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GRAIL Reports Third Quarter 2024 Financial Results

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GRAIL (GRAL) reported Q3 2024 financial results with total revenue of $28.7 million, up 38% year-over-year. Galleri revenue grew 52% to $25.4 million, with over 250,000 tests sold since launch. The company posted a net loss of $(125.7) million, including $34.6 million in amortization and $19.0 million in restructuring charges. Gross loss was $(22.2) million, while adjusted gross profit reached $11.8 million. The company maintains a strong cash position of $853.6 million, providing runway into 2028.

GRAIL (GRAL) ha riportato i risultati finanziari del terzo trimestre 2024 con un fatturato totale di 28,7 milioni di dollari, in aumento del 38% rispetto all'anno precedente. Il fatturato di Galleri è cresciuto del 52% arrivando a 25,4 milioni di dollari, con oltre 250.000 test venduti dalla sua introduzione. L'azienda ha registrato una perdita netta di (125,7) milioni di dollari, inclusi 34,6 milioni di dollari in ammortamenti e 19,0 milioni di dollari in oneri di ristrutturazione. La perdita lorda è stata di (22,2) milioni di dollari, mentre l'utile lordo rettificato ha raggiunto 11,8 milioni di dollari. L'azienda mantiene una solida posizione di liquidità con 853,6 milioni di dollari, garantendo così una copertura fino al 2028.

GRAIL (GRAL) reportó resultados financieros del tercer trimestre de 2024 con ingresos totales de 28,7 millones de dólares, un aumento del 38% en comparación con el año anterior. Los ingresos de Galleri crecieron un 52% alcanzando 25,4 millones de dólares, con más de 250,000 pruebas vendidas desde su lanzamiento. La compañía reportó una pérdida neta de (125,7) millones de dólares, incluidos 34,6 millones de dólares en amortización y 19,0 millones de dólares en cargos de reestructuración. La pérdida bruta fue de (22,2) millones de dólares, mientras que el ingreso bruto ajustado alcanzó 11,8 millones de dólares. La compañía mantiene una sólida posición de efectivo de 853,6 millones de dólares, asegurando una solvencia hasta 2028.

GRAIL (GRAL)은 2024년 3분기 재무 실적을 발표하며 총 수익이 2,870만 달러로 전년 대비 38% 증가했다고 밝혔습니다. Galleri의 수익은 52% 증가하여 2,540만 달러에 도달하였으며, 출시 이후 250,000건 이상의 테스트가 판매되었습니다. 회사는 (1억 2,570만) 달러의 순손실을 기록했으며, 여기에는 3,460만 달러의 감가상각과 1,900만 달러의 구조조정 비용이 포함되어 있습니다. 총 손실은 (2,220만) 달러였으며, 조정된 총 이익은 1,180만 달러에 도달했습니다. 회사는 8억 5,360만 달러의 강력한 현금 보유액을 유지하고 있어 2028년까지 운영할 수 있는 여유를 확보하고 있습니다.

GRAIL (GRAL) a annoncé ses résultats financiers pour le troisième trimestre 2024 avec un chiffre d'affaires total de 28,7 millions de dollars, en hausse de 38 % par rapport à l'année précédente. Les revenus de Galleri ont augmenté de 52 % pour atteindre 25,4 millions de dollars, avec plus de 250 000 tests vendus depuis le lancement. La société a enregistré une perte nette de (125,7) millions de dollars, incluant 34,6 millions de dollars d'amortissement et 19,0 millions de dollars de charges de restructuration. La perte brute s'élevait à (22,2) millions de dollars, tandis que le bénéfice brut ajusté atteignait 11,8 millions de dollars. L'entreprise maintient une solide position de liquidités de 853,6 millions de dollars, garantissant une marge de manœuvre jusqu'en 2028.

