Welcome to our dedicated page for Hepion Pharmaceuticals news (Ticker: HEPA), a resource for investors and traders seeking the latest updates and insights on Hepion Pharmaceuticals stock.
Hepion Pharmaceuticals, Inc. (NASDAQ: HEPA) is a biopharmaceutical company headquartered in Edison, New Jersey. Founded in 2013, the company focuses on developing advanced drug therapies for chronic liver diseases. Hepion's core mission is to enhance treatment options for liver conditions such as non-alcoholic steatohepatitis (NASH), viral hepatitis, and hepatocellular carcinoma (HCC).
The company's flagship product is Rencofilstat, a pan-cyclophilin inhibitor designed to target multiple pathological pathways involved in liver disease progression. This pleiotropic drug therapy has shown promising results in preclinical and clinical trials, including recently completed Phase I trials. Rencofilstat is currently being studied for its potential to address complex liver pathologies, including fibrosis and cancerous conditions associated with NASH and hepatitis.
Another significant development from Hepion is Tenofovir Exalidex, a lipid acyclic nucleoside phosphonate intended to deliver high intracellular concentrations of tenofovir diphosphate, an active antiviral agent. This drug aims to offer more effective treatment options for Hepatitis B patients.
Hepion Pharmaceuticals has also made headlines with its adoption of artificial intelligence (AI)-driven drug development, focusing on precision medicine for chronic diseases. Recent research has revealed that Rencofilstat may exert anti-cancer activity through mechanisms such as altering DNA accessibility, silencing oncogenes, and activating tumor suppressor genes.
The company was formerly known as ContraVir Pharmaceuticals, Inc. before rebranding to Hepion Pharmaceuticals in July 2019 to better align with its focus on liver disease therapies. With a commitment to cutting-edge research and development, Hepion Pharmaceuticals continues to advance its clinical programs and partnerships, offering hope to patients suffering from debilitating liver diseases.
Hepion Pharmaceuticals (NASDAQ:HEPA) will present virtual findings at The Liver Meeting Digital Experience 2020, hosted by the American Association for the Study of Liver Diseases, from November 13-16, 2020. The presentation will focus on the lead drug candidate CRV431, which demonstrated superior antifibrotic efficacy against liver fibrosis compared to other NASH drug candidates in an expanded study by FibroFind. Dr. Daren Ure, Chief Scientific Officer, highlighted CRV431’s unique mechanism targeting fibrotic scar formation. The session will occur on November 13, covering various aspects of NASH treatment.
Hepion Pharmaceuticals (NASDAQ:HEPA) announced the enrollment of the last patient in the 75 mg CRV431 cohort of its Phase 2a 'AMBITION' clinical trial, focused on non-alcoholic steatohepatitis (NASH). This milestone is crucial for assessing CRV431's safety, tolerability, and early efficacy indicators. The trial will involve 18 F2 and F3 NASH patients over 28 days. Data collected will utilize Hepion's AI-POWR platform for further analysis. Anticipated results from this cohort are expected by the end of 2020, highlighting Hepion's commitment to addressing the significant healthcare burden posed by NASH.
Hepion Pharmaceuticals (NASDAQ:HEPA) announced its participation in two virtual conferences focusing on therapeutic approaches for COVID-19 and liver diseases. On October 28, 2020, Dr. Robert Foster will present CRV431, a drug candidate with demonstrated anti-viral activity against SARS-CoV-2, during the Roth Capital Healthcare event. The following day, Hepion will discuss CRV431’s potential for treating non-alcoholic steatohepatitis (NASH) at the B. Riley Securities event. Hepion aims to highlight CRV431's broad therapeutic potential, including anti-fibrotic and anti-inflammatory effects.
Hepion Pharmaceuticals (NASDAQ:HEPA) has announced the launch of AI-POWR™, a proprietary AI and machine learning platform aimed at improving drug development for non-alcoholic steatohepatitis (NASH). AI-POWR™ utilizes a multi-omics approach to enhance patient selection and optimize clinical trial outcomes for Hepion's lead drug candidate, CRV431, which is currently in a Phase 2a trial. The initiative is expected to reduce costs and development timelines while enhancing the likelihood of clinical success.
Hepion Pharmaceuticals (NASDAQ:HEPA) announced that CEO Dr. Robert Foster will present virtually at the H.C. Wainwright 4th Annual NASH Conference on October 5, 2020, at 4:00 p.m. E.T. The presentation will be accessible live and archived on the company’s website under the 'Events' section. Hepion focuses on developing therapies for liver diseases, particularly non-alcoholic steatohepatitis (NASH). Its lead candidate, CRV431, targets liver fibrosis and exhibits antiviral properties, showcasing potential in treating various liver diseases.
Hepion Pharmaceuticals (NASDAQ:HEPA) announced positive findings from a study by the National Institute of Allergy and Infectious Diseases (NIAID), showing that its drug candidate CRV431 exhibits significant antiviral activity against SARS-CoV-2. The study found CRV431 inhibited viral production with an IC90 of 1.5 μM, nearly five times more potent than a control compound. No significant cellular toxicity was observed. Hepion aims to advance CRV431 through further studies while maintaining focus on its current phase 2a program for NASH.
Hepion Pharmaceuticals announced the completion of CRV431 dosing in all subjects for its Phase 1b multiple ascending dose study. This study aimed to evaluate the safety, tolerability, and pharmacokinetics of CRV431, with doses ranging from 75 mg to 375 mg administered to healthy volunteers. The drug was well tolerated at all levels. Hepion is advancing to its Phase 2a AMBITION trial, expecting to complete the 75 mg dosing by the end of 2020. The study's outcomes are vital for further drug development targeting liver diseases like NASH.
Hepion Pharmaceuticals (NASDAQ:HEPA) announced it will present a poster on CRV431's antifibrotic activity at the Digital International Liver Congress™ 2020 from August 27-29. Dr. Joseph Kuo will discuss a preclinical study highlighting CRV431's ability to reduce hepatic fibrosis and weight gain in a NASH mouse model. The presentation is scheduled for August 28, 2020, under poster number FRI-239. Hepion aims to develop targeted therapies for liver diseases, with CRV431 showing promise in reducing fibrosis and hepatocellular carcinoma tumor burden.
Hepion Pharmaceuticals announced a study published in PLOS ONE demonstrating that its lead drug candidate, CRV431, effectively inhibits hepatitis C virus (HCV) infection in a humanized liver mouse model. The study showed that CRV431 administration resulted in complete suppression of HCV replication with no viral rebound observed five months post-treatment. The findings highlight CRV431's potential utility against various viral infections, including COVID-19. Hepion is advancing CRV431 through a Phase 2a clinical trial for NASH.
Hepion Pharmaceuticals announced that a peer-reviewed study published in PLOS ONE demonstrated that CRV431, its leading drug candidate, effectively inhibited hepatitis C virus (HCV) infection in a humanized liver mouse model with no observed viral rebound after five months. This study supports CRV431's antiviral potential and adds to existing data indicating its efficacy against multiple viral infections, including hepatitis B and HIV. The drug is currently in a Phase 2a clinical trial for treating liver disease due to NASH.
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