Calidi Biotherapeutics Confirms Featured Speaker Presentation Tomorrow at the ASGCT Conference in Boston
Rhea-AI Summary
Calidi Biotherapeutics (NYSE American: CLDI) announced that Chief Scientific Officer Dr. Antonio F. Santidrian will present at the ASGCT conference in Boston. He will discuss the company’s RedTail systemic virotherapy platform and new preclinical data for lead programs CLD-401 and CLD-501.
AI-generated analysis. Not financial advice.
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News Market Reaction – CLDI
On the day this news was published, CLDI gained 8.11%, reflecting a notable positive market reaction. Argus tracked a peak move of +2.1% during that session. Argus tracked a trough of -9.2% from its starting point during tracking. Our momentum scanner triggered 6 alerts that day, indicating moderate trading interest and price volatility. This price movement added approximately $228K to the company's valuation, bringing the market cap to $3.05M at that time.
Data tracked by StockTitan Argus on the day of publication.
Key Figures
Market Reality Check
Peers on Argus
CLDI was down 6.8% while key peers like APRE (-4.76%) and GNPX (-2.35%) also declined. Momentum scanner shows mixed action (APRE and ERNA up, GLMD down), indicating stock-specific factors rather than a unified sector move.
Historical Context
| Date | Event | Sentiment | Move | Catalyst |
|---|---|---|---|---|
| Apr 29 | AI partnership | Positive | -6.9% | TransferAI collaboration to streamline IND submission process for CLD-401. |
| Apr 21 | AACR data CLD-401 | Positive | -11.3% | Preclinical CLD-401 data with tumor-restricted IL-15 superagonist expression. |
| Apr 20 | AACR TCE data | Positive | -9.0% | RedTail in situ T-cell engagers and new CLD-501 TROP2-targeting candidate. |
| Apr 14 | IOVC presentation | Positive | -4.4% | IOVC talk on systemic delivery, tumor-selective replication and payload expression. |
| Apr 07 | ASGCT preview | Positive | -1.3% | Announcement of upcoming ASGCT presentation on RedTail systemic virotherapy. |
Recent scientifically positive updates on RedTail and CLD-401 have repeatedly coincided with negative 24h price reactions.
Over the past month, Calidi has repeatedly highlighted its RedTail virotherapy platform and lead asset CLD-401 across AACR, IOVC, and ASGCT-focused announcements, alongside a new AI-enabled IND partnership with TransferAI. Each update emphasized tumor-selective IL‑15 superagonist delivery, in situ T‑cell engager strategies, and a targeted IND filing by end of 2026. Despite the constructive scientific and strategic tone, the stock saw 24‑hour declines from -1.31% to -11.35% after these events, suggesting a pattern of weak price follow-through on positive R&D news.
Market Pulse Summary
The stock moved +8.1% in the session following this news. A strong positive reaction aligns with Calidi’s ongoing effort to showcase its RedTail platform and lead asset CLD-401 across major conferences such as ASGCT and AACR. Historically, similar preclinical and platform updates had negative 24‑hour moves despite constructive content, so a large gain would have contrasted with that pattern. Investors have monitored execution toward the stated end‑2026 IND goal and potential partnerships as key benchmarks for translating scientific promise into tangible progress.
Key Terms
virotherapy medical
tumor microenvironment medical
il-15 superagonist medical
nk-cell medical
gamma delta (γδ) t-cells medical
t cell engagers medical
AI-generated analysis. Not financial advice.
SAN DIEGO, May 13, 2026 (GLOBE NEWSWIRE) -- Antonio F. Santidrian, PhD, Chief Scientific Officer and Head of Technical Operations for Calidi Biotherapeutics, Inc. (NYSE American: CLDI) (“Calidi” or “the Company”), a biotechnology company pioneering the development of targeted genetic medicines, will speak tomorrow at the annual conference of the American Society for Gene and Cell Therapy (ASGCT) in Boston, Massachusetts. Dr. Santidrian was invited to speak at the conference and detail the exciting promise of Calidi’s RedTail platform and pipeline. The Company’s proprietary RedTail platform is a systemically delivered virotherapy platform engineered to selectively target tumors, remodel the tumor microenvironment (“TME”), and enable high-level expression of therapeutic genetic payloads directly within tumors.