GRAIL (GRAL) hat die Finanzzahlen für das dritte Quartal 2024 veröffentlicht, mit einem Gesamtumsatz von 28,7 Millionen Dollar, was einem Anstieg von 38% im Jahresvergleich entspricht. Der Umsatz von Galleri wuchs um 52% auf 25,4 Millionen Dollar, mit über 250.000 verkauften Tests seit dem Start. Das Unternehmen meldete einen Nettoverlust von (125,7) Millionen Dollar, einschließlich 34,6 Millionen Dollar an Abschreibungen und 19,0 Millionen Dollar an Umstrukturierungskosten. Der Bruttoverlust betrug (22,2) Millionen Dollar, während der bereinigte Bruttoertrag 11,8 Millionen Dollar erreichte. Das Unternehmen hält eine starke Liquiditätsposition von 853,6 Millionen Dollar, die bis 2028 reicht.

Positive
  • Revenue growth of 38% YoY to $28.7 million
  • Galleri revenue increased 52% YoY to $25.4 million
  • Strong cash position of $853.6 million providing runway into 2028
  • Net loss improved by 86% ($765.8 million) YoY
  • Adjusted EBITDA improved by 14% YoY
Negative
  • Net loss of $125.7 million in Q3
  • Gross loss of $22.2 million
  • Negative adjusted EBITDA of $108.2 million
  • Restructuring charge of $19.0 million

Insights

The Q3 results reveal a mixed financial picture for GRAIL. While $28.7M in total revenue shows strong 38% YoY growth and Galleri's $25.4M revenue demonstrates robust 52% growth, the company still faces significant losses. The net loss of $125.7M, though improved by 86% YoY, indicates ongoing commercialization challenges. The $853.6M cash position provides substantial runway into 2028, but the negative adjusted EBITDA of $108.2M suggests continued cash burn.

The milestone of 250,000 Galleri tests sold demonstrates market traction, but the gross loss of $22.2M highlights the need for operational efficiency improvements. The restructuring charge of $19.0M signals management's commitment to cost optimization, which is important for achieving profitability. The focus on FDA PMA submission and reimbursement strategies will be pivotal for long-term commercial viability.

The clinical validation data from the REFLECTION study shows promising results with a 42.9% positive predictive value in the VA cohort, significantly higher than many existing cancer screening methods. The preferential detection of aggressive prostate cancers, particularly high-grade cases requiring intervention, positions Galleri as a potentially valuable tool in cancer diagnostics.

The early-stage detection rate (stages I-III) in over half of identified cases is particularly significant, as earlier detection typically correlates with better treatment outcomes. However, the 1.3% signal detection rate warrants further investigation to understand the test's sensitivity across different population demographics. The ongoing registrational studies will be important for FDA approval and widespread clinical adoption.

Galleri Revenue Grew 52% Year-Over-Year to $25.4 Million

Commercial Galleri Sales Surpassed 250,000 Tests Since Launch

Cash Balance of $853.6 Million Provides Runway Into 2028

MENLO PARK, Calif., Nov. 12, 2024 /PRNewswire/ -- GRAIL, Inc. (Nasdaq: GRAL), a healthcare company whose mission is to detect cancer early when it can be cured, today reported business and financial results for the third quarter 2024.

Revenue in the third quarter was $28.7 million, representing 38% growth year over year, and revenue for Galleri was $25.4 million, representing 52% growth year over year. Net loss for the quarter was $(125.7) million, which includes amortization of Illumina acquisition-related intangible items of $34.6 million and a restructuring charge of $19.0 million. Gross loss was $(22.2) million. Non-GAAP adjusted gross profit was $11.8 million and non-GAAP adjusted EBITDA was $(108.2) million.1

"In our first operating quarter as a public company, GRAIL continued to deliver U.S. commercial growth, with more than 250,000 Galleri® tests sold as of September 30. Over the quarter, we reduced our expense base and continued to advance our mission," said Bob Ragusa, Chief Executive Officer at GRAIL. "We will continue to focus on cost management as we work towards completing our registrational studies to support our U.S. FDA PMA submission and pursuing broad reimbursement."

For the three months ended September 30, 2024, as compared to the three months ended October 1, 2023, GRAIL reported:

  • Revenue: Total revenue, comprised of screening and development services revenue, was $28.7 million, an increase of $7.9 million or 38%.
  • Net loss: Net loss was $125.7 million, an improvement of $765.8 million or 86%.
  • Gross loss: Gross loss was $(22.2) million, an improvement of $4.8 million or 18%.
  • Adjusted gross profit1: Adjusted gross profit was $11.8 million, an increase of $4.8 million or 68%.
  • Adjusted EBITDA1: Adjusted EBITDA was $(108.2) million, an improvement of $17.9 million or 14%.
  • Cash position: Cash and cash equivalents totaled $853.6 million as of September 30, 2024.

