Illumina advances NovaSeq X Series, delivering single-flow-cell system, software upgrade, and new kits to enable multiomic applications

Rhea-AI Summary

Illumina (NASDAQ: ILMN) has announced significant updates to its NovaSeq X Series, including a new single-flow-cell system, software upgrade v1.3, and new 25B kits. The single-flow-cell system offers the same quality and speed as the NovaSeq X Plus at a more accessible cost for lower-volume labs. The v1.3 software upgrade enhances sequencing performance with improved accuracy and higher yields.

The company began shipping new NovaSeq X 25B 100-cycle and 200-cycle kits in December, optimized for counting applications and assays at scale. Additionally, Illumina launched Single-Cell Prep (formerly Fluent PipSeq V), compatible with NextSeq 1000/2000, NovaSeq 6000, and NovaSeq X platforms. This technology enables scalable experiments from hundreds to millions of cells, offering lower equipment and per-cell costs.

Positive

• Introduction of more affordable single-flow-cell system for lower-volume labs
• Software v1.3 upgrade improves sequencing accuracy and yields
• New 25B kits enable cost-effective runs with shorter turnaround times
• Launch of Single-Cell Prep technology with broad platform compatibility

Negative

• None.

Insights

Biotech Product Analyst

The NovaSeq X Series upgrades represent a strategic product evolution that expands Illumina's market reach and strengthens its competitive position. The single-flow-cell system addresses a important market gap by making high-throughput sequencing accessible to lower-volume labs, potentially unlocking a new customer segment. The new 25B kits and software v1.3 upgrade significantly enhance the platform's capabilities, particularly for multiomics applications.

Technical improvements in v1.3, including reduced PhiX dependency and improved sequencing accuracy, translate to higher operational efficiency and cost savings for labs. The validation from prestigious institutions like Génome Québec and Broad Clinical Labs adds credibility to these enhancements. The compatibility with Illumina Single-Cell Prep positions the company strongly in the growing single-cell analysis market.

Market Research Analyst

This product enhancement strengthens Illumina's market leadership in DNA sequencing. The single-flow-cell system's introduction is particularly strategic as it could expand the addressable market by capturing mid-sized laboratories that previously found the dual-flow-cell system oversized for their needs. The software upgrade and new kits demonstrate Illumina's commitment to continuous innovation and customer-centric development.

The integration of Fluent's technology (now Illumina Single-Cell Prep) shows successful post-acquisition product integration, potentially driving additional revenue streams through the single-cell analysis market, estimated to grow significantly. The expanded capabilities could help defend against emerging competitors in the sequencing space while maintaining premium pricing power.

Financial Analyst

These developments should positively impact Illumina's financial performance through multiple channels. The single-flow-cell system could drive market expansion and new customer acquisition, while software upgrades and new kits should boost consumables revenue from existing customers. The enhanced efficiency and reduced PhiX dependency could improve margins for both Illumina and its customers.

The strategic timing of these releases, coinciding with the start of 2025, positions Illumina well for potential revenue growth in the coming quarters. The expansion into single-cell analysis with integrated workflows represents a valuable upsell opportunity and could drive higher consumables utilization rates across the installed base.

Software upgrade advances complete workflow solutions

New NovaSeq X 25B 100-cycle and 200-cycle kits enhance multiomic capabilities on NovaSeq X, and enable newly released Illumina Single-Cell Prep

SAN DIEGO, Jan. 7, 2025 /PRNewswire/ -- Illumina, Inc. (NASDAQ: ILMN), a global leader in DNA sequencing and array-based technologies, today announced a series of updates to its NovaSeq X Series, delivering the NovaSeq X single-flow-cell system alongside a cutting-edge software upgrade and new kits.

Now in the market for the first time, the single-flow-cell NovaSeq X Sequencing System offers the same high-quality flow cells and speed as the NovaSeq X Plus Sequencing System—Illumina's most rapidly adopted and utilized high-throughput sequencing platform to date—at a more accessible cost for labs with lower volume. The sequencers began shipping in December, and simultaneously the company introduced the software v1.3 upgrade for the NovaSeq X Series to elevate sequencing performance and advance data quality. Additionally, new NovaSeq X 25B 100- and 200-cycle kits began shipping in December, which will be key enablers of multiomic applications, including the Illumina Single-Cell 3' RNA Prep (Illumina Single Cell Prep), now available under Illumina's brand following the company's acquisition of Fluent.

"This is the same instrument the scientific community has come to rely on for next-generation sequencing, now with upgraded software, new kits, and the option for a lower volume," said Steve Barnard, PhD, chief technology officer of Illumina. "Based on customer input, we've invested heavily in innovations to make the platform even stronger and more versatile, supporting total workflows with flexible applications spanning genomics and multiomics. Customers are already raving about the powerful capabilities of the software upgrade."

Customers affirm the value of the software upgrade 

The newly launched software upgrade delivers key enhancements that optimize sequencing workflows. Version 1.3 provides laboratories with improved sequencing accuracy and higher yields to ensure dependable and precise results, even with challenging, low-diversity samples. The reduction in PhiX dependency also means more usable data per run, helping researchers maximize their throughput and their confidence in their sequencing outputs. 

Génome Québec is a nonprofit organization that provides genomic services for researchers in the academic and industrial fields of 45 countries. In their experience testing the v1.3 software they noted a significant leap in data quality across a broad variety of library types. Geneviève DonPierre, team leader of NGS Sequencing at Génome Québec, stated, "The increased yield, enhanced sequencing accuracy, reduced PhiX dependency, and optimized handling of low-diversity libraries have transformed our operations. This update ensures consistently reliable outputs and empowers us to achieve superior results, reinforcing our confidence in every sequencing run." 

