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Passage Bio, Inc. - PASG STOCK NEWS

Welcome to our dedicated page for Passage Bio news (Ticker: PASG), a resource for investors and traders seeking the latest updates and insights on Passage Bio stock.

Overview

Passage Bio, Inc. (PASG) is a clinical stage genetic medicines company focused on the development and advancement of transformative gene therapies for rare, monogenic central nervous system (CNS) disorders. The company is at the forefront of pioneering innovative treatments using sophisticated gene replacement strategies that leverage engineered adeno-associated virus (AAV) vectors. With an emphasis on addressing neurodegenerative diseases, Passage Bio targets conditions that have significant unmet needs in both pediatric and adult patient populations.

Innovative Gene Therapy Platform

At the heart of Passage Bio's approach is its robust gene therapy platform. The company utilizes proprietary AAV capsids, such as AAVHU68 and AAV1, to deliver functional copies of critical genes to the brain and peripheral tissues. This technology is designed to provide a one-time treatment capable of addressing the underlying genetic defects that lead to CNS disorders. By replacing dysfunctional genes, the therapies aim to restore lysosomal function and improve cellular health in affected tissues.

Key Clinical Programs

Passage Bio has focused its research on several critical therapeutic areas:

  • Infantile GM1 Gangliosidosis: The company is advancing PBGM01, which employs its proprietary AAVHU68 capsid to deliver a functional GLB1 gene. This therapy aims to restore the production of the enzyme lysosomal acid beta-galactosidase to counteract the effects of GM1 gangliosidosis.
  • Frontotemporal Dementia (FTD): PBFT02 is designed to address FTD due to progranulin deficiency. Using an AAV1 vector, this therapy delivers a functional GRN gene to elevate progranulin levels within the central nervous system, with the objective of improving lysosomal function and mitigating disease progression.
  • Infantile Krabbe Disease: PBKR03 utilizes the same proprietary AAVHU68 platform to transport a functional GALC gene, aimed at restoring the activity of the galactosylceramidase enzyme, a key factor in the pathogenesis of Krabbe disease.

Strategic Collaborations and Licensing

To enhance its research and development capabilities, Passage Bio has engaged in several strategic collaborations. The company maintains a significant partnership with the University of Pennsylvania's Gene Therapy Program, which has bolstered its preclinical research initiatives. Additionally, Passage Bio has established agreements with key service providers, such as Catalent Maryland, to support clinical supply and development services. Notably, the company has executed out-license agreements with GEMMA Biotherapeutics for its pediatric lysosomal storage disease programs, thereby effectively expanding its operational focus towards adult neurodegenerative conditions and optimizing its resource allocation.

Operational Strategy and Research Excellence

Beyond its innovative therapeutic strategies, Passage Bio has implemented disciplined operational strategies, including workforce reorganization and the transition to an outsourced analytical testing model. These measures, which extend the company's operating cash runway, reflect a commitment to maintaining a lean operational structure while continuing to generate impactful clinical data. Such actions underscore the company’s dedication to delivering therapies that address the critical underlying pathology of neurodegenerative diseases.

Market Significance and Clinical Impact

Within the competitive landscape of genetic medicines and biopharmaceutical innovation, Passage Bio distinguishes itself through its rigorous scientific approach and strategic collaborations. The company’s focus on CNS disorders, supported by extensive preclinical evidence and evolving clinical data, positions it as a critical contributor to the transformation of therapies for rare neurodegenerative diseases. By targeting the root genetic causes with one-time treatments, Passage Bio is committed to not only advancing clinical research but also providing a clear framework for understanding the potential impact of gene therapies in an area of significant unmet medical need.

Commitment to Scientific Rigor and Patient Care

Passage Bio’s operations are driven by a rigorous scientific process combined with a deep understanding of the complexities inherent in CNS disorders. The company remains focused on constructing a coherent narrative that bridges advanced technology with clinical applicability, ensuring that every step—from research and development to strategic licensing—is meticulously planned and executed. This unwavering commitment to scientific excellence and patient care enhances its credibility among stakeholders while reinforcing its reputation as an expert in the field of genetic medicines.

