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Inmune Bio Inc - INMB STOCK NEWS

Welcome to our dedicated page for Inmune Bio news (Ticker: INMB), a resource for investors and traders seeking the latest updates and insights on Inmune Bio stock.

Overview of INmune Bio Inc

INmune Bio Inc (NASDAQ: INMB) is a clinical-stage biotechnology company specializing in the development of novel immunotherapies. With a unique commitment to harnessing the patient’s innate immune system, the company’s approach is grounded in precision medicine and innovative biological mechanisms. By targeting key drivers of immune dysfunction, INmune Bio aims to address complex and life-threatening conditions in oncology, neurodegenerative diseases, and chronic inflammation.

Core Business and Value Proposition

At its core, INmune Bio concentrates on reprogramming the body’s natural defense mechanisms to combat disease. The company operates two major product platforms, each designed to tackle distinct pathological processes:

  • The Dominant-Negative TNF (DN-TNF) Platform: This platform utilizes dominant-negative technology to selectively neutralize soluble tumor necrosis factor (sTNF) without interfering with trans-membrane TNF or TNF receptors. This selective inhibition aims to alleviate chronic inflammation and restore normal immune function. Product candidates within this platform are being assessed in clinical trials for conditions such as cancer, early Alzheimer’s disease, and treatment-resistant psychiatric disorders.
  • The Natural Killer (NK) Cell Priming Platform: INKmune, the flagship product of this platform, employs a pharmaceutical-grade, replication-incompetent human tumor cell line to prime resting NK cells into tumor killing memory-like NK cells. This therapy is designed to eliminate residual malignant cells by enhancing the cytotoxic function of NK cells, particularly in a hostile tumor microenvironment where conventional therapies may fall short.

Scientific Foundations and Mechanism of Action

INmune Bio’s approach is deeply rooted in immunology and cellular biology. By targeting the innate immune system, the company seeks to modulate critical pathways that drive chronic disease. The DN-TNF platform focuses on the inflammatory cascade by reducing soluble TNF levels, which may contribute to neuroinflammation and cancer progression. In parallel, the INKmune platform provides multi-channel activation signals to NK cells, thereby converting them into potent, long-lived effectors capable of recognizing and eliminating a broad spectrum of tumors.

Clinical Development and Pipeline

The company’s pipeline is robust and comprehensive, with multiple product candidates under clinical evaluation. The development strategy emphasizes the use of precision medicine techniques tailored to patient-specific biomarkers. Candidates such as INKmune, XPro™, and INB03 are undergoing various stages of clinical trials in diseases ranging from metastatic cancers to early Alzheimer’s disease. Each clinical program is designed to validate the therapeutic potential through a mechanism of action that addresses the underlying pathology at a cellular level.

Market Position and Competitive Landscape

Despite operating in a field characterized by intense competition and rapid scientific advances, INmune Bio differentiates itself with its dual-platform approach and commitment to leveraging both innate immune modulation and precision medicine. While many biotechnology companies focus on a single therapeutic area or mechanism, INmune Bio’s diversified pipeline offers a multi-pronged strategy to tackle residual and treatment-resistant disease. This positioning is integral to its strategy to fill gaps in current treatment paradigms.

Precision Medicine and Patient-Centric Approach

INmune Bio’s research and development are anchored in the principles of precision medicine. By identifying patients with specific biomarkers indicative of immune dysfunction, the company aims to tailor its therapies for maximal efficacy. This patient-centric focus is supported by rigorous clinical trial designs that yield detailed insights into immunologic responses, enhancing the overall therapeutic index of its investigational products.

Clinical Trial Design and Regulatory Environment

The company’s clinical trials are structured to meet high standards of scientific rigor and regulatory compliance. With trial methodologies that integrate novel endpoints and advanced biomarker assessments, every study is designed to generate reproducible and meaningful data. Although all clinical data are subject to the uncertainties inherent in early-stage research, INmune Bio’s protocols underscore its commitment to safety and efficacy without resorting to time-sensitive claims.

