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Merck KGaA, Darmstadt, Germany, released topline results from the Phase II INTR@PID BTC 047 study of bintrafusp alfa in second-line treatment for patients with locally advanced or metastatic biliary tract cancer (BTC). The study involved 159 patients and showed an objective response rate (ORR) of 10.1%, which did not meet the regulatory threshold for submission. Despite the results, bintrafusp alfa's single-agent efficacy offers insights for future studies. An ongoing Phase II/III trial is assessing bintrafusp alfa combined with chemotherapy for BTC.
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