Broad Clinical Labs also participated in early-access testing. The organization's director of Laboratory Operations, Tom Howd, said: "We have observed significant high-quality data yield increases in early testing of the version 1.3 update on our NovaSeq X Plus fleet. We are eager to make these yield increases available to all our users to continue to advance their science."

Bert Groet, laboratory specialist clinical genetics and team leader of the NGS core facility at University Medical Center Utrecht, affirms: "With the release of software version 1.3 on the NovaSeq X Plus, Illumina brings to our genome lab a decisive development to transition from whole-exome-based to whole-genome-based analysis. The significant increase in total sequencing yield, without compromise to high Q30 scores, ensures the promise of high throughput and high-quality whole-genome sequencing we can rely on to deliver answers to those we will be serving."

Expanding capabilities with the 25B 100-cycle and 200-cycle kits

The new 25B 100-cycle and 200-cycle kits for the NovaSeq X Series, which began shipping in December, are optimized for counting applications and other assays at scale, offering shorter turnaround times and more cost-effective runs. By providing flexibility in run sizes and cycle counts, the 25B kits address the evolving needs of clinical specialty labs, academic core labs, and service providers.

Illumina Single-Cell Prep

Also announced today, Illumina Single-Cell Prep, formerly Fluent PipSeq V, is now available and shipping to customers with broad compatibility across Illumina's NGS platform portfolio, including NextSeq 1000/2000, NovaSeq 6000, and NovaSeq X. The single-cell sample prep technology removes many of the barriers and limitations of current methods, enabling scalability of experiments from hundreds to millions of cells with the same process and turnaround time. Low equipment cost, lower cost per cell, and high sensitivity allow for customers who are new to single-cell sequencing to adopt the technology quickly and easily, with exceptional performance while providing cost-efficient scaling to large numbers of cells for analysis that is possible only on the NovaSeq X 25B flow cell.

At the annual meeting of the American Society of Human Genetics in November, Shane Liddelow, PhD, associate professor in the Department of Neuroscience and Physiology at NYU Grossman School of Medicine, presented early access data and insights on the innovative technology enabling the sequencing of challenging cell types, such as astrocytes and brain tissue, which are notoriously difficult to analyze with microfluidic devices due to issues like clogging and other technical barriers.

The new 25B kits for the NovaSeq X Series are compatible with Illumina Single-Cell Prep, introducing highly efficient, affordable, and accurate workflows for large scale, single-cell analysis projects. Illumina Single-Cell Prep provides streamlined bioinformatics workflows from NovaSeq X Series sequencers streaming data directly into automated DRAGEN analysis in Illumina's informatics cloud solutions. Partek Flow enables comprehensive visualization and interpretation of large-scale Illumina Single-Cell Prep data sets for differential expression and biomarker discovery.

Use of forward-looking statements

This release may contain forward-looking statements that involve risks and uncertainties. Among the important factors to which our business is subject that could cause actual results to differ materially from those in any forward-looking statements are: (i) challenges inherent in developing and launching new products and services, including modifying and scaling manufacturing operations, and reliance on third-party suppliers for critical components; (ii) our ability to manufacture robust instrumentation and consumables; and (iii) the acceptance by customers of our newly launched products, which may or may not meet our and their expectations, together with other factors detailed in our filings with the Securities and Exchange Commission, including our most recent filings on Forms 10-K and 10-Q, or in information disclosed in public conference calls, the date and time of which are released beforehand. We undertake no obligation, and do not intend, to update these forward-looking statements, to review or confirm analysts' expectations, or to provide interim reports or updates on the progress of the current quarter.

About Illumina

Illumina is improving human health by unlocking the power of the genome. Our focus on innovation has established us as a global leader in DNA sequencing and array-based technologies, serving customers in the research, clinical, and applied markets. Our products are used for applications in the life sciences, oncology, reproductive health, agriculture, and other emerging segments. To learn more, visit illumina.com and connect with us on X, Facebook, LinkedIn, Instagram, TikTok, and YouTube.

Contacts

Investors:
Salli Schwartz
858-291-6421
IR@illumina.com

Media:
Christine Douglass
PR@illumina.com

View original content to download multimedia:https://www.prnewswire.com/news-releases/illumina-advances-novaseq-x-series-delivering-single-flow-cell-system-software-upgrade-and-new-kits-to-enable-multiomic-applications-302344230.html

SOURCE Illumina, Inc.

FAQ

What new features does Illumina's NovaSeq X Series software v1.3 upgrade offer?

The v1.3 software upgrade provides improved sequencing accuracy, higher yields, reduced PhiX dependency, and optimized handling of low-diversity samples, resulting in more usable data per run.

How does ILMN's new single-flow-cell NovaSeq X system differ from NovaSeq X Plus?

The single-flow-cell system offers the same high-quality flow cells and speed as the NovaSeq X Plus, but at a more accessible cost for laboratories with lower volume requirements.

What are the benefits of Illumina's new 25B kits for NovaSeq X Series?

The 25B 100-cycle and 200-cycle kits are optimized for counting applications and assays at scale, offering shorter turnaround times and more cost-effective runs with flexible run sizes.

What capabilities does ILMN's Single-Cell Prep technology offer?

Single-Cell Prep enables scalable experiments from hundreds to millions of cells, featuring low equipment cost, lower cost per cell, high sensitivity, and compatibility across multiple Illumina platforms.