ImmunityBio, Inc. - IBRX STOCK NEWS

Amyris and ImmunityBio have finalized their joint venture to commercialize a next-generation COVID-19 vaccine. This collaboration aims to leverage their combined strengths in vaccine technology and manufacturing capabilities. They plan to begin human trials and seek regulatory approval to deliver the vaccine by 2022, targeting underserved areas affected by vaccine accessibility challenges. The partnership aims to provide robust immunity against COVID-19 variants and adapt to future viruses. Further updates on trial outcomes will be provided as they become available.

CytRx Corporation (OTCQB:CYTR) has highlighted recent clinical developments from ImmunityBio, Inc. (NASDAQ:IBRX) concerning the cancer treatment aldoxorubicin. ImmunityBio's QUILT 88 study has shown promising results in patients with metastatic pancreatic cancer, with 90% exceeding historical survival rates. Furthermore, CytRx has the potential for up to $343 million in milestone payments and royalties from its collaboration with ImmunityBio. Aldoxorubicin is also being evaluated for triple-negative breast cancer, head and neck cancer, and glioblastoma.

ImmunityBio has announced the initiation of Phase 3 enrollment for the SISONKE Universal Boost COVID T-Cell vaccine trial in previously vaccinated participants in South Africa. The company has also expanded its GMP manufacturing capacity for various vaccine platforms across the U.S., South Africa, and Botswana. Significant clinical developments include a planned data cutoff for bladder cancer trials in January 2022 and a BLA filing expected in Q1 2022. ImmunityBio raised $470 million in financing in 2021 to support its clinical trials and expand operations. Key milestones include progressing 13 Phase 2/3 trials and securing pivotal patents.

ImmunityBio has expanded its vaccine programs to include self-amplifying self-adjuvating RNA (SASA-RNA) and recombinant protein candidates. This comprehensive platform aims to provide broad, durable protection against SARS-CoV-2 variants. Key developments include the Phase 2 SISONKE Boost trial in South Africa and partnerships with Amyris and Baylor College to accelerate production. The next-generation vaccines are designed to be cost-effective for global distribution, particularly in low- and middle-income countries, with enhanced stability and storage requirements.

CytRx Corporation (OTCQB:CYTR) reported its Q3 2021 results, ending on September 30 with approximately $16.5 million in cash and a net loss of $1.7 million, an improvement from a $2.8 million loss in Q3 2020. General and administrative expenses decreased to $1.5 million from $2.2 million year-over-year. The company paid $165,000 as part of a $10 million securities purchase agreement. CytRx continues to explore strategic partnerships for clinical testing while supporting ImmunityBio's Phase 2 pancreatic cancer trial and Orphazyme's regulatory pursuits regarding arimoclomol.

Amyris, Inc. (Nasdaq: AMRS) has formed a 50:50 joint venture with ImmunityBio, Inc. (Nasdaq: IBRX) to commercialize a next-generation COVID-19 vaccine. The binding term sheet has been signed, with a definitive agreement expected soon. ImmunityBio will handle vaccine manufacturing post-human trials in South Africa, while Amyris provides its RNA technology and sustainable squalene. The venture aims to deliver one billion doses in 2022, targeting vaccine access in developing countries and addressing supply chain challenges.

ImmunityBio, Inc. (NASDAQ: IBRX) announced that Dr. Patrick Soon-Shiong will present at the 2021 Jefferies London Healthcare Conference from November 16-18, 2021. His presentation on November 18 will focus on advancements in the company’s infectious disease and oncology programs. Attendees can access the on-demand webcast starting at 8:00 am GMT. ImmunityBio is advancing over 40 clinical trials, including their lead product Anktiva™ for bladder cancer, which has received FDA's Breakthrough Therapy designation.

ImmunityBio announced positive results from its Phase 2/3 trial of Anktiva (N-803) combined with BCG for treating BCG-unresponsive non-muscle invasive bladder cancer. Both cohorts met primary endpoints: 57% disease-free survival after 12 months in cohort B (papillary disease) and a 72% complete response rate in cohort A (carcinoma in situ). Importantly, the therapy had no severe adverse events. A key patent for Anktiva use in bladder cancer has been granted, extending coverage until 2035.

CytRx Corporation highlights the early efficacy of its licensed drug aldoxorubicin in ImmunityBio's Phase 2 trial for advanced pancreatic cancer. The trial shows that 90% of evaluable patients exceeded historical survival rates, with 87% of those with extremely advanced disease also surpassing these rates. Mature data is expected in Q1 2022, and ImmunityBio is expanding enrollment due to positive early results. CytRx has potential milestone payments of up to $343 million from ImmunityBio for aldoxorubicin.