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GRI Bio, Inc. (symbol: GRI) is a pioneering clinical-stage biotech company dedicated to fundamentally transforming the treatment of inflammatory diseases. Specializing in the innovative development of therapies targeting dysregulated immune responses, GRI Bio focuses on inflammatory, fibrotic, and autoimmune disorders.
The company's core technology revolves around Natural Killer T (NKT) cell-based therapies. NKT cells are unique as they possess characteristics of both NK and T cells, serving as a critical bridge between innate and adaptive immune responses. Notably, Type 1 NKT cells are instrumental in initiating and propagating inflammatory responses and mediate the hepatic injury observed in liver diseases.
GRI Bio's lead program, GRI-0621, is an orally administered small molecule that acts as an inhibitor of Type 1 NKT cells. This groundbreaking therapy is being developed for the treatment of acute liver failure, aiming to curb hepatic inflammation by restoring immune system balance. Additionally, GRI-0621 serves as a RAR-beta and gamma dual agonist, further enhancing its therapeutic potential.
In addition to GRI-0621, the company boasts other promising candidates including GRI-0803, a novel oral agonist targeting Type 2 NKT cells. This candidate holds significant promise as a potential treatment for autoimmune disorders, further broadening GRI Bio's therapeutic arsenal.
GRI Bio's dedication to innovation and commitment to addressing unmet medical needs position it as a significant player in the biotech industry. With ongoing advancements and a robust pipeline, GRI Bio continues to drive forward in its mission to improve patient outcomes through cutting-edge science and targeted therapies.
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