STOCK TITAN

Kazia Therapeutics Limited American Depositary Shares - KZIA STOCK NEWS

Welcome to our dedicated page for Kazia Therapeutics American Depositary Shares news (Ticker: KZIA), a resource for investors and traders seeking the latest updates and insights on Kazia Therapeutics American Depositary Shares stock.

Kazia Therapeutics Limited (NASDAQ: KZIA) is an innovative biotechnology company focused on oncology, based in Sydney, Australia. The company is dedicated to developing cutting-edge anti-cancer drugs, with a robust pipeline aimed at addressing various forms of cancer.

The lead program for Kazia is paxalisib, an investigational brain-penetrant inhibitor of the PI3K / Akt / mTOR pathway. Paxalisib is primarily developed for treating glioblastoma multiforme, a highly aggressive brain cancer. Licensed from Genentech in late 2016, paxalisib has been the subject of numerous clinical trials. A Phase II study reported promising clinical activity, and the drug is currently undergoing pivotal trials, with additional studies targeting brain metastases and other central nervous system (CNS) cancers.

Besides paxalisib, Kazia is advancing EVT801, a small-molecule VEGFR3 inhibitor, licensed from Evotec SE in April 2021. EVT801 has shown preclinical efficacy across a range of tumor types and synergy with immuno-oncology agents. It's currently in Phase I clinical trials for advanced solid tumors.

Another notable drug in Kazia’s pipeline is Cantrixil (TRXE-002-1), under development for ovarian cancer and in Phase I clinical trials in Australia and the United States.

Kazia’s commitment to innovation and collaboration is evident through strategic partnerships and licensing agreements. For example, they recently signed a non-binding Letter of Intent with a biotechnology company to develop and commercialize paxalisib outside oncology, targeting epilepsy related to focal cortical dysplasia type 2 and tuberous sclerosis complex.

Financially, Kazia remains focused on securing funding to sustain its research and development endeavors. The company recently announced a direct offering expected to generate approximately $2 million.

Additionally, Kazia's forward-looking strategy includes addressing market listing requirements and ensuring compliance with Nasdaq’s Minimum Bid Price Requirement.

For more information, visit www.kaziatherapeutics.com or follow them on Twitter @KaziaTx.

Rhea-AI Summary
Kazia Therapeutics provides a preliminary update on the Phase 2 clinical trial evaluating paxalisib as a monotherapy treatment for relapsed/refractory primary central nervous system lymphoma (r/r PCNSL). The study aims to assess the efficacy and safety of paxalisib in up to 25 patients based on objective response rate, duration of response, progression-free survival, and overall survival. So far, 14 patients have been enrolled, and early clinical activity has been observed. However, some patients experienced treatment-related adverse events, leading to dose reductions and early termination. The protocol is being optimized to improve tolerability and durability of response.
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-2.38%
Tags
-
Rhea-AI Summary
Kazia Therapeutics presents selected clinical data from Phase 1 trial of EVT801 at ESMO 2023
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-4.69%
Tags
-
Rhea-AI Summary
Kazia Therapeutics announces intention to de-list from ASX
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-15.79%
Tags
none
Rhea-AI Summary
Kazia Therapeutics provides update on upcoming data presentations at international scientific meetings
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
4.4%
Tags
conferences
-
Rhea-AI Summary
Kazia Therapeutics' data from Phase II study of paxalisib selected for oral presentation at SNO Annual Meeting
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-4.76%
Tags
-
Rhea-AI Summary
Kazia Therapeutics' lead program, paxalisib, has been granted Fast Track Designation (FTD) by the FDA for the treatment of brain metastases. All patients in the ongoing Phase 1 clinical trial responded positively to the combination of paxalisib with radiotherapy. Brain metastases are a common complication of many tumors and survival rates are generally low. Paxalisib is also being studied in other clinical trials for glioblastoma and pediatric patients with diffuse midline gliomas.
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-8.55%
Tags
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
2.44%
Tags
conferences
-
Rhea-AI Summary

Kazia Therapeutics Limited (NASDAQ: KZIA; ASX: KZA) announced on April 14, 2023, that it has regained compliance with Nasdaq's minimum bid price requirement. This follows a notification received on December 9, 2022, indicating non-compliance due to the company's American Depository Shares (ADSs) closing below US$ 1.00 for 30 consecutive business days. To maintain compliance, the company needed its ADS bid price to stay at or above US$ 1.00 for ten consecutive business days, which was achieved from March 29 to April 12, 2023. Kazia is focused on developing oncology treatments, specifically its lead program, paxalisib, aimed at various brain cancers, with clinical studies ongoing and promising interim data reported.

Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
9.09%
Tags
none
-
Rhea-AI Summary

Kazia Therapeutics Limited (NASDAQ: KZIA) announced significant data on its drug candidates paxalisib and EVT801 at the AACR Annual Meeting in Orlando from April 14-19, 2023. Five presentations will highlight new findings, particularly for paxalisib's effectiveness in melanoma and childhood brain cancer, indicating enhanced overall survival in preclinical models. Additionally, EVT801's novel biomarker strategy is expected to yield initial clinical data in 2023. The presentations reinforce Kazia's ongoing collaboration with Evotec and suggest promising therapeutic paths for both compounds, particularly in combination therapies.

Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
6.8%
Tags
none
Rhea-AI Summary

Kazia Therapeutics Limited (ASX: KZA; NASDAQ: KZIA) announced a placement of shares to institutional investors, aiming to raise A$4.5 million at A$0.11 per share, a 13% premium to the 15-day volume-weighted average price. The placement includes an unconditional portion of A$2,792,572 for 25,387,018 new shares, and a conditional A$1,707,428 placement, subject to shareholder approval. An Extraordinary General Meeting is scheduled for February 24, 2023. The funds will advance Kazia's clinical program, specifically towards the paxalisib GBM AGILE study.

Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-- %
Tags
none

FAQ

What is the current stock price of Kazia Therapeutics American Depositary Shares (KZIA)?

The current stock price of Kazia Therapeutics American Depositary Shares (KZIA) is $3.02 as of December 26, 2024.

What is the market cap of Kazia Therapeutics American Depositary Shares (KZIA)?

The market cap of Kazia Therapeutics American Depositary Shares (KZIA) is approximately 13.0M.

What is Kazia Therapeutics’ primary focus?

Kazia Therapeutics focuses on developing innovative oncology drugs, with their lead program being paxalisib for brain cancer.

What is paxalisib?

Paxalisib is an investigational brain-penetrant inhibitor of the PI3K / Akt / mTOR pathway, developed to treat various forms of brain cancer including glioblastoma.

What stage are paxalisib’s clinical trials in?

Paxalisib has completed Phase II clinical trials with promising results and is currently in pivotal trials and various other studies targeting CNS cancers.

What other drugs are in Kazia’s pipeline?

Kazia is also developing EVT801, a VEGFR3 inhibitor for solid tumors, and Cantrixil, aimed at treating ovarian cancer.

How is Kazia financing its projects?

Kazia is securing funding through direct offerings, such as a recent transaction expected to raise approximately $2 million.

What recent partnerships has Kazia formed?

Kazia has signed a non-binding Letter of Intent to develop and commercialize paxalisib for non-oncology indications like epilepsy.

What are the latest clinical trial developments for EVT801?

EVT801 is currently in Phase I clinical trials targeting advanced solid tumors. Preliminary data has shown favorable immune activity and tumor stabilization.

How does Kazia ensure compliance with Nasdaq’s listing requirements?

Kazia actively monitors its stock performance and considers all available options, including potential changes in ADS to ordinary share ratios, to meet Nasdaq’s Minimum Bid Price Requirement.

What is the significance of Kazia’s licensing agreement with Sovargen Co., Ltd?

The agreement allows Sovargen to develop, manufacture, and commercialize paxalisib for treating epilepsy associated with focal cortical dysplasia type 2 and tuberous sclerosis complex, expanding paxalisib’s potential beyond oncology.

Where can I find more information about Kazia Therapeutics?

For more information, visit Kazia's official website at www.kaziatherapeutics.com or follow them on Twitter @KaziaTx.

Kazia Therapeutics Limited American Depositary Shares

Nasdaq:KZIA

KZIA Rankings

KZIA Stock Data

12.98M
4.35M
7.06%
0.56%
Biotechnology
Pharmaceutical Preparations
Link
United States of America
NEW SOUTH WALES 2113