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RELIEF THERAPEUTICS Holding SA, traded as RLFTF, is a biopharmaceutical company dedicated to providing innovative treatment options for select specialty, unmet, and rare diseases. The company focuses on advancing treatment paradigms and delivering improvements in efficacy, safety, and convenience to benefit patients. Relief Therapeutics offers a diversified portfolio of marketed products, proprietary platform technologies, and a targeted clinical development pipeline. With a mission to provide therapeutic relief to those suffering from rare diseases, Relief Therapeutics is led by an experienced team of industry leaders. Headquartered in Geneva, the company is listed on the SIX Swiss Exchange and quoted on the OTCQB.
Relief Therapeutics will issue 1 billion new shares from its authorized capital around July 27, 2021, as part of a strategic transformation into a diversified commercial-stage pharmaceutical company. Approximately 140 million shares will be used for the acquisition of AdVita, and about 206.8 million shares for APR. The remaining shares are reserved for future financing and corporate purposes. The acquisitions bolster Relief's pipeline, particularly its lead candidate, RLF-100, targeting respiratory deficiency due to COVID-19.
Relief Therapeutics reported a significant finding from its partner, NRx Pharmaceuticals, indicating that aviptadil effectively prevents cytokine surges in critically ill COVID-19 patients. This data, derived from a U.S. Phase 2b/3 trial, has been submitted to the U.S. FDA as a supplement for Emergency Use Authorization. NRx is also addressing FDA requests for additional data on this application. Relief is focused on clinical-stage programs, with aviptadil as a lead candidate in late-stage testing against COVID-19 respiratory failure, while also expanding its pipeline through collaborations and acquisitions.
Relief Therapeutics is collaborating with NRx Pharmaceuticals and Quantum Leap Healthcare Collaborative to treat COVID-19 patients using inhaled aviptadil in the I-SPY COVID Trial. This phase 2 trial targets those severely affected by the virus. Relief's lead candidate, RLF-100 (aviptadil), is undergoing late-stage testing for respiratory issues due to COVID-19. Recently, Relief also partnered with Acer Therapeutics to develop ACER-001, aimed at treating Urea Cycle Disorders. Relief is traded on the SIX Swiss Exchange under RLF and OTCQB as RLFTF.
NRx Pharmaceuticals (Nasdaq: NRXP) announced the initiation of clinical training for ICU physicians in Georgia on using intravenous ZYESAMI™ (Aviptadil-acetate) for emergency COVID-19 treatment. Additionally, the ongoing phase 2/3 trial for inhaled ZYESAMI™ will be extended to Georgia and potentially neighboring countries. Clinical drug supplies are expected to ship within two weeks. The partnership is partially funded through Relief Therapeutics. ZYESAMI™ aims to address COVID-19-related respiratory failure by targeting cellular mechanisms affected by the virus.
Relief Therapeutics announced the acquisition of APR Applied Pharma Research for CHF 21.5 million in cash and CHF 45 million in shares, with contingent payments based on milestones. This acquisition aims to diversify Relief's pipeline with commercial and clinical-stage products, enhancing its infrastructure for future launches. Relief gains access to APR's R&D expertise, which includes the marketed product Golike for PKU and the promising APR-TD011 for epidermolysis bullosa. The deal is viewed as a significant step in Relief's transformation into a robust commercial-stage biopharmaceutical firm.
Relief Therapeutics Holding AG held its Annual General Meeting (AGM) on June 20, 2021, where all agenda items were approved by over 90% of represented votes. The meeting, conducted virtually due to COVID-19, saw participation equivalent to 41.54% of total outstanding shares. Key outcomes include the approval of the 2020 financial statements, a CHF 20,009,867 loss carryforward, and increases in authorized and conditional share capital. New board members Dr. Patrice Jean and Paolo Galfetti were elected to aid in the company’s growth strategy, focusing on the development of RLF-100 and other business opportunities.
Relief Therapeutics Holding AG (OTCQB: RLFTF) reported on June 16, 2021, that its collaboration partner, NRx Pharmaceuticals, announced results from the U.S. Expanded Access Protocol (EAP) for the drug RLF-100 (aviptadil). The EAP involved 240 ICU patients with critical COVID-19 respiratory failure. NRx intends to submit these findings as "real world" evidence to the FDA, supporting earlier clinical trial results. Relief focuses on clinical-stage programs, with RLF-100 in late-stage development for COVID-19 and a collaboration for the treatment of Urea Cycle Disorders.
Relief Therapeutics Holding AG (OTCQB: RLFTF) has announced that NRx Pharmaceuticals submitted an application to the FDA for Emergency Use Authorization (EUA) for its drug aviptadil to treat critical COVID-19 patients with respiratory failure. The EUA submission is based on a successful phase 2b/3 clinical trial in the U.S. Relief anticipates the decision from the FDA and is optimistic about the drug's potential to provide effective treatment options. The company also acknowledges NRx's recent Nasdaq listing and aims to advance aviptadil's development in Europe.
NRx Pharmaceuticals (Nasdaq: NRXP) has applied for Emergency Use Authorization (EUA) from the FDA for its drug, ZYESAMI™ (Aviptadil-acetate), aimed at treating critically ill COVID-19 patients with respiratory failure.
The study revealed a significant improvement in patient survival and reduced hospital stays compared to a placebo. Enrolled were 196 participants, and the findings support ZYESAMI™ as the first medication showing effectiveness for patients in advanced stages of COVID-19. The clinical trial had positive implications for patient recovery despite prior treatments.
Relief Therapeutics has appointed Dr. Taneli Jouhikainen as its new Chief Operating Officer, effective June 1, 2021. This newly created role aims to support the company’s transition from a clinical-stage entity to a diversified product-driven firm. Dr. Jouhikainen brings over 25 years of life sciences experience, having held significant positions in various biopharmaceutical companies. His responsibilities include overseeing product development and integration of new activities to bolster Relief’s growth strategy.