Welcome to our dedicated page for Silence Therapeutics Plc news (Ticker: SLN), a resource for investors and traders seeking the latest updates and insights on Silence Therapeutics Plc stock.
Silence Therapeutics plc (Nasdaq: SLN) generates a steady flow of news as a global clinical-stage biotechnology company developing siRNA (short interfering RNA) therapies. Its updates focus on the progress of programs built on its proprietary mRNAi GOLD™ platform, which is designed to create precision engineered siRNAs that target and silence disease-associated genes in the liver.
Investors following SLN news can expect detailed coverage of clinical trial milestones, particularly for divesiran, the company’s first-in-class siRNA candidate for polycythemia vera (PV). Recent announcements describe additional Phase 1 data presented at major hematology meetings, durable hematocrit control and reduced need for phlebotomies in PV patients, and the completion of enrollment in the global, randomized SANRECO Phase 2 study.
Silence also issues news on its broader pipeline and strategy, including updates on zerlasiran for cardiovascular disease, extra-hepatic siRNA targeting work, and its collaboration program SLN312 licensed to AstraZeneca. Financial result press releases provide context on research and development spending, cash and investment balances, and the company’s stated cash runway expectations, alongside commentary on operational priorities.
Corporate governance and leadership developments feature in SLN news as well, such as changes to the Board of Directors, executive transitions and outcomes of shareholder votes at the annual general meeting. Conference participation announcements highlight company presentations at healthcare and investor events, where management discusses the siRNA platform, clinical data and pipeline priorities.
By monitoring this news page, readers can review a chronological record of Silence Therapeutics’ clinical, financial and corporate disclosures related to SLN, with an emphasis on the evolution of its siRNA programs in cardiovascular disease, hematology and rare diseases.
Silence Therapeutics (SLN) reported its full year 2024 financial results, ending with $147.3 million in cash and investments. The company's collaboration revenue increased to $43.1 million from $30.9 million in 2023, while net loss improved to $45.3 million ($0.33 per share) from $54.2 million in 2023.
Key developments include: positive regulatory feedback for zerlasiran's Phase 3 study design, though initiation depends on securing a partnership; anticipated full enrollment in divesiran's SANRECO Phase 2 study for PV by end of 2025; and planned Phase 1 studies for SLN548 in H2 2025. R&D expenses increased to $67.9 million from $56.9 million, while G&A expenses slightly rose to $26.9 million.
The company has extended its cash guidance into 2027, focusing on rare condition treatments where they can deliver first-in-class and/or best-in-class siRNAs.
Silence Therapeutics (Nasdaq: SLN), a global clinical-stage company focused on developing siRNA therapies, has scheduled its fourth quarter and full year 2024 financial results release for February 27, 2025. The company will host a conference call and webcast at 8:00 a.m. ET / 1:00 p.m. GMT on the same day, where management will discuss financial results and provide a business update. The webcast will be accessible through the Investors section of Silence's website and will remain archived for future reference.
Silence Therapeutics presented additional Phase 1 results for divesiran in polycythemia vera (PV) patients at the ASH Annual Meeting. The SANRECO study data showed substantial reduction in phlebotomy frequency and lower hematocrit levels in 19 PV patients. Following treatment, only five phlebotomies were required during the 18-week treatment period, compared to 79 phlebotomies before enrollment.
The company also announced dosing of the first subject in the Phase 2 portion of the SANRECO study. Divesiran demonstrated sustained hematocrit reduction, favorable effects on iron metabolism, and consistent target engagement through increased hepcidin levels. The treatment has been well-tolerated with no dose-limiting toxicities.
Silence Therapeutics (Nasdaq: SLN), a global clinical stage biotechnology company focused on developing precision engineered medicines for disease treatment, has announced its participation in the Piper Sandler 36th Annual Healthcare Conference. The company will engage in a fireside chat on Wednesday, December 4th at 10:00 a.m. ET. Interested parties can access the live webcast through the Investors section of Silence's website, with an archived replay available after the conference.
Silence Therapeutics (SLN) presented end-of-treatment data from its Phase 2 ALPACAR-360 study of zerlasiran, showing significant results in treating high lipoprotein(a) levels in ASCVD patients. The study demonstrated >80% mean time-averaged placebo-adjusted Lp(a) reductions over 36 weeks, with maximum reductions exceeding 90%. The treatment, administered at various doses and intervals, showed persistent effects up to 60 weeks after initial dosing with no safety concerns. The data was presented at the AHA Scientific Sessions 2024 and published in JAMA, marking the first study to report time-averaged Lp(a) analyses.
Silence Therapeutics (SLN) reported its Q3 2024 financial results with cash position of £129.0 million ($172.7 million) as of September 30, 2024. The company's collaboration revenue decreased to £1.1 million in Q3 2024 from £2.7 million in Q3 2023. R&D expenses increased to £15.3 million from £8.9 million year-over-year, while G&A expenses rose to £5.6 million from £5.0 million. Net loss widened to £27.0 million from £8.2 million in Q3 2023.
The company will present results from the ALPACAR-360 Phase 2 study of zerlasiran at AHA and Phase 1 results of divesiran at ASH in December 2024. Starting January 2025, SLN will be classified as a 'large accelerated filer' by SEC.
Silence Therapeutics (Nasdaq: SLN), a global clinical stage biotechnology company focused on developing precision engineered medicines that silence diseases, has announced its participation in an upcoming fireside chat at the Jefferies London Healthcare Conference. The event is scheduled for Wednesday, November 20th at 2:00 p.m. GMT.
Interested parties can access the live webcast through the Investors section of Silence's website, with an archived replay available after the conference.
Silence Therapeutics, a biotechnology company focused on silencing diseases through precision engineered medicines, has announced its participation in four upcoming investor conferences in September 2024. The company will present overviews at the:
1. Morgan Stanley Global Healthcare Conference on September 5 at 5:35pm ET
2. HC Wainwright Global Investment Conference on September 10 at 11:30am ET
3. Cantor Global Healthcare Conference on September 17 at 10:20am ET
4. Chardan Genetic Medicines Conference on September 30 at 9:00am ET
Live audio webcasts of all presentations will be available on Silence Therapeutics' website, with replays accessible within 48 hours after each event.
Silence Therapeutics (Nasdaq: SLN) reported its Q2 2024 financial results and business highlights. Key points include:
- Positive clinical results for zerlasiran in cardiovascular disease and divesiran in hematological diseases
- $120 million equity raise and collaboration milestones strengthening financial position
- Cash position of £149.6 million ($189.2 million) as of June 30, 2024
- Collaboration revenue of £12.9 million for H1 2024
- Net loss of £17.4 million for H1 2024
The company is advancing its siRNA technology and evaluating partnering opportunities for its mRNAi GOLD™ platform and zerlasiran program.
Silence Therapeutics announced positive results from its Phase 1 SANRECO study of divesiran (SLN124) in polycythemia vera (PV) patients.
The 34-week study evaluated divesiran in 24 patients, with doses administered subcutaneously every 6 weeks for four doses, followed by a 16-week follow-up.
All 8 well-controlled patients (HCT ≤ 45%) required no phlebotomies, while only 2 out of 8 patients with HCT > 45% required one phlebotomy.
Divesiran was well tolerated with no major safety issues. The treatment showed sustained reductions in hematocrit and positive effects on iron metabolism and hepcidin levels.
The company plans to advance divesiran to Phase 2 by the end of the year.
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