STOCK TITAN

Enlivex Therapeutics Ltd - ENLV STOCK NEWS

Welcome to our dedicated page for Enlivex Therapeutics news (Ticker: ENLV), a resource for investors and traders seeking the latest updates and insights on Enlivex Therapeutics stock.

Overview of Enlivex Therapeutics Ltd

Enlivex Therapeutics Ltd (ENLV) is an Israel-based, clinical-stage biopharmaceutical company specializing in the field of immunotherapy. The company focuses on developing an allogeneic, off-the-shelf cell therapy designed to rebalance dysregulated immune responses by reprogramming macrophages to a homeostatic state. This innovative approach is applied across several therapeutic areas including severe inflammatory conditions, osteoarthritis, and various autoimmune and infectious diseases. Early clinical investigations target severe sepsis, complications in hematopoietic stem cell transplants, and inflammatory joint diseases such as psoriatic arthritis and knee osteoarthritis.

Clinical Development and Mechanism of Action

At the heart of Enlivex's research is Allocetra, a cell therapy candidate developed to reset abnormal, non-homeostatic macrophages. Unlike traditional treatments, Allocetra utilizes the body’s own natural regulatory mechanisms to modulate immune responses. This strategy not only addresses immediate clinical symptoms but also tackles the underlying pathophysiological processes of immune dysregulation. The company has successfully initiated multiple investigator-sponsored trials and randomized controlled studies to assess the therapy’s safety profile and potential clinical benefits. Ongoing research in conditions such as osteoarthritis and psoriatic arthritis highlights the broad potential of Allocetra to offer transformative treatment alternatives where existing therapies have limited efficacy.

Position in the Immunotherapy Landscape

Enlivex Therapeutics operates in a highly competitive and innovative segment of the life sciences industry. By focusing on macrophage reprogramming, the company distinguishes itself from other immunotherapy and cell therapy firms. Its strategy of using allogeneic cells enables off-the-shelf availability, thereby potentially reducing production complexities and shortening time-to-treatment. This unique value proposition underlines its relevance in contemporary immunotherapeutic paradigms while also addressing significant unmet medical needs in various clinical settings.

Key Business Areas and Research Focus

  • Macrophage Reprogramming: Employing its proprietary cell therapy to reset dysregulated immune cells.
  • Clinical Trials: Advancing early-phase trials in conditions like severe sepsis, graft versus host disease, and inflammatory joint diseases, which serve as proof-of-concept studies for the therapy’s mechanism of action.
  • Innovative Cell Therapy: Developing universal, off-the-shelf treatments with the potential to overcome limitations associated with autologous cell therapies.
  • Market Differentiation: Focusing on rare and difficult-to-treat conditions where conventional therapies have shown limited success.

Scientific Rationale and Industry Terminology

The scientific framework behind Enlivex's approach revolves around concepts such as immune homeostasis and macrophage plasticity. By targeting the inflammatory cascade and enabling macrophages to revert to their native, balanced state, Allocetra is posited as a potentially transformative intervention in areas where an exaggerated immune response leads to tissue damage and systemic complications. The rigorous clinical assessments being conducted are designed to quantify endpoints like pain reduction, improved joint function, and overall patient well-being using established indices and statistical methodologies.

Competitive Landscape and Investment Considerations

Within the biopharmaceutical industry, Enlivex stands out by focusing on a mechanism of action that taps into the regulatory potential of the immune system, thereby offering a counterpoint to therapies that rely solely on immunosuppression. This strategy positions the company in a unique niche that blends the principles of cellular therapy with precision immunomodulation. Investors and industry analysts typically examine parameters such as the safety profile observed in early-stage trials, the scalability of the off-the-shelf approach, and the breadth of the potential market for inflammatory and autoimmune indications. The transparent and phased clinical development strategy underscores the company’s commitment to rigorous scientific validation and adherence to regulatory standards.

Conclusion

Enlivex Therapeutics Ltd is a focused and innovative clinical-stage company working to bridge key gaps in the treatment of complex immune-mediated conditions. By emphasizing a cell therapy that rebalances the immune system through macrophage reprogramming, the company continues to build a robust clinical pipeline aimed at addressing some of the most challenging therapeutic areas in modern medicine. With its clear scientific rationale, structured developmental approach, and commitment to high-quality clinical research, Enlivex remains a noteworthy subject for in-depth investment research and clinical analysis.

