C4 Therapeutics Announces Delivery of Second Development Candidate to Biogen
C4 Therapeutics (Nasdaq: CCCC) has successfully delivered a second development candidate to Biogen, earning an $8 million milestone payment. This marks the final development candidate under their strategic collaboration. The delivered candidate is a highly catalytic, brain penetrant orally bioavailable BiDAC™ degrader.
C4T's TORPEDO® platform has demonstrated its potential to design innovative degraders against various target classes. Since 2015, C4T has advanced four development candidates for its clinical pipeline and delivered two to Biogen. Under the 2018 collaboration, C4T provided expertise in targeted protein degradation, while Biogen offered scientific and drug development capabilities. Biogen is responsible for future clinical development and commercialization of the delivered candidates.
C4 Therapeutics (Nasdaq: CCCC) ha conseguito con successo un secondo candidato allo sviluppo per Biogen, guadagnando un pagamento per milestone di 8 milioni di dollari. Questo segna l'ultimo candidato allo sviluppo nell'ambito della loro collaborazione strategica. Il candidato consegnato è un degradatore BiDAC™ altamente catalitico, penetrante nel cervello e bio disponibile per via orale.
La piattaforma TORPEDO® di C4T ha dimostrato il suo potenziale nel progettare degradatori innovativi contro varie classi di target. Dal 2015, C4T ha avanzato quattro candidati allo sviluppo per il suo pipeline clinico e ne ha consegnati due a Biogen. Nell'ambito della collaborazione del 2018, C4T ha fornito competenze nella degradazione mirata delle proteine, mentre Biogen ha offerto capacità scientifiche e di sviluppo dei farmaci. Biogen è responsabile dello sviluppo clinico e della commercializzazione futura dei candidati consegnati.
C4 Therapeutics (Nasdaq: CCCC) ha entregado con éxito un segundo candidato para el desarrollo a Biogen, obteniendo un pago por hito de 8 millones de dólares. Esto marca el último candidato de desarrollo bajo su colaboración estratégica. El candidato entregado es un degradador BiDAC™ altamente catalítico, que penetra en el cerebro y es bio disponible por vía oral.
La plataforma TORPEDO® de C4T ha demostrado su potencial para diseñar degradadores innovadores contra diversas clases de objetivos. Desde 2015, C4T ha avanzado cuatro candidatos para el desarrollo para su pipeline clínico y ha entregado dos a Biogen. En la colaboración de 2018, C4T proporcionó experiencia en la degradación proteica dirigida, mientras que Biogen ofreció capacidades científicas y de desarrollo de fármacos. Biogen es responsable del desarrollo clínico futuro y la comercialización de los candidatos entregados.
C4 Therapeutics (Nasdaq: CCCC)는 Biogen에 두 번째 개발 후보를 성공적으로 전달하여 800만 달러의 이정표 지급금을 받았습니다. 이는 그들의 전략적 협력 하의 마지막 개발 후보를 의미합니다. 전달된 후보는 고도로 촉매적이며, 두뇌 침투가 가능하고 경구 생체이용 가능한 BiDAC™ 분해제입니다.
C4T의 TORPEDO® 플랫폼은 다양한 표적 클래스에 대한 혁신적인 분해제를 설계할 수 있는 잠재력을 입증하였습니다. 2015년 이후 C4T는 4개의 개발 후보를 임상 파이프라인으로 발전시켰고, 두 개를 Biogen에 전달하였습니다. 2018년 협력 하에 C4T는 표적 단백질 분해에 대한 전문 지식을 제공하였고 Biogen은 과학적 및 약물 개발 능력을 제공하였습니다. Biogen은 전달된 후보의 향후 임상 개발 및 상용화에 대한 책임이 있습니다.
C4 Therapeutics (Nasdaq: CCCC) a remis avec succès un deuxième candidat pour le développement à Biogen, recevant un paiement d'étape de 8 millions de dollars. Cela marque le dernier candidat au développement dans le cadre de leur collaboration stratégique. Le candidat livré est un dégradateur BiDAC™ à forte catalyse, pénétrant dans le cerveau et bio disponible par voie orale.
La plateforme TORPEDO® de C4T a démontré son potentiel à concevoir des dégradateurs innovants contre diverses classes cibles. Depuis 2015, C4T a fait progresser quatre candidats au développement pour son pipeline clinique et en a livré deux à Biogen. Dans le cadre de la collaboration de 2018, C4T a apporté son expertise en dégradation ciblée des protéines, tandis que Biogen a offert des capacités scientifiques et de développement des médicaments. Biogen est responsable du développement clinique futur et de la commercialisation des candidats livrés.
C4 Therapeutics (Nasdaq: CCCC) hat erfolgreich einen zweiten Entwicklungskandidaten an Biogen geliefert, was zu einer Meilenstein-Zahlung von 8 Millionen Dollar führt. Dies markiert den letzten Entwicklungskandidaten im Rahmen ihrer strategischen Zusammenarbeit. Der gelieferte Kandidat ist ein hoch katalytischer, im Gehirn durchdringender, oral bioverfügbarer BiDAC™-Degrader.
