Cibus' Confirms Important Milestone for Nutrient Use Efficiency Trait Development
Cibus announced a significant milestone in developing Nutrient Use Efficiency (NUE) traits in Canola. This achievement marks the first gene edits for NUE in a major North American crop. These edits aim to improve fertilizer efficiency, potentially reducing environmental impact. Cibus' Rapid Trait Development System (RTDS) technology was pivotal in this advancement. The achievement was a result of a collaboration with an industry-leading third party. The NUE trait aims to increase crop yield while using fewer resources, contributing to sustainability by lowering CO2 emissions.
- First successful Nutrient Use Efficiency (NUE) gene edits in Canola.
- Potential to improve crop yields while reducing fertilizer use and costs.
- Significant reduction in environmental impact, potentially cutting CO2 emissions.
- Demonstrates Cibus' ability to accelerate trait development through its RTDS technology.
- Collaboration with a reputable third party, enhancing credibility and capabilities.
- Potential to improve resource sustainability and positively impact air, water, and soil quality.
- Success of the NUE trait still dependent on controlled environment tests.
- Potential delays and uncertainties in commercializing the NUE trait.
- Reliance on partnerships with third parties for trait development.
- No immediate financial gains reported from this development.
Insights
Gene editing in agriculture is revolutionizing the way we approach crop improvement. The successful edit of Canola's Nutrient Use Efficiency (NUE) trait marks a notable advancement in this field. Given that only
From a scientific standpoint, Cibus' use of its Rapid Trait Development System™ (RTDS®) for this innovation is significant. It showcases how modern biotechnology can accelerate the integration of complex traits into crops, which traditionally required long breeding cycles. The involvement of a third-party trait further highlights the versatility and collaborative potential of Cibus' technology.
In the short term, while controlled environment tests are critical, the real test will be large-scale field trials. If successful, this could pave the way for broader application in other crops, enhancing global agricultural productivity.
The announcement underscores Cibus' strategic positioning in the agricultural biotechnology sector. By successfully editing the NUE trait in Canola, Cibus demonstrates its ability to bring innovative traits to commercialization. This can solidify its revenue model based on licensing traits to seed companies, potentially leading to recurring income through royalties.
The market for improved nutrient use efficiency is substantial, given the global reliance on nitrogen fertilizers. Reducing fertilizer costs can be a compelling value proposition for farmers, potentially driving demand for seeds with Cibus' edited traits. Additionally, the environmental benefits might attract regulatory support and subsidies, enhancing market adoption.
In the long-term, Cibus' trait development capabilities, as evidenced by the successful integration of third-party traits, could result in a diversified pipeline, mitigating risks associated with reliance on a few key products. However, investors should monitor the progress of field trials and subsequent commercial adoption to assess the financial impact accurately.
From an environmental economics perspective, the development of the NUE trait by Cibus could have significant positive externalities. By increasing the efficiency of nitrogen fertilizer use, the technology promises to reduce nitrogen runoff, which is a major source of water pollution. Additionally, it can lower CO2 emissions from fertilizer production, contributing to climate change mitigation efforts.
Quantifying these benefits, a
However, the real impact will depend on widespread adoption and the ability to demonstrate these benefits in diverse agricultural settings. Long-term success will hinge on regulatory frameworks and policies that support sustainable farming practices.
Nutrient Use Efficiency Traits are an Important Large Category of Traits that can Make Fertilizer Use More Efficient on a Global Basis
The First Case of Cibus Using its Trait Machine Process for a Third Party Developed Trait
SAN DIEGO, June 17, 2024 (GLOBE NEWSWIRE) -- Cibus, Inc. ("Cibus" or the "Company") (Nasdaq: CBUS), a leading agricultural technology company that develops and licenses plant traits to seed companies for royalties, today announced it has confirmed it has successfully made edits in Canola for its initial Nutrient Use Efficiency (NUE) trait. These newly edited plants will now be tested in controlled environments. If successful, Cibus expects this will mark a milestone of what is believed to be the first NUE gene edits in a major crop in North America.