Recent business highlights include:

  • Published results of GRAIL's Galleri Multi-Cancer Early Detection Blood Test in prostate cancer in JCO Precision Oncology. The analysis of the study demonstrated that when Galleri detected prostate cancer, most were high-grade and clinically significant, and usually indicated an aggressive disease where additional diagnostic evaluation is necessary. These data, previously shared at AACR in March, build on earlier findings regarding Galleri's preferential detection of aggressive, deadly cancers.
  • Presented early results from REFLECTION real-world experience study of Galleri at the Early Detection of Cancer Conference in October. This initial analysis included data from seven US Department of Veterans Affairs (VA) sites with 180 days of post-test follow-up. The signal detection rate for the veteran cohort was 1.3% and the positive predictive value (PPV) of the test was 42.9%. More than half of the cases were identified at early stages (I-III).

Conference Call and Webcast
A webcast and conference call will be held today, November 12, 2024, at 1:30 p.m. PT / 4:30 p.m. ET. Individuals interested in listening to the conference call may access it on the investor relations section of GRAIL's website at investors.grail.com.

A replay of the webcast will be available on GRAIL's website for 30 days.





















1 See "Non-GAAP Disclosure" and the associated reconciliations for important information about our use of non-GAAP measures.

 

About GRAIL
GRAIL, Inc. is a healthcare company whose mission is to detect cancer early, when it can be cured. GRAIL is focused on alleviating the global burden of cancer by using the power of next-generation sequencing, population-scale clinical studies, and state-of-the-art machine learning, software, and automation to detect and identify multiple deadly cancer types in earlier stages. GRAIL's targeted methylation-based platform can support the continuum of care for screening and precision oncology, including multi-cancer early detection in symptomatic patients, risk stratification, minimal residual disease detection, biomarker subtyping, treatment and recurrence monitoring. GRAIL is headquartered in Menlo Park, CA with locations in Washington, D.C., North Carolina, and the United Kingdom. GRAIL's common stock is listed under the ticker symbol "GRAL" on the NASDAQ Stock Exchange.

For more information, visit grail.com.

About Galleri® 
The Galleri multi-cancer early detection test is a proactive tool to screen for cancer. With a simple blood draw, the Galleri test can identify DNA shed by cancer cells, which can act as a unique "fingerprint" of cancer, to help screen for some of the deadliest cancers that don't have recommended screening today, such as pancreatic, esophageal, ovarian, liver, and others.* The Galleri test can be used to screen for cancer before a person becomes symptomatic, when cancer may be more easily treated and potentially curable. The Galleri test can indicate the origin of the cancer, giving healthcare providers a roadmap of where to explore further. The Galleri test requires a prescription from a licensed healthcare provider and should be used in addition to recommended cancer screenings such as mammography, colonoscopy, prostate-specific antigen (PSA) test, or cervical cancer screening. The Galleri test is recommended for adults with an elevated risk for cancer, such as those aged 50 or older.

For more information, visit galleri.com.

* Sensitivity in study participants with – Pancreas cancer: 83.7% overall (61.9% stage I, 60.0% stage II, 85.7% stage III, 95.9% stage IV). Esophagus cancer 85.0% overall (12.5% stage I, 64.7% stage II, 94.7% stage III, 100% stage IV). Ovary cancer: 83.1% overall (50.0% stage I, 80.0% stage II, 87.1% stage III, 94.7% stage IV). Liver/bile duct cancer: 93.5% overall (100% stage I, 70.0% stage II, 100% stage III, 100% stage IV).

Laboratory/Test Information
GRAIL's clinical laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA) and accredited by the College of American Pathologists. The Galleri test was developed, and its performance characteristics were determined by GRAIL. The Galleri test has not been cleared or approved by the U.S. Food and Drug Administration. GRAIL's clinical laboratory is regulated under CLIA to perform high-complexity testing. The Galleri test is intended for clinical purposes.

