Theravance Biopharma, Inc. Reports First Quarter 2026 Financial Results and Provides Corporate Update
Rhea-AI Summary
Theravance Biopharma (NASDAQ: TBPH) reported Q1 2026 results and a corporate update on May 7, 2026. Total revenue was $17.7 million, driven by a 15% increase in Viatris collaboration revenue. Quarter-end cash was $394.7 million with no debt. Q1 net loss was $4.9 million; non-GAAP net income from operations was $0.6 million. YUPELRI collaboration revenue rose on higher net sales and operating leverage; Viatris-reported Q1 U.S. YUPELRI net sales were $62.4 million (+7% YoY). TRELEGY global net sales were $873 million (+2% YoY) and the company expects a potential $100 million 2026 milestone. The Board's Strategic Review Committee is evaluating strategic alternatives. The company is executing a restructuring to reduce operating expenses ~60% and wind down R&D.
Positive
- Viatris collaboration revenue +15% YoY to $17.7M
- Implied 35% share of YUPELRI net sales $21.9M (Q1)
- Operating expenses (ex-restructuring) reduced ~20% YoY in Q1
- Quarter-end cash balance of $394.7M and no debt
- Non-GAAP net income from operations of $0.6M in Q1
Negative
- Net loss of $4.9M in Q1 2026
- CYPRESS study did not meet primary endpoint; ampreloxetine program winding down
- Organizational restructuring will impact ~50% of workforce
- Full cash benefit of restructuring expected only by Q3 2026
News Market Reaction – TBPH
In the May 7 session, TBPH gained 0.47%, reflecting a mild positive market reaction.
Data tracked by StockTitan Argus on the day of publication.
Key Figures
Previous Earnings Reports
| Date | Event | Sentiment | 24h Move | Catalyst |
|---|---|---|---|---|
| Mar 19 | Q4/FY 2025 earnings | Positive | +1.3% | Strong 2025 revenue, milestones, cash build and cost-cutting plans. |
| Nov 10 | Q3 2025 earnings | Positive | +22.7% | Record YUPELRI sales, non-GAAP breakeven and solid cash position. |
| Nov 10 | Q3 2025 earnings | Positive | +22.7% | Repeat entry: same strong Q3 2025 metrics and outlook details. |
| Aug 12 | Q2 2025 earnings | Positive | +4.2% | Strong YUPELRI growth, TRELEGY royalty sale and positive net income. |
| May 08 | Q1 2025 earnings | Positive | -9.3% | Solid YUPELRI and TRELEGY growth but shares fell post-release. |
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
Earnings releases have generally coincided with positive price reactions, with one notable negative reaction despite strong product metrics.
Over the last year, Theravance’s earnings updates have highlighted growing YUPELRI sales, TRELEGY milestone payments and a strengthening cash position, often producing positive price responses (e.g., +22.68% on Nov 10, 2025). The latest 10-K and earnings reinforced a pivot toward a streamlined, YUPELRI-focused model and accelerated strategic review. Today’s Q1 2026 results, with higher collaboration revenue, reduced operating expenses and a sizeable cash balance, extend this narrative of operational tightening following the CYPRESS outcome.
Key Terms
hatch-waxman regulatory
long-acting muscarinic antagonist medical
copd medical
non-gaap financial
AI-generated analysis. How Rhea-AI works. Not financial advice.
- YUPELRI® Collaboration Revenue increased
15% year-over-year1, from$15.4 million $17.7 million - All Hatch-Waxman litigation relating to YUPELRI® has been resolved following settlement with Mankind Pharma in March
- Organizational restructuring and cost reduction initiatives on track; delivered ~
20% reduction in Operating Expenses year-over-year (excluding restructuring items) - Q1 2026 TRELEGY net sales, reported by GSK, of
$873 million 2% year-over-year; high confidence in achieving the$100 million - Strategic Review Committee actively evaluating a range of opportunities to maximize shareholder value
- Quarter-end cash balance of
$395 million
"We delivered strong financial performance in the first quarter, reinforcing the quality of our commercial asset, our robust balance sheet and the important actions underway to reshape our cost structure, following the outcome of the CYPRESS study," said Rick E Winningham, Chief Executive Officer of Theravance Biopharma. "YUPELRI® continues to deliver sustained net sales growth and expanding profitability, supported by growing community and hospital adoption, improved net pricing, and the recent resolution of generic litigation, driving increased long-term value for the franchise. TRELEGY also continued to perform well, and we remain confident that we will achieve the
Strategic Review Committee
In 2024, the Theravance Board of Directors formed a Strategic Review Committee (the "Committee") composed entirely of independent directors to assess all strategic alternatives available to the Company. Since then, the Committee has been working on an ongoing basis with Lazard, its independent financial advisor, to evaluate opportunities to maximize shareholder value, including under multiple potential outcomes for the CYPRESS study, which the Company announced on March 3rd did not meet the primary endpoint. Building upon this work, the Committee is acting with urgency to evaluate a broad range of value maximizing and tax efficient alternatives, including but not limited to a sale of the Company. In connection with the Company's March 3rd announcement to wind down the ampreloxetine program and implement an organizational restructuring, the Committee has accelerated its evaluation of strategic alternatives for the Company. There can be no assurance that the Committee's strategic review process will result in any transaction. Theravance Biopharma does not intend to disclose further developments on this review process unless and until it determines that such disclosure is appropriate or necessary.
