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Geron Corp - GERN STOCK NEWS

Welcome to our dedicated page for Geron news (Ticker: GERN), a resource for investors and traders seeking the latest updates and insights on Geron stock.

Overview

Geron Corp (GERN) is a clinical-stage biopharmaceutical company committed to pioneering innovative therapies in the field of oncology. At the heart of its research is the development of first-in-class telomerase inhibitors, which target the underlying cellular mechanism that enables cancer cells to maintain telomere length—a key factor that contributes to their unchecked replication. This advanced approach positions Geron as a focused innovator within the broad landscape of cancer treatment development, emphasizing a precision-driven strategy that seeks to fundamentally alter how hematologic cancers are managed.

Core Business and Therapeutic Focus

The company’s main product candidate, imetelstat, is a potent, specific inhibitor designed to disrupt telomerase activity. This mechanism is central to the survival and proliferation of cancer cells, particularly in hematologic malignancies. By inhibiting telomerase, imetelstat potentially restricts the limitless division of malignant cells, thereby offering a novel therapeutic pathway for conditions such as myelodysplastic syndromes and myelofibrosis. The clinical-stage exploration of imetelstat underscores Geron Corp's commitment to transforming cancer treatment protocols and deepening our understanding of oncology therapy.

Revenue Model and Corporate Strategy

Geron Corp operates with a revenue model rooted in strategic collaborations within the pharmaceutical and biotechnology sectors. The company leverages licensing agreements, milestone-based payments, and royalty structures to support its research and operational endeavors. This multifaceted approach not only diversifies the financial underpinnings of its business strategy but also reinforces its role as an essential contributor to the oncology therapeutic landscape.

Industry Position and Research Emphasis

Within the competitive framework of biopharmaceutical research, Geron distinguishes itself by focusing exclusively on the development of innovative cancer therapies. Its research-driven approach is underscored by rigorous clinical studies and a deep understanding of the molecular biology of cancer. The company is positioned among specialized entities that are exploring targeted treatment options, relying on sophisticated scientific methodologies to bridge the gap between research innovations and practical, clinical applications.

Scientific and Clinical Expertise

Geron Corp marries scientific inquiry with clinical application through its emphasis on personalized and mechanism-based approaches in treating cancer. Its efforts in developing imetelstat represent a blend of cutting-edge research and meticulous clinical evaluation, providing insights into the potential of telomerase inhibition as a therapeutic modality. By prioritizing expert analysis over speculative claims, Geron consistently communicates an evidence-based narrative that underpins its clinical trials and strategic partnerships.

Operational and Strategic Highlights

  • Innovative Mechanism of Action: The focus on telomerase inhibition addresses a fundamental aspect of cancer cell immortality, offering a concrete rationale behind the therapeutic potential of imetelstat.
  • Focused Clinical Applications: With a targeted approach to hematologic malignancies, Geron becomes a key player in the niche area of blood cancer therapies.
  • Strategic Collaborations: Revenue generation through partnerships and licensing highlights the company’s integrated approach to research, development, and commercial strategy.
  • Scientific Rigor: The company’s operations are underpinned by robust clinical research, embodying the principles of precise and evidence-based innovation in oncology.

Conclusion

In summary, Geron Corp represents a paradigm of focused research and development within the biopharmaceutical industry. Its innovative approach to cancer treatment, primarily through the development of a first-in-class telomerase inhibitor, underscores its commitment to addressing complex oncological challenges through scientific precision and clinical expertise. This detailed exploration helps investors, analysts, and industry watchers gain a nuanced understanding of Geron Corp’s operations, setting a clear context for its role in the evolving landscape of cancer therapeutics.