Non-GAAP Disclosure
In addition to our financial results, this press release also includes financial measures that are not calculated in accordance with U.S. generally accepted accounting principles ("GAAP"). Our non-GAAP financial disclosure includes Adjusted Gross Profit (Loss) and Adjusted EBITDA. We encourage investors to carefully consider our results under GAAP in conjunction with our supplemental non-GAAP information and the reconciliation between these presentations.

  • Adjusted Gross Profit/(Loss) is a key performance measure that our management uses to assess our operational performance, as it represents the results of revenues and direct costs, which are key components of our operations. We believe that this non-GAAP financial measure is useful to investors and other interested parties in analyzing our financial performance because it reflects the gross profitability of our operations, and excludes the indirect costs associated with our sales and marketing, product development, general and administrative activities, and depreciation and amortization, and the impact of our financing methods and income taxes.
     
    We calculate Adjusted Gross Profit/(Loss) as gross profit/(loss) (as defined below) adjusted to exclude amortization of intangible assets and stock-based compensation allocated to cost of revenue. Adjusted Gross Profit/(Loss) should be viewed as a measure of operating performance that is a supplement to, and not a substitute for, operating income or loss from operations, net earnings or loss and other GAAP measures of income (loss) or profitability. The following table presents a reconciliation of gross loss, the most directly comparable financial measure calculated in accordance with GAAP, to Adjusted Gross Profit.
     
  • Adjusted EBITDA is a key performance measure that our management uses to assess our financial performance and is also used for internal planning and forecasting purposes. We believe that this non-GAAP financial measure is useful to investors and other interested parties in analyzing our financial performance because it provides a comparable overview of our operations across historical periods. In addition, we believe that providing Adjusted EBITDA, together with a reconciliation of net income (loss) to Adjusted EBITDA, helps investors make comparisons between our company and other companies that may have different capital structures, different tax rates, different operational and ownership histories, and/or different forms of employee compensation.

    Adjusted EBITDA is used by our management team as an additional measure of our performance for purposes of business decision-making, including managing expenditures. Period-to-period comparisons of Adjusted EBITDA help our management identify additional trends in our financial results that may not be shown solely by period-to-period comparisons of net income or income from operations. Our management recognizes that Adjusted EBITDA has inherent limitations because of the excluded items, and may not be directly comparable to similarly titled metrics used by other companies.

    Adjusted EBITDA should be viewed as a measure of operating performance that is a supplement to, and not a substitute for, operating income or loss from operations, net earnings or loss and other U.S. GAAP measures of income (loss). Additionally, it is not intended to be a measure of free cash flow for management's discretionary use, as it does not consider certain cash requirements such as interest and tax payments. Further, our definition of Adjusted EBITDA may differ from similarly titled measures used by other companies and therefore may not be comparable among companies. The following table presents a reconciliation of net loss, the most directly comparable financial measure calculated in accordance with U.S. GAAP, to Adjusted EBITDA on a consolidated basis.

Full reconciliation of these non-GAAP measures to the most comparable GAAP measures is set forth in tabular form below.

Forward-Looking Statements
This press release contains forward-looking statements. In some cases, you can identify these statements by forward-looking words such as "aim," "anticipate," "believe," "continue," "could," "estimate," "expect," "intend," "may," "might," "plan," "potential," "predict," "should," "would," or "will," the negative of these terms, and other comparable terminology. These forward-looking statements, which are subject to risks, uncertainties, and assumptions about us, may include expectations and projections of our future financial performance, future tests or products, technology, clinical studies, regulatory compliance, potential market opportunity, anticipated growth strategies, restructuring costs, sufficiency of cash on hand to finance our business, cost savings, budgets and strategies, restructuring and stock-based compensation costs, impact of the restructuring on our operations and growth and anticipated trends in our business.

These statements are only predictions based on our current expectations and projections about future events and trends. There are important factors that could cause our actual results, level of activity, performance, or achievements to differ materially and adversely from those expressed or implied by the forward-looking statements, including those factors and numerous associated risks discussed under the section entitled "Risk Factors" in our Quarterly Report on Form 10-Q for the period ended September 30, 2024 (the "Form 10-Q"). Moreover, we operate in a dynamic and rapidly changing environment. New risks emerge from time to time. It is not possible for our management to predict all risks, nor can we assess the impact of all factors on our business or the extent to which any factor, or combination of factors, may cause actual results, level of activity, performance, or achievements to differ materially and adversely from those contained in any forward-looking statements we may make.

