Immunocore Holdings plc American Depositary Shares - IMCR STOCK NEWS

Immunocore has presented new data on KIMMTRAK (tebentafusp-tebn) for metastatic uveal melanoma at the SITC 2022 Annual Meeting. The analysis shows that gp100 protein expression remains unchanged relative to baseline during tumor progression. Notably, patients with progressive disease who maintain antigen processing machinery show longer overall survival. The study involved biopsies from 18 patients, highlighting a correlation between higher expression of antigen processing machinery components and better survival outcomes despite disease progression. KIMMTRAK aims to treat advanced melanoma effectively.

Immunocore Holdings Plc (Nasdaq: IMCR) will present at the Jefferies London Healthcare Conference on November 17, 2022, at 9:45 a.m. GMT. The presentation will be available via live webcast on Immunocore's website and a replay will follow temporarily. As a pioneering biotechnology company, Immunocore develops T cell receptor (TCR) bispecific immunotherapies targeting various diseases, including cancer. Their advanced treatment, KIMMTRAK, is approved for metastatic uveal melanoma in several key markets.

Immunocore reported Q3 2022 revenues of £36.3 million ($40.4 million) for KIMMTRAK, marking a 20% increase from Q2. The company's cash reserves stand at £347 million ($387 million). Clinical updates emphasize promising data from IMC-F106C targeting PRAME, highlighting its potential across tumor types. The company has expanded its prescribing accounts to 180 in the U.S. and received significant added benefit ratings in Germany. Additionally, Immunocore plans trials for tebentafusp in melanoma and other cancers, setting a positive outlook for continued growth.

Immunocore presented initial Phase 1 data for its off-the-shelf TCR therapy, IMC-F106C, targeting PRAME at the ESMO 2022 Congress. Results show that the therapy activates T cells and demonstrates durable RECIST responses and a reduction in circulating tumor DNA across various solid tumors. As of July 2022, 55 patients were treated, with manageable adverse events primarily involving Grade 1 cytokine release syndrome. Expansion arms are now enrolling for melanoma, ovarian, lung, and endometrial cancers.

Acacia Research Corporation (ACTG) reported a Q2 2022 revenue of $16.7 million, down from $17.4 million in Q2 2021. The company recorded $11.5 million in realized gains, including $5.2 million from its Life Science Portfolio. Acacia repurchased 6.1 million shares at an average price of $4.64 as part of a $40 million buyback program. Additionally, the company repaid $50 million in debt. However, there was a substantial GAAP net loss of $61.5 million compared to a net income of $19.7 million last year.

Immunocore reported Q2 2022 revenues of £27.7 million ($33.7 million) from KIMMTRAK, with U.S. sales at £18.1 million and European sales at £5.9 million. The company transitioned over 50 patients to commercial supply in Germany and finalized a randomized Phase 2/3 trial protocol for tebentafusp in advanced melanoma. Cash equivalents stood at £208 million ($253 million) as of June 30, 2022, following a £117 million PIPE financing in July. KIMMTRAK is now approved in over 30 countries, marking significant growth for the company.

Immunocore Holdings plc (Nasdaq: IMCR) will announce its Second Quarter 2022 Earnings on August 10, 2022, prior to market opening. Following this, the company will host a live teleconference and webcast at 8:00 a.m. EDT. The company focuses on developing T cell receptor bispecific immunotherapies for various diseases, including cancer. Its leading oncology drug, KIMMTRAK, is FDA-approved for treating unresectable or metastatic uveal melanoma, showing significant survival benefits in clinical trials.

Immunocore has announced an upcoming oral presentation of initial data from its Phase 1 study of IMC-F106C, a bispecific T cell receptor candidate targeting PRAME, at the ESMO Congress 2022. The presentation is scheduled for September 9, 2022, at 4:50 PM CEST, along with four additional poster presentations on September 10. This study represents a significant milestone in Immunocore's development of ImmTAC therapies for solid tumors, showcasing their innovative approach to cancer treatment.

Immunocore announced a $140 million private placement financing, agreeing to sell 3,733,333 shares, including 2,000,000 American Depository Shares at $37.50 each. The financing, with participation from existing investors like RTW Investments and General Atlantic, aims to fund clinical developments for oncology and infectious diseases.

Proceeds will support the advancement of tebentafusp in advanced cutaneous melanoma among other candidate programs and working capital through 2025.