Rhea-AI Summary
Geron Corporation announces publication of abstracts from the IMerge Phase 3 clinical trial of imetelstat in patients with lower risk myelodysplastic syndromes (MDS). The abstracts highlight that imetelstat achieved transfusion independence (TI) in patients across different risk groups and mutational profiles. Nearly 20% of imetelstat-treated patients achieved sustained TI for over 1 year with a median duration of TI of more than 2 years and a median hemoglobin increase of more than 5 g/dL. Imetelstat demonstrated efficacy in patients reclassified as higher risk using molecular international prognostic scoring system (IPSS-M).
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Geron Corporation reported business highlights and financial results for Q3 2023. Imetelstat, a telomerase inhibitor, is under regulatory review by the FDA and EMA for the treatment of transfusion-dependent anemia in adult patients with lower risk MDS. The FDA assigned a PDUFA action date of June 16, 2024. Planning is ongoing for a potential commercial launch in the U.S. in mid-2024. Geron has approximately $382 million on the balance sheet as of the end of the quarter.
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Geron Corporation will release its Q3 2023 financial results and business highlights on November 2, 2023. A conference call will be held at 9:00 a.m. ET the same day.
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Geron Corporation grants stock options to newly hired employees.
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Geron Corporation's Marketing Authorization Application (MAA) for imetelstat has been validated by the European Medicines Agency (EMA), bringing them closer to potentially offering the treatment to lower risk MDS patients in the EU. Clinical results have shown significant efficacy, with higher transfusion independence rates and increased hemoglobin levels in imetelstat-treated patients compared to placebo. The MAA is now under regulatory review and expected to take approximately 14 months. The company is also awaiting a decision from the U.S. FDA with a PDUFA action date of June 16, 2024.
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Geron Corporation appoints Michelle Robertson as CFO and Treasurer, effective September 25, 2023. Olivia Bloom retires after 30 years with the company. Robertson brings over 30 years of financial experience. Inducement grants of 1.6 million shares of Geron common stock planned for Robertson.
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Geron announces positive data from IMerge Phase 3 trial for imetelstat in lower risk MDS, with significant increases in transfusion independence and hemoglobin levels, improvement in fatigue, and manageable safety profile. New Drug Application for imetelstat accepted for review by FDA with PDUFA action date of June 16, 2024.
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Geron CEO to participate in fireside chat at Baird 2023 Global Healthcare Conference
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Geron Corporation announced FDA review and PDUFA action date of June 16, 2024 for imetelstat NDA. Expecting US launch by H1 2024, subject to FDA approval.
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Geron's NDA for imetelstat accepted by FDA for the treatment of anemia in MDS patients. Positive efficacy results and significant increase in hemoglobin levels. Expectation of changing standard of care in lower risk MDS. Safety consistent with prior clinical experience. FDA has up to 74 days to notify PDUFA action date. MAA submission in EU expected in Q4 2023.
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FAQ

What is the current stock price of Geron (GERN)?

The current stock price of Geron (GERN) is $1.38 as of April 4, 2025.

What is the market cap of Geron (GERN)?

The market cap of Geron (GERN) is approximately 901.2M.

What is Geron Corp's primary focus?

Geron Corp is dedicated to the research and development of innovative cancer therapies, particularly through the use of first-in-class telomerase inhibitors.

How does the company plan to treat cancers?

The company is exploring the use of imetelstat, a potent telomerase inhibitor, to target the cell replication process in hematologic malignancies such as myelodysplastic syndromes and myelofibrosis.

What makes Geron Corp's approach unique?

Geron Corp employs a targeted mechanism-based strategy by inhibiting telomerase, a key enzyme that allows cancer cells limitless replication, thus addressing a fundamental aspect of cancer biology.

How does Geron generate revenue?

The company generates revenue primarily through collaboration agreements, licensing arrangements, milestone payments, and royalties, which support its research and clinical operations.

How is Geron positioned within the oncology research space?

Geron Corp is recognized for its focused research on telomerase inhibition, situating it among specialized entities within the broader oncology and biopharmaceutical sectors.

What therapeutic areas are targeted by imetelstat?

Imetelstat is primarily being developed for hematologic malignancies, with a focus on diseases such as myelodysplastic syndromes and myelofibrosis, where traditional treatment options are limited.
Geron Corp

Nasdaq:GERN

GERN Rankings

GERN Stock Data

901.22M
632.75M
0.1%
78.42%
9.17%
Biotechnology
Pharmaceutical Preparations
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United States
FOSTER CITY