Forward-looking statements relate to the future and, accordingly, are subject to inherent uncertainties, risks, and changes in circumstances that are difficult to predict and many of which are outside of our control. Although we believe the expectations and projections expressed or implied by the forward-looking statements are reasonable, we cannot guarantee future results, level of activity, performance, or achievements. Our actual results and financial condition may differ materially from those indicated in the forward-looking statements. Except to the extent required by law, we undertake no obligation to update any of these forward-looking statements after the date of this press release to conform our prior statements to actual results or revised expectations or to reflect new information or the occurrence of unanticipated events.

GRAIL
Condensed Consolidated Balance Sheets





(in thousands, except for per share data)

September 30, 2024


December 31, 2023

Assets

(unaudited)



Current assets:




Cash and cash equivalents

$                 853,551


$                    97,287

Accounts receivables, net

15,211


16,942

Supplies

21,213


21,695

Prepaid expenses and other current assets

19,721


20,141

Total current assets

909,696


156,065

Property and equipment, net

73,886


84,995

Operating lease right-of-use assets

70,625


84,386

Restricted cash

3,918


4,225

Intangibles assets, net

2,051,473


2,687,223

Goodwill


888,936

Other non-current assets

8,356


7,984

Total assets

$              3,117,954


$              3,913,814

Liabilities and stockholders'/member's (deficit) equity




Current liabilities:




Accounts payable

$                     7,321


$                   19,673

Accrued liabilities

71,830


73,806

Incentive plan liabilities


54,513

Operating lease liabilities, current portion

13,524


14,809

Other current liabilities

1,593


809

Total current liabilities

94,268


163,610

Operating lease liabilities, net of current portion

58,667


69,598

Deferred tax liabilities, net

375,122


32,921

Other non-current liabilities

2,261


1,498

Total liabilities

530,318


267,627

Preferred stock, par value of $0.001 per share; 50,000,000 shares
authorized, no shares issued and outstanding as of September 30, 2024
and December 31, 2023


Common stock $0.001 par value per share, 1,500,000,000 shares
authorized, 33,203,744 shares issued and outstanding as of September
30, 2024, no shares authorized, issued and outstanding as of December
31, 2023

33


Additional paid-in capital

12,291,681


Member's equity


11,421,446

Accumulated other comprehensive income

2,186


1,066

Accumulated deficit

(9,706,264)


(7,776,325)

Total stockholders'/member's equity

2,587,636


3,646,187

Total liabilities and stockholders'/member's equity

3,117,954


3,913,814

 

GRAIL
Condensed Consolidated Statements of Operations
(Unaudited)






Three Months Ended


Nine months ended

(in thousands except for per share data)

September 30,
2024


October 1,
2023


September 30,
2024


October 1,
2023

Revenue:








Screening revenue

$            25,374


$            16,745


$            77,076


$            52,344

Development services revenue

3,278


3,977


10,267


10,435

Total revenue

28,652


20,722


87,343


62,779

Costs and operating expenses:








Cost of screening revenue (exclusive of amortization of intangible
assets)

15,970


12,829


45,481


34,379

Cost of development services revenue

1,442


1,489


3,499


4,944

Cost of revenue — amortization of intangible assets

33,473


33,473


100,417


100,417

Research and development

78,231


80,076


274,052


254,659

Sales and marketing

35,625


36,597


123,433


123,169

General and administrative

47,418


50,183


171,745


147,534

Goodwill and intangible impairment


718,466


1,420,936


718,466

Total costs and operating expenses

212,159


933,113


2,139,563


1,383,568

Loss from operations

(183,507)


(912,391)


(2,052,220)


(1,320,789)

Other income (expense):








Interest income

11,661


2,529


17,367


6,603

Other expense, net

561


196


514


421

Total other income, net

11,100


2,333


16,853


6,182

Loss before income taxes

(172,407)


(910,058)


(2,035,367)


(1,314,607)

Benefit from income taxes

46,719


18,610


105,428


36,449

Net loss

$        (125,688)