Scientific Collaboration and Expertise

INmune Bio benefits from close collaborations with academic institutions, leading clinical researchers, and renowned experts in neuropsychology and immunology. These partnerships reinforce the company’s technical expertise and provide a foundation for its complex therapeutic strategies. The cross-disciplinary collaboration helps ensure that each investigational product is backed by robust preclinical data and a thorough understanding of the underlying disease mechanisms.

Conclusion

In summary, INmune Bio Inc represents a sophisticated and methodical approach to addressing unmet medical needs through innovative immunotherapy solutions. By leveraging two distinct but complementary product platforms, the company works at the intersection of oncology, immunology, and neuroscience. Its rigorous clinical trial programs, focus on precision medicine, and deep-rooted scientific expertise have positioned it as an important player in the evolving landscape of clinical-stage biotechnology. The comprehensive strategy adopted by INmune Bio is a testament to its mission to harness the innate immune system to fight disease in a targeted, efficient, and ultimately patient-friendly manner.

Rhea-AI Summary
INmune Bio, Inc. (NASDAQ: INMB) dosed the first patient in the Phase I/II trial for INKmune™, a biologic therapy for metastatic castration-resistant prostate cancer (mCRPC), on December 27, 2023. The therapy aims to harness the patient’s innate immune system to fight disease, with promising potential in targeting NK cells abundant in the tumor microenvironment. Professor Matt Rettig, a leading expert, expressed optimism in this novel strategy.
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INmune Bio Inc. (NASDAQ: INMB) is accelerating enrollment in its Phase II study using XProTM to treat patients with Alzheimer’s Disease with neuroinflammation outside the US, maintaining its timeline for the trial. However, the Phase II study remains on clinical hold in the US pending additional information on long-term stability, with the Company expecting to provide the necessary data before the end of 2023. The Company is on track to complete enrollment of its Phase II clinical trial in patients with early Alzheimer’s Disease and biomarkers of inflammation in 2024. The trial is open in Australia, Canada, the United Kingdom, Poland, France, Spain, and is expected to open soon in several additional EU countries.
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INmune Bio, Inc. (NASDAQ: INMB) presents data on the use of INB03, a dominant-negative TNF inhibitor, to improve the potency of trastuzumab deruxtecan (T-DXd, ENHERTU®) in the treatment of high-risk MUC4 expressing HER2 positive breast cancer. The work demonstrates that INB03 decreases resistance to T-DXd therapy in three ways, suggesting that it may allow for lower doses of T-DXd to be effective in women with MUC4 expressing HER2+ breast cancer and improve the response to T-DXd in women with resistant HER2+ disease.
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INmune Bio, Inc. (INMB) has received authorization from the European Medicines Agency (EMA) to initiate a Phase II trial in Early Alzheimer’s Disease (AD) with XPro™. The trial is currently enrolling patients in Australia, Canada, the United Kingdom, France, and Spain. The Phase II clinical trial is a global, multi-center, randomized clinical study in patients diagnosed with early Alzheimer's disease who have biomarkers of elevated inflammation. In a prior Phase I open-label trial, INmune Bio met all primary and secondary endpoints. Patients with AD who received XPro™ demonstrated notable decreases in neuroinflammation, enhanced axonal integrity, and improved synaptic function.
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INmune Bio, Inc. (NASDAQ: INMB) has received regulatory approval to extend its Phase II trial of XPro™ in individuals with early Alzheimer’s disease in Poland, with additional EU countries expected to open soon. The company also received a cash refund of approximately $2.8M USD pursuant to an Australian Research and Development Tax Incentive.
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INmune Bio Inc. announces Q3 2023 financial results and provides business update. Highlights include authorization to initiate a Phase II trial for XPro™ in Early Alzheimer's Disease, expansion of MRI biomarker data, and positive preclinical data for INB03. Net loss for Q3 2023 was $8.6 million. The company had cash and cash equivalents of $41.8 million as of September 30, 2023.
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INmune Bio, Inc. receives a favorable patentability opinion for its international patent application covering its proprietary cell line, INB16, and the therapeutic composition INKmune™. The application contains patentable subject matter and explores potential commercial applications in cancer research and treatment. The company plans to leverage the opinion to accelerate examination and patent issuance. INB16 is a tumor cell line that can prime natural killer (NK) cells to enhance their ability to fight cancer. The company has safely treated five patients with hematological cancers using INKmune™ and plans to initiate a US trial in metastatic castration-resistant prostate cancer.
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INmune Bio, Inc. is presenting data on the use of INB03, a dominant-negative inhibitor of soluble TNF, in the treatment of high-risk MUC4 expressing HER2+ breast cancer. INB03 is an innate immune checkpoint inhibitor working through the SIRPα-CD47 pathway to promote ADCP. The research shows that INB03 downregulates SIRPα expression to eliminate the 'don’t eat me signal' and promote ADCP.
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Cumulus Neuroscience presented data at the Clinical Trials on Alzheimer's Disease (CTAD) Annual Meeting, validating the utility of their Cumulus Neuroassessment Platform in clinical studies for patients with mild to moderate cognitive impairment. The data showed that the platform can be used by patients with Alzheimer's Disease over long periods of time, even at home. The findings also demonstrated that digital technologies have construct validity and can measure change in dementia-relevant cognitive functions. Cumulus aims to accelerate Alzheimer's clinical studies by capturing longitudinal electrophysiological correlates of the disease in decentralized trials.
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INmune Bio highlights important findings from data presented at the 16th annual Clinical Trial in Alzheimer’s Disease
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FAQ

