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About Hikma Pharmaceuticals PLC

Hikma Pharmaceuticals PLC (symbol: HIK) is a multinational pharmaceutical company dedicated to improving global health by providing high-quality, accessible medicines. Headquartered in the United Kingdom, Hikma has established a robust presence across North America, the Middle East, North Africa (MENA), and Europe. With over 45 years of experience, the company leverages its expertise to develop, manufacture, and distribute a broad portfolio of branded and non-branded generic medicines. Hikma is recognized for its ability to transform cutting-edge science into practical solutions that address critical healthcare needs, making it a trusted partner for healthcare providers and governments worldwide.

Core Business Model

Hikma's business model revolves around the production and distribution of generic and branded pharmaceuticals. The company operates through three main divisions: Generics, Branded, and Injectables. Its Generics division focuses on producing cost-effective alternatives to brand-name drugs, ensuring affordability without compromising quality. The Branded division caters to specific regional markets, offering tailored solutions to meet local healthcare needs. The Injectables division specializes in critical care medicines, including sterile injectables used in hospitals and emergency settings. Revenue streams include direct product sales, licensing agreements, and partnerships with healthcare organizations and government entities.

Product Portfolio and Industry Impact

Hikma's diverse product portfolio addresses a wide range of therapeutic areas, including oncology, cardiovascular health, pain management, and infectious diseases. A notable highlight is its production of naloxone-based products, such as KLOXXADO® (naloxone HCl nasal spray 8 mg), which plays a pivotal role in combating the opioid overdose epidemic. By manufacturing both branded options like KLOXXADO® and generic injectable naloxone, Hikma ensures widespread access to life-saving treatments. The company also supports public health initiatives by donating hundreds of thousands of naloxone doses and partnering with government and non-profit organizations to expand awareness and training.

Global Market Presence

Hikma's operations span multiple continents, with a strong local presence in key markets. In North America, the company is a leading supplier of generic injectables and overdose reversal medicines. Its MENA operations benefit from deep regional insights, allowing it to cater to specific healthcare demands effectively. In Europe, Hikma continues to strengthen its footprint by offering high-quality generics and branded medicines. This global reach, combined with localized expertise, enables Hikma to address diverse healthcare challenges and maintain a competitive edge in the pharmaceutical industry.

Commitment to Quality and Innovation

Quality and innovation are central to Hikma's mission. The company adheres to stringent regulatory standards across its manufacturing facilities, ensuring the safety and efficacy of its products. Hikma's venture capital arm invests in innovative health technologies, furthering its commitment to advancing medical science. By fostering partnerships with industry leaders and leveraging state-of-the-art manufacturing capabilities, Hikma continues to deliver solutions that improve patient outcomes and enrich communities worldwide.

Competitive Landscape

In the competitive pharmaceutical industry, Hikma differentiates itself through its focus on high-quality generics, strategic partnerships, and proactive public health initiatives. Key competitors include Teva Pharmaceuticals, Mylan, and other multinational generic drug manufacturers. Hikma's emphasis on accessibility, combined with its ability to address urgent healthcare needs like opioid overdoses, positions it as a significant player in the global market.

Rhea-AI Summary

Hikma Pharmaceuticals has announced an exclusive six-year commercial partnership with Emergent BioSolutions for the sale of KLOXXADO® (naloxone HCl nasal spray 8 mg) in the U.S. and Canada. KLOXXADO® received FDA approval in April 2021 for emergency treatment of suspected opioid overdose in adults and pediatric patients.

Under the agreement, Emergent will incorporate KLOXXADO® into its naloxone product portfolio and handle all North American sales and marketing. Hikma will continue manufacturing the 8 mg naloxone HCl nasal spray at its Columbus, Ohio facility as the exclusive supplier to Emergent. The partnership combines Hikma's manufacturing capabilities with Emergent's established commercial expertise in naloxone nasal spray distribution.

Hikma will maintain production and marketing of its other naloxone products, including injectable vials and prefilled syringes, ensuring wide accessibility to healthcare providers and the public health community.

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Hikma Pharmaceuticals participated in a naloxone training event with U.S. Congressman Buddy Carter ahead of National Fentanyl Awareness and Prevention Day. The event, held at Groves High School in Savannah, Georgia, marks Hikma's milestone of donating over 600,000 doses of naloxone in the past three years. Hikma is working with government officials and the White House Office of National Drug Control Policy to expand access to naloxone, a vital tool for reversing overdoses.

Hikma manufactures multiple forms of naloxone, including generic injectable vials, prefilled syringes, and KLOXXADO® (naloxone 8mg) intranasal spray. The company's Hikma Community Health initiative partners with frontline organizations to expand naloxone access through donations, partnerships, and awareness programs. Hikma also provides a Co-Pay Assistance Program for KLOXXADO® to increase accessibility and reduce out-of-pocket costs.

