Twist Bioscience Begins Shipping of Synthetic RNA Controls for UK Variant Strain of SARS-CoV-2

Rhea-AI Summary

Twist Bioscience Corporation (Nasdaq: TWST) has started shipping new synthetic RNA reference controls, including the SARS-CoV-2 variant strain B1.1.7. This strain's mutations may result in false negative COVID-19 test results due to some RT-PCR probes failing to detect the S gene. CEO Emily M. Leproust stated these controls help customers update testing protocols to reduce false negatives. Twist's controls support monitoring viral evolution and are used globally in various assays, demonstrating its commitment to improving health outcomes.

Positive

• Launch of synthetic RNA reference controls for the B1.1.7 variant enhances COVID-19 testing accuracy.
• Supports global testing efforts and assists customers in avoiding false negatives.
• Continues to innovate with additional SARS-CoV-2 controls to adapt to viral evolution.

Negative

• None.

Twist Bioscience Corporation (Nasdaq: TWST), a company enabling customers to succeed through its offering of high-quality synthetic DNA using its silicon platform, today announced that it has started shipping its new synthetic RNA reference controls, which includes the new variant strain of SARS-CoV-2 identified in the United Kingdom. With this new strain (B1.1.7 lineage, variant under investigation VUI-202012/01), which contains multiple mutations in the spike protein and other areas of the viral genome, some of the RT-PCR probes used widely in COVID-19 testing no longer detect the S gene that codes for the spike protein. This can lead to false negative test results.

“By offering synthetic controls for this specific mutation, our customers are able to update their testing protocols, which will help to potentially avoid false negative results when testing for SARS-CoV-2 infection,” said Emily M. Leproust, Ph.D., CEO and co-founder of Twist Bioscience. “These controls, used alone or in conjunction with our SARS-CoV-2 NGS RUO Assay to identify all SARS-CoV-2 nucleic acid sequences, are invaluable research tools for monitoring viral evolution and for population-scale surveillance.”

For more information on the Twist products to combat COVID-19, please visit: https://www.twistbioscience.com/coronavirus-research-tools.

In March, Twist launched synthetic SARS-CoV-2 RNA distinct reference sequences as positive controls for the development of both next-generation sequencing (NGS) and reverse transcription-polymerase chain reaction (RT-PCR) assays to test for SARS-CoV-2. These controls continue to be included in many different assays worldwide and can be used to determine the limit of detection, monitor day-to-day test variations and are included on the U.S. Food and Drug Administration (FDA) website as reference materials for SARS-CoV-2. Twist has subsequently released additional SARS-CoV-2 controls to cover the evolution of the virus, and remains committed to using its DNA synthesis platform to offer valuable products that improve health and sustainability.

The Twist synthetic controls are designed based on specific SARS-CoV-2 variants, cover the full viral genome and are sequence-verified. For customers interested in alternative variants of SARS-CoV-2, Twist can provide custom controls and offers a suite of research tools, including next-generation sequencing (NGS) products for SARS-CoV-2 as well as a broad respiratory panel and the most comprehensive viral panel.

Customers purchasing synthetic controls are subject to Twist’s leading biosecurity screening protocols and applicable laws and regulations.

About Twist Bioscience Corporation

Twist Bioscience is a leading and rapidly growing synthetic biology and genomics company that has developed a disruptive DNA synthesis platform to industrialize the engineering of biology. The core of the platform is a proprietary technology that pioneers a new method of manufacturing synthetic DNA by “writing” DNA on a silicon chip. Twist is leveraging its unique technology to manufacture a broad range of synthetic DNA-based products, including synthetic genes, tools for next-generation sequencing (NGS) preparation, and antibody libraries for drug discovery and development. Twist is also pursuing longer-term opportunities in digital data storage in DNA and biologics drug discovery. Twist makes products for use across many industries including healthcare, industrial chemicals, agriculture and academic research.

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FAQ

What is the new product launched by Twist Bioscience Corporation?

Twist Bioscience Corporation has launched new synthetic RNA reference controls, including the SARS-CoV-2 B1.1.7 variant.

How does the B1.1.7 variant affect COVID-19 testing?

The B1.1.7 variant may lead to false negative results in COVID-19 testing as some RT-PCR probes fail to detect its S gene.

What are the benefits of the synthetic RNA reference controls?

These controls help update testing protocols, reducing the risk of false negatives in SARS-CoV-2 detection.

When did Twist Bioscience start shipping the synthetic RNA reference controls?

Twist Bioscience has started shipping these new controls recently, as part of its ongoing efforts to enhance COVID-19 testing.