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Rapt Therapeutics, Inc. - RAPT STOCK NEWS

Welcome to our dedicated page for Rapt Therapeutics news (Ticker: RAPT), a resource for investors and traders seeking the latest updates and insights on Rapt Therapeutics stock.

Company Overview

RAPT Therapeutics, Inc. is a clinical-stage immunology-based biopharmaceutical company focused on the discovery, development, and commercialization of oral small molecule therapies. Leveraging its proprietary discovery and development engine, the company is addressing significant unmet needs in both oncology and inflammatory diseases with a focus on modulating key immune drivers.

Core Business and Clinical Strategy

The company operates at the intersection of immunology and precision medicine, and is dedicated to the development of highly selective small molecules. Its innovative approach is centered on targeting the C-C motif chemokine receptor 4 (CCR4), a pivotal immune pathway implicated in the regulation of immune cell migration. By impeding the movement of regulatory T cells and type 2 T helper cells, RAPT aims to normalize immune responses in both cancer and inflammatory contexts.

Pipeline and Drug Candidates

RAPT Therapeutics has advanced multiple drug candidates through its development pipeline. Key assets include:

  • Tivumecirnon (FLX475): Designed to block the migration of regulatory T cells into tumors, potentially enhancing anti-tumor immune responses.
  • Zelnecirnon (RPT193): Engineered to inhibit the migration of specific T cell subsets into inflamed tissues, targeting inflammatory diseases.
  • RPT904: A clinical-stage anti-immunoglobulin E (IgE) antibody developed under a global licensing arrangement to address allergic disorders such as food allergy and chronic spontaneous urticaria.

Each candidate is a testament to the company’s commitment to precision pharmacology and medicinal chemistry, aiming to provide tailored therapeutic solutions while maintaining a robust platform for early-stage target discovery.

Research, Development, and Clinical Insights

Utilizing deep expertise in immunology, RAPT integrates rigorous scientific evaluation with methodical clinical development. Its research programs are designed to modulate immune responses by directly targeting critical pathways, and the company has steadily progressed in a highly competitive landscape. The strategic clinical trials encompass both monotherapy and combination approaches, allowing the company to assess therapeutic synergies and optimize clinical outcomes.

Competitive Positioning and Intellectual Rigor

Within the biopharmaceutical arena, RAPT stands apart by focusing on the modulation of immune cell migration. This strategy is particularly significant given the limitations of existing therapies in oncology and inflammatory conditions. The company’s methodical approach, which combines a proprietary discovery engine with precise clinical execution, establishes it as an informed participant in the competitive biotech sector. Its strategic partnerships and licensing deals further reinforce its commitment to diversifying and strengthening its therapeutic portfolio.

Business Model and Market Impact

The business model is built on robust R&D investment, strategic collaborations, and a well-structured pipeline aimed at delivering high specificity treatments. Investors can note the company’s methodical transition from early clinical trials to confirmation of pharmacodynamic effects, which supports its long-term mission to address critical immune-mediated conditions. RAPT Therapeutics represents a specialized venture into areas where there is a significant unmet need, thereby setting the stage for potential market differentiation through scientifically driven innovation.

Summary

RAPT Therapeutics is not just advancing a series of drug candidates; it is pioneering a targeted approach in the realm of immunology. Its clear focus on modulating specific immune mechanisms and its strategic clinical development make the company a subject of continued interest in the biopharmaceutical investment landscape. Through precise, selective targeting and rigorous clinical evaluation, RAPT demonstrates deep domain expertise and a commitment to addressing complex medical challenges.

