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Corcept Therapeutics Inc - CORT STOCK NEWS

Welcome to our dedicated page for Corcept Therapeutics news (Ticker: CORT), a resource for investors and traders seeking the latest updates and insights on Corcept Therapeutics stock.

Corcept Therapeutics Inc. (NASDAQ: CORT) is a commercial-stage pharmaceutical company dedicated to the discovery and development of innovative medications that target the underlying effects of abnormal cortisol levels. Cortisol, a hormone essential for various bodily functions, can become dysregulated and contribute to a range of serious health conditions, including metabolic disorders, oncologic diseases, and neuropsychiatric illnesses. Corcept leverages its deep scientific expertise to address these challenges by developing drugs that modulate the glucocorticoid receptor (GR), a key mediator of cortisol's effects.

Core Business Areas

Corcept's business model is centered on the research, development, and commercialization of GR antagonists. The company’s flagship product, mifepristone, is approved for the treatment of hypercortisolism in certain conditions. Beyond this, Corcept has built an extensive pipeline of over 300 proprietary molecules, each designed to selectively block the GR without affecting the progesterone receptor. This specificity minimizes side effects and enhances therapeutic potential.

Addressing Unmet Medical Needs

Corcept’s innovative compounds are being evaluated in clinical trials for their ability to treat a variety of severe and life-threatening conditions. These include:

  • Hypercortisolism: A disorder characterized by excessive cortisol levels, often linked to Cushing's syndrome.
  • Oncologic Applications: Advanced ovarian cancer, prostate cancer, and other malignancies where cortisol plays a role in disease progression.
  • Neuropsychiatric Disorders: Conditions such as post-traumatic stress disorder (PTSD), mild cognitive impairment, and Alzheimer’s disease.
  • Metabolic Diseases: Non-alcoholic steatohepatitis (NASH) and other metabolic syndromes influenced by cortisol dysregulation.

Scientific Approach and Differentiation

What sets Corcept apart in the competitive pharmaceutical landscape is its singular focus on GR antagonism. Unlike traditional therapies that may broadly target hormonal pathways, Corcept’s compounds are designed to selectively block the GR, thereby mitigating the adverse effects of excess cortisol while preserving other hormonal functions. This approach is supported by extensive scientific literature and represents a promising avenue for treating diseases with high unmet medical needs.

Market Position and Growth Potential

Operating in the dynamic pharmaceutical industry, Corcept occupies a niche position as a pioneer in cortisol modulation therapies. Its focus on conditions with limited treatment options provides a strategic advantage, as does its robust pipeline of proprietary molecules. However, the company faces challenges typical of the sector, including regulatory approvals, competition from larger pharmaceutical firms, and the inherent risks of clinical trial outcomes. Despite these hurdles, Corcept’s unique scientific approach and targeted focus position it as a significant player in its field.

Commitment to Innovation

Corcept’s commitment to advancing medical science is evident in its investment in research and development. By exploring the role of cortisol in various diseases and developing compounds that address these mechanisms, the company aims to deliver transformative therapies that improve patient outcomes. Its strategic focus on unmet medical needs underscores its potential to make a lasting impact on the healthcare landscape.

Conclusion

Corcept Therapeutics Inc. exemplifies the intersection of scientific innovation and patient-focused care. Through its pioneering work in cortisol modulation, the company addresses some of the most pressing challenges in modern medicine. With a strong foundation in research, a growing pipeline of proprietary compounds, and a commitment to addressing unmet medical needs, Corcept is well-positioned to contribute significantly to the pharmaceutical industry.

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Corcept Therapeutics (NASDAQ: CORT) announced encouraging results from a Phase 2 trial involving 178 patients with recurrent platinum-resistant ovarian cancer. The trial, featured at ESMO 2021, showed that women treated with nab-paclitaxel and relacorilant experienced significant improvement in progression-free survival (PFS). The Intermittent arm demonstrated a median PFS of 5.6 months compared to 3.8 months in the Comparator arm. Corcept plans to initiate a pivotal Phase 3 trial in early 2022 to confirm these findings.

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Corcept Therapeutics (CORT) announced positive results from its 178-patient Phase 2 trial of relacorilant combined with nab-paclitaxel for treating recurrent platinum-resistant ovarian cancer. The findings will be presented at the ESMO conference on September 17, 2021. The trial demonstrated a significant benefit in delaying disease progression without increasing side effects. CEO Joseph K. Belanoff expressed optimism about the drug's potential and revealed plans to initiate a pivotal Phase 3 trial in early 2022 to validate these results.

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Corcept Therapeutics (NASDAQ: CORT) announced the appointment of William Guyer, PharmD, as Chief Development Officer effective August 16, 2021. Guyer, who previously worked at Gilead Sciences, brings nearly 30 years of experience in medical affairs and drug development. His expertise includes launching treatments in complex disease areas, advancing compounds from research to commercialization. Under his leadership, Corcept aims to enhance its clinical programs for cortisol modulation, targeting severe metabolic, oncologic, and psychiatric disorders. The company's drug Korlym is FDA-approved for Cushing's syndrome.