$        (891,448)


$    (1,929,939)


$    (1,278,158)

Net loss per share — Basic and Diluted

$              (3.94)


$            (28.71)


$           (61.61)


$           (41.17)

Weighted average shares of common stock—
  basic and diluted

31,880,054


31,049,148


31,326,117


31,049,148

 

GRAIL
Condensed Consolidated Statements of Cash Flows
(Unaudited)




Nine Months Ended

(in thousands)

September 30,
2024


October 1,
2023

Net cash used by operating activities

$          (483,666)


$          (466,902)

Net cash used by investing activities

(4,905)


(8,992)

Net cash provided by financing activities

1,244,300


377,780

Effect of exchange rate changes on cash, cash equivalents, and restricted cash

228


49

Net increase (decrease) in cash, cash equivalents, and restricted cash

$            755,957


$            (98,065)

Cash, cash equivalents and restricted cash — beginning of period

$            101,512


$            246,128

Cash, cash equivalents and restricted cash — end of period

$            857,469


$            148,063

 

GRAIL
Reconciliation of GAAP to Non-GAAP Financial Measures
(Unaudited)






Three Months Ended


Nine Months Ended

(in thousands)

September 30,
2024


October 1,
2023


September 30,
2024


October 1,
2023

Gross loss (1)

$          (22,233)


$          (27,069)


$          (62,054)


$          (76,961)

Amortization of intangible assets

33,473


33,473


100,417


100,417

Stock-based compensation

578


625


1,522


1,448

Adjusted Gross Profit

$            11,818


$              7,029


$            39,885


$            24,904
























(1) 

Gross profit/(loss) is calculated as total revenue less cost of revenue (exclusive of amortization of intangible assets), cost of revenue—related parties, and cost of revenue—amortization of intangible assets.

 

GRAIL
Reconciliation of GAAP to Non-GAAP Financial Measures
(Unaudited)






Three Months Ended


Nine Months Ended

(in thousands)

September 30,
2024


October 1,
2023


September 30,
2024


October 1,
2023

Net loss

$        (125,688)


$        (891,448)


$    (1,929,939)


$    (1,278,158)

Adjusted to exclude the following:








Interest income

(11,661)


(2,529)


(17,367)


(6,603)

Benefit from income tax expense

(46,719)


(18,610)


(105,428)


(36,449)

Amortization of intangible assets (1)

34,583


34,583


103,750


103,750

Depreciation

4,647


5,216


14,865


15,018

Goodwill and intangible impairment(2)


718,466


1,420,936


718,466

Illumina/GRAIL merger & divestiture legal
and professional services costs (3)

226


2,944


22,158


11,198

Stock-based compensation (4)

17,449


25,319


72,502


72,383

Restructuring(5)

19,007



19,007


Adjusted EBITDA

$        (108,156)


$        (126,059)


$        (399,516)


$        (400,395)
























(1) 

Represents amortization of intangible assets, including developed technology and trade names.

(2) 

Reflects impairment of the goodwill and intangible assets recognized as a result of Illumina's acquisition of the Company in August 2021 ("the Acquisition").

(3) 

Represents legal and professional services costs associated with the Acquisition and corresponding antitrust litigation, including compliance with the hold separate arrangements imposed by the European Commission, and legal and professional services costs associated with the divestiture.

(4) 

Represents all stock-based compensation recognized on our standalone financial statements for the periods presented.

(5) 

Represents employee severance, benefits, payroll taxes, and other costs associated with the Restructuring Plan.

 

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SOURCE GRAIL, Inc.

FAQ

What was GRAL's revenue growth in Q3 2024?

GRAL reported total revenue of $28.7 million in Q3 2024, representing 38% growth year-over-year.

How many Galleri tests has GRAL sold as of September 30, 2024?

GRAL has sold more than 250,000 Galleri tests as of September 30, 2024.

What was GRAL's cash position in Q3 2024?

GRAL reported cash and cash equivalents of $853.6 million as of September 30, 2024, providing runway into 2028.

What was GRAL's net loss in Q3 2024?

GRAL reported a net loss of $125.7 million in Q3 2024, which includes $34.6 million in amortization and $19.0 million in restructuring charges.

GRAIL, Inc.

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