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RAPT Therapeutics, Inc. announces positive safety and efficacy data from Phase 2 trial of tivumecirnon in combination with pembrolizumab for advanced head and neck squamous cell carcinoma. The study showed a confirmed objective response rate of 15.6% in all patients, 17.4% in PD-L1+ patients, and 22.2% in HPV+ patients, with a median duration of treatment in responders of 19.6 months. The combination treatment was well-tolerated with no increased toxicity observed, demonstrating promise in various oncology indications.
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RAPT Therapeutics Inc. reports financial results for Q4 and year ended December 31, 2023, with a net loss of $30.9 million in Q4 and $116.8 million for the year. The company maintains a solid cash position of $158.9 million. RAPT is focused on lifting the clinical hold on Phase 2 trials of zelnecirnon in atopic dermatitis and asthma while continuing the Phase 2 study of tivumecirnon in cancer.
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RAPT Therapeutics, Inc. announces the acceptance of three late-breaking abstracts for poster presentation, including phase 2 clinical data for tivumecirnon in head and neck squamous cell carcinoma at the AACR Annual Meeting in April 2024.
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RAPT Therapeutics, Inc. announces FDA clinical hold on Phase 2b trial of zelnecirnon for atopic dermatitis due to serious adverse event of liver failure. Dosing halted in both atopic dermatitis and asthma trials. Investigation ongoing. No liver toxicity in other trial participants. Webcast conference call scheduled for more information.
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RAPT Therapeutics, Inc. appoints Nipun Davar, Ph.D., as Senior Vice President of Technical Operations. Nipun brings over 27 years of biopharmaceutical experience and will aid in advancing zelnecirnon and tivumecirnon in late-stage clinical trials for inflammatory diseases and oncology.
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RAPT Therapeutics, Inc. (RAPT), a clinical-stage biotech company, will have its CEO participate in a fireside chat at the Guggenheim Healthcare Talks 6th Annual Biotechnology Conference on February 7, 2024. The discussion will be available via live webcast on the company's website.
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RAPT Therapeutics, Inc. (Nasdaq: RAPT) to present company overview at 42nd Annual J.P. Morgan Healthcare Conference
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RAPT Therapeutics, a clinical-stage, immunology-based biopharmaceutical company (Nasdaq: RAPT), announced the publication of Phase 1a/1b clinical trial results of zelnecirnon in Allergy. The findings demonstrated positive clinical and molecular effects in patients with moderate-to-severe atopic dermatitis, with significant improvements in key efficacy measures.
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RAPT Therapeutics, Inc. (Nasdaq: RAPT) maintains a strong cash position of $184.8 million. The company reported a net loss of $31.4 million for the third quarter of 2023, with research and development expenses increasing due to higher development costs related to zelnecirnon and early-stage programs. General and administrative expenses also saw an increase, with a cash balance expected to support operations through mid-2025.
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RAPT Therapeutics announces positive safety and efficacy data from its Phase 2 trial of FLX475 in patients with advanced non-small cell lung cancer (NSCLC). The combination of FLX475 and pembrolizumab showed a confirmed objective response rate (ORR) of 40% in PD-L1 positive patients and a median progression-free survival (PFS) of 6.3 months. The ORR for the combination in PD-L1 low and high subsets were 38% and 50% respectively. The data were presented at the Society for Immunotherapy of Cancer (SITC) 38th Annual Meeting.
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FAQ

What is the current stock price of Rapt Therapeutics (RAPT)?

The current stock price of Rapt Therapeutics (RAPT) is $1.06 as of April 4, 2025.

What is the market cap of Rapt Therapeutics (RAPT)?

The market cap of Rapt Therapeutics (RAPT) is approximately 144.5M.

What is the primary focus of RAPT Therapeutics, Inc.?

RAPT Therapeutics primarily focuses on discovering, developing, and commercializing oral small molecule therapies to address unmet needs in oncology and inflammatory diseases.

How does RAPT Therapeutics generate its drug candidates?

The company utilizes a proprietary discovery and development engine to create highly selective small molecules that modulate key immune drivers, particularly targeting the CCR4 pathway.

Which therapeutic areas does RAPT address?

RAPT addresses critical challenges in oncology by inhibiting tumor immune suppression, and in inflammatory diseases by modulating immune cell migration into inflamed tissues.

What distinguishes RAPT’s approach to drug development?

RAPT’s approach is distinguished by its focus on precision immunology, selective targeting of immune pathways, and a strategy that integrates both monotherapy and combination therapy clinical trials.

Can you explain the significance of the CCR4 target in their pipeline?

CCR4 plays a key role in regulating immune cell migration. By targeting this receptor, RAPT aims to prevent the infiltration of cells that suppress immune responses in cancer or exacerbate inflammation in chronic diseases.

What are some of the key drug candidates in RAPT's pipeline?

Key drug candidates include tivumecirnon (FLX475) for oncology, zelnecirnon (RPT193) for inflammatory conditions, and RPT904 which is aimed at allergic conditions such as food allergy and chronic spontaneous urticaria.

How does RAPT Therapeutics position itself within the competitive biopharmaceutical landscape?

RAPT is positioned as a specialized enterprise that applies targeted immunotherapy approaches. Its proprietary platform and strategic clinical development efforts underpin its competitive differentiation in areas of high unmet need.

What type of clinical trials does the company undertake?

The company conducts a range of clinical trials, including Phase 1/2 studies that integrate both monotherapy and combination regimens, aimed at evaluating safety, pharmacodynamics, and efficacy across various cancer and inflammatory disease indications.
Rapt Therapeutics, Inc.

Nasdaq:RAPT

RAPT Rankings

RAPT Stock Data

144.55M
99.83M
0.49%
96.43%
1.99%
Biotechnology
Pharmaceutical Preparations
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United States
SOUTH SAN FRANCISCO