Dr. Santidrian will discuss the engineering of the RedTail platform and present new data on CLD-401, the first lead from the RedTail platform. CLD-401 is a systemically delivered virotherapy designed to selectively target tumors and enable high-level expression of IL-15 superagonist (“IL-15 SA”), a known T- and NK-cell activator, driving profound immune changes in the TME, including the recruitment and activation of NK, NK-T, and gamma delta (γδ) T-cells that lead to a robust therapeutic response in immunocompetent animal models. The Company expects to file an IND for CLD-401 by the end of 2026. In addition to IL-15 SA delivery with CLD-401, the RedTail platform has also been shown to enable in situ expression of tumor-targeted T cell engagers, as demonstrated in a separate American Association for Cancer Research (AACR) presentation focused on the CLD-501 program.
“The data I will discuss tomorrow demonstrates the potential of the RedTail platform as systemic virotherapy that can deliver genetic medicine to metastatic sites after systemic administration,” said Dr. Santidrian. “The ability of CLD-401 to induce high levels of IL15-SA expression in the TME while maintaining low circulating levels may dramatically expand the therapeutic window of IL-15-mediated treatment.”
The Company continues to expand the functionality of the RedTail platform, with data presented at AACR across multiple programs including CLD-401 and CLD-501, and is also actively pursuing strategic partnerships to accelerate clinical development and broaden the impact of its RedTail platform.
About Calidi
Calidi Biotherapeutics (NYSE American: CLDI) is a biotechnology company pioneering the development of targeted therapies with the potential to deliver genetic medicines to distal sites of disease. The company’s proprietary RedTail platform features an engineered enveloped oncolytic virus designed for systemic delivery and targeting of metastatic sites. This advanced enveloped technology is intended to shield the virus from immune clearance, allowing virotherapy to effectively reach tumor sites, induce tumor lysis, and deliver potent genetic medicine(s) to metastatic locations.
CLD-401, the lead candidate from the RedTail platform, currently in IND-enabling studies, targets non-small cell lung cancer, head and neck cancer, and other tumor types with high unmet medical need. Calidi continues to advance its pipeline utilizing the RedTail platform including its novel approach to incorporate in situ T-cell engagers in solid tumors.
Calidi Biotherapeutics is headquartered in San Diego, California. For more information, please visit www.calidibio.com or view Calidi’s Corporate Presentation here.
Forward-Looking Statements
This press release may contain forward-looking statements for purposes of the “safe harbor” provisions under the United States Private Securities Litigation Reform Act of 1995. Terms such as “anticipates,” “believe,” “continue,” “could,” “estimate,” “expect,” “intends,” “may,” “might,” “plan,” “possible,” “potential,” “predicts,” “project,” “should,” “towards,” “would” as well as similar terms, are forward-looking in nature, but the absence of these words does not mean that a statement is not forward-looking. These forward-looking statements include, but are not limited to, statements concerning key milestones, including certain pre-clinical data, planned clinical trials, and statements relating to the safety and efficacy of Calidi’s therapeutic candidates in development. Any forward-looking statements contained in this discussion are based on Calidi’s current expectations and beliefs concerning future developments and their potential effects and are subject to multiple risks and uncertainties that could cause actual results to differ materially and adversely from those set forth or implied in such forward-looking statements. These risks and uncertainties include, but are not limited to, the risk that Calidi is not able to raise sufficient capital to support its current and anticipated clinical trials, the risk that early results of clinical trials do not necessarily predict final results and that one or more of the clinical outcomes may materially change following more comprehensive review of the data, and as more patient data becomes available, the risk that Calidi may not receive FDA approval for some or all of its therapeutic candidates. Other risks and uncertainties are set forth in the section entitled “Risk Factors” and “Cautionary Note Regarding Forward-Looking Statements” in the Company’s annual report filed with the SEC on Form 10-K on March 27, 2026, as may be amended or supplemented by other reports we file with the SEC from time to time. We disclaim any obligation to update any forward-looking statement to reflect events or circumstances after the date of this press release or to reflect the occurrence of unanticipated events.
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