancer through the inhibition of semaphorin 4D (SEMA4D). The Company’s lead drug candidate, pepinemab, blocks SEMA4D, a potent biological effector that it believes triggers damaging inflammation in chronic diseases of the brain and prevents infiltration and activation of immune cells in tumors. Pepinemab is being studied as a monotherapy in the Phase 1b/2 SIGNAL-AD study in Alzheimer’s Disease, and the Company has previously published promising Phase 2 data in Huntington’s disease. Because it is well-tolerated, pepinemab could be an important contributor to combination therapy in AD. In oncology, pepinemab is being evaluated in combination with KEYTRUDA® in the Phase 1b/2 KEYNOTE-B84 study in recurrent or metastatic head and neck cancer (HNSCC) and in combination with BAVENCIO® in a Phase 1b/2 study in patients with metastatic pancreatic adenocarcinoma (PDAC). The oncology clinical program also includes several investigator-sponsored studies in solid tumors including breast cancer and melanoma.

Vaccinex has global commercial and development rights to pepinemab and is the sponsor of the KEYNOTE-B84 study which is being performed in collaboration with Merck Sharp & Dohme Corp, a subsidiary of Merck and Co, Inc.  Kenilworth, NJ, USA. Additional information about the study is available at: clinicaltrials.gov.

KEYTRUDA is a registered trademark of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co. Inc., Kenilworth, NJ, USA. BAVENCIO®/avelumab is provided by Merck KGaA, Darmstadt, Germany, previously as part of an alliance between the healthcare business of Merck KGaA, Darmstadt, Germany and Pfizer.

Forward Looking Statements
To the extent that statements contained in this presentation are not descriptions of historical facts regarding Vaccinex, Inc. (“Vaccinex,” “we,” “us,” or “our”), they are forward-looking statements reflecting management’s current beliefs and expectations. Such statements include, but are not limited to, statements about our plans, ability to capitalize on, expectations and objectives with respect to the “Antigen Virus” applications of the ActivMab® platform, and other statements identified by words such as “believe,” “being,” “could,” “will,” “potential,” and similar expressions or their negatives (as well as other words and expressions referencing future events, conditions, or circumstances). Forward-looking statements involve substantial risks and uncertainties that could cause the outcome of our research and pre-clinical development programs, clinical development programs, future results, performance, or achievements to differ significantly from those expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, uncertainties inherent in the execution, cost and completion of preclinical studies and clinical trials, that interim and preliminary data may not be predictive of final results and does not ensure success in later preclinical studies and clinical trials, uncertainties related to regulatory approval, risks related to our dependence on our lead product candidate pepinemab, the possible delisting of our common stock from Nasdaq if we are unable to regain compliance with the Nasdaq listing standards, and other matters that could affect our development plans or the commercial potential of our product candidates. Except as required by law, we assume no obligation to update these forward-looking statements. For a further discussion of these and other factors that could cause future results to differ materially from any forward-looking statement, see the section titled “Risk Factors” in our periodic reports filed with the Securities and Exchange Commission (“SEC”) and the other risks and uncertainties described in the Company’s annual year-end Form 10-K and subsequent filings with the SEC.

Investor Contact                                        

Elizabeth Evans, PhD

Chief Operating Officer, Vaccinex, Inc.

(585) 271-2700

eevans@vaccinex.com


FAQ

What companies has Vaccinex (VCNX) partnered with for its ActivMAb platform?

Vaccinex has partnered with Amgen, Merck, Chugai, Absci, Gigagen (Grifols), Merus, Soleil, ThirdArc, and Incyte, along with strategic partners including Charles River Labs, OmniAb, and Adimab.

What is the main purpose of Vaccinex's (VCNX) ActivMAb technology?

ActivMAb technology enables expression of functional, properly folded complex proteins on poxvirus membrane for antibody discovery, particularly useful for developing immunotherapies like bi-specifics, antibody drug conjugates, and CAR-T cells.

Where will Vaccinex (VCNX) present its ActivMAb technology data in 2024?

Vaccinex will present data at the Society for Immunotherapy of Cancer's 29th Annual Meeting in Houston, TX, on November 9, 2024, showcasing antibody discovery campaigns against oncology targets.

Vaccinex, Inc.

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