Rhea-AI Summary

Enlivex Therapeutics (Nasdaq: ENLV) announced the issuance of European patent No. 3,258,943 for AllocetraTM, enhancing its intellectual property portfolio. This patent covers a combination immune therapy aimed at controlling cytokine storms associated with CAR-T therapies for cancer. CEO Oren Hershkovitz expressed satisfaction with the patent grant in Europe, reinforcing the potential of Allocetra in cancer treatment. Allocetra is designed to reprogram macrophages to address severe conditions like sepsis, COVID-19, and solid tumors.

Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
0.51%
Tags
none
-
Rhea-AI Summary

Enlivex Therapeutics Ltd. (Nasdaq: ENLV) announced its participation in the Jefferies 2021 Virtual Healthcare Conference on June 4, 2021, at 10:00 EDT. The presentation will be accessible via the conference website.

Enlivex is focused on Allocetra™, a universal cell therapy aimed at reprogramming macrophages to restore immune system balance. This therapy has potential applications in treating solid cancers, sepsis, and COVID-19, targeting unmet medical needs with an innovative immunotherapeutic approach.

Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-0.82%
Tags
conferences
-
Rhea-AI Summary

Enlivex Therapeutics (Nasdaq: ENLV) announced the issuance of Canadian Patent No. 2,893,962 for its immunotherapy product candidate AllocetraTM, providing additional protection for its pharmaceutical compositions and manufacturing methods. The patent enhances Enlivex's intellectual property portfolio, contributing to its focus on treating life-threatening diseases such as sepsis, COVID-19, and solid tumors. CEO Oren Hershkovitz emphasized the importance of this patent in supporting their clinical development efforts aimed at addressing significant unmet medical needs.

Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
6.3%
Tags
none
Rhea-AI Summary

Enlivex Therapeutics has received a $1.1 million grant from the Israel Innovation Authority, bringing its total non-dilutive funding to approximately $6.6 million for clinical trials and product development. This funding supports Enlivex's ongoing Phase IIb clinical trial of Allocetra for treating organ dysfunctions related to sepsis. Allocetra is designed to reprogram macrophages into their homeostatic state to combat severe diseases, including sepsis and COVID-19, addressing unmet medical needs.

Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
5.5%
Tags
-
Rhea-AI Summary

Enlivex Therapeutics Ltd. (Nasdaq: ENLV) has partnered with Yale Cancer Center to explore the efficacy of Allocetra™ in combination with immune checkpoint inhibitors to target hard-to-treat solid tumors. This collaboration aims to conduct pre-clinical studies assessing the synergies between Allocetra™ and approved therapies. Enlivex recently reported positive Phase Ib and II results for Allocetra™ in COVID-19 and plans to initiate a Phase IIb study in sepsis. This strategic alliance emphasizes the potential of Allocetra™ to rebalance anti-tumor macrophages in the tumor microenvironment.

Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-4.43%
Tags
none
-
Rhea-AI Summary

Enlivex Therapeutics (Nasdaq: ENLV), a clinical-stage immunotherapy company, announced its participation in two upcoming investor conferences. Management will join the 2nd Annual European Healthtech CEO Forum on March 9, focusing on patient care during the pandemic. They will also present at the H.C. Wainwright Global Life Sciences Conference on March 10, addressing innovative allogeneic cell-based immunotherapy in oncology. Enlivex is developing Allocetra™, a cell therapy aimed at reprogramming macrophages to their homeostatic state, potentially aiding in severe diseases like COVID-19 and solid cancers.

Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-2.31%
Tags
conferences
Rhea-AI Summary

Enlivex Therapeutics Ltd. (Nasdaq: ENLV) announced that the Japan Patent Office has granted a notice of allowance for a new patent covering AllocetraTM, its macrophage reprogramming immunotherapy product. This patent, titled “Combination Immune Therapy and Cytokine Control Therapy for Cancer Treatment,” will protect certain methods and uses of AllocetraTM in conjunction with CAR-T therapies in Japan. The company anticipates the patent will be officially issued in Q2 2021, further strengthening its intellectual property portfolio.

Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-0.08%
Tags
none
-
Rhea-AI Summary

Enlivex Therapeutics Ltd. announced a collaboration with Mount Sinai Health System on March 1, 2021, to explore the use of Allocetra™ in combination with immune-checkpoint inhibitors for treating solid tumors. This pre-clinical program aims to investigate potential synergies between Allocetra™ and approved checkpoint inhibitors, enhancing anti-tumor responses by reprogramming macrophages. Enlivex reported positive interim results from trials involving COVID-19 and sepsis patients, indicating a promising future for Allocetra™ in immunotherapy.

Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-2.62%
Tags
none
-
Rhea-AI Summary

Enlivex Therapeutics Ltd. (Nasdaq: ENLV) announced that the China National Intellectual Property Administration granted a notice of allowance for a new patent covering AllocetraTM, its macrophage reprogramming immunotherapy. This patent will enhance intellectual property protection in China, covering methods and uses for AllocetraTM. The product aims to reprogram macrophages to their homeostatic state, potentially addressing diseases like sepsis, COVID-19, and solid tumors. Issuance of the patent is expected in the coming months.

Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-10.11%
Tags
none
Rhea-AI Summary

Enlivex Therapeutics Ltd. (NASDAQ: ENLV) announced a partial exercise of its bought deal offering, resulting in the purchase of 268,205 ordinary shares at $20.00 each, generating approximately $51.3 million in gross proceeds. The funds will support clinical, regulatory, manufacturing, and R&D activities, along with potential acquisitions. The offering was conducted under an effective shelf registration statement. H.C. Wainwright & Co. served as the book-running manager. The company develops AllocetraTM, an innovative cell therapy aimed at reprogramming macrophages for better immune response.

Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-8.17%
Tags
none

FAQ

What is the current stock price of Enlivex Therapeutics (ENLV)?

The current stock price of Enlivex Therapeutics (ENLV) is $0.95 as of April 1, 2025.

What is the market cap of Enlivex Therapeutics (ENLV)?

The market cap of Enlivex Therapeutics (ENLV) is approximately 20.7M.

What is the core focus of Enlivex Therapeutics Ltd?

Enlivex Therapeutics Ltd is focused on developing an allogeneic cell therapy aimed at rebalancing immune responses through macrophage reprogramming, addressing conditions such as severe sepsis and inflammatory joint diseases.

How does Allocetra work as a therapeutic option?

Allocetra works by reprogramming non-homeostatic macrophages into their natural, balanced state, thereby helping to modulate the immune system and potentially reduce damaging inflammatory responses.

In which therapeutic areas is Enlivex conducting clinical trials?

Enlivex is investigating Allocetra in various clinical settings including severe sepsis, conditions associated with graft versus host disease, osteoarthritis, and psoriatic arthritis, among other inflammatory conditions.

What differentiates Enlivex from other companies in the immunotherapy space?

Enlivex differentiates itself by focusing on a unique mechanism of action through macrophage reprogramming, which offers a novel and off-the-shelf solution compared to traditional immunosuppressive or autologous cell therapies.

Why is immune rebalancing important in treating inflammatory diseases?

Immune rebalancing is crucial because it targets the underlying dysregulation in the immune system, potentially mitigating tissue damage and systemic complications that occur when the body’s natural response becomes excessive or misdirected.

What are the advantages of an off-the-shelf cell therapy product like Allocetra?

An off-the-shelf cell therapy can be made readily available, reducing the complexity and waiting times associated with autologous therapies. This approach also has the potential for scalable manufacturing and consistent quality control.

How does the company ensure the safety and efficacy of its therapy?

The safety and efficacy of Allocetra are evaluated through multiple phases of clinical trials, including rigorous safety run-ins and randomized, placebo-controlled studies that measure endpoints such as pain reduction and functional improvement.

What kind of investor or research interest does Enlivex attract?

Enlivex attracts interest from investors and analysts focused on innovative biopharmaceuticals, particularly those looking at next-generation cell therapies and immunomodulatory treatments that address significant unmet medical needs.
Enlivex Therapeutics Ltd

Nasdaq:ENLV

ENLV Rankings

ENLV Stock Data

20.74M
19.34M
5.59%
22.15%
0.52%
Biotechnology
Healthcare
Link
Israel
Ness Ziona