Operational Highlights
YUPELRI® (revefenacin) inhalation solution, the first and only once-daily, nebulized LAMA (long-acting muscarinic antagonist) bronchodilator approved in the
- Quarterly
U.S. net sales of$62.4 million 7% year-over-year (YoY) (Q1 2026 vs Q1 2025)1 driven by customer demand growth of4% YoY (Q1 2026 vs Q1 2025)3, consistent with typical first quarter seasonality, and improved net pricing. - Increased doses pulled through the hospital channel by
19% YoY (Q1 2026 vs Q1 2025), reflecting another excellent quarter of growth.4 - Theravance and Viatris (Mylan) entered into a settlement in March with Mankind Pharma Ltd. with a licensed launch date of April 23, 2039, subject to certain exceptions and other provisions customary for agreements of this type.
- With this settlement agreement, all Hatch-Waxman litigation relating to YUPELRI® (revefenacin) inhalation solution has been resolved.
TRELEGY
GSK reported first quarter 2026 global net sales of
- FY 2025 global net sales of approximately
$3.9 billion $50M - FY 2026 global net sales of
~ required to trigger an additional$3.5 billion $100M
Organizational Restructuring Update
- Following the announcement of the Company's Phase 3 CYPRESS results in March, Theravance has made progress on its organizational restructuring.
- As an early indicator of this progress, Operating Expenses (excluding restructuring costs) decreased approximately
20% year-over-year in Q1 2026 compared to Q1 2025, with more material reductions expected in Q2 2026 and full run-rate savings anticipated beginning in Q3 2026. - The Company reaffirms it is on track to reduce operating expenses by approximately
60% , resulting in approximately$60 $70 million
First Quarter Financial Results
- Revenue: Total revenue for the first quarter of 2026 was
$17.7 million $2.3 million 15% , in the first quarter compared to the same period in 2025. The Viatris collaboration revenue represents amounts receivable from Viatris and comprises the Company's35% share of net sales of YUPELRI, as well as its proportionate amount of the total shared commercial costs incurred by the two companies. The non-shared YUPELRI costs incurred by Theravance Biopharma are recorded within operating expenses. While Viatris records the total net sales of YUPELRI within its financial statements, Theravance Biopharma's implied35% share of net sales of YUPELRI for the first quarter of 2026 was$21.9 million 7% increase compared to the same period in 2025.
- Research and Development (R&D) Expenses: R&D expenses for the first quarter of 2026 were
$5.8 million $11.5 million $0.6 million
- Selling, General and Administrative (SG&A) Expenses: SG&A expenses for the first quarter of 2026 were
$17.7 million $18.4 million $2.9 million
- Restructuring Expenses: Restructuring expenses for the first quarter of 2026 were
$3.6 million $2.6 million $1.0 million
- Share-Based Compensation: Total share-based compensation expenses for the first quarter of 2026 were
$4.5 million $3.5 million $4.9 million $0.6 million $2.9 million $1.0 million
- Net Loss: Net loss was
$4.9 million $13.6 million
- Non-GAAP Net Income (Loss) from Operations6: Non-GAAP net income from operations was
$0.6 million $8.6 million
- Cash Position: Cash, cash equivalents and marketable securities totaled
$394.7 million $25.0 million U.S. sales milestone from Viatris in January 2026 and a$50.0 million
- Shares Outstanding: The Company had 51,514,968 ordinary shares outstanding as of March 31, 2026.
2026 Financial Guidance
Theravance Biopharma is implementing an organizational restructuring to streamline costs and align its resources with its commercial focus on YUPELRI. The restructuring will involve winding down the R&D function and significantly reducing the G&A function. The restructuring is expected to reduce operating expenses by approximately
Together, the cost savings from the restructuring and continued sales from YUPELRI are expected to result in the Company generating approximately
The restructuring is expected to impact approximately
Conference Call
Beginning last quarter, earnings results are being released via press release only. The Company will not host a conference call or webcast to discuss quarterly results.
About Theravance Biopharma
Theravance Biopharma, Inc.'s focus is to deliver Medicines that Make a Difference® in people's lives. In pursuit of its purpose, Theravance Biopharma leverages decades of expertise, which has led to the development of FDA-approved YUPELRI® (revefenacin) inhalation solution indicated for the maintenance treatment of patients with chronic obstructive pulmonary disease (COPD). The Company is committed to creating/driving shareholder value.
