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Nkarta, Inc. (Nasdaq: NKTX) is a pioneering clinical-stage biotechnology company located in South San Francisco, California. Founded in 2015, Nkarta leverages proprietary natural killer (NK) cell expansion and engineering technologies to develop next-generation immunotherapies for the treatment of cancer and autoimmune diseases. The company’s mission is to harness the innate power of NK cells, which are the body's first line of defense, to create treatments that are more potent, better tolerated, and readily available to a broad patient population.
The core focus of Nkarta lies in its two lead candidates, NKX101 and NKX019. NKX101 is an off-the-shelf immunotherapy that targets NKG2D ligands on tumor cells, using engineered NK cells derived from healthy donors. This candidate shows promising results in treating acute myeloid leukemia (AML), with complete responses observed in high-risk patients. NKX019 targets CD19, a biomarker for B cell malignancies and autoimmune diseases such as lupus nephritis. This candidate has been designed to provide enhanced tumor cell targeting and greater persistence and activity.
Nkata's technological platform combines NK cell expansion and cryopreservation with advanced cell engineering techniques, including CRISPR-based genome engineering. This ensures a robust supply of NK cells and enables precise modification for enhanced therapeutic effectiveness. The company's cell therapies aim to be accessible for broad outpatient treatment, offering off-the-shelf solutions that minimize patient burden and reduce treatment delays.
Recent milestones include the clearance of an Investigational New Drug (IND) application by the U.S. FDA to evaluate NKX019 for lupus nephritis, expansion of their pipeline into autoimmune diseases, and strategic financial moves to extend their cash runway into 2026. Nkarta continues to provide updates on its clinical programs and looks forward to presenting additional data throughout 2024.
The company's financial backing comes from prominent investors such as SR One, NEA, and Novo Ventures, which underscores confidence in Nkarta's potential to revolutionize cell therapy. With a commitment to rigorous clinical development and strategic resource allocation, Nkarta is well-positioned to advance its innovative cell therapy candidates and deliver transformative treatments to patients in need.
SOUTH SAN FRANCISCO, Calif., April 22, 2022 – Nkarta, Inc. (Nasdaq: NKTX) will hold a conference call on April 25, 2022, at 8:00 a.m. ET to discuss clinical data from ongoing Phase 1 trials for its lead programs, NKX101 and NKX019. Leading investigators will join management for the update. NKX101 targets NKG2D ligands in patients with acute myeloid leukemia and myelodysplastic syndromes, while NKX019 targets CD19 in B cell malignancies. The results will provide insights into the safety and anti-tumor activity of these investigational therapies.
Nkarta, Inc. (Nasdaq: NKTX) presented four preclinical data abstracts at the AACR Annual Meeting 2022, showcasing advancements in its engineered NK cell therapies for cancer treatment. Key highlights included findings on multiplexed gene knockout strategies that enhance the efficacy of CD70 CAR NK cells, particularly in combating renal cell carcinoma. The company continues to expand its NK cell platform and pipeline, including its NK+T cell program, indicating a robust commitment to innovative cancer therapies.
Nkarta, Inc. (Nasdaq: NKTX), a biopharmaceutical company focused on engineered natural killer cell therapies for cancer, will participate in the 21st Annual Needham Virtual Healthcare Conference on April 12, 2022, at 4:30 p.m. ET. A webcast of the presentation will be available in the Investors section of Nkarta’s website and can be accessed after the live event for approximately four weeks. Nkarta specializes in developing off-the-shelf NK cell therapies designed for outpatient treatments, leveraging advanced cell engineering and cryopreservation technologies.
Nkarta, Inc. (Nasdaq: NKTX) announced the appointment of Angela M. Thedinga to its Board of Directors. With extensive experience in supply chain and commercial manufacturing, Thedinga previously served as Chief Technology Officer at Adverum Biotechnologies and has a strong background at AveXis and Abbott Laboratories. CEO Paul J. Hastings highlighted her expertise will enhance Nkarta's operational strategy and support its in-house manufacturing capabilities for NK cell therapies. Thedinga expressed enthusiasm about contributing to Nkarta's mission of developing effective cancer treatments.
Nkarta, Inc. (NKTX) reported financial results for 2021, highlighting significant progress in its clinical development programs. The company is on track to present initial Phase 1 clinical trial data for NKX101 and NKX019 in 2022, targeting acute myeloid leukemia and B cell malignancies, respectively. As of December 31, 2021, Nkarta had cash and equivalents of $240.2 million. R&D expenses totaled $63.4 million for the year, contributing to a net loss of $86.1 million. The company anticipates its financial resources will support operations through at least the second half of 2023.
Nkarta, Inc. (Nasdaq: NKTX) announced that it will present four posters at the American Association for Cancer Research (AACR) Annual Meeting from April 8 to 13, 2022. The posters will cover topics such as the development of CAR NK cell therapies and preclinical models for multiple myeloma, showcasing the company's advancements in engineered NK cell therapies. Nkarta aims to leverage its proprietary technologies for broad outpatient treatment access. All abstracts will be available on the AACR e-poster website starting April 8, 2022.
Nkarta, a biopharmaceutical company focused on engineered natural killer (NK) cell therapies for cancer, will present at three key investor conferences:
- SVB Leerink 11th Annual Global Healthcare Conference on February 17, 2022, at 1:40 p.m. ET.
- Cowen 42nd Annual Health Care Conference on March 7, 2022, at 10:30 a.m. ET.
- Oppenheimer 32nd Annual Healthcare Conference on March 16, 2022, at 10:00 a.m. ET.
Webcasts of these presentations will be available on the company's website, with replays archived for approximately four weeks.
Nkarta, Inc. (Nasdaq: NKTX) announced that the FDA granted orphan drug designation (ODD) to NKX101 for treating acute myeloid leukemia (AML). This investigational NK cell therapy leverages the NKG2D receptor to enhance cancerous cell targeting. With a five-year survival rate of only 26% in AML patients, ODD emphasizes the urgent need for alternative treatments. NKX101 is undergoing a Phase 1 clinical trial for relapsed/refractory AML. The ODD may provide Nkarta with development incentives, including potential tax credits and marketing exclusivity upon FDA approval.
Nkarta, Inc. (NASDAQ: NKTX) presented a trial in progress poster for NKX019, an investigational therapy targeting relapsed and refractory B-cell malignancies, at the 63rd ASH Annual Meeting. NKX019 utilizes allogeneic NK cells engineered to express a CAR targeting CD19. The Phase 1 clinical trial is evaluating safety and anti-tumor activity. Initial data is expected in 2022. The treatment aims to overcome limitations of existing therapies. B-cell cancers remain a significant health challenge, with over half a million new non-Hodgkin lymphoma cases diagnosed yearly.
Nkarta, Inc. (Nasdaq: NKTX) presented four preclinical data abstracts at the SITC 36th Annual Meeting, highlighting advancements in its NK cell therapy platform. The research demonstrates enhanced NK cell ability to target tumors through innovative approaches, including gene-editing strategies. Notably, the combination of CD70 CAR and CISH knockout showed increased cytotoxicity and persistence of NK cells. Additionally, methods for large-scale expansion of NK cells could lead to efficient off-the-shelf therapies. These findings underscore Nkarta's ongoing collaboration with CRISPR Therapeutics and its commitment to advancing cancer treatments.
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