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Panbela Therapeutics (Nasdaq: PBLA) is conducting a Phase 1 clinical trial of SBP-101, an investigational agent for patients with metastatic pancreatic ductal adenocarcinoma (PDA), in combination with standard care agents gemcitabine and nab-paclitaxel. The independent data safety monitoring board (DSMB) has recommended pausing SBP-101 dosing due to reports of visual disturbances in some patients, while other trial activities will continue. Panbela is finalizing a visual screening program and remains confident in SBP-101's potential benefits. All trial enrollments were completed by December 2020.