Welcome to our dedicated page for Crinetics Pharmaceuticals news (Ticker: CRNX), a resource for investors and traders seeking the latest updates and insights on Crinetics Pharmaceuticals stock.
Crinetics Pharmaceuticals, Inc. (NASDAQ: CRNX) is a clinical-stage pharmaceutical company dedicated to the discovery, development, and commercialization of novel therapeutics for rare endocrine diseases and endocrine-related tumors. Founded with a mission to create impactful treatments, Crinetics focuses on advancing its innovative pipeline of orally delivered small molecule drugs.
The company's leading product candidate, paltusotine, is an investigational somatostatin receptor type 2 (SST2) agonist, currently in Phase 3 development for acromegaly and Phase 2 for carcinoid syndrome associated with neuroendocrine tumors. Paltusotine promises a convenient, once-daily oral treatment alternative to monthly injections, simplifying patient care and improving quality of life.
Moreover, Crinetics is advancing CRN04894 (atumelnant), a first-in-class oral ACTH antagonist in Phase 2 trials for congenital adrenal hyperplasia and ACTH-dependent Cushing's disease. This promising candidate aims to address significant unmet needs in these patient populations by reducing disease drivers and normalizing hormone levels.
Crinetics' in-house drug discovery efforts have resulted in several ongoing programs targeting conditions such as hyperparathyroidism, polycystic kidney disease, Graves' disease, thyroid eye disease, diabetes, and obesity. The company's robust pipeline highlights its commitment to developing transformative therapies for patients with rare endocrine disorders.
Recent achievements include a successful private placement of $350 million, strengthening their financial position to support ongoing research and development. The company also reported positive topline results from its Phase 2 study of paltusotine for carcinoid syndrome, as well as from its Phase 3 PATHFNDR-2 study for acromegaly, reinforcing the potential of paltusotine in providing both symptom and biochemical control.
With strategic partnerships, including collaborations with top institutional investors and the National Institutes of Health, Crinetics is well-positioned for future growth. The company remains committed to bringing innovative treatments to market and improving the lives of patients worldwide.
Crinetics Pharmaceuticals (Nasdaq: CRNX) has appointed Caren Deardorf to its board of directors. With over 20 years of experience in biotechnology, she previously led commercial efforts at Biogen, focusing on rare neurological diseases. Scott Struthers, CEO, emphasized her expertise as crucial for the company's shift towards commercialization, especially regarding CRN04777's upcoming patient studies for congenital hyperinsulinism. Crinetics is advancing its lead candidate, paltusotine, through Phase 3 trials for acromegaly and plans to pursue additional trials for related conditions.
Crinetics Pharmaceuticals (Nasdaq: CRNX) announced on March 10, 2022, that its Compensation Committee granted stock options to purchase 121,500 shares to five new non-executive employees. This award is part of the 2021 Employment Inducement Incentive Award Plan, aimed at attracting talent. The options have an exercise price of $19.73 per share, representing the closing price on the grant date, and will vest over four years. The company specializes in developing therapeutics for rare endocrine diseases, including paltusotine for acromegaly, with ongoing clinical trials.
Crinetics Pharmaceuticals (NASDAQ: CRNX) appointed James Hassard as Chief Commercial Officer, bringing over 30 years of commercial experience in biotechnology. Hassard will focus on the company’s lead candidate, paltusotine, currently in Phase 3 trials for acromegaly. His previous roles include leadership positions at Arrowhead Pharmaceuticals and Coherus BioSciences. The company will grant Hassard a non-qualified stock option for 160,000 shares, with a vesting schedule starting on February 28, 2023. This appointment is expected to bolster Crinetics’ commercial strategy and readiness in the market.
Crinetics Pharmaceuticals (Nasdaq: CRNX) has announced a strategic partnership with Sanwa Kagaku Kenkyusho Co., Ltd. to exclusively develop and commercialize paltusotine in Japan, aimed at treating acromegaly and neuroendocrine tumors. The agreement includes a $13 million upfront payment, milestone payments, and tiered royalties on net sales. Sanwa will handle all clinical trial costs and has the exclusive rights in Japan, while Crinetics retains global rights. The partnership anticipates significant market potential with around 21,000 patients affected by these conditions in Japan.
Crinetics Pharmaceuticals (Nasdaq: CRNX) announced its participation in the SVB Leerink Global Healthcare Conference from February 14-18, 2022. A fireside chat featuring company management is scheduled for February 16, 2022, at 1:00 p.m. Eastern Time. Investors can access the live webcast through a provided link and find the archived presentation on the company’s website. Crinetics focuses on developing novel therapeutics for rare endocrine diseases, with its lead candidate, paltusotine, currently in a Phase 3 clinical program for acromegaly.
Crinetics Pharmaceuticals (Nasdaq: CRNX) announced on February 1, 2022, that its Compensation Committee granted non-qualified stock options for 135,000 shares to seven new non-executive employees. This grant follows the 2021 Inducement Plan to incentivize employees joining the company, in compliance with Nasdaq rules. The options have an exercise price of $18.84 per share, matching Crinetics' closing stock price on the grant date. Shares will vest over four years, contingent on continued employment.
Crinetics Pharmaceuticals (NASDAQ: CRNX) provided a company update at the J.P. Morgan Healthcare Conference on January 12, 2022. Key highlights include the expected Phase 1 data for CRN04894 and CRN04777 in 1Q 2022, alongside the initiation of a Phase 2 trial for paltusotine in carcinoid syndrome, also anticipated in 2022. The company aims to advance multiple clinical trials, including the ongoing Phase 3 PATHFNDR trials for paltusotine in acromegaly, with topline data expected in 2023. Crinetics is well-positioned for growth, supported by a robust clinical pipeline and strong financial health.
Crinetics Pharmaceuticals, Inc. (Nasdaq: CRNX) has appointed Dr. Rogério Vivaldi Coelho to its board of directors. Dr. Vivaldi brings more than 20 years of experience in pharmaceuticals and a deep understanding of rare diseases. He previously served as CEO of Sigilon Therapeutics and held key positions at Bioverativ and Genzyme, where he led successful product launches. This appointment aims to leverage his expertise to advance Crinetics' clinical programs and develop treatments for rare endocrine diseases. The company's lead candidate, paltusotine, is currently undergoing a Phase 3 trial for acromegaly.
Crinetics Pharmaceuticals (NASDAQ: CRNX) will participate in the 4th Annual Evercore ISI HealthCONx Conference from November 30 to December 2, 2021. Management will engage in a fireside chat on December 2, 2021, at 12:35 PM ET. Investors can access the webcast here. A replay will be available for 90 days following the event. Crinetics focuses on novel therapies for rare endocrine diseases and is advancing its lead candidate, paltusotine, for treating acromegaly.
Crinetics Pharmaceuticals (Nasdaq: CRNX) announced promising new data from the ACROBAT Advance trial of paltusotine in patients with acromegaly, to be presented at the Society for Endocrinology BES congress in Edinburgh. A total of 84% of eligible participants continued from previous Phase 2 studies. After 51 weeks of treatment, median IGF-1 levels were maintained at lower than washout levels, indicating effective management of the disease. The treatment was generally well tolerated, reinforcing paltusotine's potential as a preferred oral alternative to injected therapies.
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