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Corcept Therapeutics (CORT) reported Q2 2021 revenue of $91.6 million, up from $88.6 million in Q2 2020, with a GAAP net income of $26.5 million ($0.21 per share), down from $28.3 million in the previous year. Non-GAAP net income was $38.2 million ($0.30 per share). The company's cash and investments increased to $471.6 million. Corcept reiterated its 2021 revenue guidance of $355 – $385 million. The CEO highlighted growth due to easing COVID-19 restrictions and advancements in clinical trials, particularly for their treatment relacorilant.

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Corcept Therapeutics (NASDAQ: CORT) is set to announce its second quarter financial results and provide a corporate update on July 29, 2021, at 5:00 p.m. ET. The company, known for treating severe metabolic, oncologic, and psychiatric disorders through cortisol modulation, will host a conference call that day. Interested participants can join via a provided link or by dialing in 15 minutes prior to the call. A replay of the call will be available until August 12, 2021.

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Corcept Therapeutics (NASDAQ: CORT) announced the appointment of Amy Flood as Chief Human Resources and Communications Officer. Flood brings nearly 25 years of experience, mainly from Gilead Sciences, where she played a key role in team development and communications. CEO Joseph K. Belanoff expressed confidence in her abilities to help Corcept tackle challenges as it expands its commercial business and develops its portfolio of selective cortisol modulators.

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Corcept Therapeutics (NASDAQ: CORT) has halted enrollment in its RELIANT trial for relacorilant combined with nab-paclitaxel in patients with metastatic pancreatic cancer. Interim results show a 6% partial response and 48% stable disease among treated patients; however, the benefits do not justify further studies for end-stage pancreatic cancer. The company is moving forward with a Phase 3 trial in platinum-resistant ovarian cancer and evaluating relacorilant for earlier-stage pancreatic cancer and other solid tumors.

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Corcept Therapeutics (NASDAQ: CORT) announced a settlement with Sun Pharmaceutical Industries, resolving ongoing patent litigation regarding Korlym®, a treatment for Cushing's syndrome. The agreement allows Sun to market a generic version starting October 1, 2034, or earlier under specific circumstances. CEO Joseph K. Belanoff emphasized that this resolution enables the company to focus on growing the Korlym business and advancing its pipeline, including relacorilant. The settlement awaits court approval and must be reviewed by the FTC and DOJ. Related litigation remains pending against two other companies.

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Corcept Therapeutics (NASDAQ: CORT) announced Joshua M. Murray's appointment to its Board of Directors. Murray is a seasoned finance executive, currently with Orca Bio, and previously spent 15 years at Goldman Sachs. His expertise is expected to support Corcept in expanding its commercial reach for Korlym® and advancing its portfolio of selective cortisol modulators. This leadership addition may enhance strategic oversight and foster growth opportunities for the company, especially in navigating challenges within the biopharmaceutical sector.

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Corcept Therapeutics (CORT) reported a first quarter 2021 revenue of $79.4 million, down from $93.2 million in the same quarter of 2020, attributed to COVID-19 disruptions. GAAP diluted net income fell to $0.18 per share from $0.25. Non-GAAP diluted income decreased to $0.20 from $0.34. The company has $454.8 million in cash and investments, down from $476.9 million at year-end 2020. Corcept modified its revenue guidance for 2021 to between $355 million and $385 million and is progressing towards a Phase 3 trial for relacorilant in ovarian cancer.

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FAQ

What is the current stock price of Corcept Therapeutics (CORT)?

The current stock price of Corcept Therapeutics (CORT) is $74.45 as of April 4, 2025.

What is the market cap of Corcept Therapeutics (CORT)?

The market cap of Corcept Therapeutics (CORT) is approximately 7.9B.

What does Corcept Therapeutics specialize in?

Corcept Therapeutics specializes in developing drugs that modulate the effects of cortisol to treat metabolic, oncologic, and neuropsychiatric disorders.

What is Corcept’s flagship product?

Corcept’s flagship product is mifepristone, approved for treating hypercortisolism in specific conditions.

What makes Corcept’s approach unique?

Corcept focuses on selective glucocorticoid receptor (GR) antagonism, which targets cortisol's effects without affecting other hormonal pathways.

What diseases are Corcept’s compounds being developed to treat?

Corcept’s compounds are being developed to treat hypercortisolism, advanced cancers, PTSD, Alzheimer’s disease, and metabolic disorders like NASH.

How does Corcept generate revenue?

Corcept generates revenue through the commercialization of its approved drugs and ongoing development of its proprietary pipeline.

What challenges does Corcept face in its industry?

Corcept faces challenges such as regulatory approvals, competition from larger pharmaceutical companies, and the risks inherent in clinical trials.

What is the significance of glucocorticoid receptor antagonism?

Glucocorticoid receptor antagonism helps mitigate the adverse effects of excess cortisol, offering potential treatments for various serious conditions.

What is Corcept’s competitive advantage?

Corcept’s competitive advantage lies in its focus on cortisol modulation and its extensive pipeline of proprietary GR antagonists.

What industries does Corcept Therapeutics operate in?

Corcept operates in the pharmaceutical and biotechnology industries, focusing on drug development for unmet medical needs.

How does Corcept contribute to addressing unmet medical needs?

Corcept develops innovative therapies targeting diseases with limited treatment options, such as hypercortisolism and advanced cancers.
Corcept Therapeutics Inc

Nasdaq:CORT

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CORT Stock Data

7.87B
93.36M
11.44%
81.8%
15.21%
Biotechnology
Pharmaceutical Preparations
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United States
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