ProQR Appoints John Maraganore, PhD, as Strategic Advisor to the Supervisory Board

Rhea-AI Summary

ProQR Therapeutics N.V. (Nasdaq: PRQR) announced the appointment of Dr. John Maraganore as a strategic advisor to its Supervisory Board. Maraganore, a biopharma leader and founding CEO of Alnylam Pharmaceuticals, will aid in defining ProQR's future direction as the company analyzes data from its Illuminate trial of sepofarsen. Despite recent setbacks, Maraganore highlighted ProQR's solid fundamentals, including deep RNA expertise and a strong cash position. This partnership is expected to bring valuable insights to advance ProQR's RNA therapies for genetic eye diseases.

Positive

• Appointment of Dr. John Maraganore as a strategic advisor brings extensive biopharma experience.
• Maraganore's involvement may enhance strategic direction and operational insights.
• ProQR has a strong cash position to support its RNA therapy pipeline.

Negative

• Company has experienced a recent setback, which raises concerns about current projects.

LEIDEN, Netherlands & CAMBRIDGE, Mass., March 07, 2022 (GLOBE NEWSWIRE) -- ProQR Therapeutics N.V. (Nasdaq: PRQR) (the “Company”), a company dedicated to changing lives through the creation of transformative RNA therapies for genetic eye diseases, today announced that John Maraganore, PhD, biopharma industry leader and the former founding CEO of Alnylam Pharmaceuticals, has joined ProQR as a strategic advisor. 

“It is a great honor to have John engaged with ProQR as a strategic advisor to the Supervisory Board to support us in defining the next steps for the Company, while we continue to analyze data from the Illuminate trial of sepofarsen and identify next steps for the program, if any,” said Daniel A. de Boer, Founder and CEO of ProQR. “As the founding CEO of Alnylam, he built and led one of the most successful biopharma companies, while pioneering RNA oligonucleotides as an important class of medicines that transformed the field and now help patients every day. He has been a mentor, friend, and supporter of ProQR from its earliest days and his perspective and experience will be extremely valuable as we evaluate the strategic direction of our pipeline of RNA therapies for genetic eye diseases and our proprietary RNA-editing platform technology.”

“I first met Daniel more than a decade ago through Henri Termeer and was always impressed with the Company’s RNA science and its focus on patients,” said Dr. Maraganore. “Although the Company has experienced a recent setback, I see its fundamentals as solid – ProQR has deep RNA expertise, a pipeline beyond sepofarsen, an exciting RNA-editing platform, and a strong cash position to fund its strategy. I look forward to working with the Supervisory Board and team to create value for all stakeholders, as they work to bring RNA medicines to patients and advance next-generation RNA editing approaches.”

About John M. Maraganore, Ph.D.

Dr. John Maraganore served as the founding CEO and a Director of Alnylam from 2002 to 2021, where he built and led the company from early platform research on RNA interference through global approval and commercialization of the first four RNAi therapeutic medicines, ONPATTRO®, GIVLAARI®, OXLUMO®, and Leqvio®. At Alnylam, he also led the company’s value creation strategy, building $25B in market capitalization, and also forming over 20 major pharmaceutical alliances. He continues to serve on the Alnylam Scientific Advisory Board. Prior to Alnylam, he served as an officer and a member of the management team for Millennium Pharmaceuticals, Inc., where he was responsible for the company’s product franchises in oncology, and cardiovascular, inflammatory and metabolic diseases, in addition to leadership of M&A, strategy, and biotherapeutics functions. Before Millennium, he served as Director of Molecular Biology and Director of Market and Business Development at Biogen, Inc. where he invented and led the discovery and development of ANGIOMAX® (bivalirudin) for injection. Previously, he was a scientist at ZymoGenetics, Inc. and the Upjohn Company. Dr. Maraganore received his M.S. and Ph.D. in biochemistry and molecular biology at the University of Chicago. He is currently a Venture Partner at ARCH Venture Partners, a Venture Advisor at Atlas Ventures, and an Executive Partner at RTW Investments. He is also Chair of the Board of Directors of Hemab Therapeutics and a member of the Board of Directors of Agios Pharmaceuticals, Beam Therapeutics, Kymera Therapeutics, and the Biotechnology Industry Organization, where he was Chair from 2017-2019. In addition, he serves on the Board of the Termeer Foundation, as Chair of the n-Lorem Foundation Advisory Council, on the Advisory Board of Ariadne Labs, and as a strategic advisor to a number of innovative companies.

