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ACELYRIN, INC. (Nasdaq: SLRN) is a Los Angeles area-based late-stage clinical biopharmaceutical company with additional operations in the San Francisco Bay area. The company is focused on providing patients with life-changing new treatment options by identifying, acquiring, and accelerating the development and commercialization of transformative medicines. ACELYRIN is at the forefront of innovative treatments in the field of immunology, with a strong pipeline of late-stage clinical programs designed to address significant unmet medical needs.
Core Business: ACELYRIN’s primary focus is on developing transformative therapies in the fields of immunology and inflammation. The company’s lead product candidates include izokibep and lonigutamab. Izokibep is a next-generation inhibitor of IL-17A with a robust potential for tissue penetration and extended half-life. It is being evaluated in multiple late-stage trials targeting moderate-to-severe hidradenitis suppurativa (HS), psoriatic arthritis (PsA), and uveitis. Lonigutamab is a subcutaneously delivered monoclonal antibody targeting the IGF-1 receptor, aimed at treating thyroid eye disease (TED).
Recent Achievements: In March 2024, ACELYRIN announced long-term data from a Phase 2b clinical trial of izokibep in hidradenitis suppurativa, demonstrating significant clinical improvements over time. Additionally, ACELYRIN disclosed positive results from its global Phase 2b/3 clinical trial of izokibep in psoriatic arthritis, which met the primary endpoint of ACR50 with high statistical significance. These results underscore izokibep’s potential as a differentiated treatment option for multiple immunologic conditions.
Current Projects: The company is currently advancing izokibep through Phase 3 trials for hidradenitis suppurativa and psoriatic arthritis. Long-term efficacy results from these trials continue to show promising improvements in quality of life for patients. ACELYRIN is also progressing through a Phase 1/2 trial of lonigutamab for thyroid eye disease, demonstrating rapid clinical benefits and a favorable safety profile.
Financial Condition: As of December 31, 2023, ACELYRIN reported cash, cash equivalents, and short-term marketable securities totaling $721.3 million, which is expected to fund operations into 2026. This financial stability allows ACELYRIN to continue advancing its clinical programs through key developmental milestones.
Partnerships and Collaborations: ACELYRIN leverages strategic collaborations with contract research organizations (CROs) and other vendors to conduct its clinical trials. Despite recent challenges with trial execution errors by its CRO, ACELYRIN remains committed to ensuring quality control and transparency in its clinical development processes.
For more information about ACELYRIN, visit us at www.acelyrin.com or follow us on LinkedIn and X.
ACELYRIN, INC. (Nasdaq: SLRN), a late-stage clinical biopharma company specializing in immunology, has announced its upcoming second quarter 2024 financial results and corporate update. The company will host a conference call on Tuesday, August 13, 2024, at 5:00 p.m. ET to discuss these matters. Investors and interested parties can access a live webcast of the conference call through the company's website under the Events & Presentations section. For those unable to attend the live event, a replay of the webcast will be available on ACELYRIN's website for 90 days following the call, providing ample opportunity for stakeholders to review the information presented.
ACELYRIN (Nasdaq: SLRN) has announced positive 16-week results from its global Phase 2b/3 trial of izokibep, a novel IL-17A inhibitor, in treating psoriatic arthritis (PsA).
The findings will be presented at the 2024 European Alliance of Associations for Rheumatology Congress in Vienna, Austria. The trial, which is double-blind, placebo-controlled, and multicenter, demonstrates the efficacy and safety of izokibep in patients with active PsA.
The presentation, titled 'Efficacy and Safety of Izokibep in Patients with Active Psoriatic Arthritis: Week 16 Results,' will be delivered by Dr. Philip Mease on June 15, 2024, at 9:30 am CEST.
ACELYRIN announced that positive proof-of-concept data from its Phase 1/2 trial of lonigutamab, a subcutaneous anti-IGF-1R antibody, will be presented at the Endocrine Society's Annual Meeting (ENDO 2024) in Boston. Lonigutamab is designed to treat thyroid eye disease (TED). The presentation, led by Dr. Shoaib Ugradar, will take place on June 3, 2024, from 2:00pm to 2:15pm ET. This announcement is significant as lonigutamab is the first subcutaneous treatment to show clinical responses in TED patients, utilizing the only FDA-approved mechanism for the disease.
ACELYRIN, INC. provided a business update, highlighting milestones such as completing enrollment in Phase 3 trials and reporting positive data for lonigutamab and izokibep. The company aims to accelerate the development of transformative medicines while maintaining financial stability. Changes in the leadership team were also announced.
ACELRYIN, INC. announced a leadership transition with Mina Kim appointed as the new CEO and board member, replacing founder Shao-Lee Lin, who stepped down. The company focuses on developing transformative medicines in immunology and has seen early positive data in clinical trials. Shep Mpofu becomes the Chief Medical Officer, Gil Labrucherie takes on the role of Chief Business Officer, in addition to being the CFO, and Sanam Pangali is named Chief Legal Officer and Head of People.
On May 13, 2024, ACELYRIN, INC. (SLRN) will host a conference call to discuss its first quarter 2024 financial results and corporate update. The company focuses on transformative medicines in immunology, with a live webcast and replay available on its website.
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