What is the current stock price of Inmune Bio (INMB)?

The current stock price of Inmune Bio (INMB) is $7.59 as of April 1, 2025.

What is the market cap of Inmune Bio (INMB)?

The market cap of Inmune Bio (INMB) is approximately 172.5M.

What is the core focus of INmune Bio Inc?

INmune Bio Inc is focused on developing novel immunotherapies that harness the patient’s innate immune system to treat complex diseases such as cancer and neurodegenerative disorders.

How does the DN-TNF platform work?

The DN-TNF platform uses dominant-negative technology to selectively neutralize soluble TNF, a key driver of chronic inflammation and immune dysfunction, while leaving essential components of the immune response intact.

What is the mechanism behind INKmune™?

INKmune™ primes resting natural killer (NK) cells by delivering multiple activation signals, converting them into tumor killing memory-like cells capable of targeting residual malignant cells even within challenging tumor microenvironments.

What diseases are INmune Bio’s products targeting?

Their investigational products are being evaluated for a range of conditions including various cancers, early-stage Alzheimer’s disease, treatment-resistant depression, and chronic inflammatory disorders.

How does INmune Bio integrate precision medicine?

The company tailors its therapeutic strategies based on patient-specific biomarkers to identify those most likely to benefit, thereby enhancing the efficacy and safety of its investigational products.

What distinguishes INmune Bio from other biotech companies?

INmune Bio differentiates itself with its dual-platform approach that targets both the inflammatory pathways via the DN-TNF platform and the enhancement of innate immune response through NK cell priming.

Are INmune Bio’s therapies tumor agnostic?

Yes, particularly the INKmune™ therapy is designed to be tumor agnostic, meaning it can be utilized against a broad spectrum of NK-resistant tumors, including both hematologic and solid malignancies.

What is the regulatory status of their product candidates?

All product candidates, including those in the DN-TNF and NK cell priming platforms, are currently in various stages of clinical trials. Regulatory approvals have not yet been secured, and the research is ongoing.
Inmune Bio Inc

Nasdaq:INMB

INMB Rankings

INMB Stock Data

172.46M
16.49M
23.96%
23.87%
24.43%
Biotechnology
Biological Products, (no Disgnostic Substances)
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United States
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