Welcome to our dedicated page for Carisma Therapeutics news (Ticker: CARM), a resource for investors and traders seeking the latest updates and insights on Carisma Therapeutics stock.
Carisma Therapeutics, Inc. (Nasdaq: CARM) is a cutting-edge clinical-stage biopharmaceutical company headquartered in Philadelphia, PA. The company is dedicated to developing transformative immunotherapies for cancer and other serious diseases using its proprietary chimeric antigen receptor macrophage (CAR-M) and monocyte cell engineering platforms.
Carisma is pioneering the use of engineered macrophages and monocytes, which are types of white blood cells essential for immune response. By harnessing these cells, Carisma aims to create innovative treatments for diseases with unmet medical needs. The company's leading product candidates include CT-0508 and CT-0525, both targeting HER2-overexpressing tumors.
CT-0508 is a CAR-M therapy currently in a Phase 1 clinical trial, marking the first time engineered macrophages are being tested in humans. It targets patients with recurrent or metastatic HER2-overexpressing solid tumors who have not responded to standard treatments. CT-0525, on the other hand, is an autologous chimeric antigen receptor-monocyte (CAR-Monocyte) cellular therapy. Recently cleared by the FDA, it has shown promising preclinical results and is expected to begin Phase 1 trials shortly.
The company's collaboration with Moderna, Inc. to develop in vivo CAR-M therapeutics highlights Carisma's commitment to innovative partnerships. This joint effort aims to leverage Moderna's mRNA and lipid nanoparticle (LNP) technologies to create new cancer treatments.
Carisma has also made significant strides in non-oncology applications. Recently, preclinical data demonstrated the efficacy of engineered macrophages in treating liver fibrosis, indicating potential for broader applications of their technology.
Financially, Carisma is robust, with $94.1 million in cash, cash equivalents, and marketable securities as of September 30, 2023. This financial stability enables the company to sustain its planned operations into the first quarter of 2025.
For more information, please visit www.carismatx.com.
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