Cornerstone Pharmaceuticals to Present Pancreatic Cancer, Clear Cell Sarcoma and Biliary Tract Cancer Research Featuring CPI-613® (Devimistat) at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting

Rhea-AI Summary

Cranbury, NJ, June 1, 2022 - Cornerstone Pharmaceuticals, formerly Rafael Pharmaceuticals, announced three abstracts will be presented at the ASCO Annual Meeting from June 3-7, 2022, in Chicago. These abstracts focus on CPI-613® (devimistat) in treating rare cancers, specifically clear cell sarcoma and biliary tract cancer, with special emphasis on pancreatic cancer. Key presentations will be made by notable researchers, discussing promising trial results. The company aims to advance treatment options for patients suffering from rare cancers.

Cranbury, NJ, June 01, 2022 (GLOBE NEWSWIRE) -- Cornerstone Pharmaceuticals, Inc. (“Cornerstone” or the “Company”), a company focused on rare cancer therapeutics and formerly known as Rafael Pharmaceuticals, today announced that the Company and its partners will present three abstracts at the American Society of Clinical Oncology (ASCO) Annual Meeting taking place June 3 – June 7, 2022 in Chicago.

The three abstracts from Cornerstone’s partners and principal investigators, Mark Agulnik, Vaibhav Sahai and Philip Philip, highlight its ongoing trials studying CPI-613^® (devimistat) in clear cell sarcoma and biliary tract cancer, with a special discussion on pancreatic cancer.

“We are incredibly proud to have promising research findings to share in the three rare cancer areas that we’re focused on at ASCO’s Annual Meeting,” said Sanjeev Luther, President and CEO of Cornerstone Pharmaceuticals. “Our research provides hope for the future as we continue to put patients with rare cancer diagnoses at the forefront and move the needle towards progress for potentially life-saving therapy.”

Poster Session Details:
Title: Phase 1b results of a multicenter, randomized phase 1b/2 study of gemcitabine and cisplatin +/- CPI-613 as first-line therapy for patients with advanced biliary tract cancer (BilT-04)
Presenter: Vaibhav Sahai, MBBS, MS, Associate Professor, University of Michigan Health
Date: Saturday, June 4, 2022
Time: 8:00 a.m. CDT
Location: Hall A | In-Person & On Demand

Poster Presentation and Poster Discussion Session Details:
Session: Gastrointestinal Cancer—Gastroesophageal, Pancreatic, and Hepatobiliary
Title: Phase 3, multicenter, randomized study of CPI-613 with modified FOLFIRINOX (mFFX) versus FOLFIRINOX (FFX) as first-line therapy for patients with metastatic adenocarcinoma of the pancreas (AVENGER500)
Presenter: Philip Philip, M.D., PhD, FRCP, Professor, GI & Neuroendocrine Oncology, Henry Ford Cancer Institute, Wayne State University School of Medicine
Date: Saturday, June 4, 2022
Time: Poster Presentation – 8 a.m. CDT, Poster Discussion Session – 1:15 p.m. CDT
Location: Poster Presentation – Hall A, Poster Discussion Session – McCormick Place: Hall D2 | In-Person & Live Stream

Poster Session Details:
Title: Phase 1/2 study of devimistat in combination with hydroxychloroquine (HCQ) in patients with relapsed or refractory (R/R) clear cell sarcoma (CCS)
Presenter: Mark Agulnik, M.D., City of Hope's section chief of sarcoma medical oncology
Date: Sunday, June 5, 2022
Time: 8:00 a.m. CDT
Location: Hall A | In-Person & On Demand

“As biliary tract cancer cases continue to rise globally, I am pleased to partner with Cornerstone Pharmaceuticals and study the use of devimistat as a potential therapy option for the disease,” said Dr. Sahai. “I look forward to discussing my findings at ASCO with fellow industry professionals as we envision a future that could offer relief to patients who suffer from this aggressive cancer.”  

“It’s an honor to discuss our research in pancreatic cancer with some of the brightest minds in clinical oncology at ASCO,” said Dr. Philip. “Although pancreatic cancer remains a challenge for both patients and clinicians, devimistat’s promise as a potential treatment option gives us great hope for the future of care.”

“Currently, patients who live with relapsed or refractory clear cell sarcoma (CCS) have limited treatment options,” said Dr. Agulnik. “In partnership with Cornerstone Pharmaceuticals, I am energized by the opportunity to share my research at ASCO on the promising Phase I and Phase II data using devimistat.”

About Cornerstone Pharmaceuticals, Inc.
Cornerstone Pharmaceuticals (“Cornerstone”) is committed to the development of therapies for rare cancers that have few to no treatment options available. Cornerstone’s lead compound, CPI-613® (devimistat), is designed to target the mitochondria of cancer cells in order to disrupt their energy production, cutting off the fuel for disease growth. Devimistat is undergoing multiple clinical trials and has been granted orphan drug designation by the U.S. Food and Drug Administration (FDA) for the following indications: Burkitt’s lymphoma, biliary tract cancer, soft tissue sarcoma, myelodysplastic syndrome (MDS) and peripheral T-cell lymphoma. In addition, the European Medicines Agency (EMA) has granted orphan drug designation to devimistat for Burkitt’s lymphoma.

With science stemming from the world’s most renowned institutions and compassion that runs deep, Cornerstone strives to improve the lives of people with rare cancers, inaugurating a new era of hope. For more information, please visit www.cornerstonepharma.com.

Safe Harbor Statement
This press release contains forward-looking statements. These statements relate to future events or the company’s future financial performance. In some cases, you can identify forward-looking statements by terminology such as "may", "will", "should", "expect", "plan", "anticipate", "believe", "estimate", "predict", "potential" or "continue", the negative of such terms, or other comparable terminology. These statements are only predictions. Actual events or results may differ materially from those in the forward-looking statements as a result of various important factors. Although we believe that the expectations reflected in the forward-looking statements are reasonable, such statements should not be regarded as a representation by the company, or any other person, that such forward-looking statements will be achieved. The business and operations of the company are subject to substantial risks which increase the uncertainty inherent in forward-looking statements. We undertake no duty to update any of the forward-looking statements, whether as a result of new information, future events or otherwise. In light of the foregoing, readers are cautioned not to place undue reliance on such forward-looking statements.

FAQ

What is the significance of Cornerstone Pharmaceuticals' presentation at ASCO 2022?

Cornerstone Pharmaceuticals is presenting three abstracts at ASCO 2022, showcasing research on CPI-613® (devimistat) for rare cancers, which could impact treatment protocols.

When and where will Cornerstone Pharmaceuticals present their findings?

Cornerstone Pharmaceuticals will present their findings at the ASCO Annual Meeting in Chicago from June 3-7, 2022.

What types of cancer are being studied with devimistat?

The studies focus on clear cell sarcoma and biliary tract cancer, with additional discussions on pancreatic cancer.

Who are the key presenters at Cornerstone Pharmaceuticals' ASCO session?

Notable presenters include Mark Agulnik, Vaibhav Sahai, and Philip Philip, who will discuss various studies involving CPI-613®.

What is CPI-613® and its importance in cancer treatment?

CPI-613® (devimistat) is designed to target cancer cell mitochondria, disrupting energy production and offering potentially life-saving therapy for rare cancers.