Die TORPEDO®-Plattform von C4T hat ihr Potenzial gezeigt, innovative Degrader gegen verschiedene Zielklassen zu entwerfen. Seit 2015 hat C4T vier Entwicklungskandidaten vorangebracht für seine klinische Pipeline und zwei an Biogen geliefert. Im Rahmen der Zusammenarbeit von 2018 hat C4T Fachwissen in der gezielten Proteinabbau bereitgestellt, während Biogen wissenschaftliche und Arzneimittelentwicklungsfähigkeiten angeboten hat. Biogen ist verantwortlich für die zukünftige klinische Entwicklung und Vermarktung der gelieferten Kandidaten.
- Earned $8 million milestone payment from Biogen
- Successfully delivered second and final development candidate to Biogen
- Demonstrated effectiveness of TORPEDO® platform in designing innovative degraders
- Advanced four development candidates for clinical pipeline since 2015
- Delivered two development candidates to Biogen under strategic collaboration
- None.
Insights
The delivery of a second development candidate to Biogen marks a significant milestone for C4 Therapeutics, resulting in an
C4 Therapeutics' success in delivering two development candidates to Biogen is a remarkable achievement in the challenging field of targeted protein degradation. The company's BiDAC™ degrader technology, particularly its brain-penetrant and orally bioavailable properties, addresses key hurdles in drug development for neurological disorders. This accomplishment validates C4T's scientific approach and positions them as a leader in the protein degradation space. The delivery of four internal and two partnered development candidates since 2015 is impressive for a company of C4T's size, indicating strong R&D productivity. This track record could enhance C4T's appeal for future collaborations and potentially accelerate its own pipeline development.
The successful completion of C4 Therapeutics' collaboration with Biogen could have broader implications for the targeted protein degradation market. This field is gaining traction and C4T's ability to deliver multiple candidates demonstrates the scalability and versatility of their platform. The collaboration's success may encourage other big pharma companies to seek partnerships with protein degradation specialists, potentially driving up valuations in this sector. For C4T, this achievement could lead to increased investor interest and potentially higher valuation multiples. However, the company will need to continue demonstrating success in its clinical pipeline to maintain momentum. The market will likely watch closely for updates on Biogen's progress with these candidates as a gauge of C4T's technology's long-term potential.
Milestone Results in
WATERTOWN, Mass., Sept. 10, 2024 (GLOBE NEWSWIRE) -- C4 Therapeutics, Inc. (C4T) (Nasdaq: CCCC), a clinical-stage biopharmaceutical company dedicated to advancing targeted protein degradation science, today announced it has successfully delivered a second development candidate to Biogen and earned an
“We are thrilled to deliver a highly catalytic, brain penetrant orally bioavailable BiDAC™ degrader development candidate to Biogen in their pursuit of discovering, developing and delivering innovative therapies that improve the lives of patients,” said Andrew Hirsch, president and chief executive officer. “It is rare that discovery collaborations deliver one, much less two, development candidates to the partner. This result is a testament to the dedication of the Biogen and C4T teams and the productivity of our TORPEDO® platform, which has demonstrated its potential to design innovative degraders against a broad range of target classes. Since our founding in 2015, we have discovered and advanced four development candidates for our clinical pipeline and delivered two development candidates to Biogen, an impressive feat for a company of our size. We are proud to continue advancing the exciting field of targeted protein degradation and bring new medicines to patients.”
Under the terms of the strategic collaboration established in 2018, C4T provided expertise and research services in targeted protein degradation and Biogen provided scientific and drug development capabilities. Biogen is responsible for all future clinical development and commercialization for development candidates delivered under the collaboration. Previously, C4T earned an
About C4 Therapeutics
C4 Therapeutics (C4T) (Nasdaq: CCCC) is a clinical-stage biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of medicines that transforms patients’ lives. C4T is progressing targeted oncology programs through clinical studies and leveraging its TORPEDO® platform to efficiently design and optimize small-molecule medicines to address difficult-to-treat diseases. C4T’s degrader medicines are designed to harness the body’s natural protein recycling system to rapidly degrade disease-causing proteins, offering the potential to overcome drug resistance, drug undruggable targets and improve patient outcomes. For more information, please visit www.c4therapeutics.com.
Forward-Looking Statements
This press release contains “forward-looking statements” of C4 Therapeutics, Inc. within the meaning of the Private Securities Litigation Reform Act of 1995. These forward-looking statements may include, but may not be limited to, express or implied statements regarding our ability to develop potential therapies for patients; the potential productivity of our TORPEDO® platform; and our ability to deliver development candidates to our discovery collaboration partners or for our proprietary programs. Any forward-looking statements in this press release are based on management’s current expectations and beliefs of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to: uncertainties related to the initiation, timing, advancement and conduct of proprietary or collaboration partner programs; the risk that any one or more of our programs will cost more to develop or may not result in a product candidate that can be successfully developed and commercialized; and the risk that sufficient capital to fund our future operations will be available to us on acceptable terms or at the times required. For a discussion of these and other risks and uncertainties, and other important factors, any of which could cause our actual results to differ from those contained in the forward-looking statements, see the section entitled “Risk Factors” in C4 Therapeutics’ most recent Annual Report on Form 10-K and/or Quarterly Report on Form 10-Q, as filed with the Securities and Exchange Commission. All information in this press release is as of the date of the release, and C4 Therapeutics undertakes no duty to update this information unless required by law.
Contacts:
Investors:
Courtney Solberg
Senior Manager, Investor Relations
CSolberg@c4therapeutics.com
Media:
Loraine Spreen
Senior Director, Corporate Communications & Patient Advocacy
LSpreen@c4therapeutics.com
FAQ
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