About ProQR

ProQR Therapeutics is dedicated to changing lives through the creation of transformative RNA therapies for the treatment of severe genetic rare diseases such as Leber congenital amaurosis 10, Usher syndrome and retinitis pigmentosa. Based on our unique proprietary RNA repair platform technologies we are growing our pipeline with patients and loved ones in mind.

Learn more about ProQR at www.proqr.com.

FORWARD-LOOKING STATEMENTS

This press release contains forward-looking statements. All statements other than statements of historical fact are forward-looking statements, which are often indicated by terms such as "anticipate," "believe," "could," "estimate," "expect," "goal," "intend," "look forward to", "may," "plan," "potential," "predict," "project," "should," "will," "would" and similar expressions. Such forward-looking statements include, but are not limited to, statements regarding our business, technology platform, our pipeline of programs targeting inherited retinal dystrophies and our product candidates, including the clinical development and the therapeutic potential thereof. Forward-looking statements are based on management's beliefs and assumptions and on information available to management only as of the date of this press release. Our actual results could differ materially from those anticipated in these forward-looking statements for many reasons, including, without limitation, the risks, uncertainties and other factors in our filings made with the Securities and Exchange Commission, including certain sections of our annual report filed on Form 20-F. These risks and uncertainties include, among others, the cost, timing and results of preclinical studies and clinical trials and other development activities by us and our collaborative partners whose operations and activities may be slowed or halted by the COVID-19 pandemic; the likelihood of our clinical programs being executed on timelines provided and reliance on our contract research organizations and predictability of timely enrollment of subjects and patients to advance our clinical trials and maintain their own operations; our reliance on contract manufacturers to supply materials for research and development and the risk of supply interruption from a contract manufacturer; the potential for future data to alter initial and preliminary results of early-stage clinical trials; the unpredictability of the duration and results of the regulatory review of applications or clearances that are necessary to initiate and continue to advance and progress our clinical programs; the ability to secure, maintain and realize the intended benefits of collaborations with partners, including the collaboration with Lilly; the possible impairment of, inability to obtain, and costs to obtain intellectual property rights; possible safety or efficacy concerns that could emerge as new data are generated in research and development; and general business, operational, financial and accounting risks, and risks related to litigation and disputes with third parties. Given these risks, uncertainties and other factors, you should not place undue reliance on these forward-looking statements, and we assume no obligation to update these forward-looking statements, even if new information becomes available in the future, except as required by law.

Cautionary Note on Future Updates

The statements contained in this press release reflect our current views with respect to future events, which may change significantly as the global consequences of the ongoing COVID-19 pandemic rapidly develop. Accordingly, we do not undertake and specifically disclaim any obligation to update any forward-looking statements.

ProQR Therapeutics N.V.

Investor Contact:
Sarah Kiely
ProQR Therapeutics N.V.
T: +1 617 599 6228
skiely@proqr.com
or
Hans Vitzthum
LifeSci Advisors
T: +1 617 430 7578
hans@lifesciadvisors.com

Media Contact:
Robert Stanislaro
FTI Consulting
T: +1 212 850 5657
robert.stanislaro@fticonsulting.com

FAQ

Who is the new strategic advisor at ProQR Therapeutics?

Dr. John Maraganore has been appointed as a strategic advisor at ProQR Therapeutics.

What is Dr. Maraganore's background?

Dr. Maraganore is the former founding CEO of Alnylam Pharmaceuticals and a leader in the biopharma industry.

What is the significance of Dr. Maraganore's appointment?

His experience is expected to provide valuable insights for ProQR's strategic direction and RNA therapy development.

What trial data is ProQR Therapeutics currently analyzing?

ProQR is analyzing data from the Illuminate trial of sepofarsen.

What recent challenges has ProQR faced?

ProQR has experienced a recent setback, causing concern regarding its current projects.