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Passage Bio, Inc. (PASG) will participate in investor conferences like TD Cowen 44th Annual Health Care Conference and Leerink Partners Global Biopharma Conference to discuss their clinical-stage genetic medicines for neurodegenerative diseases. A webcast will be available for investors on the company's website.
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Passage Bio, Inc. (PASG) announced that its CEO will participate in a fireside chat at Guggenheim Healthcare Talks 6th Annual Biotechnology Conference. The event will be live webcasted and available for replay on the company's website. The focus of the company is on genetic medicines for neurodegenerative diseases.
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Passage Bio, Inc. (Nasdaq: PASG) announced initial safety and biomarker data from three Cohort 1 patients in the ongoing global Phase 1/2 upliFT-D clinical trial evaluating PBFT02, an adeno-associated virus (AAV)-delivery gene therapy for the treatment of patients with frontotemporal dementia (FTD) with granulin (GRN) mutations. The data showcased PBFT02's ability to elevate CSF progranulin to supraphysiologic levels at the lowest tested dose, Dose 1, up to six months post-treatment. The company also shared strategic priorities aimed at further optimizing its portfolio for the treatment of neurodegenerative conditions.
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Passage Bio, Inc. (Nasdaq: PASG) grants 10,400 shares of common stock as an inducement award to a new employee, in accordance with Nasdaq Listing Rule 5635(c)(4). The options have an exercise price of $0.628 per share, equal to the closing price on November 15, 2023. The shares will vest over four years, with 25% vesting after one year, and the remainder in 36 equal monthly installments, subject to continued employment.
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Passage Bio, Inc. (PASG) reports progress in clinical trials for FTD and GM1 treatment, with a strong financial position and extended cash runway. The company expects to present initial safety and biomarker data from three Cohort 1 patients in the upliFT-D trial for FTD in Q4 2023 and from Dose 3 patients in the Imagine-1 trial for GM1 in mid-2024. With a robust balance sheet, Passage Bio is well-positioned to achieve meaningful clinical milestones.
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Passage Bio, Inc. (NASDAQ: PASG) announced that its CEO, William Chou, will participate in a fireside chat at Guggenheim’s 5th Annual Inflammation, Neurology & Immunology Conference on November 6, 2023 at 2:30 p.m. ET. The event will be webcasted live on Passage Bio's website.
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Passage Bio grants inducement awards to new employees
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Passage Bio's CEO to participate in fireside chat at Chardan's Genetic Medicines Conference
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Passage Bio announces new interim safety, biomarker, and survival data from the Imagine-1 clinical study. Dose 2 of PBGM01 shows substantial improvements in CSF biomarkers and achieves normal levels of CSF β-Gal activity and GM1 gangliosides. Initial evidence of improved survival relative to natural history data. Dose 3 data expected by mid-2024.
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FAQ

What is the current stock price of Passage Bio (PASG)?

The current stock price of Passage Bio (PASG) is $0.386 as of April 1, 2025.

What is the market cap of Passage Bio (PASG)?

The market cap of Passage Bio (PASG) is approximately 23.9M.

What is the core focus of Passage Bio, Inc.?

Passage Bio, Inc. is focused on developing advanced gene therapies for rare monogenic central nervous system disorders, addressing critical unmet needs in neurodegenerative diseases.

How does Passage Bio use gene therapy in its treatments?

The company employs proprietary AAV capsid platforms to deliver functional genes to the brain and peripheral tissues, aiming to restore proper enzyme function and cellular health in affected tissues.

Which disease areas are targeted by Passage Bio's therapies?

Their pipeline targets major disorders including infantile GM1 gangliosidosis, frontotemporal dementia (FTD) caused by progranulin deficiency, and infantile Krabbe disease.

What strategic collaborations has Passage Bio established?

Passage Bio collaborates with institutions such as the University of Pennsylvania and partners like Catalent Maryland, while also executing licensing agreements with GEMMA Biotherapeutics to advance its programs.

How does the company optimize its operational efficiency?

The company has implemented strategic workforce adjustments and transitioned to an outsourced analytical testing model, ensuring a lean operational setup that supports its clinical and research milestones.

What distinguishes Passage Bio in the competitive gene therapy market?

Its focus on rare, monogenic CNS disorders combined with innovative AAV-based gene delivery and strategic partnerships underlines its commitment to addressing underlying genetic causes rather than just symptoms.

What role do out-license agreements play in Passage Bio's business model?

Out-license agreements help the company expand its developmental reach and focus on its core therapeutic assets while leveraging partnerships to commercialize specific pediatric lysosomal storage disease programs.

How does Passage Bio ensure scientific rigor in its operations?

The company emphasizes extensive preclinical research, collaborative clinical trial designs, and strategic partnerships, all of which reinforce its commitment to high standards of scientific and operational excellence.
Passage Bio, Inc.

Nasdaq:PASG

PASG Rankings

PASG Stock Data

23.93M
54.81M
0.48%
60.63%
2.93%
Biotechnology
Biological Products, (no Disgnostic Substances)
Link
United States
PHILADELPHIA