Welcome to our dedicated page for Esperion Therapeutics news (Ticker: ESPR), a resource for investors and traders seeking the latest updates and insights on Esperion Therapeutics stock.
Esperion Therapeutics, Inc. (NASDAQ: ESPR) is a leading pharmaceutical company specializing in the development and commercialization of innovative, first-in-class, oral therapies aimed at lowering low-density lipoprotein cholesterol (LDL-C). The company's flagship product, ETC-1002, is a potent inhibitor of ATP citrate lyase, an enzyme integral to the cholesterol biosynthesis pathway. This pathway also includes HMG-CoA reductase, the enzyme targeted by statins.
Esperion has made significant progress with ETC-1002, completing Phase 1 and Phase 2 clinical trials, and is set to initiate Phase 3 trials. The company's product lineup includes NEXLETOL and NEXLIZET, both of which are oral, once-daily, non-statin medications designed to tackle elevated LDL-C levels. These drugs have recently received expanded FDA approval for cardiovascular risk reduction and are indicated for both primary and secondary prevention patients.
In recent news, Esperion announced that both NEXLETOL and NEXLIZET have received broad new label expansions. These labels now cover cardiovascular risk reduction and expanded LDL-C lowering, either alone or in combination with statins. This approval allows over 70 million patients to access these life-saving drugs, positioning them as the non-statin drugs of choice for cardiovascular risk management.
Esperion is also ramping up its marketing and promotional efforts, enhancing patient support programs, and working with payers to improve patient access. The company is committed to breaking barriers in cardiovascular care and continues to focus on underserved populations, including women and Hispanic/Latinx patients, as demonstrated by their recent CLEAR Outcomes trial.
The company's forward-looking strategy includes ongoing clinical development, financial management, and expansion into new markets. Esperion's dedication to transforming cardiovascular care is evident in its robust pipeline and strategic initiatives aimed at addressing critical unmet medical needs.
Esperion Therapeutics (NASDAQ: ESPR) has secured a third tranche of $50 million in funding from an investor group led by Oberland Capital Management, bringing total funding to $80 million. This funding is part of a revenue-based agreement that allows Esperion to regain 100% revenue rights after repayment. Additionally, the company announced an expansion of a commercial agreement in strategic non-U.S. markets. CFO Rick Bartram emphasized the financial benefits and confidence in Esperion's potential, underscoring its commitment to lipid management.
Esperion Therapeutics announced a licensing agreement with Daiichi Sankyo, granting exclusive rights to commercialize bempedoic acid and its combination tablet in select Asian, Middle Eastern, and Latin American countries. The deal includes a $30 million upfront payment and up to $175 million in milestone payments, contributing to a total of $1.1 billion in potential milestones. This partnership aims to strengthen market reach and address unmet cardiovascular needs globally. The terms allow Esperion to retain rights in several regions, including the U.S.
Esperion (NASDAQ: ESPR) will report its first quarter 2021 financial results after U.S. markets close on May 4, 2021. Management will host a conference call at 4:30 p.m. ET to discuss these results and business developments. The call can be accessed via a dedicated phone line or through a live audio webcast on their investor website. Esperion focuses on LDL-C management, providing oral medication to patients unable to reach cholesterol goals with current therapies. They emphasize the critical need for effective treatments in a substantial portion of the U.S. population.
Esperion (NASDAQ: ESPR) announced that CEO Tim M. Mayleben will participate in an analyst-led fireside chat at the 20th Annual Needham Virtual Healthcare Conference on April 13, 2021, at 9:30 a.m. ET. The event will include a live audio webcast, accessible via the company's investor relations website, and a replay will be available for 90 days post-event. Esperion aims to develop new LDL-C lowering medicines to combat cardiovascular disease, which affects over 96 million adults in the U.S.
Esperion announced positive results from a Phase 2 study published in Atherosclerosis, evaluating the combination of NEXLETOL (bempedoic acid), ezetimibe, and atorvastatin in hypercholesterolemia patients. The triple therapy resulted in a 60.5% reduction in LDL-C levels compared to placebo, with over 90% of patients achieving LDL-C levels <70 mg/dL. Despite these promising results, the small sample size and brief duration limit the study's conclusions. Adverse events were mostly mild to moderate, affirming the need for more research to confirm long-term effects.
ESPERION reported significant growth in its fourth quarter 2020, with total revenue reaching $9.6 million, a substantial increase from $1.0 million in Q4 2019. U.S. product revenue for the same period was $8.2 million, marking a 150% increase from Q3 2020. The company has over 21,000 patients on its NEXLETOL® and NEXLIZET® medications. Despite a net loss of $104.5 million for Q4 2020, the balance sheet remains strong with $305.0 million in cash and cash equivalents. Looking ahead, expected operating expenses for 2021 range from $320 million to $340 million.
Esperion (NASDAQ: ESPR) will announce its fourth quarter and full year 2020 financial results on February 23, 2021. Following the announcement, management will host a conference call at 4:30 p.m. ET to discuss the results and business progress. The call is accessible domestically at (877) 831-3840 and internationally at (253) 237-1184 with access code 2689156. A live audio webcast will also be available on Esperion's investor website, along with a replay accessible for 90 days.
Esperion (NASDAQ: ESPR) announced on January 28, 2021, that its Compensation Committee granted stock options and restricted stock units (RSUs) to 10 new employees, notably including newly appointed COO Sheldon Koenig. The stock options total 150,000 shares with an exercise price of $32.12, matching the closing stock price on the grant date. Additionally, 49,567 RSUs were awarded, 30,000 to Koenig. Vesting is structured with 25% after one year and the remainder in quarterly installments, contingent on continued employment.
Esperion reported preliminary fourth-quarter 2020 U.S. net product revenue of $8.0 to $8.5 million, achieving over 140% sequential growth for its products, NEXLETOL and NEXLIZET. The company projects total operating expenses for 2021 will range from $320 million to $340 million, which includes $30 million in non-cash stock compensation. Esperion has also in-licensed an oral PCSK9 inhibitor program, enhancing its portfolio of LDL-C lowering medications, and indicating a strategic expansion in non-statin treatment options.
Esperion (NASDAQ: ESPR) announced that CEO Tim M. Mayleben will present at the 39th Annual J.P. Morgan Healthcare Conference on January 13, 2021, at 7:30 a.m. ET. The event will be conducted virtually, featuring a presentation and individual investor meetings. A live audio webcast will be available on the company’s investor relations page and can be accessed for 90 days post-event. Esperion is dedicated to developing oral medicines for LDL-C reduction, addressing the needs of millions with elevated cholesterol levels in the U.S.
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