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Phio Pharmaceuticals Corp. (Nasdaq: PHIO), headquartered in Marlborough, Massachusetts, is a clinical-stage biotechnology company focused on developing innovative immuno-oncology therapeutics. The company's proprietary INTASYL™ siRNA gene silencing technology is at the forefront of its efforts to enhance the effectiveness of immune cells in targeting and destroying tumor cells.
Phio's core product pipeline includes:
- PH-762: Targets the checkpoint protein PD-1 on immune cells, enhancing their ability to attack tumors. Currently in Phase 1b clinical trials, PH-762 is being tested for its efficacy in treating cutaneous squamous cell carcinoma, melanoma, and Merkel cell carcinoma.
- PH-804: Focuses on the suppressive immune receptor TIGIT, present on T cells and natural killer cells, to bolster immune responses against cancer.
- PH-790: Aims to silence the PD-L1 protein, which normally prevents immune cells from attacking non-harmful cells, thereby boosting the body's natural defenses against cancer.
Phio Pharmaceuticals collaborates with leading institutions such as Gustave Roussy, Medigene AG, and Helmholtz Zentrum München to advance their research and development efforts. The company's financial health, as of the latest reports, shows a cash position of $6.5 million, with a significant reduction in research and development expenses aimed at transitioning from discovery to product development.
Phio's latest updates include the presentation of new data on PH-762 at various scientific conferences and the initiation of new partnerships. These efforts underscore Phio's commitment to delivering cutting-edge cancer treatments and improving patient outcomes.
For more details, visit the company's website at www.phiopharma.com.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) announced new data presentations at the upcoming 24th Annual Meeting of the ASGCT (May 11-14, 2021) and the ASCO Annual Meeting (June 4-8, 2021). At ASGCT, the poster titled "INTASYL PH-762 Self-Delivering RNAi Targeting PD-1 Enhances the Therapeutic Efficacy of HER2-Targeted CAR-T Cells" will be presented by Benjamin Cuiffo et al. Additionally, ASCO will feature a poster on INTASYL therapy targeting BRD4 and PD-1. Archived presentations will be available on the company's website.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) announced promising new in vivo data indicating that its INTASYL (mPH-762) therapy achieves significant tumor growth inhibition through intratumoral administration in both PD-1 responsive and refractory cancer models. This method shows potential for enhanced local immune checkpoint blockade without the systemic side effects of traditional therapies. The company plans to initiate a first-in-human clinical study for mPH-762 in advanced melanoma by Q4 2021, showcasing its commitment to advancing innovative cancer treatments.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) reported a net loss of $8.8 million for 2020, a slight improvement from $8.9 million in 2019. The company had cash of $14.2 million at year-end, up from $6.9 million in 2019, bolstered by $21.7 million raised in equity financing. Developmental progress includes new collaborations with AgonOx, Inc. and plans to initiate two clinical studies for PH-762 in 2021. R&D expenses rose to $4.4 million, while G&A expenses decreased to $4.4 million, reflecting reduced legal and hiring costs. Overall, the company maintains a solid financial outlook for the next two years.
Phio Pharmaceuticals Corp. announced new study data on its product candidate, PH-762, which targets PD-1 and shows promise in tumor control. This presentation will be part of the AACR Annual Meeting 2021, held virtually from April 10-15 and May 17-21. The poster titled "Intratumoral INTASYL™ self-delivering RNAi targeting PD-1" will explore the treatment's effects similar to systemic anti-PD-1 antibodies. Further details will be available on the Company’s website after the presentation.
Phio Pharmaceuticals Corp. has entered a clinical collaboration with AgonOx, Inc. to advance T cell-based cancer immunotherapies utilizing PH-762 and AgonOx's DP tumor-infiltrating lymphocyte (TIL) technology. The collaboration aims to enhance TIL therapeutic efficacy, with a clinical study expected to enroll patients later this year. Preclinical data suggests PH-762 significantly boosts the tumor-killing activity of CD8 DP TILs. AgonOx will receive financial support for the trial, while Phio stands to gain from future development milestones and royalties.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) announced its CEO, Dr. Gerrit Dispersyn, will present at the H.C. Wainwright Global Life Sciences Conference on March 9-10, 2021. The presentation will be available on-demand starting at 7 a.m. ET on March 9, and can be accessed through the company's website. Phio is focused on advancing its proprietary self-delivering RNAi therapeutic platform, INTASYL™, aimed at treating cancer by enhancing immune response against tumor cells.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) has successfully completed a registered direct offering of 2,246,784 shares of common stock at $3.42 per share, yielding gross proceeds of approximately $7.7 million. The funds will primarily support working capital needs and the advancement of its immuno-oncology programs. The offering was conducted under a shelf registration statement declared effective by the SEC in 2018. H.C. Wainwright & Co. served as the placement agent for this offering.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) has announced a registered direct offering of 2,246,784 shares of common stock priced at $3.42 per share, raising approximately $7.7 million. The offering is expected to close around February 17, 2021, pending customary closing conditions. The funds will primarily support general working capital, including the development of immuno-oncology programs. H.C. Wainwright & Co. serves as the exclusive placement agent. The shares are offered under an effective shelf registration statement.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) announced the closing of a private placement, issuing 4,560,928 shares at $3.07 each, alongside warrants for 3,420,696 shares. This transaction raised approximately $14.0 million before expenses. The company plans to use the funds for its immuno-oncology research and general working capital. The warrants have an exercise price of $3.00 and are valid for five and a half years. Phio must file a registration statement covering the resale of the shares by February 1, 2021.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) has announced a private placement to raise approximately $14.0 million by issuing 4,560,928 shares of common stock at $3.07 per share, along with warrants for 3,420,693 shares at an exercise price of $3.00. The placement is expected to close around January 25, 2021. Proceeds will be used for the development of immuno-oncology programs and general working capital. The company is required to file a registration statement within ten days for the resale of shares issued to investors.