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Nuvectis Pharma, Inc. (NASDAQ: NVCT) is a clinical-stage biopharmaceutical company dedicated to developing innovative precision medicines for treating serious conditions of unmet medical need in oncology. The company's core focus lies in the development of novel small molecule therapeutics targeting genetically defined patient populations in cancer.
Nuvectis Pharma’s pipeline includes two promising drug candidates, NXP800 and NXP900. NXP800 is an oral small molecule currently in a Phase 1b clinical trial for the treatment of platinum-resistant, ARID1a-mutated ovarian carcinoma. The U.S. Food and Drug Administration (FDA) has granted Fast Track Designation to the NXP800 program for this indication and Orphan Drug Designation for the treatment of cholangiocarcinoma. Recently, Nuvectis announced a collaboration with Mayo Clinic to evaluate NXP800 in an investigator-sponsored clinical trial for cholangiocarcinoma.
NXP900, on the other hand, is a novel small molecule SRC/YES1 kinase inhibitor currently undergoing a Phase 1a dose escalation study. NXP900 has shown potential as a standalone treatment and in combination with other therapies in preclinical studies, particularly in non-small cell lung cancer (NSCLC) resistant to EGFR inhibitors like osimertinib and ALK inhibitors like alectinib.
Financially, Nuvectis remains robust, with cash and cash equivalents of $19.1 million as of December 31, 2023. However, the company recorded a net loss of $22.3 million for the same period, largely due to its focused investment in research and development. Despite this, the company maintains a cash-efficient strategy, ensuring sufficient runway to continue its critical work.
In 2024, Nuvectis anticipates several key clinical milestones, including updates from ongoing trials of NXP800 and NXP900. The company is positioned as a significant player in the biopharmaceutical landscape, driven by its commitment to addressing unmet medical needs in oncology through precision medicine.
Nuvectis Pharma, Inc. (NASDAQ: NVCT) announced a publication in the Journal of Experimental Medicine regarding NXP900's efficacy in treating metastatic castration resistant prostate cancer (mCRPC) resistant to enzalutamide (XTANDI®). The publication suggests that NXP900, also known as eCF506, may reverse resistance to XTANDI® when combined with it. The CEO, Ron Bentsur, emphasized the drug's potential as a leading SRC/YES1 kinase inhibitor, with expectations for clinical advancement. Nuvectis Pharma is focused on addressing unmet medical needs in oncology and is also developing NXP800, which targets ARID1a mutations.
Nuvectis Pharma, Inc. (NASDAQ: NVCT) announced a collaboration with ENGOT and GOG Foundation to conduct the NXP800 Phase 1b clinical trial targeting ARID1A-mutated ovarian clear cell and endometrioid carcinomas. Dr. Susana Banerjee leads the trial, with co-leads Dr. Shannon Westin and Dr. Ramez Eskander. The ongoing Phase 1a trial demonstrates promising results, supporting the safety and effectiveness of NXP800. The FDA has granted Fast Track Designation for the drug, highlighting its potential in addressing significant unmet medical needs in oncology.
Nuvectis Pharma (NASDAQ: NVCT) announced on December 1, 2022, that the FDA granted Fast Track Designation to its drug candidate NXP800, aimed at treating platinum-resistant, ARID1A-mutated ovarian carcinoma. This designation highlights the drug's potential to meet urgent medical needs in oncology. CEO Ron Bentsur expressed confidence in NXP800's ability to improve patient outcomes. Nuvectis is also developing NXP900, a SRC/YES1 kinase inhibitor, currently in preclinical studies. Fast Track allows for expedited drug development and review for serious conditions.
Nuvectis Pharma (NASDAQ: NVCT) announced its Q3 2022 financial results and progress in drug development. The Phase 1a trial for NXP800 is ongoing, with Phase 1b set to start in Q1 2023. Positive preclinical data for NXP800 was reported, highlighting its potential for treating ARID1a-mutated gastric cancer. NXP900 is advancing towards IND submission expected in Q1 2023, with new insights on its activity profile. Cash reserves grew to $23.6 million, but net losses increased to $5.9 million from $4.7 million year-on-year, primarily due to R&D costs.
Nuvectis Pharma, based in Fort Lee, NJ, announced upcoming presentations at the 34th EORTC-NCI-AACR Symposium from October 26-28, 2022. The two posters will address key developments in their drug candidates, NXP800 and NXP900. NXP800 focuses on HSF1 pathway inhibition, with a predictive biomarker identified for therapeutic responsiveness. NXP900 shows a significantly higher sensitivity in cancer cell lines compared to dasatinib, suggesting potential advantages for certain patient subgroups. Nuvectis remains committed to addressing unmet medical needs in oncology.
Nuvectis Pharma, a biopharmaceutical firm focused on innovative oncology treatments, announced management participation at the Roth Inaugural Healthcare Opportunities Conference.
The event is scheduled for October 6, 2022, at 8:15 a.m. ET in New York.
Nuvectis is advancing its pipeline, which includes NXP800 and NXP900, aimed at treating unmet medical needs.
Nuvectis Pharma announced the formation of a Scientific Advisory Board (SAB) on September 28, 2022, to enhance its research and development strategy. The SAB comprises prominent experts in oncology, including Prof. Shannon N. Westin, Prof. Gordon B. Mills, and Prof. Paul Workman. Chairman and CEO Ron Bentsur emphasized the importance of this collaboration in advancing the company's innovative precision medicine initiatives, particularly for treating serious unmet medical needs in oncology.
Nuvectis Pharma announced promising preclinical results for NXP800, targeting ARID1a-mutated gastric carcinoma. Following successful outcomes in ovarian carcinoma models, the company is optimistic about expanding NXP800's development to gastric cancer, which affects 20-25% of the 26,000 annual U.S. diagnoses. The current prognosis for gastric cancer is poor, with a 5-year survival rate of just 32%. Nuvectis is on track with the Phase 1a study and anticipates beginning Phase 1b in Q1 2023.
Nuvectis Pharma, a biopharmaceutical company focused on developing precision medicines for oncology, announced that CEO Ron Bentsur will present at three investment conferences in September 2022. The first event is the HC Wainwright 24th Annual Global Investment Conference on September 13 at 10:30 a.m. ET in New York, followed by the Cantor Oncology Conference on September 28 at 9:00 a.m. ET, and the Ladenburg Thalmann Healthcare Conference on September 29 at 2:00 p.m. ET. Webcasts of the presentations will be available for 90 days.
Nuvectis Pharma (NASDAQ: NVCT) reported progress in its NXP800 Phase 1 clinical program, with the Phase 1b expansion expected to start in Q1 2023. The FDA cleared the IND for NXP800, allowing U.S. and U.K. sites to enroll patients. The company also detailed advancements in NXP900, with IND-enabling studies projected for completion by year-end 2022. A recent private placement raised $15.9 million, extending the cash runway into H2 2024. For Q2 2022, Nuvectis reported a net loss of $3.6 million, a decrease from $5.9 million in Q2 2021, while R&D expenses fell to $2.5 million.
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