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Trevi Therapeutics, Inc. (Nasdaq: TRVI) is a late-stage biopharmaceutical company devoted to addressing chronic pruritic conditions and chronic cough through its investigational therapy, Haduvio™ (oral nalbuphine ER). Haduvio is an oral extended-release formulation of nalbuphine, a synthetic opioid with a dual mechanism of action: as a ĸ-opioid receptor agonist and µ-opioid receptor antagonist. This unique mechanism has shown promise in clinical trials for reducing symptoms associated with chronic cough, particularly in idiopathic pulmonary fibrosis (IPF), refractory chronic cough (RCC), and prurigo nodularis, a dermatologic condition characterized by pruriginous lesions.
Trevi is advancing various pruritic conditions through clinical development, including prurigo nodularis, which currently has no approved therapies in the US or EU. The company's lead indication involves extensive studies and trials, such as the recent Phase 2b/3 PRISM (Pruritus Relief through Itch-Scratch Modulation) trial, which demonstrated Haduvio's efficacy and safety over 52 weeks.
In the chronic cough segment, Trevi's Haduvio is undergoing trials like the Phase 2a RIVER study for RCC and the Phase 2b CORAL trial for chronic cough in IPF. The RIVER trial is a double-blind, placebo-controlled study evaluating Haduvio's impact on 24-hour cough frequency, while the CORAL trial investigates three dose levels of Haduvio against a placebo in IPF patients, assessing endpoints like cough frequency reduction and quality of life improvements.
Trevi's innovative approach aims to provide relief where current treatments fail, supported by promising clinical data and ongoing trials. The company's commitment to addressing unmet medical needs is reflected in its thorough and transparent communication with investors and stakeholders, ensuring that all developments are promptly shared, including financial results and future plans.
For more detailed information on Trevi Therapeutics, its clinical trials, and its forward-looking statements, visit TreviTherapeutics.com and follow the company on Twitter and LinkedIn.
Trevi Therapeutics, Inc. (Nasdaq: TRVI) announced that its President and CEO, Jennifer Good, will present at the 2022 BIO International Convention on June 13 at 4 PM PT in San Diego, CA. The convention is expected to attract over 15,000 leaders in biotechnology and pharma, focusing on networking and partnership opportunities. Trevi is developing Haduvio™, an investigational therapy for pruritus in prurigo nodularis and chronic cough in idiopathic pulmonary fibrosis, and is currently conducting Phase 2b/3 and Phase 2 clinical trials for these conditions.
Trevi Therapeutics, Inc. (Nasdaq: TRVI) announced significant advancements in its clinical development for Haduvio, targeting chronic cough in idiopathic pulmonary fibrosis (IPF) and chronic pruritus in prurigo nodularis (PN). The Phase 2 CANAL trial demonstrated a 77.3% reduction in cough frequency, leading to expedited development. The company completed a private placement raising $55 million to fund further clinical trials. As of March 31, 2022, Trevi reported $29.1 million in cash and cash equivalents and a net loss of $7.3 million for the quarter.
Trevi Therapeutics, Inc. (Nasdaq: TRVI) will host a conference call on May 12, 2022, at 4:30 p.m. EDT to discuss its Q1 2022 financial results and provide a corporate update. The call can be accessed via phone or through a live audio webcast on the company's website. Trevi is focused on developing Haduvio™, an investigational therapy aimed at treating pruritus in prurigo nodularis and chronic cough in idiopathic pulmonary fibrosis. Haduvio has received Fast Track designation from the FDA for its proposed indication.
Trevi Therapeutics, Inc. (Nasdaq: TRVI), a clinical-stage biopharmaceutical company, will present at two significant events in May 2022. The LifeSci Partners Immunology & Inflammation Symposium is scheduled for May 11, featuring Jennifer Good (President and CEO) and Dr. Bill Forbes (CDO). Additionally, Trevi will participate in the H.C. Wainwright Global Investment Conference from May 23-26, with a virtual presentation on May 24. Trevi is developing Haduvio (nalbuphine ER) for treating chronic pruritus in prurigo nodularis and chronic cough in idiopathic pulmonary fibrosis.
Trevi Therapeutics, a clinical-stage biopharmaceutical company, will participate in a fireside chat at the 21st Annual Needham Virtual Healthcare Conference on April 12, 2022, from 10:15 a.m. to 10:55 a.m. EDT. CEO Jennifer Good and Dr. Bill Forbes will discuss the investigational therapy Haduvio for treating pruritus in prurigo nodularis and chronic cough in idiopathic pulmonary fibrosis. The event will be available via live webcast on the company’s website, with an archived replay accessible for 30 days.
Trevi recently reported significant results from its CANAL trial, showing a 77% reduction in daytime cough frequency.
Trevi Therapeutics (Nasdaq: TRVI) announced a private placement to raise approximately $55 million through the sale of 4,580,526 shares at $1.90 each and pre-funded warrants at $1.899. The funds will support the clinical development of Haduvio for chronic cough in idiopathic pulmonary fibrosis (IPF) and for working capital. The deal, led by Frazier Life Sciences and Venrock Healthcare Capital Partners, is expected to close around April 11, 2022, pending customary conditions. The shares are unregistered under the Securities Act and will be resold upon effective registration.
Trevi Therapeutics (TRVI) announced its participation in the 21st Annual Needham Virtual Healthcare Conference on April 12, 2022. The fireside chat, featuring CEO Jennifer Good and CDO Bill Forbes, will take place from 8:00 a.m. to 8:40 a.m. EDT. The discussion will highlight findings from the Phase 2 CANAL trial, where Haduvio showed a 77% reduction in daytime cough frequency in patients with idiopathic pulmonary fibrosis. Additionally, top-line data from the Phase 2b/3 PRISM trial for pruritus in prurigo nodularis is anticipated in the second quarter of 2022.
Trevi Therapeutics (TRVI) announced a webinar on March 30, 2022, focusing on chronic cough in idiopathic pulmonary fibrosis (IPF) patients. Dr. William Forbes will discuss the challenges faced by IPF patients, including a lack of approved treatments for chronic cough, which affects up to 85% of the 130,000 estimated US patients. Trevi will present recent positive interim results from its Phase 2 CANAL trial of Haduvio (nalbuphine ER) aimed at addressing chronic cough in IPF. The webinar will also include a live Q&A session.
Trevi Therapeutics (Nasdaq: TRVI) has announced significant updates regarding its clinical trials and financial performance. The Phase 2 CANAL trial for Haduvio™ in treating chronic cough in idiopathic pulmonary fibrosis (IPF) showed a highly significant reduction in cough events (p < 0.0001), leading to early enrollment closure. Additionally, enrollment in the Phase 2b/3 PRISM trial for pruritus due to prurigo nodularis is complete, with top-line results expected by Q2 2022. For Q4 2021, Trevi reported a net loss of $8.5 million and had cash reserves of $36.8 million as of December 31, 2021.
Trevi Therapeutics concludes early enrollment for its Phase 2 CANAL trial, focusing on chronic cough in idiopathic pulmonary fibrosis (IPF). The trial's interim analysis revealed a statistically significant 77.3% reduction in daytime cough frequency with Haduvio™ (nalbuphine ER) compared to 25.7% with placebo (p<0.0001). A total of approximately 40 subjects were enrolled. Full efficacy and safety results are anticipated in Q3 2022, following the successful interim findings.
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