Cibus is a leader in developing complex gene-edited traits in plants. The Company focuses on key strategic areas like disease and other productivity traits like NUE. The aim of its NUE trait development efforts is to significantly improve crop production with lower inputs through more efficient use of soil-borne nutrients without compromising the yield growers expect. Today, only about a third of applied nitrogen fertilizer is absorbed by the plant, limiting the plant's biomass generation and grain yield. Beyond yield and cost reduction, an NUE trait also has the potential to improve resource sustainability and positively impact air, water, and soil quality. Globally,
Steve Sanders, PhD and Executive Director of Molecular Discovery and Computational Biology at Cibus, commented, “We are excited with the speed with which we have completed the first edited NUE plants. This was a product of collaboration with a third party to develop this mode of action for NUE. We believe this further validates how Cibus' technologies can accelerate the time to edit additional complex traits. We believe we continue to demonstrate that our approach to trait development is additive to established industry standards, accelerating timelines compared to conventional breeding programs.”
Peter Beetham, PhD, Co-Founder, President, and COO of Cibus, added, “This latest development with NUE is particularly notable in that we took a trait developed and characterized by a highly reputable industry-leading third party and successfully integrated it into a Canola plant utilizing our patented RTDS technology platform – the Trait Machine™ process. This coordination and efficiency speaks to Cibus' unique capabilities to accelerate development timelines for growers, the agriculture industry, and the environment.”
Rory Riggs, Co-Founder, Chairman, and CEO of Cibus, concluded, “Through the Calyxt merger, we solidified our position as a leading gene editing and trait development company for major crops, with a model geared toward licensing traits to our seed company partners for the benefit of their farmer customers. We are armed with three Developed traits – two Rice Herbicide Tolerance (HT) traits and our Canola Pod Shatter Reduction (PSR) trait – and backed by extensive field trials to support commercialization with customers. Further, trait patents such as the one recently issued for our Pod Shatter Trait, are accompanied with field trial results supporting the patented claim.”
“We are actively engaging with industry participants to bring their traits and other research & development efforts to life with our Trait Machine™ process. This latest development with NUE is important because it establishes a third Advanced trait in our pipeline to complement our ongoing work with our two other advanced traits: White Mold (Sclerotinia) and HT2; we have now made successful edits for each of the advanced traits.”
“A key element of our trait business is the single-cell regeneration technology that lets us take a single cell from a customer's elite germplasm, edit the cell, and regenerate the cell into the customers' seed with the specific edit. We call these single cell regeneration models our crop platforms. At the time of the Calyxt merger, we had crop platforms in Canola, Rice, Potato, Peanut, Flax, Sugar Beet, and Cassava. Since the merger, we have added a Wheat platform and expect to complete our Soybean platform in 2024. We have edited and returned plants with desired edit configurations and trait performance to both Canola and Rice.”
“This recent NUE edit is a great example showing the versatility of our crop platform approach. It demonstrates our ability as a development partner to take customer-identified gene targets and successfully make edits in Cibus' crop platforms to develop a trait.”
About Nutrient Use Efficiency
Cibus' objective for nutrient use efficiency (NUE) traited plants is to enable lower fertilizer use while maintaining or improving expected crop yields. For example, nitrogen is one of the most essential nutrients for plant growth. Each plant species has specific nitrogen requirements to grow and thrive, and is one of the primary determinants of crop yield. Plants themselves are inefficient at using the nitrogen to which they have access. In addition, nitrogen can be leached from the soil during flooding events or fertilizer overuse, polluting the air, rivers, soils, and seas. Moreover, nitrous oxide emissions from fertilizer use are 300 times more potent than carbon dioxide and deplete the ozone layer. The amount of reactive nitrogen in our environment has already breached safe limits, dramatically impacting plant biodiversity, plant and soil health, and climate. Managing nutrient and fertilizer use while maintaining crop yields is one of the most critical needs to reducing the effects of climate change and feeding our growing population.
About Cibus
Cibus is a leading agricultural technology company that develops and licenses plant traits to seed companies for royalties. Cibus is a leader in the new era of next generation gene-edited trait development, where plant traits (or specific genetic characteristics) that are indistinguishable from traits developed using traditional breeding are now created using gene editing. A key element of Cibus’ technology breakthrough is its patented RTDS® technology platform: the Trait Machine™-- the industry’s first semi-automated stand-alone trait production facility. Cibus’ Trait Machine™ materially changes the speed, breadth, and scale of trait development. This breakthrough is central to Cibus’ vision for the Future of Breeding: “High Throughput Gene Editing Systems operating as an extension of seed company breeding programs”. The ability to develop complex traits at a fraction of the time and cost of conventional breeding will be critical for addressing the sustainability challenges presented by Climate Change.
CIBUS CONTACTS:
INVESTOR RELATIONS
Karen Troeber
ktroeber@cibus.com
858-450-2636
MEDIA RELATIONS
media@cibus.com
Colin Sanford
colin@bioscribe.com
203-918-4347
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