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Molecular Partners AG (NASDAQ: MOLN) is a clinical-stage biopharmaceutical company headquartered in Zurich-Schlieren, Switzerland, with an additional office in Concord, Massachusetts. The company specializes in the development of DARPin therapeutics, a new class of custom-built protein drugs designed to tackle complex diseases such as cancer and sight-threatening disorders.
Molecular Partners has a diversified product pipeline focusing primarily on oncology and ophthalmology. In the field of oncology, the firm is advancing multiple DARPin candidates including MP0533, a novel tetra-specific T cell-engaging DARPin for acute myeloid leukemia, which is currently in Phase 1/2a clinical trials. The company's latest innovation, the Switch-DARPin platform, aims to deliver multispecific candidates for conditional activation of targeted immune responses. Another exciting area of development is the Radio-DARPin Therapy (RDT) platform, which uses DARPin technology to enhance tumor uptake and reduce kidney reabsorption of radiopharmaceutical drugs, with lead candidate MP0712 targeting DLL3 in small-cell lung cancer.
On the ophthalmology front, Molecular Partners is developing therapies for retinal diseases, including wet age-related macular degeneration and diabetic macular edema. The firm's dedication to innovation is further evidenced by its strategic collaborations with prominent pharmaceutical companies such as Novartis and Orano Med.
Financially, the company reported CHF 186.9 million in cash and short-term deposits as of year-end 2023 and maintains a strong cash runway well into 2026. Despite a net loss of CHF 62 million for 2023, Molecular Partners continues to invest in its robust pipeline and transformative research initiatives.
Recent news highlights Molecular Partners' presentation at the 42nd Annual J.P. Morgan Healthcare Conference where they provided a business overview and 2024 outlook. The company anticipates significant milestones in 2024, including further clinical data from its lead oncology program MP0533 and progression of its RDT and Switch-DARPin platforms.
For more information, visit www.molecularpartners.com, or follow them on LinkedIn and X @MolecularPrtnrs.
Molecular Partners AG (SIX: MOLN; NASDAQ: MOLN) provides an update following Novartis' quarterly earnings call, where CEO Vas Narasimhan mentioned that the Emergency Use Application (EUA) for ensovibep requires additional clinical data for FDA authorization. The ongoing omicron wave complicates clinical investigations. Novartis is coordinating with the FDA to design a potential Phase 3 study to gather necessary data for EUA or full approval. Molecular Partners continues to develop its DARPin therapeutics in collaboration with major pharmaceutical companies.
Molecular Partners AG (SIX: MOLN; NASDAQ: MOLN) announced that late-breaker data from the EMPATHY study of ensovibep will be presented at the 32nd European Congress of Clinical Microbiology and Infectious Diseases in Lisbon from April 23-26, 2022. Dr. N. Kumarasamy will present interim results from the phase II/III study focused on mild-to-moderate COVID-19 patients. Additionally, a symposium on COVID-19 variants and DARPin therapeutic efficacy will occur on April 26, featuring insights from Novartis and Molecular Partners' executives.
Molecular Partners AG (SIX: MOLN; NASDAQ: MOLN), a clinical-stage biotech company, announced participation in the Kempen Life Sciences investor conference on April 20-21, 2022. CFO Andreas Emmenegger and COO Michael Stumpp will present on April 20 at 16:30 CET (10:30 AM EDT). The company focuses on developing DARPin therapeutics, a new class of custom-built protein drugs aimed at addressing unmet medical needs in areas like infectious disease and oncology. More details will be available on the Molecular Partners website.
Molecular Partners AG (SIX: MOLN; NASDAQ: MOLN) announced that all shareholder motions were approved during its recent Annual General Meeting. Key outcomes included the re-election of the Board of Directors, with Bill Burns remaining as Chairman. KPMG AG Zurich was confirmed as statutory auditors for 2022. Shareholders authorized the Board to increase share capital until April 2024 and approved the annual financial statements for 2021. The meeting was conducted virtually due to COVID-19 regulations, without physical attendance.
Molecular Partners AG (SIX: MOLN; NASDAQ: MOLN) announced significant preclinical findings for MP0317, its second immuno-oncology candidate, published in Cancer Immunology Research. MP0317 targets FAP and CD40 to foster localized immune activation in tumors while minimizing systemic toxicity. The study demonstrates that MP0317 effectively induces tumor-localized immune activation, potentially offering a wider therapeutic window compared to traditional CD40-targeting therapies. Currently undergoing a Phase 1 clinical trial, initial results are anticipated in late 2022.
Molecular Partners AG (SIX: MOLN, NASDAQ: MOLN) has announced the details of its Annual General Meeting (AGM) scheduled for April 13, 2022, at 2 PM CET. The meeting will be held virtually due to ongoing pandemic concerns, allowing shareholders to participate only through written or electronically submitted instructions to an independent proxy. Key upcoming financial events include the Interim Management Statement Q1 2022 on May 12, 2022, and Half-year results 2022 on August 25, 2022. Molecular Partners is focused on developing DARPin therapeutics for various medical applications.
Molecular Partners AG (SIX: MOLN, NASDAQ: MOLN) released its financial results for 2021, noting a total revenue of CHF 9.8 million and a net loss of CHF 63.8 million. The company received CHF 150 million from Novartis following positive Phase 2 results for ensovibep, a DARPin therapeutic for COVID-19. Ensovibep has FDA Fast Track designation, with plans for global Phase 3 trials. Molecular Partners maintains strong financial health, projecting cash runway into 2025. The company aims to broaden its pipeline, including oncology and virology programs, while preparing for key regulatory submissions.
ZURICH-SCHLIEREN, Switzerland and CONCORD, Mass., Feb. 25, 2022 – Molecular Partners AG (SIX: MOLN; NASDAQ: MOLN), a clinical-stage biotech firm, announced CEO Patrick Amstutz's participation in two investor events in March 2022. Key dates include the Credit Suisse London Global Healthcare Conference on March 1-2, and a Fireside chat at the Cowen Health Care Conference on March 9. Additionally, the FY 2021 annual report will be published on March 15, followed by an investor conference call on March 16. Webcasted presentations will be accessible via the company's website.
Molecular Partners AG (SIX: MOLN; NASDAQ: MOLN) has announced that CEO Patrick Amstutz, Ph.D., will participate in the SVB Leerink 11th Annual Global Healthcare Conference 2022. The presentation is scheduled for February 16, 2022, at 9:20 am ET. This clinical-stage biotech company specializes in developing DARPin therapeutics, a novel class of custom-built protein drugs aimed at addressing healthcare challenges. Their work spans infectious disease, oncology, and ophthalmology, with partnerships among leading pharmaceutical companies.
Molecular Partners AG (SIX: MOLN; NASDAQ: MOLN) has announced that its partner Novartis requested Emergency Use Authorization (EUA) from the U.S. FDA for ensovibep, a DARPin antiviral therapeutic candidate aimed at treating COVID-19. This request builds on positive Phase 2 trial results from the EMPATHY study involving 407 symptomatic patients infected with SARS-CoV-2. Ensovibep is designed to inhibit the virus's entry into cells by targeting the spike protein, showing potential advantages in treating COVID-19.
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