For more information, please visit www.theravance.com.
THERAVANCE BIOPHARMA®, THERAVANCE® and the Cross/Star logo are registered trademarks of the Theravance Biopharma group of companies (in the
YUPELRI® is a registered trademark of Viatris Specialty LLC. Trademarks, trade names or service marks of other companies appearing on this press release are the property of their respective owners.
Forward-Looking Statements
This press release contains certain "forward-looking" statements as that term is defined in the Private Securities Litigation Reform Act of 1995 regarding, among other things, statements relating to goals, plans, objectives, expectations and future events. Theravance Biopharma, Inc. (the "Company") intends such forward-looking statements to be covered by the safe harbor provisions for forward-looking statements contained in Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995. Examples of such statements include statements relating to: the Company's expectations regarding its future profitability, expenses and uses of cash, the Company's goals, designs, strategies, plans and objectives, future growth of YUPELRI sales and future royalty payments, the winddown of the Company's ampreloxetine program and R&D function and significant reduction of its G&A function, the consideration of strategic alternatives for the Company, the ability to provide value to shareholders, the Company's regulatory strategies, and contingent milestone payments due to the Company from the sale of the Company's TRELEGY royalty interests. These statements are based on the current estimates and assumptions of the management of Theravance Biopharma as of the date of this press release and are subject to risks, uncertainties, changes in circumstances, assumptions and other factors that may cause the actual results of Theravance Biopharma to be materially different from those reflected in the forward-looking statements. Important factors that could cause actual results to differ materially from those indicated by such forward-looking statements include, among others, risks related to: factors that could increase the Company's expenses beyond its expectations and any factors that could adversely affect its profitability, whether the TRELEGY milestone thresholds will be achieved, delays or difficulties in winding down clinical studies, the timing of any potential strategic transaction with respect to the Company, if at all, risks of collaborating with or relying on third parties to develop, manufacture and commercialize products, and risks associated with establishing and maintaining sales, marketing and distribution capabilities with appropriate technical expertise and supporting infrastructure, the ability of the Company to protect and to enforce its intellectual property rights, volatility and fluctuations in the trading price and volume of the Company's shares, and general economic and market conditions. Other risks affecting the Company are in the Company's Form 10-K filed with the SEC on March 23, 2026, and other periodic reports filed with the SEC. In addition to the risks described above and in Theravance Biopharma's filings with the SEC, other unknown or unpredictable factors also could affect Theravance Biopharma's results. No forward-looking statements can be guaranteed, and actual results may differ materially from such statements. Given these uncertainties, you should not place undue reliance on these forward-looking statements. Theravance Biopharma assumes no obligation to update its forward-looking statements on account of new information, future events or otherwise, except as required by law.
Non-GAAP Financial Measures
Theravance Biopharma provides a non-GAAP metric in this press release. Theravance Biopharma believes that non-GAAP net income (loss) provides meaningful information to assist investors in assessing prospects for future performance and actual performance as they provide better metrics for analyzing the performance of its business by excluding items that may not be indicative of core operating results and the Company's cash position. Because non-GAAP financial targets and metrics, such as non-GAAP net income (loss), are not standardized, it may not be possible to compare these measures with other companies' non-GAAP targets or measures having the same or a similar name. Thus, Theravance Biopharma's non-GAAP measures should be considered in addition to, not as a substitute for, or in isolation from, the Company's actual GAAP results and other targets.
Please see the appendix attached to this press release for a reconciliation of non-GAAP net income (loss) to its corresponding measure, net income (loss). A reconciliation of non-GAAP net income (loss) to its corresponding GAAP measure is not available on a forward-looking basis without unreasonable effort due to the uncertainty regarding, and the potential variability of, expenses and other factors in the future.