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Hikma Pharmaceuticals PLC announces the shelf-life extension of KLOXXADO® (naloxone HCl) nasal spray 8mg from 24 to 36 months. This change applies to products manufactured from March 2024 onwards. KLOXXADO® contains twice the naloxone dose of Narcan® Nasal Spray 4mg, offering a important treatment option for opioid overdose reversal.

The extended shelf-life is particularly beneficial for frontline responders and individuals carrying KLOXXADO® for emergency use. This development comes as organizations like the CDC and American Medical Association note that higher doses of naloxone may be necessary to counteract poisoning from illicit fentanyl and other synthetic opioids. Hikma emphasizes its role in combating the opioid crisis, especially as International Overdose Awareness Day approaches on August 31st.

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Hikma Pharmaceuticals collaborates with the Office of National Drug Control Policy to combat the opioid overdose epidemic in the US, focusing on expanding access to naloxone. The company welcomed Dr. Rahul Gupta to its Columbus facility for discussions and a tour regarding the production of overdose reversal medicine.
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Hikma Pharmaceuticals PLC announces the launch of COMBOGESIC IV, an opioid-free pain relief medicine in the US. The medicine is a combination of acetaminophen and ibuprofen approved by the US FDA for adult pain management. It provides superior analgesia efficacy and shorter onset to analgesia compared to individual drugs. The Phase 3 clinical trial showed more than double pain relief compared to individual drugs, making it a promising alternative for hospitals and healthcare providers.
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Activ Surgical completes its first international surgery at Abdali Hospital in Jordan using its ActivSight technology, which provides enhanced visualization and real-time surgical insights. Dr. Mohamad Rassoul Abu-Nuwar, trained at the Esophageal Institute - West Penn Hospital, performed a surgical bariatric revision procedure using ActivPerfusion Mode. Hikma Ventures, a lead investor, supports the global expansion of ActivSight.
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Guardant Health, Inc. (Nasdaq: GH) and Hikma Pharmaceuticals PLC announced a partnership to promote Guardant Health’s cancer screening and monitoring tests in the Middle East and North Africa. The agreement aims to improve access to next-generation sequencing tests in the region, where cancer cases are estimated to double by 2040.
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Guardant Health, a leading precision oncology company (Nasdaq: GH), partners with Hikma Pharmaceuticals PLC to promote its cancer screening and tumor mutation profiling tests in the Middle East and North Africa. The agreement provides Hikma with exclusive rights to commercialize Guardant Health's products in the majority of countries in the MENA region. This partnership aims to improve access to next-generation sequencing tests in a region where cancer cases are estimated to double by 2040.
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Hikma Pharmaceuticals announces donation of over 375,000 doses of KLOXXADO® to combat opioid overdose epidemic
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Hikma Pharmaceuticals announced a $15 million investment from its venture capital arm, Hikma Ventures, in Activ Surgical, enhancing the Series B financing to a total of $60 million. Activ Surgical is developing AI-driven surgical technologies aimed at improving surgical outcomes. The ActivSight imaging module, which enhances visualization during surgery, has received FDA clearance and is set for broader availability in 2022. This investment will facilitate Activ Surgical's global launch, empowering surgeons with advanced decision-making tools and improving patient safety.

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FAQ

What does Hikma Pharmaceuticals do?

Hikma Pharmaceuticals develops, manufactures, and distributes branded and generic medicines across multiple therapeutic areas, including injectables and overdose reversal treatments.

What markets does Hikma serve?

Hikma operates globally, with a strong presence in North America, the Middle East, North Africa (MENA), and Europe.

What is KLOXXADO®?

KLOXXADO® is a naloxone HCl nasal spray (8 mg) produced by Hikma, used for the emergency treatment of opioid overdoses.

How does Hikma generate revenue?

Hikma generates revenue through the sale of branded and generic medicines, licensing agreements, and partnerships with healthcare organizations.

What makes Hikma different from its competitors?

Hikma stands out for its focus on high-quality generics, public health initiatives, and its role in addressing urgent healthcare needs like opioid overdose treatments.

What therapeutic areas does Hikma focus on?

Hikma's portfolio includes treatments for oncology, cardiovascular health, pain management, infectious diseases, and emergency care.

Where are Hikma's manufacturing facilities located?

Hikma operates manufacturing facilities in the United States, Europe, and the MENA region, adhering to stringent quality standards.

What partnerships does Hikma engage in?

Hikma collaborates with government agencies, healthcare providers, and non-profits to expand access to essential medicines and address public health crises.
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