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eFFECTOR Therapeutics, Inc., headquartered in San Diego, is a cutting-edge biotechnology company that focuses on developing a novel class of oncology drugs known as selective translation regulator inhibitors (STRIs). The company's mission is to advance cancer treatment by targeting key molecular mechanisms that drive the disease.
eFFECTOR's flagship product, zotatifin, is currently under Phase 1/2 clinical trials for ER+/HER2- metastatic breast cancer. Recently, zotatifin received Fast Track designation from the U.S. FDA in combination with fulvestrant and abemaciclib, underscoring its potential in treating advanced or metastatic breast cancer. In these trials, zotatifin showed promising results with a 26% partial response rate in heavily pretreated patients.
Another key product in eFFECTOR's pipeline is tomivosertib, an MNK inhibitor being evaluated in a Phase 2b trial for metastatic non-small cell lung cancer (NSCLC). The company's research extends to other biomarker-positive solid tumors, including ER+ breast cancer and KRAS-mutant NSCLC.
eFFECTOR is also collaborating globally with Pfizer to develop inhibitors targeting eIF4E, further enhancing its research capabilities and clinical development. This partnership aims to streamline the translation of groundbreaking findings into viable treatments for cancer patients.
Financially, eFFECTOR continues to strengthen its position through strategic offerings, raising approximately $15 million in recent direct offerings. This capital helps advance their research projects and maintain a robust developmental pipeline.
Additionally, eFFECTOR announced a reverse stock split aimed at regaining compliance with Nasdaq's minimum bid price requirements, effective January 12, 2024. This move is intended to better position the company within the stock market, ensuring long-term growth and stability.
Stay updated with eFFECTOR's latest developments as they continue to innovate in the field of oncology, pushing the boundaries of cancer treatment.
eFFECTOR Therapeutics has announced that a poster presentation highlighting results from a Phase 2 expansion study of zotatifin in ER+ Metastatic Breast Cancer will be presented at the ASCO 2023 Annual Meeting. The results will be discussed in a conference call following the presentation on June 4, 2023. Abstracts will be available on May 25, 2023. eFFECTOR, a leader in selective translation regulator inhibitors (STRIs), focuses on developing innovative oncology drugs targeting critical cancer pathways. The lead candidate, tomivosertib, is undergoing a Phase 2b trial in combination with pembrolizumab for metastatic non-small cell lung cancer. Zotatifin is also under evaluation in various biomarker-positive solid tumors.
eFFECTOR Therapeutics has announced a clinical collaboration to evaluate zotatifin, an eIF4A inhibitor, in patients with ER+ breast cancer. This trial, led by Dr. Jennifer Caswell-Jin at Stanford Medicine, will focus on specific genomic subgroups, including high-risk patients. The goal is to assess zotatifin's impact on tumor growth compared to standard care, particularly in patients at risk of relapse. The trial's primary objective is to measure changes in tumor proliferation after treatment. This collaboration aims to leverage genomic predictive technologies to improve treatment outcomes for breast cancer patients. Through this study, eFFECTOR hopes to enhance the precision of targeted therapies and address the high rates of relapse observed in ER+ breast cancer.
eFFECTOR Therapeutics, Inc. (NASDAQ: EFTR) announced its participation in two upcoming investor conferences, emphasizing its focus on cancer treatment through selective translation regulator inhibitors (STRIs). The events include a Fireside Chat at Cantor's Future of Oncology Virtual Symposium on April 3, 2023, at 11 AM ET and another at Stifel's Targeted Oncology Days on April 25, 2023, at 2 PM ET. A live webcast of the Stifel event will be accessible on the company's Investors page, with replays available for 90 days. eFFECTOR is advancing innovative therapies targeting critical protein synthesis pathways to combat tumor growth, with lead candidate tomivosertib currently in Phase 2b trials.
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