Contact:
investor.relations@theravance.com
650-808-4045
1 | In the |
2 | Payment from Royalty Pharma (RP) will be triggered if RP receives certain minimum royalty payments from GSK based on TRELEGY global net sales. |
3 | Source: Viatris Customer Demand (Q1'26). |
4 | Source: IQVIA DDD, HDS, VA and Non-Reporting Hospital through Mar '26. |
5 | GSK-reported Net Sales in USD. |
6 | Non-GAAP profit (loss) consists of GAAP net income (loss) before taxes less (i) share-based compensation expense, (ii) non-cash interest expense, and (iii) non-recurring revenue and income items. See the section titled "Non-GAAP Financial Measures" for more information. |
THERAVANCE BIOPHARMA, INC. | |||||
CONDENSED CONSOLIDATED BALANCE SHEETS | |||||
(In thousands) | |||||
March 31, | December 31, | ||||
2026 | 2025 | ||||
Assets | (Unaudited) | (1) | |||
Current assets: | |||||
Cash and cash equivalents and short-term marketable securities | $ | 394,666 | $ | 315,357 | |
Receivables from collaborative arrangements | 15,584 | 45,539 | |||
Receivables from milestone and royalty assets | - | 50,000 | |||
Other prepaid and current assets | 7,384 | 7,564 | |||
Total current assets | 417,634 | 418,460 | |||
Long-term marketable securities | - | 11,128 | |||
Property and equipment, net | 5,539 | 5,895 | |||
Operating lease assets | 23,001 | 24,371 | |||
Restricted cash | 836 | 836 | |||
Other assets | 25,303 | 24,880 | |||
Total assets | $ | 472,313 | $ | 485,570 | |
Liabilities and Shareholders' Equity | |||||
Current liabilities | $ | 31,775 | $ | 38,302 | |
Long-term operating lease liabilities | 29,752 | 31,758 | |||
Future royalty payment contingency | 32,795 | 32,795 | |||
Unrecognized tax benefits | 87,153 | 85,679 | |||
Other long-term liabilities | 244 | 313 | |||
Shareholders' equity | 290,594 | 296,723 | |||
Total liabilities and shareholders' equity | $ | 472,313 | $ | 485,570 | |
________________________________ | ||||||
(1) | The condensed consolidated balance sheet as of December 31, 2025 has been derived from the audited consolidated financial | |||||
THERAVANCE BIOPHARMA, INC. | ||||||
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS | ||||||
(In thousands, except per share data) | ||||||
Three Months Ended March 31, | ||||||
2026 | 2025 | |||||
(Unaudited) | ||||||
Revenue: | ||||||
Viatris collaboration agreement (1) | $ | 17,699 | $ | 15,388 | ||
Total revenue | 17,699 | 15,388 | ||||
Costs and expenses: | ||||||
Research and development (2) | 5,829 | 11,452 | ||||
Selling, general and administrative (2) | 17,720 | 18,370 | ||||
Restructuring expenses (2) (3) | 3,633 | - | ||||
Total costs and expenses | 27,182 | 29,822 | ||||
Loss from operations | (9,483) | (14,434) | ||||
Interest expense (non-cash) | - | (643) | ||||
Interest income and other income, net | 3,013 | 939 | ||||
Loss before income taxes | (6,470) | (14,138) | ||||
Provision for income tax benefit | 1,537 | 559 | ||||
Net loss | $ | (4,933) | $ | (13,579) | ||
Net loss per share: | ||||||
Net loss per share - basic and diluted | $ | (0.10) | $ | (0.27) | ||
Shares used to compute net loss per share - basic and diluted | 51,279 | 49,706 | ||||
Non-GAAP net income (loss) | $ | 639 | $ | (8,618) | ||
________________________________ | ||||||
(1) While Viatris, Inc. records the total YUPELRI net sales, the Company is entitled to a | ||||||
Three Months Ended March 31, | ||||||
(In thousands) | 2026 | 2025 | ||||
YUPELRI net sales ( | $ | 62,430 | $ | 58,344 | ||
YUPELRI net sales (Theravance Biopharma implied | 21,851 | 20,420 | ||||
(2) Amounts include share-based compensation expense as follows: | ||||||
Three Months Ended March 31, | ||||||
(In thousands) | 2026 | 2025 | ||||
Research and development | $ | 627 | $ | 1,070 | ||
Selling, general and administrative | 2,849 | 3,807 | ||||
Restructuring expenses | 1,028 | - | ||||
Total share-based compensation expense | $ | 4,504 | $ | 4,877 | ||
(3) Restructuring expenses were comprised of: | ||||||
Three Months Ended March 31, | ||||||
(In thousands) | 2026 | 2025 | ||||
Cash-related expenses | $ | 2,605 | $ | - | ||
Non-cash related expenses | 1,028 | - | ||||
Total restructuring expenses | $ | 3,633 | $ | - | ||
THERAVANCE BIOPHARMA, INC. | ||||||
Reconciliation of GAAP Net Loss to Non-GAAP Net Income (Loss) | ||||||
(In thousands) | ||||||
Three Months Ended March 31, | ||||||
2026 | 2025 | |||||
(Unaudited) | ||||||
GAAP net loss | $ | (4,933) | $ | (13,579) | ||
Adjustments: | ||||||
Share-based compensation expense | 4,504 | 4,877 | ||||
Non-cash interest expense | - | 643 | ||||
Income tax benefit | (1,537) | (559) | ||||
Restructuring expense (excl. share-based compensation) | 2,605 | - | ||||
Non-GAAP net income (loss) | $ | 639 | $ | (8,618) | ||
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SOURCE Theravance Biopharma, Inc.