Propanc Biopharma’s CEO Comments on the 39 Granted Patents and 26 Patent Applications Under Examination in Key Global Jurisdictions

Rhea-AI Summary

Propanc Biopharma, Inc. (OTCQB: PPCB) announced a robust intellectual property portfolio with 39 granted patents and 26 pending applications for its lead product candidate, PRP, aimed at treating solid tumors. The unique formulation targets and eradicates cancer stem cells using proenzymes trypsinogen and chymotrypsinogen. Future applications are expected to enhance treatment options for advanced cancer patients. The company is advancing a synthetic version of PRP and is optimistic about its market position against competitors in the proenzyme space.

Positive

• 39 granted patents and 26 pending patent applications for PRP and related compounds.
• Unique approach with proenzymes targeting cancer stem cells in solid tumors.
• Development of a synthetic version of PRP, enhancing manufacturing capabilities.

Negative

• None.

Current Patents and Planned Future Patent Applications Covers the Company’s Lead Product Candidate, PRP, and Backup Clinical Compounds

MELBOURNE, Australia--(BUSINESS WIRE)-- Propanc Biopharma, Inc. (OTCQB: PPCB) (“Propanc” or the “Company”), a biopharmaceutical company developing novel cancer treatments for patients suffering from recurring and metastatic cancer, today announced that CEO and Co-Founder, Mr. James Nathanielsz, BAS, MEI, expresses confidence over the Company’s growing intellectual property portfolio. Presently, there are 39 granted patents and a further 26 patent applications under examination in key global jurisdictions relating to proenzymes as an effective therapeutic agent against solid tumors, covering the lead product candidate, PRP.

The Company’s patent portfolio covers compositions of the PRP formulation and method of use claims for the treatment of solid tumors by targeting and eradicating cancer stem cells. Further patent applications are anticipated capturing the application of PRP in the clinic as an addition to the treatment process for advanced cancer patients suffering from solid tumors, as well as describing novel pharmaceutical compositions of PRP. The development of a synthetic version of PRP, which is produced in the laboratory and not derived from animal sources is also underway via the Company’s “POP1”, Joint Research and Drug Discovery Program with the Universities of Jaén and Granada, and is also advancing towards the Company filing for patent protection in key global jurisdictions.

“When Dr. Kenyon and I cofounded Propanc back in the late 2000’s, we were told there were limited opportunities for patentability of proenzymes for cancer treatment, especially when the key pharmaceutical ingredients are naturally derived,” said Mr. Nathanielsz. “Nevertheless, Dr Kenyon and I were determined to advance our scientific research programs because we believe in the potential of proenzymes as an effective, less toxic, long term treatment option for advanced cancer patients, based on the observations from the compassionate use investigator study implemented by Dr. Kenyon. The fact there was limited prior art meant that our approach to cancer is unique if we could identify a novel formulation. PRP reflects the tireless efforts of Dr. Kenyon and our team of researchers who identified a unique, synergistic combination of two proenzymes, trypsinogen and chymotrypsinogen, when exposed to solid tumors, target and eradicate cancer stem cells, irreversibly. Over a decade later, we have filed multiple patents covering compositions of proenzymes and a method to treat metastatic cancer by targeting CSCs. We’re now at the stage where the advancement of PRP along the development pathway, as well as development of backup clinical compounds have strong potential to add to our intellectual property portfolio. Given there are no other companies that we are aware of pursuing the application of proenzymes against metastatic cancer, means that we are in a privileged position to make a significant contribution to the way we treat cancer patients suffering from late-stage metastatic cancer as a long term, therapeutic option. We remain passionate and resolute in our belief in the potential of this treatment today, as we were 15 years ago when we co-founded our Company. We strongly desire to unlock the value of our IP for our longtime shareholders who share in our belief in the Company and its technology.”

PRP is a mixture of two proenzymes, trypsinogen and chymotrypsinogen from bovine pancreas administered by intravenous injection. A synergistic ratio of 1:6 inhibits growth of most tumor cells. Examples include kidney, ovarian, breast, brain, prostate, colorectal, lung, liver, uterine and skin cancers.

About Propanc Biopharma, Inc.

Propanc Biopharma, Inc. (the “Company”) is developing a novel approach to prevent recurrence and metastasis of solid tumors by using pancreatic proenzymes that target and eradicate cancer stem cells in patients suffering from pancreatic, ovarian and colorectal cancers. For more information, please visit www.propanc.com.

The Company’s novel proenzyme therapy is based on the science that enzymes stimulate biological reactions in the body, especially enzymes secreted by the pancreas. These pancreatic enzymes could represent the body’s primary defense against cancer.

To view the Company’s “Mechanism of Action” video on its anti-cancer lead product candidate, PRP, please click on the following link: http://www.propanc.com/news-media/video

Forward-Looking Statements

All statements other than statements of historical facts contained in this press release are “forward-looking statements,” which may often, but not always, be identified by the use of such words as “may,” “might,” “will,” “will likely result,” “would,” “should,” “estimate,” “plan,” “project,” “forecast,” “intend,” “expect,” “anticipate,” “believe,” “seek,” “continue,” “target” or the negative of such terms or other similar expressions. These statements involve known and unknown risks, uncertainties and other factors, which may cause actual results, performance or achievements to differ materially from those expressed or implied by such statements. These factors include uncertainties as to the Company’s ability to continue as a going concern absent new debt or equity financings; the Company’s current reliance on substantial debt financing that it is unable to repay in cash; the Company’s ability to successfully remediate material weaknesses in its internal controls; the Company’s ability to reach research and development milestones as planned and within proposed budgets; the Company’s ability to control costs; the Company’s ability to obtain adequate new financing on reasonable terms; the Company’s ability to successfully initiate and complete clinical trials and its ability to successful develop PRP, its lead product candidate; the Company’s ability to obtain and maintain patent protection; the Company’s ability to recruit employees and directors with accounting and finance expertise; the Company’s dependence on third parties for services; the Company’s dependence on key executives; the impact of government regulations, including FDA regulations; the impact of any future litigation; the availability of capital; changes in economic conditions, competition; and other risks, including, but not limited to, those described in the Company’s periodic reports that are filed with the Securities and Exchange Commission and available on its website at http://www.sec.gov. These forward-looking statements speak only as of the date hereof and the Company disclaims any obligations to update these statements except as may be required by law.

View source version on businesswire.com: https://www.businesswire.com/news/home/20220705005473/en/

Investor Relations and Media:

Mr. James Nathanielsz

Propanc Biopharma, Inc.

irteam@propanc.com

+61-3-9882-0780

Source: Propanc Biopharma, Inc.

FAQ

What is the current status of Propanc Biopharma's patent portfolio?

Propanc Biopharma has 39 granted patents and 26 pending applications related to its lead product candidate, PRP.

How does PRP function in cancer treatment?

PRP uses a combination of proenzymes, trypsinogen and chymotrypsinogen, to target and eradicate cancer stem cells in solid tumors.

What are the future plans for Propanc Biopharma's PRP product?

The company plans to file for additional patent protections and further develop PRP as part of its ongoing research.

What is the significance of the 'POP1' Joint Research Program?

The 'POP1' program involves developing a synthetic version of PRP, which is essential for patenting and potential commercialization.

What types of cancers can PRP potentially treat?

PRP is aimed at treating various solid tumors, including kidney, ovarian, breast, and colorectal cancers.