Welcome to our dedicated page for Silence Therapeutics Plc news (Ticker: SLN), a resource for investors and traders seeking the latest updates and insights on Silence Therapeutics Plc stock.
Silence Therapeutics plc (Nasdaq: SLN) generates a steady flow of news as a global clinical-stage biotechnology company developing siRNA (short interfering RNA) therapies. Its updates focus on the progress of programs built on its proprietary mRNAi GOLD™ platform, which is designed to create precision engineered siRNAs that target and silence disease-associated genes in the liver.
Investors following SLN news can expect detailed coverage of clinical trial milestones, particularly for divesiran, the company’s first-in-class siRNA candidate for polycythemia vera (PV). Recent announcements describe additional Phase 1 data presented at major hematology meetings, durable hematocrit control and reduced need for phlebotomies in PV patients, and the completion of enrollment in the global, randomized SANRECO Phase 2 study.
Silence also issues news on its broader pipeline and strategy, including updates on zerlasiran for cardiovascular disease, extra-hepatic siRNA targeting work, and its collaboration program SLN312 licensed to AstraZeneca. Financial result press releases provide context on research and development spending, cash and investment balances, and the company’s stated cash runway expectations, alongside commentary on operational priorities.
Corporate governance and leadership developments feature in SLN news as well, such as changes to the Board of Directors, executive transitions and outcomes of shareholder votes at the annual general meeting. Conference participation announcements highlight company presentations at healthcare and investor events, where management discusses the siRNA platform, clinical data and pipeline priorities.
By monitoring this news page, readers can review a chronological record of Silence Therapeutics’ clinical, financial and corporate disclosures related to SLN, with an emphasis on the evolution of its siRNA programs in cardiovascular disease, hematology and rare diseases.
Silence Therapeutics plc announced its acquisition of exclusive worldwide rights to two siRNA drug targets previously under collaboration with Mallinckrodt Pharmaceuticals. No upfront payment is required, but future success-based milestones and low royalties on net sales are expected. This strategic move aims to enhance Silence's portfolio in complement-mediated diseases, showcasing confidence in the mRNAi GOLD™ platform. The ongoing collaboration with Mallinckrodt since July 2019 will retain rights to the SLN501 program. Silence continues to focus on developing treatments for significant unmet medical needs in cardiovascular and hematological areas.
Silence Therapeutics plc (Nasdaq: SLN) reports its financial results for Q4 and full year 2022, highlighting a net loss of £40.5 million, up from £39.4 million in 2021. Revenue increased to £17.5 million from £12.4 million, attributed to advancing collaborations. R&D expenses rose to £35.6 million, reflecting enhanced clinical studies. Notably, the company is progressing with its clinical pipeline, including the SLN360 program for cardiovascular diseases and SLN124 for hematological conditions, with topline data expected in Q4 2023. As of December 31, 2022, liquidity stood at £71.1 million, sufficient to fund operations into Q1 2024.
Silence Therapeutics plc (NASDAQ: SLN) will announce its fourth quarter and full year financial results for the period ending December 31, 2022, on March 15, 2023. The company specializes in developing precision medicines via its proprietary mRNAi GOLD™ platform, leveraging RNA interference technology to target specific genes related to diseases. A conference call is scheduled for 8:00 a.m. EDT / 12:00 p.m. GMT on the same day to discuss the results and provide a business update. The call will be accessible via webcast on the company's website.
The report titled "Polycythemia Vera Market Insights, Epidemiology, and Market Forecast -2032" offers a comprehensive analysis of the Polycythemia Vera market. In 2022, the U.S. Polycythemia Vera market size was approximately USD 1,500 million and is projected to grow through 2032. The report highlights that PharmaEssentia's Besremi is the only first-line therapy approved, while Incyte's Jakafi is the sole second-line treatment. Additionally, competition may arise from Protagonist Therapeutics' Rusfertide and Imago Biosciences' Bomedemstat, expected to launch in late 2024 and 2026 respectively. The report also discusses emerging therapies with potential market impact, including Silence Therapeutics' SLN124.
The Global Small Interfering RNA (SiRNA) Market is projected to reach $964.17 Million by 2030, with a CAGR of 8.6% from 2023 to 2030. Key insights show that liposome-based systemic therapy represents 52.01% of the market share. The cancer segment leads therapeutics with a 38.14% share, while research institutions account for 43.07% of applications. North America dominated the market in 2022 due to robust R&D activities. Significant partnerships, such as Silence Therapeutics with Hansoh Pharmaceutical, are accelerating market growth in the APAC region. The report emphasizes a focus on RNA functions and its therapeutic potential for various genetic disorders.
Silence Therapeutics plc, trading on Nasdaq under the symbol SLN, will have its President and CEO, Craig Tooman, present at the virtual SVB Securities Global Biopharma Conference on February 15 at 3:00 p.m. ET. The presentation will be accessible via the Investors section of the company’s website. Silence is focused on innovating precision medicines through RNA interference technology, targeting diseases with significant unmet needs. Key product candidates include SLN360 for cardiovascular risk and SLN124 for hematological diseases, complemented by collaborations with notable partners like AstraZeneca.
Silence Therapeutics plc, trading under Nasdaq: SLN, has appointed J.P. Gabriel as Chief Technical Operations Officer following the retirement of Jørgen Wittendorff. Gabriel brings over 25 years of experience in supply chain and manufacturing, crucial for advancing the company's clinical pipeline. Silence focuses on RNA interference technology to target genetic diseases and has product candidates like SLN360 and SLN124. The company also collaborates with AstraZeneca and other firms to enhance its research initiatives.
Silence Therapeutics plc (NASDAQ: SLN) presented key updates on its SLN360 and SLN124 programs at the 41st Annual J.P. Morgan Healthcare Conference. The SLN360 phase 2 study for high-risk atherosclerotic cardiovascular disease has begun dosing, with enrollment completion expected by Q4 2023. Preliminary data from the phase 1 study indicate significant reductions in lipoprotein(a) levels. Additionally, the SLN124 phase 1/2 study for polycythemia vera is now enrolling participants, with data from thalassemia patients expected in Q4 2023. Silence anticipates a pivotal year ahead.
Silence Therapeutics, trading under the ticker SLN, will be presenting at the 41st Annual J.P. Morgan Healthcare Conference on January 12 at 9:45 a.m. PT. The presentation by Craig Tooman, CEO, highlights the company's commitment to innovative biotechnology solutions aimed at silencing diseases through RNA interference. A live webcast will be available on the Silence Therapeutics website, with an archived replay to follow after the event.
Silence is focusing on RNAi-based medicines and has ongoing collaborations with leading pharmaceutical companies.
Silence Therapeutics plc (Nasdaq: SLN) reported its Q3 2022 financial results, showcasing a net loss of £7.1 million, an improvement from £9.9 million in Q3 2021. Revenue rose to £3.4 million, driven by collaboration agreements. Key milestones include anticipated phase 2 studies for SLN360 and SLN124, with SLN124 receiving FDA Fast Track Designation. The company's cash position stood at £90.0 million following a successful offering raising $56.5 million in August. This reinforces the company’s commitment to advancing its innovative pipeline.
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