Welcome to our dedicated page for Senti Biosciences news (Ticker: SNTI), a resource for investors and traders seeking the latest updates and insights on Senti Biosciences stock.
Senti Biosciences, Inc. (Nasdaq: SNTI) is a pioneering biotechnology company focused on developing next-generation cell and gene therapies. The company leverages its proprietary Gene Circuit platform to engineer adaptive therapies for treating complex diseases, with a strong focus on oncology. Senti Bio's core technology harnesses synthetic biology to create precision gene circuits that can enhance the efficacy and safety of cellular therapeutics.
Founded by a team of engineers, scientists, and entrepreneurs, Senti Biosciences has rapidly advanced its research and development through strategic partnerships and significant investments. The company's innovative approach utilizes allogeneic chimeric antigen receptor natural killer (CAR-NK) cells integrated with gene circuits to address challenging diseases. Senti Bio’s primary product candidates include SENTI-202 for hematologic malignancies like Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS), and SENTI-301A for the treatment of hepatocellular carcinoma (HCC).
- SENTI-202 employs Logic Gated CAR-NK cells designed to selectively target and eliminate cancer cells expressing CD33 and/or FLT3 antigens while sparing healthy bone marrow cells. The company received clearance from the U.S. FDA for its Investigational New Drug (IND) application and plans to initiate a Phase 1 clinical trial in 2024.
- SENTI-301A is designed for the treatment of HCC and is currently being developed in collaboration with Celest Therapeutics in China.
In addition to its primary pipeline, Senti Bio is actively exploring the potential of its Gene Circuit technology in other therapeutic areas and modalities, including partnerships with Spark Therapeutics and BlueRock Therapeutics. The company is committed to advancing its clinical programs and demonstrating the transformative potential of Gene Circuits in precision medicine.
Recent achievements include the establishment of a manufacturing partnership with GeneFab to support clinical-scale production and streamline operations to focus on key clinical programs. Senti Bio’s financial results reflect ongoing investments in research and development, with strategic efforts aimed at extending its cash runway and ensuring the successful advancement of its therapeutic candidates.
Senti Biosciences stays at the forefront of biotechnology innovation, dedicated to developing superior treatments for patients facing incurable diseases. Stay updated with Senti Bio’s latest developments and progress through their website and social media channels.
Senti Biosciences (Nasdaq: SNTI) has been awarded an $8 million grant by the California Institute for Regenerative Medicines (CIRM) for the clinical development of SENTI-202, a potential first-in-class Logic Gated CAR-NK cell therapy. This therapy targets relapsed/refractory hematologic malignancies, including acute myeloid leukemia (AML). The ongoing Phase 1 trial is enrolling adult patients in the US and Australia, evaluating two dosing levels. Initial efficacy data is expected by the end of 2024, with durability data following in 2025.
Senti Bio has dosed the first patient in the Phase 1 clinical trial of SENTI-202, a Logic Gated CAR-NK cell therapy for relapsed or refractory hematologic malignancies, including AML. The therapy targets CD33 and FLT3 expressing cells while sparing healthy bone marrow. Initial efficacy data is expected by 2024 end, with durability data in 2025. The trial is enrolling adult patients in the US and Australia, evaluating two dose levels. Senti Bio aims to redefine AML care with SENTI-202.
Senti Bio reported operational updates and financial results for the first quarter of 2024, highlighting the progress in their Phase 1 clinical trial of SENTI-202 for AML and SENTI-301A for HCC in collaboration with Celest. They also presented at ASGCT 2024 Annual Meeting on platform advancements. The company reported cash and cash equivalents of $23.7 million, with R&D expenses at $8.8 million and net loss of $12.1 million for the quarter. Senti Bio plans to participate in the BIO International Convention 2024 in San Diego, CA.
Senti Bio announced the publication of preclinical data on SENTI-202, a logic-gated CAR-NK cell therapy for AML, showing improved treatment outcomes and reduced toxicity. The data supports the upcoming Phase 1 clinical trial, with patient dosing expected in Q2 2024.
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